Sejuani - League of Legends Champion
Win Rate
48.7%
Pick Rate
1.3%

Sejuanivs Vayne

FTank
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 12, 2026
MethodologyData Methodology

Sejuani vs Vayne is a decisive matchup in LoL patch 26.5. Sejuani wins with a 80.0% win rate (+60.0%) over Vayne based on 5 games. Sejuani holds the advantage in both the early and late game. Below you'll find the best Sejuani build, runes, laning stats, and strategies for the Sejuani vs Vayne matchup.

Sejuani Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Sejuani performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 80.0% win rateVayne(80.0%)
Sejuani - 80.0% win rate in this matchup
Sejuani
80.0% WR
VS
Vayne vs Sejuani matchup - 20.0% win rate
Vayne
20.0% WR

Who Wins the Sejuani vs Vayne Matchup?

Sejuani wins the Sejuani vs Vayne matchup
Winner
Sejuani
Matches: 5
80.0%
Win Rate
20.0%
5.7
CS / min
5.4
728
DMG / min
719
12,861
Gold / game
11,350
241
Heal / min
183
1,519
DMG Mitigated / min
470
1.1
CC / min
0.3
100.0%
Early Game WR
0.0%
66.7%
Late Game WR
33.3%

Sejuani vs Vayne Matchup Summary

The Sejuani vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Sejuani wins with a 80.0% win rate compared to Vayne's 20.0%, giving Sejuani a 60.0 percentage point advantage. Sejuani dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Sejuani leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Sejuani players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Sejuani vs Vayne Laning Phase Breakdown

Sejuani wins the laning phase against Vayne in League of Legends

Sejuani is favored during the laning phase against Vayne, winning 5 out of 5 key stat categories. Sejuani holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
5.7Sejuani
5.4Vayne
Sejuani and Vayne farm at nearly identical rates in this matchup, with only a 0.3 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
728Sejuani
719Vayne
Damage output is virtually even between Sejuani and Vayne, with only 9 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
12,861Sejuani
11,350Vayne
Sejuani generates a commanding 1,511 more gold per game than Vayne. This substantial economic advantage means Sejuani consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Sejuani
0.3Vayne
Sejuani provides 0.8 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Sejuani coordinate with their jungler and control the pace of skirmishes.
Sustain
1,761Sejuani
654Vayne
Sejuani vastly out-sustains Vayne, healing and mitigating 1,107 more damage per minute. This massive durability gap means Sejuani can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Sejuani Build Against Vayne

Plated Steelcaps is the optimal boots choice against Vayne, providing the mobility and stats Sejuani needs most in this matchup. The top-performing core items for Sejuani against Vayne are Bloodletter's Curse, Riftmaker and Hextech Rocketbelt. This combination gives Sejuani an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Sejuani vs Vayne matchup.

Early Game vs Late Game

Early Game
Sejuani
100.0%
+100.0% advantage
Sejuani early game win rateSejuani100.0%
Vayne early game win rateVayne0.0%
Late Game
Sejuani
66.7%
+33.3% advantage
Sejuani late game win rateSejuani66.7%
Vayne late game win rateVayne33.3%

Sejuani dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Vayne. This lopsided early game means Sejuani can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Sejuani is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Vayne. Extended games heavily favor Sejuani, whose kit and scaling make them a dominant force in team fights and objective control.

Sejuani holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Sejuani Runes Against Vayne

Sorcery rune tree - Sejuani primary runes vs VayneSorcery
Arcane Comet - best Sejuani rune vs VayneManaflow Band - best Sejuani rune vs VayneTranscendence - best Sejuani rune vs VayneScorch - best Sejuani rune vs Vayne
Resolve rune tree - Sejuani secondary runes vs VayneResolve
Unflinching - best Sejuani rune vs VayneSecond Wind - best Sejuani rune vs Vayne
100.0% WR

Running Sorcery primary with Resolve secondary allows Sejuani to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Sejuani matchup data for League of Legends patch 26.5. The table below shows Sejuani's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Sejuani build, runes, laning stats, and early vs late game analysis for that specific matchup.

