Dominate•Skill

Is Dominate good in Slay the Spire 2?

In Slay the Spire 2, Dominate is an uncommon skill from the Ironclad card pool. Its effect: Apply 1 Vulnerable. Gain Strength for each Vulnerable on the enemy. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 8 tracked runs its win rate sits at 28.6%, 15.9% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 1.5% of eligible runs. Within Ironclad runs it’s drafted 16.3% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Thrash, which lifts its win rate by +71.4% when the two share a deck. On the relic side, Red Mask is its standout companion, worth a +38.1% win-rate swing alongside it. It costs 1 energy, gets upgraded 66.7% of the time, and tends to be picked up near floor 13.

Of the runs that drafted it, 2 ended in victory against 5 deaths and 1 abandons. Its most common run-ender is Bowlbugs Normal, finishing 25.0% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Dominate fits a Ironclad deck.

Best Cards to Pair with Dominate

Dominate’s strongest card pairings so far are Thrash (+71.4%), Bully (+38.1%), and Stampede (+21.4%), each shown with the win-rate lift it adds.

Thrash+71.4%3 runsBully+38.1%3 runsStampede+21.4%3 runsInflame+21.4%3 runsDemon Form+21.4%3 runsAnger+11.4%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Dominate Win Rate by Class

Exclusive to the Ironclad, Dominate posts a 28.6% win rate over 8 tracked runs.

The Ironcladappears in 16.3% of its runs (8 tracked)

Best Relics for Dominate

The relics that swing Dominate’s win rate the most are Red Mask (+38.1%), Burning Blood (0.0%), and Bronze Scales (-28.6%), with each lift shown.

Red Mask+38.1%3 runsBurning Blood0.0%8 runsBronze Scales-28.6%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Dominate Card Details

A 1-energy uncommon skill, Dominate is upgraded 66.7% of the time and tends to enter the deck around floor 13.

Apply 1 Vulnerable. Gain Strength for each Vulnerable on the enemy.

What Ends Runs with Dominate

Runs holding Dominate end most often against Bowlbugs Normal (25.0%) — the share of its runs each accounts for is shown.

• Bowlbugs Normal25.0% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.