Karthus - League of Legends Champion
Win Rate
49.3%
Pick Rate
1.3%

Karthusvs Kayn

DMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 19, 2026
MethodologyData Methodology

Karthus vs Kayn is a decisive matchup in LoL patch 26.7. Kayn wins with a 55.9% win rate (+11.8%) over Karthus based on 34 games. Karthus wins the early laning phase while Kayn scales better into the late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Kayn matchup.

Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kayn - 44.1% win rateKayn(44.1%)
Karthus - 44.1% win rate in this matchup
Karthus
44.1% WR
VS
Kayn vs Karthus matchup - 55.9% win rate
Kayn
55.9% WR

Who Wins the Karthus vs Kayn Matchup?

Kayn wins the Karthus vs Kayn matchup
Winner
Kayn
Matches: 34
44.1%
Win Rate
55.9%
1.4
CS / min
1.1
1,122
DMG / min
794
14,486
Gold / game
14,480
295
Heal / min
543
505
DMG Mitigated / min
782
0.6
CC / min
0.4
58.3%
Early Game WR
41.7%
36.4%
Late Game WR
63.6%

Karthus vs Kayn Matchup Summary

The Karthus vs Kayn matchup is a decisive matchup in League of Legends ranked play. Based on 34 recent matches analyzed, Kayn wins with a 55.9% win rate compared to Karthus's 44.1%, giving Kayn a 11.8 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Kayn outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Kayn reaches their power spikes, while Kayn should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Kayn leads by 525 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Kayn has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Kayn overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Kayn Laning Phase Breakdown

Karthus wins the laning phase against Kayn in League of Legends

Karthus is favored during the laning phase against Kayn, winning 4 out of 5 key stat categories. Karthus holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
1.4Karthus
1.1Kayn
Karthus edges out Kayn by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
1,122Karthus
794Kayn
Karthus heavily out-damages Kayn by 329 DMG/min, dominating both short trades and all-in fights. Kayn should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
14,486Karthus
14,480Kayn
Karthus and Kayn generate nearly equal gold per game, with just a 5 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.6Karthus
0.4Kayn
Both Karthus and Kayn provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
800Karthus
1,325Kayn
Kayn vastly out-sustains Karthus, healing and mitigating 525 more damage per minute. This massive durability gap means Kayn can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Kayn

Sorcerer's Shoes is the optimal boots choice against Kayn, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Kayn are Shadowflame, Zhonya's Hourglass and Blackfire Torch. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 66.7% win rate across 3 games — well above average and making it the top item path against Kayn. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Kayn matchup.

Early Game vs Late Game

Early Game
Karthus
58.3%
+16.7% advantage
Karthus early game win rateKarthus58.3%
Kayn early game win rateKayn41.7%
Late Game
Kayn
63.6%
+27.3% advantage
Karthus late game win rateKarthus36.4%
Kayn late game win rateKayn63.6%

Karthus dominates the early game (first 15 minutes) with a commanding 58.3% win rate — a 16.7 percentage point lead over Kayn. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Kayn is far superior in the late game (25+ minutes), boasting a 63.6% win rate — 27.3 points above Karthus. Extended games heavily favor Kayn, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Kayn reaches their scaling breakpoints. If Kayn survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Karthus Runes Against Kayn

Domination rune tree - Karthus primary runes vs KaynDomination
Dark Harvest - best Karthus rune vs KaynCheap Shot - best Karthus rune vs KaynSixth Sense - best Karthus rune vs KaynUltimate Hunter - best Karthus rune vs Kayn
Precision rune tree - Karthus secondary runes vs KaynPrecision
Last Stand - best Karthus rune vs KaynTriumph - best Karthus rune vs Kayn
100.0% WR

