Caitlynvs Vayne
Caitlyn vs Vayne is a moderate matchup in LoL patch 26.9. Caitlyn wins with a 51.9% win rate (+3.8%) over Vayne based on 131 games. Caitlyn wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Caitlyn build, runes, laning stats, and strategies for the Caitlyn vs Vayne matchup.
Caitlyn Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Caitlyn performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(51.9%)Who Wins the Caitlyn vs Vayne Matchup?
Caitlyn vs Vayne Matchup Summary
The Caitlyn vs Vayne matchup is a moderate matchup in League of Legends ranked play. Based on 131 recent matches analyzed, Caitlyn wins with a 51.9% win rate compared to Vayne's 48.1%, giving Caitlyn a 3.8 percentage point advantage. Game phase dynamics play a critical role here: Caitlyn controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Caitlyn needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Caitlyn leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Caitlyn has a statistical edge, but the margin is close enough that respecting Vayne's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Caitlyn vs Vayne Laning Phase Breakdown
Caitlyn is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Caitlyn holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.
Early Game vs Late Game
Caitlyn55.2%Vayne44.8%Caitlyn49.3%Vayne50.7%Caitlyn dominates the early game (first 15 minutes) with a commanding 55.2% win rate — a 10.3 percentage point lead over Vayne. This lopsided early game means Caitlyn can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Late game (25+ minutes) is equally balanced, with Vayne at 50.7% win rate — only 1.4 points ahead of Caitlyn. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.
The power dynamics shift as the game progresses — Caitlyn has the edge early, but Vayne gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Caitlyn Runes Against Vayne
Inspiration
Sorcery
Running Inspiration primary with Sorcery secondary allows Caitlyn to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Caitlyn matchup data for League of Legends patch 26.9. The table below shows Caitlyn's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Caitlyn build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 47.35% | 245 | 6.7 | 805 | 12,722 | 47.1% | 47.5% | |
| 50.75% | 201 | 6.8 | 883 | 13,393 | 49.5% | 51.9% | |
| 45.16% | 186 | 6.5 | 838 | 12,939 | 42.2% | 47.6% | |
| 53.85% | 182 | 7.0 | 913 | 13,345 | 56.4% | 51.9% | |
| 44.51% | 173 | 7.0 | 876 | 13,568 | 52.7% | 38.4% | |
| 63.64% | 143 | 7.1 | 927 | 14,521 | 56.0% | 67.7% | |
| 51.91% | 131 | 6.8 | 909 | 13,221 | 55.2% | 49.3% | |
| 46.51% | 129 | 7.1 | 876 | 14,166 | 47.9% | 45.7% | |
| 46.05% | 76 | 6.9 | 855 | 13,407 | 45.2% | 46.7% | |
| 43.28% | 67 | 6.6 | 962 | 14,843 | 42.9% | 43.5% | |
| 51.52% | 66 | 6.6 | 880 | 14,014 | 51.7% | 51.4% | |
| 44.83% | 58 | 6.8 | 783 | 12,134 | 46.4% | 43.3% | |
| 50.00% | 56 | 6.7 | 873 | 13,287 | 30.8% | 66.7% | |
| 38.00% | 50 | 6.9 | 815 | 12,687 | 33.3% | 42.3% | |
| 62.00% | 50 | 7.0 | 922 | 13,875 | 57.1% | 65.5% | |
| 58.33% | 48 | 7.2 | 984 | 13,848 | 68.4% | 51.7% | |
| 44.44% | 45 | 6.6 | 895 | 14,039 | 33.3% | 50.0% | |
| 44.44% | 45 | 7.1 | 865 | 13,268 | 47.6% | 41.7% | |
| 42.22% | 45 | 6.9 | 906 | 14,257 | 46.7% | 40.0% | |
| 48.39% | 31 | 6.7 | 837 | 13,031 | 41.7% | 52.6% | |
| 48.39% | 31 | 7.2 | 855 | 12,167 | 50.0% | 47.1% | |
| 68.97% | 29 | 7.1 | 971 | 13,001 | 66.7% | 71.4% | |
| 50.00% | 22 | 7.2 | 1,154 | 13,688 | 40.0% | 58.3% | |
| 31.82% | 22 | 6.6 | 700 | 10,745 | 25.0% | 40.0% | |
| 42.86% | 21 | 6.9 | 718 | 12,398 | 22.2% | 58.3% | |
| 35.00% | 20 | 7.0 | 678 | 12,080 | 57.1% | 23.1% | |
| 31.58% | 19 | 7.0 | 825 | 12,008 | 25.0% | 36.4% | |
| 56.25% | 16 | 6.6 | 843 | 13,749 | 50.0% | 62.5% | |
| 68.75% | 16 | 6.5 | 868 | 12,831 | 75.0% | 62.5% | |
| 43.75% | 16 | 6.5 | 848 | 14,044 | 37.5% | 50.0% | |
| 80.00% | 15 | 6.5 | 873 | 13,989 | 100.0% | 72.7% | |
| 25.00% | 12 | 7.1 | 548 | 10,623 | 28.6% | 20.0% | |
| 45.45% | 11 | 7.3 | 757 | 12,441 | 42.9% | 50.0% | |
| 40.00% | 10 | 6.7 | 1,108 | 14,906 | 66.7% | 0.0% | |
| 70.00% | 10 | 7.6 | 623 | 13,190 | 80.0% | 60.0% | |
| 22.22% | 9 | 6.8 | 836 | 11,821 | 33.3% | 0.0% | |
| 57.14% | 7 | 7.0 | 832 | 14,459 | 66.7% | 50.0% | |
| 83.33% | 6 | 7.3 | 1,094 | 18,733 | 100.0% | 80.0% | |
| 66.67% | 6 | 7.9 | 714 | 10,541 | 75.0% | 50.0% | |
| 20.00% | 5 | 7.4 | 788 | 14,841 | 100.0% | 0.0% |
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Caitlyn vs Vayne - Frequently Asked Questions
How does Caitlyn do against Vayne in League of Legends?
Caitlyn wins the Caitlyn vs Vayne matchup with a 51.9% win rate compared to Vayne's 48.1%, a 3.8 percentage point difference. This data is based on 131 recent ranked games in patch 26.9.
How does Caitlyn do against Vayne in the early game?
In the early game, Caitlyn has the advantage against Vayne with a 55.2% win rate versus 44.8%. Caitlyn players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Caitlyn do against Vayne in the late game?
In the late game, Vayne takes over the Caitlyn vs Vayne matchup with a 50.7% win rate compared to 49.3%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Caitlyn vs Vayne matchup?
Caitlyn wins the matchup against Vayne with a 51.9% win rate in League of Legends patch 26.9. The 3.8 percentage point advantage means Caitlyn is moderately favored in this lane matchup based on 131 games analyzed.
What is the best Caitlyn build against Vayne?
The best Caitlyn build against Vayne includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Caitlyn runes against Vayne?
The best Caitlyn runes against Vayne use the Inspiration primary tree with Sorcery secondary. This rune setup achieves a 63.2% win rate in the Caitlyn vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Caitlyn counter Vayne?
Yes, Caitlyn has a favorable matchup against Vayne with a 51.9% win rate. Caitlyn has a solid advantage over Vayne in lane based on current patch 26.9 data.
How do I play Caitlyn against Vayne?
When playing Caitlyn against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.