GUARDS!!!•Skill

Is GUARDS!!! good in Slay the Spire 2?

GUARDS!!! is a rare Regent skill in Slay the Spire 2. In combat it resolves as: Transform any number of cards in your Hand into Minion Sacrifice. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 32 recorded runs, decks running it win 32.1% of the time, comfortably clear of the 19.0% average, by 13.2%. It’s a more selective pick, turning up in just 0.8% of decks that could run it. Regent players keep it in 4.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Black Hole — together they post a +19.1% swing in win rate. It also has strong chemistry with the relic Fresnel Lens, which moves its win rate by +12.9%. At 2 energy, it’s upgraded in 29.4% of runs and usually joins the deck around floor 16.

That’s 9 wins, 19 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 9.4% of its appearances. Read on for GUARDS!!!’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with GUARDS!!!

Ranked by win-rate lift, GUARDS!!! performs best alongside Black Hole (+19.1%), Spectrum Shift (+15.9%), and Know Thy Place (+14.3%).

Black Hole+19.1%8 runsSpectrum Shift+15.9%5 runsKnow Thy Place+14.3%13 runsAlignment+12.9%7 runsReflect+12.9%6 runsQuasar+12.3%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

GUARDS!!! Win Rate by Class

GUARDS!!! is drafted only by the Regent, where it holds a 32.1% win rate across 32 runs.

The Regentappears in 4.7% of its runs (32 tracked)

Best Relics for GUARDS!!!

GUARDS!!! pairs best with the relics Fresnel Lens (+12.9%), Pendulum (+10.3%), and Strike Dummy (+9.3%), ranked by win-rate lift.

Fresnel Lens+12.9%6 runsPendulum+10.3%7 runsStrike Dummy+9.3%5 runsTuning Fork+9.3%5 runsPear+8.0%3 runsScroll Boxes+8.0%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

GUARDS!!! Card Details

GUARDS!!! is a rare skill costing 2 energy; it’s upgraded in 29.4% of runs and usually picked up by floor 16.

Transform any number of cards in your Hand into Minion Sacrifice.

What Ends Runs with GUARDS!!!

GUARDS!!!’s most common run-enders are Knowledge Demon Boss (9.4%), Kaiser Crab Boss (6.3%), and The Obscura Normal (6.3%).

• Knowledge Demon Boss9.4% of runs
• Kaiser Crab Boss6.3% of runs
• The Obscura Normal6.3% of runs
• Soul Fysh Boss6.3% of runs
• Aeonglass Boss6.3% of runs

See Also

Compare GUARDS!!! with the rest of the best Slay the Spire 2 cards, relics, and classes below.