Karthus - League of Legends Champion
Win Rate
49.3%
Pick Rate
1.3%

Karthusvs Dr. Mundo

DMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 18, 2026
MethodologyData Methodology

Karthus vs Dr. Mundo is a decisive matchup in LoL patch 26.7. Dr. Mundo wins with a 81.8% win rate (+63.6%) over Karthus based on 11 games. Dr. Mundo holds the advantage in both the early and late game. Below you'll find the best Karthus build, runes, laning stats, and strategies for the Karthus vs Dr. Mundo matchup.

Karthus Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Karthus performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Dr. Mundo - 18.2% win rateDr. Mundo(18.2%)
Karthus - 18.2% win rate in this matchup
Karthus
18.2% WR
VS
Dr. Mundo vs Karthus matchup - 81.8% win rate
Dr. Mundo
81.8% WR

Who Wins the Karthus vs Dr. Mundo Matchup?

Dr. Mundo wins the Karthus vs Dr. Mundo matchup
Winner
Dr. Mundo
Matches: 11
18.2%
Win Rate
81.8%
1.5
CS / min
1.3
1,183
DMG / min
859
12,730
Gold / game
14,662
303
Heal / min
1,393
499
DMG Mitigated / min
1,858
0.7
CC / min
0.6
25.0%
Early Game WR
75.0%
14.3%
Late Game WR
85.7%

Karthus vs Dr. Mundo Matchup Summary

The Karthus vs Dr. Mundo matchup is a decisive matchup in League of Legends ranked play. Based on 11 recent matches analyzed, Dr. Mundo wins with a 81.8% win rate compared to Karthus's 18.2%, giving Dr. Mundo a 63.6 percentage point advantage. Dr. Mundo dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Dr. Mundo leads by 2,450 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Dr. Mundo has a strong advantage in this matchup. Karthus players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Dr. Mundo overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Karthus vs Dr. Mundo Laning Phase Breakdown

Karthus wins the laning phase against Dr. Mundo in League of Legends

Karthus is favored during the laning phase against Dr. Mundo, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.5Karthus
1.3Dr. Mundo
Karthus and Dr. Mundo farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
1,183Karthus
859Dr. Mundo
Karthus heavily out-damages Dr. Mundo by 324 DMG/min, dominating both short trades and all-in fights. Dr. Mundo should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
12,730Karthus
14,662Dr. Mundo
Dr. Mundo generates a commanding 1,932 more gold per game than Karthus. This substantial economic advantage means Dr. Mundo consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Karthus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.7Karthus
0.6Dr. Mundo
Both Karthus and Dr. Mundo provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
802Karthus
3,251Dr. Mundo
Dr. Mundo vastly out-sustains Karthus, healing and mitigating 2,450 more damage per minute. This massive durability gap means Dr. Mundo can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Karthus Build Against Dr. Mundo

Sorcerer's Shoes is the optimal boots choice against Dr. Mundo, providing the mobility and stats Karthus needs most in this matchup. The top-performing core items for Karthus against Dr. Mundo are Liandry's Torment, Shadowflame and Void Staff. This combination gives Karthus an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Karthus vs Dr. Mundo matchup.

Early Game vs Late Game

Early Game
Dr. Mundo
75.0%
+50.0% advantage
Karthus early game win rateKarthus25.0%
Dr. Mundo early game win rateDr. Mundo75.0%
Late Game
Dr. Mundo
85.7%
+71.4% advantage
Karthus late game win rateKarthus14.3%
Dr. Mundo late game win rateDr. Mundo85.7%

Dr. Mundo dominates the early game (first 15 minutes) with a commanding 75.0% win rate — a 50.0 percentage point lead over Karthus. This lopsided early game means Dr. Mundo can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Dr. Mundo is far superior in the late game (25+ minutes), boasting a 85.7% win rate — 71.4 points above Karthus. Extended games heavily favor Dr. Mundo, whose kit and scaling make them a dominant force in team fights and objective control.

Dr. Mundo holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Karthus Runes Against Dr. Mundo

Domination rune tree - Karthus primary runes vs Dr. MundoDomination
Dark Harvest - best Karthus rune vs Dr. MundoCheap Shot - best Karthus rune vs Dr. MundoSixth Sense - best Karthus rune vs Dr. MundoUltimate Hunter - best Karthus rune vs Dr. Mundo
Precision rune tree - Karthus secondary runes vs Dr. MundoPrecision
Presence of Mind - best Karthus rune vs Dr. MundoLast Stand - best Karthus rune vs Dr. Mundo
100.0% WR

The Domination and Precision rune setup gives Karthus the best tools to compete against Dr. Mundo in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Karthus matchup data for League of Legends patch 26.7. The table below shows Karthus's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Karthus build, runes, laning stats, and early vs late game analysis for that specific matchup.

