Debilitate Attack

Is Debilitate good in Slay the Spire 2?

In Slay the Spire 2, Debilitate is an uncommon attack from the Necrobinder card pool. Its effect: Deal 10 damage. Vulnerable and Weak are twice as effective against the enemy for the next 3 turns. Performance-wise it’s a solid if unspectacular include, rated C tier overall.

Over 301 tracked runs its win rate sits at 31.3%, 17.9% ahead of the 13.4% all-deck baseline. It sees niche play, included in only 1.8% of eligible runs. When it is actually offered players take it 20.4% of the time, and that looks correct: those runs win 31.4% against 24.0% for runs that passed, a +7.1% pick lift over 236 decided runs. Within Necrobinder runs it’s drafted 10.2% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Haunt, which lifts its win rate by +22.3% when the two share a deck. On the relic side, Fragrant Mushroom is its standout companion, worth a +28.5% win-rate swing alongside it. It costs 1 energy, gets upgraded 32.6% of the time, and tends to be picked up near floor 16.

Upgrading the card adds +2 Damage to its stat line. Of the runs that drafted it, 93 ended in victory against 204 deaths and 4 abandons. Its most common run-ender is The Insatiable Boss, finishing 4.7% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Debilitate fits a Necrobinder deck.

Pick or Skip: Debilitate

Players take Debilitate in 20.4% of the 1239 offers it appears in; those runs win 31.4% against 24.0% for runs that passed, a pick lift of +7.1% over 236 decided runs.

Taken 253 times out of 1239 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Debilitate

Of the 4 pickup windows recorded for Debilitate, Act 2 is the best: 46.3% across 95 runs.

Win rate of runs by the act Debilitate entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Debilitate

Debilitate’s strongest card pairings so far are Haunt (+22.3%), Bury (+20.9%), and Mad Science (+17.6%), each shown with the win-rate lift it adds.

Haunt+22.3%37 runsBury+20.9%19 runsMad Science+17.6%23 runsParse+16.9%40 runsDirge+15.5%51 runsEradicate+15.3%32 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Debilitate Win Rate by Class

Exclusive to the Necrobinder, Debilitate posts a 31.6% win rate over 295 tracked runs.

The Necrobinderappears in 10.2% of its runs (295 tracked)

Best Relics for Debilitate

The relics that swing Debilitate’s win rate the most are Fragrant Mushroom (+28.5%), Sturdy Clamp (+25.2%), and Centennial Puzzle (+24.9%), with each lift shown.

Fragrant Mushroom+28.5%22 runsSturdy Clamp+25.2%15 runsCentennial Puzzle+24.9%41 runsMiniature Tent+24.7%17 runsPear+24.6%26 runsBronze Scales+23.9%41 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Debilitate Card Details

A 1-energy uncommon attack, Debilitate is upgraded 32.6% of the time and tends to enter the deck around floor 16.

Deal 10 damage. Vulnerable and Weak are twice as effective against the enemy for the next 3 turns.

Upgrade: +2 Damage

What Ends Runs with Debilitate

Runs holding Debilitate end most often against The Insatiable Boss (4.7%), Test Subject Boss (4.7%), and Knowledge Demon Boss (4.7%) — the share of its runs each accounts for is shown.

• The Insatiable Boss4.7% of runs
• Test Subject Boss4.7% of runs
• Knowledge Demon Boss4.7% of runs
• Decimillipede Elite4.7% of runs
• Aeonglass Boss4.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.