Caitlynvs Vayne
Caitlyn vs Vayne is a decisive matchup in LoL patch 26.5. Caitlyn wins with a 54.8% win rate (+9.6%) over Vayne based on 343 games. Caitlyn holds the advantage in both the early and late game. Below you'll find the best Caitlyn build, runes, laning stats, and strategies for the Caitlyn vs Vayne matchup.
Caitlyn Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Caitlyn performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(54.8%)Who Wins the Caitlyn vs Vayne Matchup?
Caitlyn vs Vayne Matchup Summary
The Caitlyn vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 343 recent matches analyzed, Caitlyn wins with a 54.8% win rate compared to Vayne's 45.2%, giving Caitlyn a 9.6 percentage point advantage. Caitlyn dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Caitlyn leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Caitlyn players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Caitlyn vs Vayne Laning Phase Breakdown
Caitlyn is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Caitlyn holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.
Best Caitlyn Build Against Vayne
Berserker's Greaves is the optimal boots choice against Vayne, providing the mobility and stats Caitlyn needs most in this matchup. The top-performing core items for Caitlyn against Vayne are The Collector, Rapid Firecannon and Lord Dominik's Regards. This combination gives Caitlyn an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Caitlyn vs Vayne matchup.
Early Game vs Late Game
Caitlyn57.1%Vayne42.9%Caitlyn52.9%Vayne47.1%Caitlyn dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Vayne. This lopsided early game means Caitlyn can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Caitlyn is far superior in the late game (25+ minutes), boasting a 52.9% win rate — 5.8 points above Vayne. Extended games heavily favor Caitlyn, whose kit and scaling make them a dominant force in team fights and objective control.
Caitlyn holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Caitlyn Runes Against Vayne
Precision
Sorcery
Running Precision primary with Sorcery secondary allows Caitlyn to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Caitlyn matchup data for League of Legends patch 26.5. The table below shows Caitlyn's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Caitlyn build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 47.83% | 968 | 6.6 | 844 | 13,563 | 47.0% | 48.5% | |
| 45.94% | 849 | 6.9 | 909 | 13,818 | 43.6% | 48.0% | |
| 49.23% | 840 | 6.9 | 864 | 13,830 | 53.6% | 46.1% | |
| 45.75% | 612 | 6.8 | 838 | 13,415 | 45.5% | 46.0% | |
| 50.54% | 560 | 7.0 | 883 | 13,737 | 48.0% | 52.6% | |
| 47.84% | 485 | 7.0 | 899 | 13,913 | 49.3% | 46.8% | |
| 51.37% | 438 | 7.0 | 911 | 14,320 | 53.8% | 49.6% | |
| 54.81% | 343 | 6.8 | 964 | 14,441 | 57.1% | 52.9% | |
| 50.16% | 317 | 6.7 | 798 | 13,481 | 61.3% | 41.1% | |
| 46.81% | 282 | 6.6 | 884 | 13,656 | 48.8% | 45.3% | |
| 50.00% | 270 | 7.1 | 867 | 13,706 | 52.6% | 47.4% | |
| 52.19% | 251 | 6.6 | 892 | 13,842 | 54.8% | 50.0% | |
| 53.66% | 246 | 6.9 | 903 | 13,699 | 57.1% | 50.4% | |
| 49.17% | 240 | 7.0 | 894 | 13,906 | 56.1% | 41.9% | |
| 55.17% | 232 | 7.0 | 864 | 14,137 | 56.0% | 54.6% | |
| 54.95% | 202 | 7.0 | 981 | 14,730 | 60.5% | 51.2% | |
| 50.79% | 190 | 6.6 | 865 | 13,158 | 50.0% | 51.8% | |
| 49.18% | 183 | 6.8 | 831 | 13,572 | 43.8% | 52.7% | |
| 48.28% | 116 | 6.8 | 854 | 13,423 | 49.0% | 47.8% | |
| 47.37% | 114 | 6.5 | 976 | 13,683 | 36.6% | 53.4% | |
| 49.56% | 113 | 7.2 | 894 | 14,219 | 48.0% | 50.8% | |
| 54.46% | 112 | 6.9 | 972 | 13,884 | 58.2% | 50.9% | |
| 52.68% | 112 | 6.7 | 771 | 13,257 | 46.0% | 58.1% | |
| 33.96% | 106 | 6.8 | 832 | 13,272 | 23.3% | 41.3% | |
| 49.50% | 101 | 6.8 | 849 | 13,980 | 43.2% | 53.1% | |
| 52.69% | 93 | 6.7 | 873 | 14,640 | 56.8% | 50.0% | |
| 44.94% | 89 | 7.2 | 1,001 | 13,961 | 47.5% | 42.9% | |