Karthus matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
48.78%411.51,24613,63464.7%37.5%
45.00%401.71,19914,67650.0%41.7%
37.84%371.81,20313,45342.9%34.8%
59.46%376.81,20414,13361.1%57.9%
58.33%361.41,18514,86346.1%65.2%
42.86%351.61,14713,92340.0%45.0%
44.12%341.41,12214,48658.3%36.4%
65.63%326.31,26613,64771.4%61.1%
50.00%281.61,25415,99971.4%42.9%
44.44%276.11,21913,94641.7%46.7%
59.26%276.01,24814,69160.0%58.8%
60.00%251.51,20814,13545.5%71.4%
63.64%222.01,41215,52085.7%53.3%
63.64%226.01,33115,66162.5%64.3%
57.89%191.21,11113,72737.5%72.7%
36.84%196.51,28014,54516.7%46.1%
42.11%191.51,29515,86340.0%42.9%
57.89%191.41,15014,33071.4%50.0%
47.06%176.41,29415,52850.0%46.1%
76.47%171.21,06613,39466.7%87.5%
47.06%171.81,19814,51350.0%46.1%
75.00%161.41,29814,71466.7%80.0%
56.25%161.51,14013,02250.0%62.5%
26.67%151.31,03412,14627.3%25.0%
33.33%152.11,14213,21320.0%40.0%
35.71%141.11,12013,85225.0%50.0%
38.46%131.21,08313,38916.7%57.1%
38.46%131.41,18614,42740.0%37.5%
23.08%132.21,01010,85522.2%25.0%
46.15%136.01,24613,80450.0%44.4%
53.85%137.11,16413,19242.9%66.7%
50.00%123.71,31914,92180.0%28.6%
50.00%121.21,22814,55325.0%62.5%
25.00%126.51,36414,04133.3%16.7%
83.33%121.41,23815,11766.7%88.9%
25.00%121.61,12615,19325.0%25.0%
66.67%127.31,53918,810100.0%60.0%
25.00%121.21,07613,8870.0%60.0%
50.00%121.31,03811,95450.0%50.0%
63.64%116.81,40515,26060.0%66.7%
63.64%112.91,09213,99266.7%62.5%
27.27%111.31,12512,25020.0%33.3%
18.18%111.51,18312,73025.0%14.3%
45.45%116.71,23014,91440.0%50.0%
70.00%105.91,26912,68760.0%80.0%
60.00%107.01,16813,68960.0%60.0%
60.00%101.41,38813,38660.0%60.0%
70.00%107.11,33314,53075.0%66.7%
33.33%97.31,21213,57820.0%50.0%
44.44%93.899013,717100.0%28.6%
22.22%96.81,08812,89120.0%25.0%
66.67%91.61,56915,98675.0%60.0%
66.67%91.81,22714,33780.0%50.0%
33.33%94.81,07213,64425.0%40.0%
50.00%86.71,22114,59460.0%33.3%
37.50%81.81,33816,668100.0%28.6%
42.86%72.11,10612,56733.3%50.0%
42.86%72.21,17211,38060.0%0.0%
42.86%72.01,37413,47750.0%33.3%
42.86%77.21,12512,97033.3%50.0%
71.43%75.71,05413,5520.0%100.0%
71.43%71.21,49615,8850.0%83.3%
14.29%72.91,23213,7160.0%33.3%
57.14%72.01,19112,95466.7%50.0%
42.86%72.11,19315,03550.0%40.0%
85.71%71.61,34617,646100.0%80.0%
57.14%72.81,23515,411100.0%40.0%
50.00%66.91,27912,34425.0%100.0%
66.67%61.31,38414,20166.7%66.7%
66.67%61.396311,486100.0%50.0%
33.33%65.41,55214,5320.0%33.3%
33.33%62.481311,29650.0%0.0%
66.67%64.01,15114,6630.0%80.0%
16.67%61.41,19215,1100.0%20.0%
50.00%61.61,26817,2400.0%60.0%
60.00%55.91,19113,24966.7%50.0%
40.00%51.61,10312,8790.0%66.7%
40.00%56.81,00311,9160.0%50.0%
60.00%55.11,47719,353100.0%50.0%
20.00%52.81,10312,98150.0%0.0%
60.00%53.17289,38375.0%0.0%
60.00%57.11,03414,8450.0%75.0%
20.00%58.21,15513,53650.0%0.0%
60.00%52.382213,48466.7%50.0%

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Karthus vs Dr. Mundo - Frequently Asked Questions

How does Karthus do against Dr. Mundo in League of Legends?

Dr. Mundo wins the Karthus vs Dr. Mundo matchup with a 81.8% win rate compared to Karthus's 18.2%, a 63.6 percentage point difference. This data is based on 11 recent ranked games in patch 26.7.

How does Karthus do against Dr. Mundo in the early game?

In the early game, Dr. Mundo has the advantage against Karthus with a 75.0% win rate versus 25.0%. Dr. Mundo players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Karthus do against Dr. Mundo in the late game?

In the late game, Dr. Mundo takes over the Karthus vs Dr. Mundo matchup with a 85.7% win rate compared to 14.3%. Dr. Mundo scales better into team fights and objective contests after 25 minutes.

Who wins the Karthus vs Dr. Mundo matchup?

Dr. Mundo wins the matchup against Karthus with a 81.8% win rate in League of Legends patch 26.7. The 63.6 percentage point advantage means Dr. Mundo is significantly favored in this lane matchup based on 11 games analyzed.

What is the best Karthus build against Dr. Mundo?

The best Karthus build against Dr. Mundo includes Liandry's Torment, Shadowflame, Void Staff with Sorcerer's Shoes. Check the matchup breakdown above for the full item path and build order.

What are the best Karthus runes against Dr. Mundo?

The best Karthus runes against Dr. Mundo use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Karthus vs Dr. Mundo matchup. See the full rune breakdown in the matchup comparison above.

Does Karthus counter Dr. Mundo?

No, Karthus struggles against Dr. Mundo with only a 18.2% win rate. Dr. Mundo has the advantage in this matchup. Karthus players should focus on safe farming and avoiding extended trades to minimize Dr. Mundo's lead.

How do I play Karthus against Dr. Mundo?

When playing Karthus against Dr. Mundo, play cautiously and avoid Dr. Mundo's power spikes. Look for jungle assistance and team-dependent plays since Dr. Mundo has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.