Karthus - League of Legends Champion
Win Rate
50.0%
Pick Rate
1.1%

Karthusvs Warwick

CMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 4, 2026
MethodologyData Methodology

Karthus vs Warwick is a decisive matchup in LoL patch 26.11. Warwick wins with a 56.4% win rate (+12.7%) over Karthus based on 55 games. Warwick holds the advantage in both the early and late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Warwick matchup.

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Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 43.6% win rate in this matchup
Karthus
43.6% WR
VS
Warwick vs Karthus matchup - 56.4% win rate
Warwick
56.4% WR

Who Wins the Karthus vs Warwick Matchup?

Warwick wins the Karthus vs Warwick matchup
Winner
Warwick
Matches: 55
43.6%
Win Rate
56.4%
1.7
CS / min
1.1
1,170
DMG / min
705
13,037
Gold / game
12,873
291
Heal / min
793
498
DMG Mitigated / min
1,330
0.6
CC / min
1.0
40.0%
Early Game WR
60.0%
46.7%
Late Game WR
53.3%

Karthus vs Warwick Matchup Summary

The Karthus vs Warwick matchup is a decisive matchup in League of Legends ranked play. Based on 55 recent matches analyzed, Warwick wins with a 56.4% win rate compared to Karthus's 43.6%, giving Warwick a 12.7 percentage point advantage. Warwick dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Warwick leads by 1,335 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Warwick has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Warwick overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Warwick Laning Phase Breakdown

Karthus wins the laning phase against Warwick in League of Legends

Karthus is favored during the laning phase against Warwick, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
1.7Karthus
1.1Warwick
Karthus edges out Warwick by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 8 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
1,170Karthus
705Warwick
Karthus heavily out-damages Warwick by 464 DMG/min, dominating both short trades and all-in fights. Warwick should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
13,037Karthus
12,873Warwick
Karthus and Warwick generate nearly equal gold per game, with just a 164 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.6Karthus
1.0Warwick
Warwick provides 0.4 seconds more crowd control per minute than Karthus, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Warwick coordinate with their jungler and control the pace of skirmishes.
Sustain
788Karthus
2,123Warwick
Warwick vastly out-sustains Karthus, healing and mitigating 1,335 more damage per minute. This massive durability gap means Warwick can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Warwick

Sorcerer's Shoes is the optimal boots choice against Warwick, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Warwick are Liandry's Torment, Shadowflame and Zhonya's Hourglass. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. This build has a 33.3% win rate across 3 games. While the overall matchup may be difficult, this item path gives Karthus the best chance to compete against Warwick. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Warwick matchup.

Early Game vs Late Game

Early Game
Warwick
60.0%
+20.0% advantage
Karthus early game win rateKarthus40.0%
Warwick early game win rateWarwick60.0%
Late Game
Warwick
53.3%
+6.7% advantage
Karthus late game win rateKarthus46.7%
Warwick late game win rateWarwick53.3%

Warwick dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Karthus. This lopsided early game means Warwick can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Warwick is far superior in the late game (25+ minutes), boasting a 53.3% win rate — 6.7 points above Karthus. Extended games heavily favor Warwick, whose kit and scaling make them a dominant force in team fights and objective control.

Warwick holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Karthus Runes Against Warwick

Domination rune tree - Karthus primary runes vs WarwickDomination
Dark Harvest - best Karthus rune vs WarwickCheap Shot - best Karthus rune vs WarwickGrisly Mementos - best Karthus rune vs WarwickUltimate Hunter - best Karthus rune vs Warwick
Sorcery rune tree - Karthus secondary runes vs WarwickSorcery
Axiom Arcanist - best Karthus rune vs WarwickGathering Storm - best Karthus rune vs Warwick
37.5% WR

