Dominate•Skill

Is Dominate good in Slay the Spire 2?

In Slay the Spire 2, Dominate is an uncommon skill from the Ironclad card pool. Its effect: Apply 1 Vulnerable. Gain Strength for each Vulnerable on the enemy. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 71 tracked runs its win rate sits at 38.1%, 19.1% ahead of the 19.0% all-deck baseline. It sees niche play, included in only 1.9% of eligible runs. Within Ironclad runs it’s drafted 10.0% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Burning Pact, which lifts its win rate by +18.1% when the two share a deck. On the relic side, Razor Tooth is its standout companion, worth a +20.6% win-rate swing alongside it. It costs 1 energy, gets upgraded 52.4% of the time, and tends to be picked up near floor 17.

Of the runs that drafted it, 24 ended in victory against 39 deaths and 8 abandons. Its most common run-ender is Test Subject Boss, finishing 9.9% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Dominate fits a Ironclad deck.

Best Cards to Pair with Dominate

Dominate’s strongest card pairings so far are Burning Pact (+18.1%), Offering (+16.4%), and Demonic Shield (+14.0%), each shown with the win-rate lift it adds.

Burning Pact+18.1%13 runsOffering+16.4%8 runsDemonic Shield+14.0%5 runsSecond Wind+13.7%7 runsFight Me!+13.7%8 runsBlood Wall+13.1%18 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Dominate Win Rate by Class

Exclusive to the Ironclad, Dominate posts a 38.1% win rate over 71 tracked runs.

The Ironcladappears in 10.0% of its runs (71 tracked)

Best Relics for Dominate

The relics that swing Dominate’s win rate the most are Razor Tooth (+20.6%), Vambrace (+19.6%), and Mercury Hourglass (+15.9%), with each lift shown.

Razor Tooth+20.6%5 runsVambrace+19.6%7 runsMercury Hourglass+15.9%11 runsMeal Ticket+15.9%10 runsPetrified Toad+15.9%11 runsFragrant Mushroom+14.3%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Dominate Card Details

A 1-energy uncommon skill, Dominate is upgraded 52.4% of the time and tends to enter the deck around floor 17.

Apply 1 Vulnerable. Gain Strength for each Vulnerable on the enemy.

What Ends Runs with Dominate

Runs holding Dominate end most often against Test Subject Boss (9.9%), Knowledge Demon Boss (4.2%), and Bowlbugs Normal (4.2%) — the share of its runs each accounts for is shown.

• Test Subject Boss9.9% of runs
• Knowledge Demon Boss4.2% of runs
• Bowlbugs Normal4.2% of runs
• Kaiser Crab Boss4.2% of runs
• Queen Boss4.2% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.