Karthus - League of Legends Champion
Win Rate
51.9%
Pick Rate
1.2%

Karthusvs Anivia

SMage
Patch26.10
Matches683,599
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 17, 2026
MethodologyData Methodology

Karthus vs Anivia is a decisive matchup in LoL patch 26.10. Anivia wins with a 66.7% win rate (+33.3%) over Karthus based on 6 games. Anivia wins the early laning phase while Karthus scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Anivia matchup.

Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Anivia - 33.3% win rateAnivia(33.3%)
Karthus - 33.3% win rate in this matchup
Karthus
33.3% WR
VS
Anivia vs Karthus matchup - 66.7% win rate
Anivia
66.7% WR

Who Wins the Karthus vs Anivia Matchup?

Anivia wins the Karthus vs Anivia matchup
Winner
Anivia
Matches: 6
33.3%
Win Rate
66.7%
6.9
CS / min
7.5
1,156
DMG / min
1,101
11,251
Gold / game
13,357
89
Heal / min
271
342
DMG Mitigated / min
647
0.5
CC / min
1.9
20.0%
Early Game WR
80.0%
100.0%
Late Game WR
0.0%

Karthus vs Anivia Matchup Summary

The Karthus vs Anivia matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Anivia wins with a 66.7% win rate compared to Karthus's 33.3%, giving Anivia a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Anivia controls the early laning stage, but Karthus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Anivia needs to press advantages before Karthus reaches their power spikes, while Karthus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Anivia leads by 1.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Anivia has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Anivia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Anivia Laning Phase Breakdown

Anivia wins the laning phase against Karthus in League of Legends

Anivia is favored during the laning phase against Karthus, winning 4 out of 5 key stat categories. Anivia holds advantages in farming, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
6.9Karthus
7.5Anivia
Anivia edges out Karthus by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Anivia.
Damage
1,156Karthus
1,101Anivia
Karthus deals 55 more champion damage per minute than Anivia. While noticeable in extended trades, this gap can be offset by Anivia choosing favorable fight windows, such as engaging when Karthus's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
11,251Karthus
13,357Anivia
Anivia generates a commanding 2,106 more gold per game than Karthus. This substantial economic advantage means Anivia consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.5Karthus
1.9Anivia
Anivia brings significantly more crowd control than Karthus, with 1.4 more seconds of CC per minute. This large utility gap makes Anivia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Karthus should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
431Karthus
918Anivia
Anivia vastly out-sustains Karthus, healing and mitigating 487 more damage per minute. This massive durability gap means Anivia can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Anivia

Spellslinger's Shoes is the optimal boots choice against Anivia, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Anivia are Liandry's Torment, Rabadon's Deathcap and Blackfire Torch. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Anivia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Anivia matchup.

Early Game vs Late Game

Early Game
Anivia
80.0%
+60.0% advantage
Karthus early game win rateKarthus20.0%
Anivia early game win rateAnivia80.0%
Late Game
Karthus
100.0%
+100.0% advantage
Karthus late game win rateKarthus100.0%
Anivia late game win rateAnivia0.0%

Anivia dominates the early game (first 15 minutes) with a commanding 80.0% win rate — a 60.0 percentage point lead over Karthus. This lopsided early game means Anivia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Karthus is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Anivia. Extended games heavily favor Karthus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Anivia must aggressively press their early advantage and close out the game before Karthus reaches their scaling breakpoints. If Karthus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Karthus Runes Against Anivia

Sorcery rune tree - Karthus primary runes vs AniviaSorcery
Deathfire Touch - best Karthus rune vs AniviaManaflow Band - best Karthus rune vs AniviaAbsolute Focus - best Karthus rune vs AniviaGathering Storm - best Karthus rune vs Anivia
Domination rune tree - Karthus secondary runes vs AniviaDomination
Ultimate Hunter - best Karthus rune vs AniviaTaste of Blood - best Karthus rune vs Anivia
100.0% WR