The Domination and Sorcery rune setup gives Karthus the best tools to compete against Warwick in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.11. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.09%551.41,03012,95747.8%50.0%
43.64%551.71,17013,03740.0%46.7%
45.10%511.61,05713,34631.8%55.2%
59.18%496.31,29113,60950.0%65.5%
52.08%481.51,25914,65547.1%54.8%
42.22%451.51,01713,07143.8%41.4%
37.78%451.31,02712,76840.9%34.8%
64.44%456.51,32616,02286.7%53.3%
50.00%426.61,19713,07066.7%33.3%
43.59%396.31,21513,23850.0%36.8%
57.89%381.41,26313,76053.3%60.9%
47.37%381.51,14413,40237.5%54.5%
34.21%381.91,06712,86740.0%30.4%
43.24%371.81,21213,46357.1%34.8%
38.24%347.01,24713,84233.3%42.1%
46.88%321.81,14612,84538.5%52.6%
43.33%301.81,29414,56958.3%33.3%
55.17%296.11,20312,39066.7%42.9%
46.43%281.41,03012,47453.3%38.5%
57.14%286.61,42315,21450.0%62.5%
40.74%271.31,33515,99216.7%47.6%
28.00%251.81,16313,29530.0%26.7%
66.67%241.61,14614,33775.0%58.3%
45.45%221.51,30714,90550.0%44.4%
66.67%212.21,20113,57277.8%58.3%
55.00%201.61,26713,96860.0%50.0%
68.42%195.61,49616,092100.0%60.0%
63.16%191.31,11614,40962.5%63.6%
38.89%181.51,44814,53542.9%36.4%
55.56%186.41,27613,45466.7%44.4%
72.22%185.11,12111,32260.0%87.5%
35.29%171.51,05612,45536.4%33.3%
52.94%171.31,37015,16157.1%50.0%
76.47%176.51,26315,48280.0%75.0%
47.06%171.596012,24444.4%50.0%
52.94%176.51,33013,71966.7%45.5%
43.75%161.41,24415,49750.0%41.7%
56.25%161.31,08013,22180.0%45.5%
53.33%155.41,37313,67875.0%45.5%
35.71%141.61,23913,56744.4%20.0%
28.57%146.71,35911,93450.0%12.5%
42.86%142.41,25014,77740.0%44.4%
50.00%141.61,08215,54125.0%60.0%
69.23%136.51,30513,96557.1%83.3%
61.54%136.51,25612,93960.0%62.5%
53.85%132.51,05212,27675.0%44.4%
58.33%125.91,02710,26957.1%60.0%
83.33%121.31,22913,18380.0%85.7%
50.00%125.41,34014,96775.0%37.5%
45.45%111.41,03113,14557.1%25.0%
72.73%111.61,02712,997100.0%57.1%
27.27%115.91,13213,2320.0%42.9%
30.00%103.21,05913,47225.0%33.3%
70.00%107.41,27115,568100.0%57.1%
70.00%102.91,14415,271100.0%62.5%
50.00%107.21,13812,21650.0%50.0%
40.00%102.91,37615,5780.0%44.4%
55.56%95.51,26613,15150.0%60.0%
33.33%94.992710,92520.0%50.0%
44.44%96.21,07210,46733.3%66.7%
55.56%93.31,21214,875100.0%42.9%
55.56%91.41,25215,076100.0%42.9%
77.78%92.91,16514,15366.7%83.3%
33.33%92.11,19513,83433.3%33.3%
87.50%81.31,11314,33780.0%100.0%
25.00%81.31,28513,22250.0%16.7%
87.50%86.41,18214,46450.0%100.0%
75.00%81.71,65016,96550.0%83.3%
75.00%86.71,19715,02375.0%75.0%
62.50%82.099113,519100.0%50.0%
37.50%81.799613,5240.0%50.0%
57.14%76.31,63217,174100.0%50.0%
42.86%72.91,10811,95025.0%66.7%
14.29%71.190712,62625.0%0.0%
71.43%76.91,20214,28450.0%80.0%
85.71%75.51,33217,1080.0%85.7%
42.86%74.11,21013,9640.0%50.0%
28.57%76.01,44213,3670.0%40.0%
57.14%77.01,42713,69033.3%75.0%
57.14%72.41,12412,10740.0%100.0%
85.71%71.01,06214,10450.0%100.0%
50.00%67.11,38812,74350.0%50.0%
33.33%66.81,14411,4860.0%66.7%
66.67%64.21,44015,135100.0%60.0%
33.33%62.39659,7790.0%50.0%
33.33%62.51,07412,12050.0%0.0%
33.33%66.61,31611,4480.0%66.7%
16.67%65.81,30313,2700.0%25.0%
50.00%62.51,43716,7350.0%75.0%
20.00%56.31,40913,9390.0%33.3%
40.00%55.37986,5180.0%100.0%
40.00%51.11,41814,8040.0%50.0%
40.00%53.41,19015,0350.0%50.0%
60.00%54.61,65613,73266.7%50.0%
80.00%56.71,33110,47066.7%100.0%
60.00%52.01,29214,405100.0%50.0%
20.00%56.01,20610,84633.3%0.0%
40.00%56.71,01212,7100.0%50.0%
40.00%56.31,48213,690100.0%25.0%
60.00%55.91,40013,38366.7%50.0%
40.00%56.51,1899,67725.0%100.0%

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Karthus vs Warwick - Frequently Asked Questions

How does Karthus do against Warwick in League of Legends?

Warwick wins the Karthus vs Warwick matchup with a 56.4% win rate compared to Karthus's 43.6%, a 12.7 percentage point difference. This data is based on 55 recent ranked games in patch 26.11.

How does Karthus do against Warwick in the early game?

In the early game, Warwick has the advantage against Karthus with a 60.0% win rate versus 40.0%. Warwick players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Warwick in the late game?

In the late game, Warwick takes over the Karthus vs Warwick matchup with a 53.3% win rate compared to 46.7%. Warwick scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Warwick matchup?

Warwick wins the matchup against Karthus with a 56.4% win rate in League of Legends patch 26.11. The 12.7 percentage point advantage means Warwick is significantly favored in this lane matchup based on 55 games analyzed.

What is the best Karthus build against Warwick?

The best Karthus build against Warwick includes Liandry's Torment, Shadowflame, Zhonya's Hourglass with Sorcerer's Shoes. This build achieves a 33.3% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Warwick?

The best Karthus runes against Warwick use the Domination primary tree with Sorcery secondary. This rune setup achieves a 37.5% win rate in the Karthus vs Warwick matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Warwick?

No, Karthus struggles against Warwick with only a 43.6% win rate. Warwick has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Warwick's lead.

How do I play Karthus against Warwick?

When playing Karthus against Warwick, play cautiously and avoid Warwick's power spikes. Look for jungle assistance and team-dependent plays since Warwick has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.