| 58.44% | 77 | 6.8 | 1,029 | 15,173 | 56.7% | 59.6% | |
| 64.00% | 75 | 6.9 | 1,004 | 15,142 | 76.3% | 51.4% | |
| 55.00% | 40 | 6.6 | 803 | 14,614 | 53.3% | 56.0% | |
| 51.28% | 39 | 6.8 | 858 | 14,498 | 55.6% | 47.6% | |
| 42.11% | 38 | 6.6 | 670 | 12,691 | 50.0% | 37.5% | |
| 55.26% | 38 | 7.2 | 924 | 15,113 | 46.1% | 60.0% | |
| 30.00% | 30 | 6.5 | 868 | 13,789 | 33.3% | 26.7% | |
| 60.71% | 28 | 6.7 | 860 | 15,073 | 33.3% | 73.7% | |
| 55.00% | 20 | 6.2 | 727 | 13,067 | 55.6% | 54.5% | |
| 61.11% | 18 | 6.0 | 866 | 15,861 | 50.0% | 70.0% | |
| 47.06% | 17 | 7.2 | 884 | 14,359 | 50.0% | 45.5% | |
| 42.86% | 14 | 7.1 | 860 | 11,583 | 44.4% | 40.0% | |
| 57.14% | 14 | 6.8 | 958 | 14,530 | 57.1% | 57.1% | |
| 35.71% | 14 | 6.5 | 1,086 | 14,349 | 57.1% | 14.3% | |
| 50.00% | 12 | 6.8 | 1,078 | 15,339 | 50.0% | 50.0% | |
| 60.00% | 10 | 6.9 | 836 | 14,641 | 40.0% | 80.0% | |
| 55.56% | 9 | 6.4 | 838 | 15,529 | 100.0% | 42.9% | |
| 44.44% | 9 | 6.5 | 884 | 14,910 | 0.0% | 57.1% | |
| 66.67% | 9 | 7.4 | 1,289 | 14,406 | 80.0% | 50.0% | |
| 44.44% | 9 | 6.5 | 698 | 15,063 | 66.7% | 33.3% | |
| 44.44% | 9 | 5.8 | 797 | 11,830 | 100.0% | 16.7% | |
| 55.56% | 9 | 6.3 | 777 | 12,072 | 50.0% | 60.0% | |
| 55.56% | 9 | 7.0 | 1,115 | 15,240 | 50.0% | 60.0% | |
| 50.00% | 8 | 7.5 | 783 | 12,528 | 66.7% | 40.0% | |
| 25.00% | 8 | 7.4 | 852 | 11,262 | 25.0% | 25.0% | |
| 50.00% | 8 | 7.7 | 1,215 | 14,372 | 66.7% | 40.0% | |
| 50.00% | 8 | 6.9 | 1,192 | 13,511 | 60.0% | 33.3% | |
| 75.00% | 8 | 6.5 | 815 | 15,293 | 0.0% | 85.7% | |
| 42.86% | 7 | 6.6 | 822 | 14,914 | 0.0% | 50.0% | |
| 16.67% | 6 | 6.9 | 944 | 8,718 | 20.0% | 0.0% | |
| 16.67% | 6 | 6.5 | 817 | 14,155 | 0.0% | 33.3% | |
| 0.00% | 6 | 6.7 | 779 | 10,927 | 0.0% | 0.0% | |
| 100.00% | 5 | 5.9 | 799 | 11,313 | 100.0% | 100.0% | |
| 40.00% | 5 | 6.2 | 854 | 16,166 | 0.0% | 40.0% | |
| 60.00% | 5 | 6.7 | 1,139 | 12,502 | 33.3% | 100.0% | |
| 20.00% | 5 | 6.8 | 752 | 14,238 | 50.0% | 0.0% | |
| 80.00% | 5 | 7.3 | 1,003 | 12,345 | 100.0% | 50.0% | |
| 60.00% | 5 | 6.7 | 653 | 13,925 | 100.0% | 33.3% | |
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Caitlyn vs Vayne - Frequently Asked Questions
How does Caitlyn do against Vayne in League of Legends?
Caitlyn wins the Caitlyn vs Vayne matchup with a 54.8% win rate compared to Vayne's 45.2%, a 9.6 percentage point difference. This data is based on 343 recent ranked games in patch 26.5.
How does Caitlyn do against Vayne in the early game?
In the early game, Caitlyn has the advantage against Vayne with a 57.1% win rate versus 42.9%. Caitlyn players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Caitlyn do against Vayne in the late game?
In the late game, Caitlyn takes over the Caitlyn vs Vayne matchup with a 52.9% win rate compared to 47.1%. Caitlyn scales better into team fights and objective contests after 25 minutes.
Who wins the Caitlyn vs Vayne matchup?
Caitlyn wins the matchup against Vayne with a 54.8% win rate in League of Legends patch 26.5. The 9.6 percentage point advantage means Caitlyn is significantly favored in this lane matchup based on 343 games analyzed.
What is the best Caitlyn build against Vayne?
The best Caitlyn build against Vayne includes The Collector, Rapid Firecannon, Lord Dominik's Regards with Berserker's Greaves. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Caitlyn runes against Vayne?
The best Caitlyn runes against Vayne use the Precision primary tree with Sorcery secondary. This rune setup achieves a 56.3% win rate in the Caitlyn vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Caitlyn counter Vayne?
Yes, Caitlyn has a favorable matchup against Vayne with a 54.8% win rate. Caitlyn strongly counters Vayne in lane based on current patch 26.5 data.
How do I play Caitlyn against Vayne?
When playing Caitlyn against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.