Misery Attack

Is Misery good in Slay the Spire 2?

In Slay the Spire 2, Misery is a rare attack from the Necrobinder card pool. Its effect: Deal 7 damage. Apply any debuffs on the enemy to ALL other enemies. Performance-wise it’s a solid if unspectacular include, rated C tier overall.

Over 246 tracked runs its win rate sits at 29.6%, 15.8% ahead of the 13.8% all-deck baseline. It sees niche play, included in only 1.2% of eligible runs. Taken 26.5% of the times it is offered, it lands close to neutral on the pick-versus-skip split: 31.4% for runs that took it against 32.0% for runs that passed, a -0.6% pick lift over 188 decided runs. Within Necrobinder runs it’s drafted 6.5% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Neurosurge, which lifts its win rate by +27.0% when the two share a deck. On the relic side, Happy Flower is its standout companion, worth a +31.5% win-rate swing alongside it. It costs 0 energy, gets upgraded 18.9% of the time, and tends to be picked up near floor 18.

Upgrading the card adds +2 Damage to its stat line. Of the runs that drafted it, 72 ended in victory against 171 deaths and 3 abandons. Its most common run-ender is Knowledge Demon Boss, finishing 9.3% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Misery fits a Necrobinder deck.

Pick or Skip: Misery

Players take Misery in 26.5% of the 736 offers it appears in; those runs win 31.4% against 32.0% for runs that passed, a pick lift of -0.6% over 188 decided runs.

Taken 195 times out of 736 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Misery

Of the 3 pickup windows recorded for Misery, Act 3 is the best: 64.7% across 17 runs.

Win rate of runs by the act Misery entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Misery

Misery’s strongest card pairings so far are Neurosurge (+27.0%), Putrefy (+24.0%), and Enfeebling Touch (+22.7%), each shown with the win-rate lift it adds.

Neurosurge+27.0%28 runsPutrefy+24.0%45 runsEnfeebling Touch+22.7%53 runsSqueeze+21.8%23 runsDebilitate+19.4%45 runsRattle+16.4%30 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Misery Win Rate by Class

Exclusive to the Necrobinder, Misery posts a 29.1% win rate over 237 tracked runs.

The Necrobinderappears in 6.5% of its runs (237 tracked)

Best Relics for Misery

The relics that swing Misery’s win rate the most are Happy Flower (+31.5%), Mango (+25.8%), and Bone Flute (+24.1%), with each lift shown.

Happy Flower+31.5%40 runsMango+25.8%17 runsBone Flute+24.1%29 runsSturdy Clamp+22.2%15 runsGorget+21.4%35 runsPotion Belt+20.3%38 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Misery Card Details

A 0-energy rare attack, Misery is upgraded 18.9% of the time and tends to enter the deck around floor 18.

Deal 7 damage. Apply any debuffs on the enemy to ALL other enemies.

Upgrade: +2 Damage

What Ends Runs with Misery

Runs holding Misery end most often against Knowledge Demon Boss (9.3%), Infested Prisms Elite (6.1%), and Test Subject Boss (5.7%) — the share of its runs each accounts for is shown.

• Knowledge Demon Boss9.3% of runs
• Infested Prisms Elite6.1% of runs
• Test Subject Boss5.7% of runs
• Decimillipede Elite5.3% of runs
• The Insatiable Boss4.1% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.