Cassiopeia - League of Legends Champion
Win Rate
46.3%
Pick Rate
0.9%

Cassiopeiavs Syndra

FMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 7, 2026
MethodologyData Methodology

Cassiopeia vs Syndra is a decisive matchup in LoL patch 26.11. Syndra wins with a 52.6% win rate (+5.3%) over Cassiopeia based on 19 games. Syndra wins the early laning phase while Cassiopeia scales better into the late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Syndra matchup.

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Cassiopeia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Cassiopeia - 47.4% win rate in this matchup
Cassiopeia
47.4% WR
VS
Syndra vs Cassiopeia matchup - 52.6% win rate
Syndra
52.6% WR

Who Wins the Cassiopeia vs Syndra Matchup?

Syndra wins the Cassiopeia vs Syndra matchup
Winner
Syndra
Matches: 19
47.4%
Win Rate
52.6%
6.4
CS / min
6.9
749
DMG / min
850
10,423
Gold / game
11,392
292
Heal / min
84
569
DMG Mitigated / min
334
1.0
CC / min
1.5
44.4%
Early Game WR
55.6%
50.0%
Late Game WR
50.0%

Cassiopeia vs Syndra Matchup Summary

The Cassiopeia vs Syndra matchup is a moderate matchup in League of Legends ranked play. Based on 19 recent matches analyzed, Syndra wins with a 52.6% win rate compared to Cassiopeia's 47.4%, giving Syndra a 5.3 percentage point advantage. Game phase dynamics play a critical role here: Syndra controls the early laning stage, but Cassiopeia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Syndra needs to press advantages before Cassiopeia reaches their power spikes, while Cassiopeia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Cassiopeia leads by 443 HP/min — a difference that heavily influences the outcome of trades and skirmishes. While Syndra is slightly favored, Cassiopeia can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Syndra's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Cassiopeia vs Syndra Laning Phase Breakdown

Syndra wins the laning phase against Cassiopeia in League of Legends

Syndra is favored during the laning phase against Cassiopeia, winning 4 out of 5 key stat categories. Syndra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.4Cassiopeia
6.9Syndra
Syndra edges out Cassiopeia by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Syndra.
Damage
749Cassiopeia
850Syndra
Syndra heavily out-damages Cassiopeia by 101 DMG/min, dominating both short trades and all-in fights. Cassiopeia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Syndra's sustained damage advantage take over.
Economy
10,423Cassiopeia
11,392Syndra
Syndra generates a commanding 969 more gold per game than Cassiopeia. This substantial economic advantage means Syndra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Cassiopeia should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.0Cassiopeia
1.5Syndra
Syndra provides 0.4 seconds more crowd control per minute than Cassiopeia, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Syndra coordinate with their jungler and control the pace of skirmishes.
Sustain
860Cassiopeia
418Syndra
Cassiopeia vastly out-sustains Syndra, healing and mitigating 443 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Syndra is forced to recall. Building grievous wounds early is essential for Syndra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Cassiopeia Build Against Syndra

Immortal Path is the optimal boots choice against Syndra, providing the mobility and stats Cassiopeia needs most in this matchup. The top-performing core items for Cassiopeia against Syndra are Rod of Ages, Rylai's Crystal Scepter and Seraph's Embrace. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 4 games, proving it to be a reliable item path when facing Syndra. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Cassiopeia vs Syndra matchup.

Early Game vs Late Game

Early Game
Syndra
55.6%
+11.1% advantage
Cassiopeia early game win rateCassiopeia44.4%
Syndra early game win rateSyndra55.6%
Late Game
Cassiopeia
50.0%
+0.0% advantage
Cassiopeia late game win rateCassiopeia50.0%
Syndra late game win rateSyndra50.0%

Syndra dominates the early game (first 15 minutes) with a commanding 55.6% win rate — a 11.1 percentage point lead over Cassiopeia. This lopsided early game means Syndra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Cassiopeia at 50.0% win rate — only 0.0 points ahead of Syndra. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Syndra has the edge early, but Cassiopeia gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Cassiopeia Runes Against Syndra

Sorcery rune tree - Cassiopeia primary runes vs SyndraSorcery
Deathfire Touch - best Cassiopeia rune vs SyndraManaflow Band - best Cassiopeia rune vs SyndraCelerity - best Cassiopeia rune vs SyndraScorch - best Cassiopeia rune vs Syndra
Resolve rune tree - Cassiopeia secondary runes vs SyndraResolve
Unflinching - best Cassiopeia rune vs SyndraSecond Wind - best Cassiopeia rune vs Syndra
100.0% WR

