GUARDS!!! Skill

Is GUARDS!!! good in Slay the Spire 2?

GUARDS!!! is a rare Regent skill in Slay the Spire 2. In combat it resolves as: Transform any number of cards in your Hand into Minion Sacrifice. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 170 recorded runs, decks running it win 36.1% of the time, comfortably clear of the 13.8% average, by 22.3%. It’s a more selective pick, turning up in just 0.8% of decks that could run it. Offer data backs the pick — taken 20.7% of the time it is shown, with 41.1% for runs that took it against 31.8% for runs that did not, a +8.6% pick lift across 129 decided runs. Regent players keep it in 5.0% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Arsenal — together they post a +29.2% swing in win rate. It also has strong chemistry with the relic Fencing Manual, which moves its win rate by +28.1%. At 2 energy, it’s upgraded in 19.1% of runs and usually joins the deck around floor 17.

That’s 60 wins, 106 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Queen Boss, which closes out 5.9% of its appearances. Read on for GUARDS!!!’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Pick or Skip: GUARDS!!!

Out of 657 recorded offers GUARDS!!! is taken 20.7% of the time, and taking it is worth +8.6% in pick lift — 41.1% for runs that picked it against 31.8% for runs that skipped, across 129 decided runs.

Taken 136 times out of 657 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up GUARDS!!!

GUARDS!!! is strongest when it joins the deck in Act 2, where runs win 47.1% across 51 runs — one of 3 recorded pickup windows.

Win rate of runs by the act GUARDS!!! entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with GUARDS!!!

Ranked by win-rate lift, GUARDS!!! performs best alongside Arsenal (+29.2%), Bundle of Joy (+23.9%), and Mad Science (+22.3%).

Arsenal+29.2%20 runsBundle of Joy+23.9%26 runsMad Science+22.3%15 runsMake It So+21.7%17 runsQuasar+21.1%26 runsSupermassive+19.9%26 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

GUARDS!!! Win Rate by Class

GUARDS!!! is drafted only by the Regent, where it holds a 37.0% win rate across 166 runs.

The Regentappears in 5.0% of its runs (166 tracked)

Best Relics for GUARDS!!!

GUARDS!!! pairs best with the relics Fencing Manual (+28.1%), Miniature Cannon (+26.3%), and Orichalcum (+22.6%), ranked by win-rate lift.

Fencing Manual+28.1%20 runsMiniature Cannon+26.3%15 runsOrichalcum+22.6%21 runsGorget+22.5%32 runsVajra+22.3%27 runsPendulum+21.4%39 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

GUARDS!!! Card Details

GUARDS!!! is a rare skill costing 2 energy; it’s upgraded in 19.1% of runs and usually picked up by floor 17.

Transform any number of cards in your Hand into Minion Sacrifice.

What Ends Runs with GUARDS!!!

GUARDS!!!’s most common run-enders are Queen Boss (5.9%), Knowledge Demon Boss (5.3%), and Kaiser Crab Boss (4.7%).

• Queen Boss5.9% of runs
• Knowledge Demon Boss5.3% of runs
• Kaiser Crab Boss4.7% of runs
• Aeonglass Boss4.1% of runs
• The Insatiable Boss4.1% of runs

See Also

Compare GUARDS!!! with the rest of the best Slay the Spire 2 cards, relics, and classes below.