Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Sejuani

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 26, 2026
MethodologyData Methodology

Vayne vs Sejuani is a decisive matchup in LoL patch 26.7. Vayne wins with a 60.0% win rate (+20.0%) over Sejuani based on 5 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Sejuani matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Sejuani - 60.0% win rateSejuani(60.0%)
Vayne - 60.0% win rate in this matchup
Vayne
60.0% WR
VS
Sejuani vs Vayne matchup - 40.0% win rate
Sejuani
40.0% WR

Who Wins the Vayne vs Sejuani Matchup?

Vayne wins the Vayne vs Sejuani matchup
Winner
Vayne
Matches: 5
60.0%
Win Rate
40.0%
5.3
CS / min
4.5
1,100
DMG / min
663
15,380
Gold / game
12,440
288
Heal / min
264
571
DMG Mitigated / min
1,814
0.4
CC / min
1.1
100.0%
Early Game WR
0.0%
50.0%
Late Game WR
50.0%

Vayne vs Sejuani Matchup Summary

The Vayne vs Sejuani matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Vayne wins with a 60.0% win rate compared to Sejuani's 40.0%, giving Vayne a 20.0 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Sejuani players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Sejuani leads by 0.7s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Sejuani and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Sejuani away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Sejuani Laning Phase Breakdown

Vayne wins the laning phase against Sejuani in League of Legends

Vayne is favored during the laning phase against Sejuani, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.3Vayne
4.5Sejuani
Vayne edges out Sejuani by 0.8 CS per minute — a moderate farming advantage that adds up to roughly 12 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
1,100Vayne
663Sejuani
Vayne heavily out-damages Sejuani by 436 DMG/min, dominating both short trades and all-in fights. Sejuani should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
15,380Vayne
12,440Sejuani
Vayne generates a commanding 2,940 more gold per game than Sejuani. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Sejuani should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
1.1Sejuani
Sejuani provides 0.7 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Sejuani coordinate with their jungler and control the pace of skirmishes.
Sustain
859Vayne
2,078Sejuani
Sejuani vastly out-sustains Vayne, healing and mitigating 1,219 more damage per minute. This massive durability gap means Sejuani can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Sejuani

Berserker's Greaves is the optimal boots choice against Sejuani, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Sejuani are Blade of The Ruined King, Guinsoo's Rageblade and Wit's End. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Sejuani matchup.

Early Game vs Late Game

Early Game
Vayne
100.0%
+100.0% advantage
Vayne early game win rateVayne100.0%
Sejuani early game win rateSejuani0.0%
Late Game
Vayne
50.0%
+0.0% advantage
Vayne late game win rateVayne50.0%
Sejuani late game win rateSejuani50.0%

Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Sejuani. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Vayne at 50.0% win rate — only 0.0 points ahead of Sejuani. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Sejuani players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Sejuani

Precision rune tree - Vayne primary runes vs SejuaniPrecision
Fleet Footwork - best Vayne rune vs SejuaniAbsorb Life - best Vayne rune vs SejuaniLegend: Alacrity - best Vayne rune vs SejuaniCut Down - best Vayne rune vs Sejuani
Sorcery rune tree - Vayne secondary runes vs SejuaniSorcery
Celerity - best Vayne rune vs SejuaniNimbus Cloak - best Vayne rune vs Sejuani
100.0% WR

Running Precision primary with Sorcery secondary allows Vayne to press their advantage against Sejuani, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Sejuani - Frequently Asked Questions

How does Vayne do against Sejuani in League of Legends?

Vayne wins the Vayne vs Sejuani matchup with a 60.0% win rate compared to Sejuani's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.7.

How does Vayne do against Sejuani in the early game?

In the early game, Vayne has the advantage against Sejuani with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Sejuani in the late game?

In the late game, Vayne takes over the Vayne vs Sejuani matchup with a 50.0% win rate compared to 50.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Sejuani matchup?

Vayne wins the matchup against Sejuani with a 60.0% win rate in League of Legends patch 26.7. The 20.0 percentage point advantage means Vayne is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Vayne build against Sejuani?

The best Vayne build against Sejuani includes Blade of The Ruined King, Guinsoo's Rageblade, Wit's End with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Sejuani?

The best Vayne runes against Sejuani use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Sejuani matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Sejuani?

Yes, Vayne has a favorable matchup against Sejuani with a 60.0% win rate. Vayne strongly counters Sejuani in lane based on current patch 26.7 data.

How do I play Vayne against Sejuani?

When playing Vayne against Sejuani, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.