Cassiopeia - League of Legends Champion
Win Rate
50.6%
Pick Rate
0.9%

Cassiopeiavs Senna

BMage
Patch26.9
Matches514,344
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 9, 2026
MethodologyData Methodology

Cassiopeia vs Senna is a very close matchup in LoL patch 26.9. Cassiopeia wins with a 50.0% win rate (+0.0%) over Senna based on 6 games. Cassiopeia holds the advantage in both the early and late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Senna matchup.

Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Senna - 50.0% win rateSenna(50.0%)
Cassiopeia - 50.0% win rate in this matchup
Cassiopeia
50.0% WR
VS
Senna vs Cassiopeia matchup - 50.0% win rate
Senna
50.0% WR

Who Wins the Cassiopeia vs Senna Matchup?

Cassiopeia wins the Cassiopeia vs Senna matchup
Winner
Cassiopeia
Matches: 6
50.0%
Win Rate
50.0%
5.5
CS / min
5.4
962
DMG / min
1,031
15,454
Gold / game
16,842
349
Heal / min
543
909
DMG Mitigated / min
495
1.6
CC / min
1.4
0.0%
Early Game WR
0.0%
50.0%
Late Game WR
50.0%

Cassiopeia vs Senna Matchup Summary

The Cassiopeia vs Senna matchup is essentially a coin-flip matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Cassiopeia wins with a 50.0% win rate compared to Senna's 50.0%, giving Cassiopeia a 0.0 percentage point advantage. Cassiopeia holds a slight edge in both the early and late game, but the margins are thin enough that individual skill and jungle attention will often determine the outcome. Senna can still find windows through outplays and team coordination. The most significant statistical gap is in sustain, where Cassiopeia leads by 220 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a statistical edge, but the margin is close enough that respecting Senna's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Senna Laning Phase Breakdown

Cassiopeia wins the laning phase against Senna in League of Legends

Cassiopeia is favored during the laning phase against Senna, winning 3 out of 5 key stat categories. Cassiopeia holds advantages in farming, crowd control and sustain, making them the stronger laner in this matchup.

Farming
5.5Cassiopeia
5.4Senna
Cassiopeia and Senna farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
962Cassiopeia
1,031Senna
Senna deals 69 more champion damage per minute than Cassiopeia. While noticeable in extended trades, this gap can be offset by Cassiopeia choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
15,454Cassiopeia
16,842Senna
Senna generates a commanding 1,389 more gold per game than Cassiopeia. This substantial economic advantage means Senna consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Cassiopeia should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.6Cassiopeia
1.4Senna
Both Cassiopeia and Senna provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
1,258Cassiopeia
1,038Senna
Cassiopeia vastly out-sustains Senna, healing and mitigating 220 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Senna is forced to recall. Building grievous wounds early is essential for Senna, and focusing on burst trade patterns rather than sustained fights is critical.

Best Cassiopeia Build Against Senna

The top-performing core items for Cassiopeia against Senna are Liandry's Torment, Rylai's Crystal Scepter and Seraph's Embrace. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 2 games — well above average and making it the top item path against Senna. This streamlined build focuses on the essentials for the Cassiopeia vs Senna matchup, with room for situational adjustments based on team compositions and game state.

Early Game vs Late Game

Early Game
Cassiopeia
0.0%
+0.0% advantage
Cassiopeia early game win rateCassiopeia0.0%
Senna early game win rateSenna0.0%
Late Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia late game win rateCassiopeia50.0%
Senna late game win rateSenna50.0%

The early game (first 15 minutes) is a toss-up between Cassiopeia and Senna, with Cassiopeia holding a razor-thin 0.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.

Late game (25+ minutes) is equally balanced, with Cassiopeia at 50.0% win rate — only 0.0 points ahead of Senna. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

This matchup is remarkably even at every stage of the game. Neither Cassiopeia nor Senna has a phase-specific advantage, making this a pure skill matchup where individual mechanics, decision-making, and team coordination determine the outcome.

Best Cassiopeia Runes Against Senna

Sorcery rune tree - Cassiopeia primary runes vs SennaSorcery
Deathfire Touch - best Cassiopeia rune vs SennaManaflow Band - best Cassiopeia rune vs SennaCelerity - best Cassiopeia rune vs SennaScorch - best Cassiopeia rune vs Senna
Precision rune tree - Cassiopeia secondary runes vs SennaPrecision
Presence of Mind - best Cassiopeia rune vs SennaLegend: Haste - best Cassiopeia rune vs Senna
100.0% WR

The Sorcery primary with Precision secondary combination helps Cassiopeia maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Senna.