The Sorcery and Resolve rune setup gives Cassiopeia the best tools to compete against Syndra in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Cassiopeia matchup data for League of Legends patch 26.11. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Cassiopeia matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.54%616.383512,01164.0%36.1%
52.17%466.891312,15252.6%51.9%
48.65%376.789410,72047.4%50.0%
45.45%336.577611,98138.5%50.0%
46.88%326.685810,85138.1%63.6%
45.16%316.381210,57140.0%50.0%
51.61%317.196810,34854.5%44.4%
45.16%315.977112,56960.0%38.1%
64.52%316.792111,76266.7%62.5%
62.07%296.784312,31953.3%71.4%
42.86%286.974011,66242.9%42.9%
65.22%236.188411,04770.0%61.5%
34.78%236.178710,81440.0%30.8%
34.78%236.274110,91040.0%30.8%
31.82%226.581112,22950.0%21.4%
47.62%216.66699,96927.3%70.0%
66.67%217.095612,82280.0%62.5%
66.67%215.777111,60350.0%76.9%
60.00%206.872411,51850.0%70.0%
47.37%196.474910,42344.4%50.0%
63.16%196.489311,54970.0%55.6%
58.82%176.885811,94360.0%57.1%
52.94%176.592511,50037.5%66.7%
52.94%176.877410,92050.0%55.6%
82.35%176.789111,59488.9%75.0%
47.06%176.086412,19033.3%54.5%
37.50%166.688212,07240.0%36.4%
33.33%156.783512,4600.0%45.5%
66.67%155.781512,12850.0%77.8%
50.00%145.57939,64840.0%55.6%
71.43%146.671811,58380.0%66.7%
57.14%146.68888,74677.8%20.0%
42.86%147.096513,93966.7%25.0%
61.54%136.694413,07640.0%75.0%
33.33%127.391010,99440.0%28.6%
41.67%126.41,04012,89060.0%28.6%
33.33%126.679113,559100.0%27.3%
45.45%116.774611,84125.0%57.1%
18.18%116.278612,0890.0%28.6%
45.45%116.085011,82550.0%42.9%
63.64%115.790313,10766.7%62.5%
27.27%116.474611,72020.0%33.3%
36.36%116.596014,27050.0%28.6%
20.00%106.672610,42428.6%0.0%
40.00%106.398414,52250.0%37.5%
11.11%96.36538,76420.0%0.0%
44.44%96.987211,90440.0%50.0%
33.33%96.372412,71366.7%16.7%
44.44%96.41,27812,86950.0%42.9%
55.56%96.477611,32550.0%60.0%
55.56%96.588712,6850.0%62.5%
66.67%96.493714,897100.0%57.1%
25.00%87.380213,09033.3%20.0%
37.50%86.584312,21733.3%40.0%
57.14%75.989212,35666.7%50.0%
28.57%77.292414,4480.0%33.3%
42.86%76.277111,59450.0%33.3%
14.29%76.891611,0350.0%25.0%
71.43%76.086011,651100.0%50.0%
28.57%75.97388,49533.3%0.0%
66.67%66.592613,9850.0%100.0%
66.67%66.887313,102100.0%50.0%
33.33%66.863510,69750.0%25.0%
50.00%66.276512,03966.7%33.3%
50.00%66.765310,17766.7%33.3%
50.00%66.599812,680100.0%25.0%
60.00%56.367511,35250.0%66.7%
40.00%57.41,03413,86250.0%33.3%
20.00%58.176511,22633.3%0.0%
40.00%56.01,36511,71250.0%33.3%
40.00%55.87258,657100.0%25.0%
80.00%55.568410,127100.0%50.0%
20.00%57.31,04410,50033.3%0.0%
80.00%56.987910,244100.0%66.7%
20.00%56.27839,07950.0%0.0%
60.00%57.889613,847100.0%50.0%
40.00%55.071411,2290.0%50.0%

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Cassiopeia vs Syndra - Frequently Asked Questions

How does Cassiopeia do against Syndra in League of Legends?

Syndra wins the Cassiopeia vs Syndra matchup with a 52.6% win rate compared to Cassiopeia's 47.4%, a 5.3 percentage point difference. This data is based on 19 recent ranked games in patch 26.11.

How does Cassiopeia do against Syndra in the early game?

In the early game, Syndra has the advantage against Cassiopeia with a 55.6% win rate versus 44.4%. Syndra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Cassiopeia do against Syndra in the late game?

In the late game, Cassiopeia takes over the Cassiopeia vs Syndra matchup with a 50.0% win rate compared to 50.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.

Who wins the Cassiopeia vs Syndra matchup?

Syndra wins the matchup against Cassiopeia with a 52.6% win rate in League of Legends patch 26.11. The 5.3 percentage point advantage means Syndra is significantly favored in this lane matchup based on 19 games analyzed.

What is the best Cassiopeia build against Syndra?

The best Cassiopeia build against Syndra includes Rod of Ages, Rylai's Crystal Scepter, Seraph's Embrace with Immortal Path. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Cassiopeia runes against Syndra?

The best Cassiopeia runes against Syndra use the Sorcery primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Syndra matchup. See the full rune breakdown in the matchup comparison above.

Does Cassiopeia counter Syndra?

No, Cassiopeia struggles against Syndra with only a 47.4% win rate. Syndra has the advantage in this matchup. Cassiopeia players should focus on safe farming and avoiding extended trades to minimize Syndra's lead.

How do I play Cassiopeia against Syndra?

When playing Cassiopeia against Syndra, play cautiously and avoid Syndra's power spikes. Focus on safe farming — you outscale Syndra in the late game. Use the matchup-specific build and runes above to optimize your chances.