Sejuani matchup win rates and stats in League of Legends patch 26.5
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.62%420.959412,20235.0%59.1%
33.33%391.055212,04231.3%34.8%
46.15%390.957011,02355.0%36.8%
44.74%381.261812,12426.7%56.5%
48.57%351.860010,93158.8%38.9%
58.06%311.156411,71163.6%55.0%
50.00%301.163613,00140.0%60.0%
50.00%281.056211,27645.5%52.9%
42.86%281.056812,11160.0%33.3%
62.96%270.964613,35771.4%60.0%
65.38%261.163312,34781.8%53.3%
54.17%241.166112,29642.9%58.8%
62.50%241.468313,14170.0%57.1%
45.83%241.372610,89961.5%27.3%
47.83%231.058812,12450.0%46.7%
60.87%231.162812,82266.7%58.8%
33.33%211.860512,26244.4%25.0%
38.10%211.257812,10257.1%28.6%
42.11%191.775311,45025.0%54.5%
36.84%193.983510,63754.5%12.5%
36.84%191.067112,40950.0%30.8%
33.33%183.470810,93245.5%14.3%
47.06%171.366512,26137.5%55.6%
47.06%171.365712,55133.3%54.5%
41.18%171.157811,98742.9%40.0%
35.29%171.359210,88120.0%57.1%
43.75%162.765112,65940.0%45.5%
33.33%151.156311,46428.6%37.5%
53.33%151.056811,91042.9%62.5%
50.00%142.262212,10650.0%50.0%
50.00%145.693113,57775.0%40.0%
50.00%142.174512,65171.4%28.6%
61.54%132.769013,17966.7%60.0%
46.15%131.165712,50550.0%42.9%
46.15%130.74379,75357.1%33.3%
61.54%131.366012,33080.0%50.0%
53.85%132.164811,24428.6%83.3%
58.33%120.650410,58466.7%50.0%
58.33%122.663912,28266.7%50.0%
60.00%102.55879,77642.9%100.0%
33.33%91.982812,74533.3%33.3%
66.67%95.91,03814,85850.0%71.4%
75.00%81.154213,22666.7%80.0%
62.50%81.059511,8790.0%100.0%
37.50%80.861712,65466.7%20.0%
62.50%81.061912,2700.0%83.3%
25.00%81.069813,6980.0%25.0%
50.00%82.163611,22566.7%40.0%
50.00%81.175714,69850.0%50.0%
12.50%83.271310,04216.7%0.0%
12.50%84.36519,0150.0%33.3%
42.86%70.959612,66166.7%25.0%
71.43%73.268814,306100.0%60.0%
28.57%73.65739,11933.3%25.0%
57.14%72.174711,273100.0%50.0%
33.33%62.771811,6190.0%50.0%
33.33%64.91,06114,0460.0%40.0%
50.00%60.855911,9150.0%75.0%
100.00%61.745711,417100.0%100.0%
50.00%62.64568,41950.0%50.0%
50.00%65.675310,72666.7%33.3%
40.00%54.26188,87433.3%50.0%
60.00%53.15929,45750.0%100.0%
60.00%55.594510,82750.0%66.7%
20.00%56.069914,1410.0%20.0%
80.00%55.772812,861100.0%66.7%
60.00%51.268713,4810.0%75.0%
60.00%51.966511,26750.0%66.7%
20.00%54.566811,4130.0%20.0%
40.00%55.576213,3820.0%40.0%
40.00%50.94399,66850.0%0.0%

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Sejuani vs Vayne - Frequently Asked Questions

How does Sejuani do against Vayne in League of Legends?

Sejuani wins the Sejuani vs Vayne matchup with a 80.0% win rate compared to Vayne's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.5.

How does Sejuani do against Vayne in the early game?

In the early game, Sejuani has the advantage against Vayne with a 100.0% win rate versus 0.0%. Sejuani players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Sejuani do against Vayne in the late game?

In the late game, Sejuani takes over the Sejuani vs Vayne matchup with a 66.7% win rate compared to 33.3%. Sejuani scales better into team fights and objective contests after 25 minutes.

Who wins the Sejuani vs Vayne matchup?

Sejuani wins the matchup against Vayne with a 80.0% win rate in League of Legends patch 26.5. The 60.0 percentage point advantage means Sejuani is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Sejuani build against Vayne?

The best Sejuani build against Vayne includes Bloodletter's Curse, Riftmaker, Hextech Rocketbelt with Plated Steelcaps. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Sejuani runes against Vayne?

The best Sejuani runes against Vayne use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Sejuani vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Sejuani counter Vayne?

Yes, Sejuani has a favorable matchup against Vayne with a 80.0% win rate. Sejuani strongly counters Vayne in lane based on current patch 26.5 data.

How do I play Sejuani against Vayne?

When playing Sejuani against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.