- Win Rate
- 49.8%
- Pick Rate
- 4.2%
- Ban Rate
- 5.0%
Vayne vs Caitlyn
- Patch
- 26.21
- Games
- 8,410
- Lane
- All Lanes
- Tier
- All Tiers
- Last Updated
- Nov 3, 2026 UTC
- Author
- Dakota Chinnick
- Methodology
- Data Methodology
Vayne vs Caitlyn is a very close matchup in LoL patch 26.21. Caitlyn wins with a 50.9% win rate (+1.7%) over Vayne based on 649 games. Caitlyn wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Caitlyn matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who wins Vayne vs Caitlyn?
Vayne wins 49.7% of these games. With this many games the true rate is most likely between 45.7% and 53.6% (95% range).
- Expected
- 50.3% From both champions' overall Bot win rates
- Matchup effect
- −0.6 pts Observed minus expected
- Sample
- 610 games Lane: Bot
- vs patch 26.20
- +1.5 pts Within normal patch-to-patch noise
Lane: Bot · Ranked Solo/Duo & Flex · North America server · All ranks · Patch 26.21 · Oct 27 – Nov 3
They also met in another lane (Top): 4 games, Vayne won 50.0%.
Key takeaways
- Vayne vs Caitlyn is an even matchup: Vayne wins 49.7% of 610 games, and the 95% range (45.7–53.6%) comfortably includes 50%.
- Both champions' overall Bot win rates predict 50.3% for Vayne; the result is within the margin of error of that, so this matchup mostly reflects the two champions' general strength.
- Caitlyn usually wins the lane: 565 gold ahead of Vayne at 15 minutes on average (602 games with a 15-minute snapshot).
- Vayne players pick Guinsoo's Rageblade much less often against Caitlyn: 60.7% of their other Bot games, 55.4% here.
How we calculate this
Games: ranked Solo/Duo and Flex games on the North America server from the patch shown. Remakes (games under 5 minutes) are excluded.
A game only counts when Vayne and Caitlyn played the same position on opposite teams, so roaming, lane swaps within a team or a champion merely being in the same game never count as this matchup.
The 95% range is a Wilson score interval. Confidence comes from how wide that range is: within ±3 points is very high, ±5 high, ±8 moderate, anything wider low. Below 20 games a matchup is not classified at all.
Expected win rate combines both champions’ win rates in this lane (same games and filters) with the log5 formula: E = A(1−B) / (A(1−B) + B(1−A)). Matchup effect = observed − expected.
"What changes" compares Vayne's choices in this matchup with the same champion's other games in the same lane, and lists a change only when it is at least 3 points and statistically significant (two-proportion z-test, |z| ≥ 2, 20+ games).
Results are not split by rank: the sample per rank is too small for honest per-rank matchup numbers.
Vayne vs Caitlyn Laning Stats
At 15 minutes
Whole-game averages
Vayne vs Caitlyn Win Rate by Game Length
Vayne's win rate against Caitlyn by game length. The dot is the win rate, the bar its 95% range and the dashed line the champion's usual win rate at that length. Lengths with fewer than 25 games are left blank.
No game length stands out: Vayne's results against Caitlyn in short and long games are within the margin of error of each other.
Vayne vs Caitlyn Power Spikes
Who is ahead at each stage, measured from these games. A stage reads "Even" when the difference is inside the margin of error, and "Insufficient data" when there are too few games to tell.
- Lane (15 min)CaitlynVayne gold at 15: −565
- First itemCaitlynVayne: 13.6 min · Caitlyn: 11.6 min
- Games under 20 minInsufficient data
- 20–30 min gamesEvenVayne wins 49.1% of 222 games
- 30+ min gamesEvenVayne wins 50.1% of 349 games
What Vayne Changes Against Caitlyn
Choices Vayne players make noticeably more or less often in this matchup than in their other Bot games.
Usually60.7%vs Caitlyn55.4%−5.3 pts55.6% WR here- Q > W > Ethe Q > W > E skill orderSkill priorityUsually85.8%vs Caitlyn82.6%−3.2 pts50.8% WR here
Best Vayne Build vs Caitlyn
Usual Vayne build (Bot)
58.5% win rate · 410 games
Against Caitlyn
Not enough matchup-specific build data: only 11 of 427 Vayne games against Caitlyn carried a complete build, which is too few to recommend an item path from. Use Vayne's standard build instead.
- Vayne usually completes Blade of The Ruined King first, at 13.6 min (median of 323 games).
- Caitlyn usually completes The Collector first, at 11.6 min (median of 266 games).
- Skill priority: Q > W > E — the same as usual.
Builds are ranked by the lower edge of their win rate range, not the raw win rate, so a build seen in a handful of wins never outranks a proven one.
Best Vayne Runes vs Caitlyn
Usual Vayne runes (Bot)
Lethal Tempo
50.7% win rate · 3,727 games
Against Caitlyn
Lethal Tempo52.3% win rate · 331 games
Plan your Vayne draft in Draft Lab
Draft Lab lays out both teams lane by lane with live matchup win rates, damage profiles and game-phase lean, and suggests picks and bans from current meta data.
- Full 5v5 draft board
- Lane matchup win rates
- Pick and ban suggestions
Vayne matchup data for League of Legends patch 26.21. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Other Vayne Matchups
Hardest for Vayne
Easiest for Vayne
Win rate and games for each matchup. Lists are ranked by the edge of the 95% range so small samples cannot top them; matchups with at least 50 games only.
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Vayne vs Caitlyn FAQ - Patch 26.21
Who wins Vayne vs Caitlyn?
Vayne vs Caitlyn is an even matchup: Vayne wins 49.7% of 610 games, and the 95% range (45.7–53.6%) comfortably includes 50%.
What is Vayne's win rate against Caitlyn?
Vayne wins 49.7% of 610 Bot games against Caitlyn on patch 26.21 (95% range 45.7–53.6%). Based on both champions' overall Bot win rates, 50.3% would be expected.
Does Vayne counter Caitlyn?
Not clearly. Vayne wins 49.7% of 610 games against Caitlyn, and the 95% range (45.7–53.6%) includes 50%, so neither champion reliably counters the other on current data.
Who wins lane, Vayne or Caitlyn?
Caitlyn usually wins the lane: 565 gold ahead of Vayne at 15 minutes on average (602 games with a 15-minute snapshot).
Does Vayne outscale Caitlyn?
Not measurably: Vayne's win rate against Caitlyn in games of 25 minutes or less and in longer games is within the margin of error of each other.
When is Caitlyn strongest against Vayne?
Caitlyn is measurably ahead in: Lane (15 min), First item.
What should Vayne build against Caitlyn?
There are not enough games for a matchup-specific core, so use Vayne's usual Bot core: Jak'Sho, The Protean, Terminus, Blade of The Ruined King. The biggest change against Caitlyn: Guinsoo's Rageblade (60.7% usually, 55.4% here).
What runes should Vayne use against Caitlyn?
Lethal Tempo with Precision and Resolve — 52.3% over 331 games against Caitlyn.