Cassiopeia matchup data for League of Legends patch 26.9. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.37%386.872411,43650.0%44.4%
48.48%336.580112,21450.0%47.1%
46.43%286.570911,64358.3%37.5%
48.15%276.982711,84954.5%43.8%
53.85%266.879612,65162.5%50.0%
45.83%246.487312,40050.0%43.8%
59.09%226.995710,00064.3%50.0%
47.62%216.591812,31650.0%46.1%
42.11%196.487311,64377.8%10.0%
36.84%196.979013,54620.0%42.9%
42.11%197.183911,34738.5%50.0%
57.89%197.01,11710,29958.3%57.1%
62.50%167.691712,35080.0%33.3%
40.00%156.87339,76614.3%62.5%
33.33%156.771410,84822.2%50.0%
46.67%156.987312,40762.5%28.6%
60.00%155.792310,35650.0%66.7%
53.33%156.385312,67457.1%50.0%
46.67%156.469010,33555.6%33.3%
64.29%146.791611,98450.0%75.0%
46.15%135.872711,45450.0%44.4%
50.00%126.785710,80557.1%40.0%
41.67%126.295112,81440.0%42.9%
58.33%126.983311,580100.0%37.5%
41.67%126.283111,58150.0%33.3%
50.00%125.882012,55233.3%55.6%
41.67%127.491611,83242.9%40.0%
36.36%117.486312,27233.3%40.0%
63.64%116.51,00914,34066.7%60.0%
54.55%115.772111,86940.0%66.7%
72.73%117.01,12913,39175.0%71.4%
36.36%116.482012,00366.7%25.0%
40.00%106.57129,62442.9%33.3%
50.00%106.81,21613,82466.7%42.9%
20.00%106.399011,55233.3%0.0%
40.00%106.61,01311,86366.7%0.0%
50.00%106.078912,480100.0%37.5%
55.56%95.669510,37950.0%57.1%
44.44%96.51,06315,03350.0%42.9%
55.56%97.486011,78750.0%60.0%
66.67%96.885412,062100.0%40.0%
62.50%87.189613,34860.0%66.7%
87.50%85.91,02313,022100.0%80.0%
37.50%86.889811,71275.0%0.0%
75.00%86.868411,301100.0%66.7%
50.00%86.282311,10550.0%50.0%
57.14%76.36388,46860.0%50.0%
57.14%77.087413,14966.7%50.0%
57.14%76.889012,765100.0%40.0%
42.86%76.482910,13340.0%50.0%
71.43%76.169711,11160.0%100.0%
57.14%76.283611,17950.0%66.7%
33.33%66.061612,1020.0%40.0%
50.00%65.596215,4540.0%50.0%
83.33%67.398713,17850.0%100.0%
20.00%57.190712,365100.0%0.0%
20.00%56.91,0819,79425.0%0.0%
60.00%56.695817,0620.0%60.0%
40.00%55.092411,058100.0%25.0%
40.00%55.689411,58833.3%50.0%
40.00%57.658310,35866.7%0.0%
60.00%56.06627,57250.0%100.0%
20.00%56.481611,44850.0%0.0%

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Cassiopeia vs Senna - Frequently Asked Questions

How does Cassiopeia do against Senna in League of Legends?

Cassiopeia wins the Cassiopeia vs Senna matchup with a 50.0% win rate compared to Senna's 50.0%, a 0.0 percentage point difference. This data is based on 6 recent ranked games in patch 26.9.

How does Cassiopeia do against Senna in the early game?

In the early game, Cassiopeia has the advantage against Senna with a 0.0% win rate versus 0.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Senna in the late game?

In the late game, Cassiopeia takes over the Cassiopeia vs Senna matchup with a 50.0% win rate compared to 50.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Senna matchup?

Cassiopeia wins the matchup against Senna with a 50.0% win rate in League of Legends patch 26.9. The 0.0 percentage point advantage means Cassiopeia is slightly favored in this lane matchup based on 6 games analyzed.

What is the best Cassiopeia build against Senna?

The best Cassiopeia build against Senna includes Liandry's Torment, Rylai's Crystal Scepter, Seraph's Embrace. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Senna?

The best Cassiopeia runes against Senna use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Senna matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Senna?

Yes, Cassiopeia has a favorable matchup against Senna with a 50.0% win rate. Cassiopeia slightly edges out Senna in lane based on current patch 26.9 data.

How do I play Cassiopeia against Senna?

When playing Cassiopeia against Senna, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.