Potion Belt•Relic

Is Potion Belt good in Slay the Spire 2?

In Slay the Spire 2, Potion Belt is a common relic you can pick up on your climb. Its effect: Upon pickup, gain potion slots. Performance-wise it’s a steady, unspectacular pick rated C tier overall.

Over 361 tracked runs the win rate of decks holding it sits at 39.5%, 20.6% ahead of the 18.9% all-run baseline. It sees lighter play, carried in only 9.5% of runs. It does its best work in the hands of the Silent, who post a 47.1% win rate with it. Within Silent runs specifically, it’s carried 9.3% of the time.

Its standout card pairing is Banshee's Cry, which lifts the relic’s win rate by +60.5% when both are in play. It also works nicely with Secret Weapon, good for a +60.5% win-rate change. It typically enters the deck near floor 21. As a common relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 130 ended in victory while 199 fell to a defeat. Its most common run-ender is Test Subject Boss, finishing 5.5% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Potion Belt is worth grabbing.

Best Cards with Potion Belt

The cards that gain the most from carrying Potion Belt are Banshee's Cry (+60.5%), Secret Weapon (+60.5%), and Melancholy (+60.5%), each shown with its win-rate swing.

Banshee's Cry+60.5%4 runsSecret Weapon+60.5%4 runsMelancholy+60.5%4 runsVolley+60.5%3 runsSalvo+60.5%4 runsBelieve in You+60.5%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Potion Belt Win Rate by Class

Of the 5 classes that carry Potion Belt, it performs best with Silent (47.1%), Ironclad (42.9%), and Necrobinder (40.0%).

The Silent47.1%91 runsThe Ironclad42.9%63 runsThe Necrobinder40.0%87 runsThe Regent32.6%49 runsThe Defect30.8%71 runs

Potion Belt Details

Carried in 9.5% of runs, Potion Belt is a common relic typically acquired near floor 21.

Upon pickup, gain potion slots.

What Ends Runs with Potion Belt

Runs carrying Potion Belt end most often against Test Subject Boss (5.5%), Knowledge Demon Boss (5.0%), and Queen Boss (4.7%) — the share of its runs each accounts for is shown.

• Test Subject Boss5.5% of runs
• Knowledge Demon Boss5.0% of runs
• Queen Boss4.7% of runs
• Kaiser Crab Boss3.9% of runs
• Infested Prisms Elite3.6% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.