Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Caitlyn

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 22, 2026
MethodologyData Methodology

Vayne vs Caitlyn is a very close matchup in LoL patch 26.7. Caitlyn wins with a 51.0% win rate (+2.0%) over Vayne based on 357 games. Caitlyn wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Caitlyn matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Caitlyn - 49.0% win rateCaitlyn(49.0%)
Vayne - 49.0% win rate in this matchup
Vayne
49.0% WR
VS
Caitlyn vs Vayne matchup - 51.0% win rate
Caitlyn
51.0% WR

Who Wins the Vayne vs Caitlyn Matchup?

Caitlyn wins the Vayne vs Caitlyn matchup
Winner
Caitlyn
Matches: 357
49.0%
Win Rate
51.0%
6.0
CS / min
6.8
817
DMG / min
908
13,231
Gold / game
13,797
225
Heal / min
167
490
DMG Mitigated / min
391
0.4
CC / min
0.6
45.3%
Early Game WR
54.7%
52.0%
Late Game WR
48.0%

Vayne vs Caitlyn Matchup Summary

The Vayne vs Caitlyn matchup is a very close matchup in League of Legends ranked play. Based on 357 recent matches analyzed, Caitlyn wins with a 51.0% win rate compared to Vayne's 49.0%, giving Caitlyn a 2.0 percentage point advantage. Game phase dynamics play a critical role here: Caitlyn controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Caitlyn needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Caitlyn leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. While Caitlyn is slightly favored, Vayne can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Caitlyn's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Caitlyn Laning Phase Breakdown

Caitlyn wins the laning phase against Vayne in League of Legends

Caitlyn is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Caitlyn holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.0Vayne
6.8Caitlyn
Caitlyn significantly out-farms Vayne by 0.9 CS per minute, accumulating an estimated 13 CS lead by mid game. This substantial farming gap gives Caitlyn a major gold advantage and earlier item completions. Vayne players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
817Vayne
908Caitlyn
Caitlyn heavily out-damages Vayne by 91 DMG/min, dominating both short trades and all-in fights. Vayne should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Caitlyn's sustained damage advantage take over.
Economy
13,231Vayne
13,797Caitlyn
Caitlyn earns 566 more gold per game than Vayne, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Caitlyn slightly faster item completions.
Utility
0.4Vayne
0.6Caitlyn
Both Vayne and Caitlyn provide similar amounts of crowd control (0.3s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
715Vayne
558Caitlyn
Vayne vastly out-sustains Caitlyn, healing and mitigating 157 more damage per minute. This massive durability gap means Vayne can absorb significant punishment and remain in lane while Caitlyn is forced to recall. Building grievous wounds early is essential for Caitlyn, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Caitlyn

Plated Steelcaps is the optimal boots choice against Caitlyn, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Caitlyn are Jak'Sho, The Protean, Randuin's Omen and Stormrazor. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Caitlyn matchup.

Early Game vs Late Game

Early Game
Caitlyn
54.7%
+9.4% advantage
Vayne early game win rateVayne45.3%
Caitlyn early game win rateCaitlyn54.7%
Late Game
Vayne
52.0%
+4.0% advantage
Vayne late game win rateVayne52.0%
Caitlyn late game win rateCaitlyn48.0%

Caitlyn dominates the early game (first 15 minutes) with a commanding 54.7% win rate — a 9.4 percentage point lead over Vayne. This lopsided early game means Caitlyn can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

In the late game (25+ minutes), Vayne takes over with a 52.0% win rate, leading Caitlyn by 4.0 percentage points. Vayne scales more effectively into team fights and objective contests.

This matchup features a dramatic power shift: Caitlyn must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Caitlyn

Precision rune tree - Vayne primary runes vs CaitlynPrecision
Lethal Tempo - best Vayne rune vs CaitlynTriumph - best Vayne rune vs CaitlynLegend: Alacrity - best Vayne rune vs CaitlynCoup de Grace - best Vayne rune vs Caitlyn
Resolve rune tree - Vayne secondary runes vs CaitlynResolve
Conditioning - best Vayne rune vs CaitlynOvergrowth - best Vayne rune vs Caitlyn
51.2% WR

The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Caitlyn.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

Get the MetaBot Desktop App

Level up your gameplay with real-time overlays, automatic game detection, and instant stats — all on your desktop.

In-game overlaysAuto game detectionMulti-game supportPersonal dashboard
Download NowFree download
🔍

Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.

Report an Issue

Vayne vs Caitlyn - Frequently Asked Questions

How does Vayne do against Caitlyn in League of Legends?

Caitlyn wins the Vayne vs Caitlyn matchup with a 51.0% win rate compared to Vayne's 49.0%, a 2.0 percentage point difference. This data is based on 357 recent ranked games in patch 26.7.

How does Vayne do against Caitlyn in the early game?

In the early game, Caitlyn has the advantage against Vayne with a 54.7% win rate versus 45.3%. Caitlyn players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Caitlyn in the late game?

In the late game, Vayne takes over the Vayne vs Caitlyn matchup with a 52.0% win rate compared to 48.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Caitlyn matchup?

Caitlyn wins the matchup against Vayne with a 51.0% win rate in League of Legends patch 26.7. The 2.0 percentage point advantage means Caitlyn is slightly favored in this lane matchup based on 357 games analyzed.

What is the best Vayne build against Caitlyn?

The best Vayne build against Caitlyn includes Jak'Sho, The Protean, Randuin's Omen, Stormrazor with Plated Steelcaps. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Caitlyn?

The best Vayne runes against Caitlyn use the Precision primary tree with Resolve secondary. This rune setup achieves a 51.2% win rate in the Vayne vs Caitlyn matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Caitlyn?

No, Vayne struggles against Caitlyn with only a 49.0% win rate. Caitlyn has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Caitlyn's lead.

How do I play Vayne against Caitlyn?

When playing Vayne against Caitlyn, play cautiously and avoid Caitlyn's power spikes. Focus on safe farming — you outscale Caitlyn in the late game. Use the matchup-specific build and runes above to optimize your chances.