The Sorcery and Domination rune setup gives Karthus the best tools to compete against Anivia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.10. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.10
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
53.70%546.71,33414,54150.0%55.9%
51.16%431.21,04811,95850.0%52.2%
58.14%436.71,20812,83173.7%45.8%
40.48%426.51,29613,12741.2%40.0%
57.50%401.51,23315,07857.1%57.7%
38.46%391.31,19712,44826.3%50.0%
60.53%386.51,26714,33071.4%54.2%
50.00%361.41,14913,02452.9%47.4%
55.56%366.71,46014,98658.3%54.2%
45.71%351.51,09713,80160.0%40.0%
34.29%351.41,05512,46233.3%35.0%
58.82%341.31,14314,80861.5%57.1%
40.63%321.294712,75242.9%38.9%
46.88%326.61,37414,56245.5%47.6%
41.38%291.91,25715,09814.3%50.0%
53.57%286.51,37014,14469.2%40.0%
50.00%241.51,25915,57783.3%38.9%
75.00%241.21,01112,78677.8%73.3%
34.78%231.51,11612,54430.0%38.5%
47.83%232.41,09311,86856.3%28.6%
40.91%221.61,18512,56430.0%50.0%
42.86%211.31,17914,31028.6%50.0%
71.43%216.61,47816,88675.0%69.2%
60.00%201.11,18613,65637.5%75.0%
45.00%201.61,08311,55250.0%40.0%
35.00%201.31,04511,40125.0%50.0%
50.00%204.11,21112,62155.6%45.5%
47.37%196.51,24415,44760.0%42.9%
42.11%191.41,34614,53825.0%54.5%
42.11%191.51,24213,66828.6%50.0%
52.63%192.21,18114,28171.4%41.7%
50.00%181.51,08712,34350.0%50.0%
50.00%181.31,23014,05750.0%50.0%
77.78%181.31,08712,114100.0%42.9%
55.56%184.21,24014,43560.0%53.9%
43.75%166.31,12114,28540.0%45.5%
53.33%154.11,36816,83250.0%54.5%
80.00%152.099411,18690.0%60.0%
26.67%151.31,17912,85120.0%30.0%
60.00%151.51,10812,62683.3%44.4%
35.71%146.31,31813,13233.3%40.0%
57.14%142.31,15715,2470.0%66.7%
38.46%132.01,23814,09433.3%40.0%
76.92%132.11,28513,53085.7%66.7%
66.67%121.81,18713,32480.0%57.1%
58.33%121.31,39613,14560.0%57.1%
50.00%127.01,30213,89766.7%33.3%
58.33%126.61,38813,32750.0%62.5%
41.67%126.41,23513,14220.0%57.1%
45.45%115.895413,05333.3%50.0%
81.82%111.71,19414,61275.0%85.7%
54.55%111.31,27914,66160.0%50.0%
45.45%117.11,08011,40140.0%50.0%
36.36%111.81,02013,23414.3%75.0%
70.00%106.41,03611,954100.0%57.1%
50.00%102.41,34313,76025.0%66.7%
30.00%101.21,12712,91820.0%40.0%
70.00%105.71,17712,26566.7%71.4%
22.22%92.11,34614,6000.0%50.0%
22.22%92.21,13015,204100.0%12.5%
66.67%96.91,10014,97766.7%66.7%
33.33%96.81,13311,31225.0%40.0%
55.56%97.21,13411,62680.0%25.0%
22.22%96.71,29415,7530.0%28.6%
37.50%84.61,30111,12625.0%50.0%
50.00%85.01,42213,05933.3%60.0%
12.50%85.91,33515,2420.0%12.5%
62.50%85.11,26013,70733.3%80.0%
50.00%86.61,18114,0030.0%57.1%
62.50%85.91,18113,999100.0%57.1%
75.00%84.11,11110,85375.0%75.0%
37.50%85.31,11610,64020.0%66.7%
25.00%86.61,55912,58120.0%33.3%
50.00%82.21,10812,44733.3%60.0%
62.50%82.01,14212,80160.0%66.7%
42.86%74.01,14113,40733.3%50.0%
42.86%76.51,69212,8790.0%50.0%
28.57%76.31,35314,4450.0%40.0%
57.14%72.11,27616,60750.0%60.0%
71.43%76.91,63117,19733.3%100.0%
33.33%66.41,32513,92733.3%33.3%
33.33%66.994712,8840.0%40.0%
50.00%61.91,17712,94250.0%50.0%
66.67%62.31,10912,99950.0%75.0%
33.33%66.91,15611,25120.0%100.0%
83.33%62.31,07613,88766.7%100.0%
80.00%53.41,15614,20650.0%100.0%
60.00%53.41,49814,27150.0%66.7%
40.00%52.593710,52733.3%50.0%
40.00%53.91,51715,5010.0%50.0%
40.00%51.11,09413,00350.0%33.3%
60.00%52.71,40516,0870.0%100.0%
20.00%56.31,45211,5710.0%33.3%
60.00%56.91,14410,50466.7%50.0%

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Karthus vs Anivia - Frequently Asked Questions

How does Karthus do against Anivia in League of Legends?

Anivia wins the Karthus vs Anivia matchup with a 66.7% win rate compared to Karthus's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.10.

How does Karthus do against Anivia in the early game?

In the early game, Anivia has the advantage against Karthus with a 80.0% win rate versus 20.0%. Anivia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Anivia in the late game?

In the late game, Karthus takes over the Karthus vs Anivia matchup with a 100.0% win rate compared to 0.0%. Karthus scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Anivia matchup?

Anivia wins the matchup against Karthus with a 66.7% win rate in League of Legends patch 26.10. The 33.3 percentage point advantage means Anivia is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Karthus build against Anivia?

The best Karthus build against Anivia includes Liandry's Torment, Rabadon's Deathcap, Blackfire Torch with Spellslinger's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Anivia?

The best Karthus runes against Anivia use the Sorcery primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Anivia matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Anivia?

No, Karthus struggles against Anivia with only a 33.3% win rate. Anivia has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Anivia's lead.

How do I play Karthus against Anivia?

When playing Karthus against Anivia, play cautiously and avoid Anivia's power spikes. Focus on safe farming — you outscale Anivia in the late game. Use the matchup-specific build and runes above to optimize your chances.