Lissandra - League of Legends Champion
Win Rate
51.6%
Pick Rate
1.7%

Lissandravs Cassiopeia

AMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 6, 2026
MethodologyData Methodology

Lissandra vs Cassiopeia is a decisive matchup in LoL patch 26.11. Lissandra wins with a 66.7% win rate (+33.3%) over Cassiopeia based on 15 games. Lissandra holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Cassiopeia matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 66.7% win rate in this matchup
Lissandra
66.7% WR
VS
Cassiopeia vs Lissandra matchup - 33.3% win rate
Cassiopeia
33.3% WR

Who Wins the Lissandra vs Cassiopeia Matchup?

Lissandra wins the Lissandra vs Cassiopeia matchup
Winner
Lissandra
Matches: 15
66.7%
Win Rate
33.3%
6.9
CS / min
6.7
842
DMG / min
835
13,080
Gold / game
12,460
129
Heal / min
237
436
DMG Mitigated / min
594
1.5
CC / min
1.1
100.0%
Early Game WR
0.0%
54.5%
Late Game WR
45.5%

Lissandra vs Cassiopeia Matchup Summary

The Lissandra vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 15 recent matches analyzed, Lissandra wins with a 66.7% win rate compared to Cassiopeia's 33.3%, giving Lissandra a 33.3 percentage point advantage. Lissandra dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Cassiopeia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Cassiopeia leads by 266 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Lissandra players can confidently pick into Cassiopeia and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Cassiopeia away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Cassiopeia Laning Phase Breakdown

Lissandra wins the laning phase against Cassiopeia in League of Legends

Lissandra is favored during the laning phase against Cassiopeia, winning 4 out of 5 key stat categories. Lissandra holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
6.9Lissandra
6.7Cassiopeia
Lissandra and Cassiopeia farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
842Lissandra
835Cassiopeia
Damage output is virtually even between Lissandra and Cassiopeia, with only 7 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
13,080Lissandra
12,460Cassiopeia
Lissandra earns 621 more gold per game than Cassiopeia, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Lissandra slightly faster item completions.
Utility
1.5Lissandra
1.1Cassiopeia
Lissandra provides 0.4 seconds more crowd control per minute than Cassiopeia, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
564Lissandra
830Cassiopeia
Cassiopeia vastly out-sustains Lissandra, healing and mitigating 266 more damage per minute. This massive durability gap means Cassiopeia can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Cassiopeia

Spellslinger's Shoes is the optimal boots choice against Cassiopeia, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Cassiopeia are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 60.0% win rate across 5 games — well above average and making it the top item path against Cassiopeia. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Cassiopeia matchup.

Early Game vs Late Game

Early Game
Lissandra
100.0%
+100.0% advantage
Lissandra early game win rateLissandra100.0%
Cassiopeia early game win rateCassiopeia0.0%
Late Game
Lissandra
54.5%
+9.1% advantage
Lissandra late game win rateLissandra54.5%
Cassiopeia late game win rateCassiopeia45.5%

Lissandra dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Cassiopeia. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 54.5% win rate — 9.1 points above Cassiopeia. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

Lissandra holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Cassiopeia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Cassiopeia

Domination rune tree - Lissandra primary runes vs CassiopeiaDomination
Electrocute - best Lissandra rune vs CassiopeiaCheap Shot - best Lissandra rune vs CassiopeiaGrisly Mementos - best Lissandra rune vs CassiopeiaUltimate Hunter - best Lissandra rune vs Cassiopeia
Sorcery rune tree - Lissandra secondary runes vs CassiopeiaSorcery
Transcendence - best Lissandra rune vs CassiopeiaScorch - best Lissandra rune vs Cassiopeia
100.0% WR

Running Domination primary with Sorcery secondary allows Lissandra to press their advantage against Cassiopeia, amplifying the strengths that make this a favorable matchup.


