Debilitate•Attack

Is Debilitate good in Slay the Spire 2?

In Slay the Spire 2, Debilitate is an uncommon attack from the Necrobinder card pool. Its effect: Deal 10 damage. Vulnerable and Weak are twice as effective against the enemy for the next 3 turns. Performance-wise it’s a solid if unspectacular include, rated C tier overall.

Over 10 tracked runs its win rate sits at 22.2%, 9.6% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 1.9% of eligible runs. Within Necrobinder runs it’s drafted 5.8% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Spur, which lifts its win rate by +27.8% when the two share a deck. On the relic side, Leafy Poultice is its standout companion, worth a +27.8% win-rate swing alongside it. It costs 1 energy, gets upgraded 27.3% of the time, and tends to be picked up near floor 10.

Upgrading the card adds +2 Damage to its stat line. Of the runs that drafted it, 2 ended in victory against 7 deaths and 1 abandons. Its most common run-ender is Vantom Boss, finishing 20.0% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Debilitate fits a Necrobinder deck.

Best Cards to Pair with Debilitate

Debilitate’s strongest card pairings so far are Spur (+27.8%), Haunt (+27.8%), and Wisp (+17.8%), each shown with the win-rate lift it adds.

Spur+27.8%3 runsHaunt+27.8%4 runsWisp+17.8%5 runsGrave Warden+11.1%3 runsFriendship+11.1%3 runsBodyguard0.0%10 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Debilitate Win Rate by Class

Exclusive to the Necrobinder, Debilitate posts a 22.2% win rate over 10 tracked runs.

The Necrobinderappears in 5.8% of its runs (10 tracked)

Best Relics for Debilitate

The relics that swing Debilitate’s win rate the most are Leafy Poultice (+27.8%) and Bound Phylactery (-9.7%), with each lift shown.

Leafy Poultice+27.8%4 runsBound Phylactery-9.7%9 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Debilitate Card Details

A 1-energy uncommon attack, Debilitate is upgraded 27.3% of the time and tends to enter the deck around floor 10.

Deal 10 damage. Vulnerable and Weak are twice as effective against the enemy for the next 3 turns.

Upgrade: +2 Damage

What Ends Runs with Debilitate

Runs holding Debilitate end most often against Vantom Boss (20.0%) — the share of its runs each accounts for is shown.

• Vantom Boss20.0% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.