The Domination and Precision rune setup gives Karthus the best tools to compete against Kayn in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.7. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
48.78%411.51,24613,63464.7%37.5%
45.00%401.71,19914,67650.0%41.7%
37.84%371.81,20313,45342.9%34.8%
59.46%376.81,20414,13361.1%57.9%
58.33%361.41,18514,86346.1%65.2%
42.86%351.61,14713,92340.0%45.0%
44.12%341.41,12214,48658.3%36.4%
65.63%326.31,26613,64771.4%61.1%
50.00%281.61,25415,99971.4%42.9%
44.44%276.11,21913,94641.7%46.7%
59.26%276.01,24814,69160.0%58.8%
60.00%251.51,20814,13545.5%71.4%
63.64%222.01,41215,52085.7%53.3%
63.64%226.01,33115,66162.5%64.3%
57.89%191.21,11113,72737.5%72.7%
36.84%196.51,28014,54516.7%46.1%
42.11%191.51,29515,86340.0%42.9%
57.89%191.41,15014,33071.4%50.0%
47.06%176.41,29415,52850.0%46.1%
76.47%171.21,06613,39466.7%87.5%
47.06%171.81,19814,51350.0%46.1%
75.00%161.41,29814,71466.7%80.0%
56.25%161.51,14013,02250.0%62.5%
26.67%151.31,03412,14627.3%25.0%
33.33%152.11,14213,21320.0%40.0%
35.71%141.11,12013,85225.0%50.0%
38.46%131.21,08313,38916.7%57.1%
38.46%131.41,18614,42740.0%37.5%
23.08%132.21,01010,85522.2%25.0%
46.15%136.01,24613,80450.0%44.4%
53.85%137.11,16413,19242.9%66.7%
50.00%123.71,31914,92180.0%28.6%
50.00%121.21,22814,55325.0%62.5%
25.00%126.51,36414,04133.3%16.7%
83.33%121.41,23815,11766.7%88.9%
25.00%121.61,12615,19325.0%25.0%
66.67%127.31,53918,810100.0%60.0%
25.00%121.21,07613,8870.0%60.0%
50.00%121.31,03811,95450.0%50.0%
63.64%116.81,40515,26060.0%66.7%
63.64%112.91,09213,99266.7%62.5%
27.27%111.31,12512,25020.0%33.3%
18.18%111.51,18312,73025.0%14.3%
45.45%116.71,23014,91440.0%50.0%
70.00%105.91,26912,68760.0%80.0%
60.00%107.01,16813,68960.0%60.0%
60.00%101.41,38813,38660.0%60.0%
70.00%107.11,33314,53075.0%66.7%
33.33%97.31,21213,57820.0%50.0%
44.44%93.899013,717100.0%28.6%
22.22%96.81,08812,89120.0%25.0%
66.67%91.61,56915,98675.0%60.0%
66.67%91.81,22714,33780.0%50.0%
33.33%94.81,07213,64425.0%40.0%
50.00%86.71,22114,59460.0%33.3%
37.50%81.81,33816,668100.0%28.6%
42.86%72.11,10612,56733.3%50.0%
42.86%72.21,17211,38060.0%0.0%
42.86%72.01,37413,47750.0%33.3%
42.86%77.21,12512,97033.3%50.0%
71.43%75.71,05413,5520.0%100.0%
71.43%71.21,49615,8850.0%83.3%
14.29%72.91,23213,7160.0%33.3%
57.14%72.01,19112,95466.7%50.0%
42.86%72.11,19315,03550.0%40.0%
85.71%71.61,34617,646100.0%80.0%
57.14%72.81,23515,411100.0%40.0%
50.00%66.91,27912,34425.0%100.0%
66.67%61.31,38414,20166.7%66.7%
66.67%61.396311,486100.0%50.0%
33.33%65.41,55214,5320.0%33.3%
33.33%62.481311,29650.0%0.0%
66.67%64.01,15114,6630.0%80.0%
16.67%61.41,19215,1100.0%20.0%
50.00%61.61,26817,2400.0%60.0%
60.00%55.91,19113,24966.7%50.0%
40.00%51.61,10312,8790.0%66.7%
40.00%56.81,00311,9160.0%50.0%
60.00%55.11,47719,353100.0%50.0%
20.00%52.81,10312,98150.0%0.0%
60.00%53.17289,38375.0%0.0%
60.00%57.11,03414,8450.0%75.0%
20.00%58.21,15513,53650.0%0.0%
60.00%52.382213,48466.7%50.0%

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Karthus vs Kayn - Frequently Asked Questions

How does Karthus do against Kayn in League of Legends?

Kayn wins the Karthus vs Kayn matchup with a 55.9% win rate compared to Karthus's 44.1%, a 11.8 percentage point difference. This data is based on 34 recent ranked games in patch 26.7.

How does Karthus do against Kayn in the early game?

In the early game, Karthus has the advantage against Kayn with a 58.3% win rate versus 41.7%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Kayn in the late game?

In the late game, Kayn takes over the Karthus vs Kayn matchup with a 63.6% win rate compared to 36.4%. Kayn scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Kayn matchup?

Kayn wins the matchup against Karthus with a 55.9% win rate in League of Legends patch 26.7. The 11.8 percentage point advantage means Kayn is significantly favored in this lane matchup based on 34 games analyzed.

What is the best Karthus build against Kayn?

The best Karthus build against Kayn includes Shadowflame, Zhonya's Hourglass, Blackfire Torch with Sorcerer's Shoes. This build achieves a 66.7% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Kayn?

The best Karthus runes against Kayn use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Kayn matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Kayn?

No, Karthus struggles against Kayn with only a 44.1% win rate. Kayn has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Kayn's lead.

How do I play Karthus against Kayn?

When playing Karthus against Kayn, play cautiously and avoid Kayn's power spikes. Look for jungle assistance and team-dependent plays since Kayn has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.