Potion Belt•Relic

Is Potion Belt good in Slay the Spire 2?

In Slay the Spire 2, Potion Belt is a common relic you can pick up on your climb. Its effect: Upon pickup, gain potion slots. The data marks it as a weaker relic, settling at D tier — rarely a run-defining grab.

Over 46 tracked runs the win rate of decks holding it sits at 24.4%, 11.8% ahead of the 12.6% all-run baseline. It sees lighter play, carried in only 8.9% of runs. It does its best work in the hands of the Defect, who post a 50.0% win rate with it. Within Defect runs specifically, it’s carried 7.1% of the time.

Its standout card pairing is Haunt, which lifts the relic’s win rate by +75.6% when both are in play. It also works nicely with Adrenaline, good for a +75.6% win-rate change. It typically enters the deck near floor 18. As a common relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 10 ended in victory while 31 fell to a defeat. Its most common run-ender is Test Subject Boss, finishing 6.5% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Potion Belt is worth grabbing.

Best Cards with Potion Belt

The cards that gain the most from carrying Potion Belt are Haunt (+75.6%), Adrenaline (+75.6%), and Mad Science (+42.3%), each shown with its win-rate swing.

Haunt+75.6%7 runsAdrenaline+75.6%3 runsMad Science+42.3%3 runsGrave Warden+42.3%6 runsNeurosurge+42.3%3 runsSeance+42.3%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Potion Belt Win Rate by Class

Of the 5 classes that carry Potion Belt, it performs best with Defect (50.0%), Ironclad (50.0%), and Necrobinder (31.6%).

The Defect50.0%2 runsThe Ironclad50.0%2 runsThe Necrobinder31.6%21 runsThe Silent12.5%11 runsThe Regent10.0%10 runs

Potion Belt Details

Carried in 8.9% of runs, Potion Belt is a common relic typically acquired near floor 18.

Upon pickup, gain potion slots.

What Ends Runs with Potion Belt

Runs carrying Potion Belt end most often against Test Subject Boss (6.5%), Phrog Parasite Elite (4.3%), and Ceremonial Beast Boss (4.3%) — the share of its runs each accounts for is shown.

• Test Subject Boss6.5% of runs
• Phrog Parasite Elite4.3% of runs
• Ceremonial Beast Boss4.3% of runs
• Infested Prisms Elite4.3% of runs
• Terror Eel Elite4.3% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.