Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs Mordekaiser

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Vayne vs Mordekaiser is a decisive matchup in LoL patch 26.7. Mordekaiser wins with a 63.2% win rate (+26.5%) over Vayne based on 68 games. Mordekaiser holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Mordekaiser matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Mordekaiser - 36.8% win rateMordekaiser(36.8%)
Vayne - 36.8% win rate in this matchup
Vayne
36.8% WR
VS
Mordekaiser vs Vayne matchup - 63.2% win rate
Mordekaiser
63.2% WR

Who Wins the Vayne vs Mordekaiser Matchup?

Mordekaiser wins the Vayne vs Mordekaiser matchup
Winner
Mordekaiser
Matches: 68
36.8%
Win Rate
63.2%
6.2
CS / min
5.6
881
DMG / min
706
12,394
Gold / game
12,043
245
Heal / min
332
496
DMG Mitigated / min
1,316
0.4
CC / min
0.4
36.7%
Early Game WR
63.3%
36.8%
Late Game WR
63.2%

Vayne vs Mordekaiser Matchup Summary

The Vayne vs Mordekaiser matchup is a decisive matchup in League of Legends ranked play. Based on 68 recent matches analyzed, Mordekaiser wins with a 63.2% win rate compared to Vayne's 36.8%, giving Mordekaiser a 26.5 percentage point advantage. Mordekaiser dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Vayne players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Mordekaiser leads by 907 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Mordekaiser has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Mordekaiser overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Mordekaiser Laning Phase Breakdown

Vayne wins the laning phase against Mordekaiser in League of Legends

Vayne is favored during the laning phase against Mordekaiser, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
6.2Vayne
5.6Mordekaiser
Vayne edges out Mordekaiser by 0.6 CS per minute — a moderate farming advantage that adds up to roughly 9 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
881Vayne
706Mordekaiser
Vayne heavily out-damages Mordekaiser by 175 DMG/min, dominating both short trades and all-in fights. Mordekaiser should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
12,394Vayne
12,043Mordekaiser
Vayne earns 351 more gold per game than Mordekaiser, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Vayne slightly faster item completions.
Utility
0.4Vayne
0.4Mordekaiser
Both Vayne and Mordekaiser provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
741Vayne
1,648Mordekaiser
Mordekaiser vastly out-sustains Vayne, healing and mitigating 907 more damage per minute. This massive durability gap means Mordekaiser can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Mordekaiser

Berserker's Greaves is the optimal boots choice against Mordekaiser, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Mordekaiser are Terminus, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 57.1% win rate across 7 games — well above average and making it the top item path against Mordekaiser. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Mordekaiser matchup.

Early Game vs Late Game

Early Game
Mordekaiser
63.3%
+26.7% advantage
Vayne early game win rateVayne36.7%
Mordekaiser early game win rateMordekaiser63.3%
Late Game
Mordekaiser
63.2%
+26.3% advantage
Vayne late game win rateVayne36.8%
Mordekaiser late game win rateMordekaiser63.2%

Mordekaiser dominates the early game (first 15 minutes) with a commanding 63.3% win rate — a 26.7 percentage point lead over Vayne. This lopsided early game means Mordekaiser can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Mordekaiser is far superior in the late game (25+ minutes), boasting a 63.2% win rate — 26.3 points above Vayne. Extended games heavily favor Mordekaiser, whose kit and scaling make them a dominant force in team fights and objective control.

Mordekaiser holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Vayne players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Mordekaiser

Precision rune tree - Vayne primary runes vs MordekaiserPrecision
Press the Attack - best Vayne rune vs MordekaiserTriumph - best Vayne rune vs MordekaiserLegend: Alacrity - best Vayne rune vs MordekaiserCoup de Grace - best Vayne rune vs Mordekaiser
Resolve rune tree - Vayne secondary runes vs MordekaiserResolve
Conditioning - best Vayne rune vs MordekaiserOvergrowth - best Vayne rune vs Mordekaiser
33.3% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Mordekaiser in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs Mordekaiser - Frequently Asked Questions

How does Vayne do against Mordekaiser in League of Legends?

Mordekaiser wins the Vayne vs Mordekaiser matchup with a 63.2% win rate compared to Vayne's 36.8%, a 26.5 percentage point difference. This data is based on 68 recent ranked games in patch 26.7.

How does Vayne do against Mordekaiser in the early game?

In the early game, Mordekaiser has the advantage against Vayne with a 63.3% win rate versus 36.7%. Mordekaiser players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Mordekaiser in the late game?

In the late game, Mordekaiser takes over the Vayne vs Mordekaiser matchup with a 63.2% win rate compared to 36.8%. Mordekaiser scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Mordekaiser matchup?

Mordekaiser wins the matchup against Vayne with a 63.2% win rate in League of Legends patch 26.7. The 26.5 percentage point advantage means Mordekaiser is significantly favored in this lane matchup based on 68 games analyzed.

What is the best Vayne build against Mordekaiser?

The best Vayne build against Mordekaiser includes Terminus, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. This build achieves a 57.1% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Mordekaiser?

The best Vayne runes against Mordekaiser use the Precision primary tree with Resolve secondary. This rune setup achieves a 33.3% win rate in the Vayne vs Mordekaiser matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Mordekaiser?

No, Vayne struggles against Mordekaiser with only a 36.8% win rate. Mordekaiser has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Mordekaiser's lead.

How do I play Vayne against Mordekaiser?

When playing Vayne against Mordekaiser, play cautiously and avoid Mordekaiser's power spikes. Look for jungle assistance and team-dependent plays since Mordekaiser has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.