Misery•Attack

Is Misery good in Slay the Spire 2?

In Slay the Spire 2, Misery is a rare attack from the Necrobinder card pool. Its effect: Deal 7 damage. Apply any debuffs on the enemy to ALL other enemies. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 53 tracked runs its win rate sits at 22.4%, 3.5% ahead of the 18.9% all-deck baseline. It sees niche play, included in only 1.4% of eligible runs. Within Defect runs it’s drafted 0.2% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Dredge, which lifts its win rate by +20.9% when the two share a deck. On the relic side, Strike Dummy is its standout companion, worth a +16.6% win-rate swing alongside it. It costs 0 energy, gets upgraded 12.5% of the time, and tends to be picked up near floor 18.

Upgrading the card adds +2 Damage to its stat line. Of the runs that drafted it, 11 ended in victory against 38 deaths and 4 abandons. Its most common run-ender is Knowledge Demon Boss, finishing 11.3% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Misery fits a Necrobinder deck.

Best Cards to Pair with Misery

Misery’s strongest card pairings so far are Dredge (+20.9%), Putrefy (+20.2%), and Delay (+16.6%), each shown with the win-rate lift it adds.

Dredge+20.9%9 runsPutrefy+20.2%7 runsDelay+16.6%7 runsDebilitate+16.6%6 runsFasten+15.0%4 runsUltimate Defend+15.0%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Misery Win Rate by Class

Of the 3 classes that draft Misery, it performs best with Defect (100.0%), Necrobinder (21.3%), and Ironclad (0.0%).

The Defect100.0%1 runsThe Necrobinder21.3%51 runsThe Ironclad0.0%1 runs

Best Relics for Misery

The relics that swing Misery’s win rate the most are Strike Dummy (+16.6%), Potion Belt (+15.7%), and Royal Stamp (+15.0%), with each lift shown.

Strike Dummy+16.6%6 runsPotion Belt+15.7%9 runsRoyal Stamp+15.0%4 runsHappy Flower+13.8%10 runsAnchor+12.5%6 runsBag of Preparation+10.4%10 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Misery Card Details

A 0-energy rare attack, Misery is upgraded 12.5% of the time and tends to enter the deck around floor 18.

Deal 7 damage. Apply any debuffs on the enemy to ALL other enemies.

Upgrade: +2 Damage

What Ends Runs with Misery

Runs holding Misery end most often against Knowledge Demon Boss (11.3%), Queen Boss (7.5%), and The Insatiable Boss (7.5%) — the share of its runs each accounts for is shown.

• Knowledge Demon Boss11.3% of runs
• Queen Boss7.5% of runs
• The Insatiable Boss7.5% of runs
• Infested Prisms Elite5.7% of runs
• Test Subject Boss5.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.