Lissandra matchup data for League of Legends patch 26.11. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.02%1316.885811,86355.0%60.6%
61.60%1256.791812,36268.6%56.8%
54.47%1236.988112,08353.1%55.4%
54.95%1116.874811,41055.8%54.2%
51.52%996.684011,78453.5%50.0%
50.00%986.985712,17845.0%53.5%
55.56%816.992811,72160.5%51.2%
44.74%766.878111,74844.1%45.2%
57.53%736.785911,06161.5%52.9%
52.86%706.487411,10854.3%51.4%
48.53%687.090811,10755.0%39.3%
53.73%676.178010,94653.1%54.3%
48.28%586.778112,35453.9%43.8%
41.07%566.774210,62436.7%46.1%
58.93%566.573210,32060.6%56.5%
53.70%546.488811,71551.9%55.6%
52.08%486.888112,08468.2%38.5%
55.32%476.384311,46055.6%55.2%
51.16%436.883412,58750.0%51.9%
43.59%396.482510,76435.0%52.6%
46.15%396.577310,88341.2%50.0%
39.47%386.680212,13937.5%40.9%
56.76%376.374210,61842.1%72.2%
56.76%376.878712,41658.8%55.0%
56.76%376.880811,53576.9%45.8%
32.43%377.080410,61129.4%35.0%
48.65%377.083812,68066.7%40.0%
33.33%336.992311,15131.3%35.3%
66.67%306.784412,08075.0%61.1%
65.52%296.986511,46770.6%58.3%
53.57%286.785811,89133.3%63.2%
61.54%267.193811,18175.0%40.0%
37.50%246.470111,94744.4%33.3%
58.33%247.382212,59060.0%57.1%
50.00%227.076411,84454.5%45.5%
54.55%226.61,01413,02066.7%50.0%
31.82%226.768410,84522.2%38.5%
33.33%216.874611,90044.4%25.0%
57.14%215.782310,46554.5%60.0%
73.68%196.980510,70775.0%72.7%
57.89%196.985412,58375.0%45.5%
61.11%187.488713,06550.0%70.0%
38.89%187.294812,87866.7%25.0%
58.82%176.51,06612,41342.9%70.0%
62.50%166.268611,07572.7%40.0%
56.25%166.892312,01450.0%57.1%
66.67%156.984213,080100.0%54.5%
64.29%146.190813,43275.0%60.0%
50.00%144.254910,94350.0%50.0%
64.29%146.779211,67883.3%50.0%
57.14%147.01,08911,13070.0%25.0%
53.85%136.693411,37550.0%57.1%
58.33%127.51,05412,44966.7%50.0%
63.64%116.090612,08133.3%100.0%
45.45%115.590412,09425.0%57.1%
63.64%112.682511,48750.0%71.4%
30.00%105.47418,70242.9%0.0%
70.00%107.194411,75183.3%50.0%
70.00%106.21,13613,233100.0%50.0%
50.00%106.889914,6330.0%62.5%
70.00%106.481112,0790.0%87.5%
55.56%96.281411,09650.0%66.7%
33.33%96.885511,75450.0%20.0%
66.67%96.578212,16033.3%83.3%
22.22%92.55189,7830.0%40.0%
85.71%77.71,15311,498100.0%66.7%
71.43%76.482813,449100.0%66.7%
57.14%77.384211,22350.0%66.7%
100.00%78.28329,161100.0%100.0%
57.14%72.986810,35560.0%50.0%
42.86%77.48559,99550.0%33.3%
57.14%77.080513,44150.0%66.7%
50.00%66.469210,47333.3%66.7%
33.33%66.78659,25050.0%0.0%
50.00%65.784212,7490.0%50.0%
80.00%56.88199,894100.0%66.7%
60.00%57.671711,88250.0%66.7%
60.00%57.593814,8270.0%75.0%
40.00%52.155411,1230.0%40.0%
60.00%56.576611,909100.0%50.0%
40.00%56.95498,21433.3%50.0%
80.00%53.669512,683100.0%50.0%
60.00%52.24318,35366.7%50.0%
60.00%57.51,17014,036100.0%33.3%
40.00%55.596514,4230.0%40.0%
80.00%57.31,24116,644100.0%75.0%
80.00%56.388712,12650.0%100.0%
60.00%56.074710,44750.0%100.0%
20.00%56.67479,3500.0%33.3%

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Lissandra vs Cassiopeia - Frequently Asked Questions

How does Lissandra do against Cassiopeia in League of Legends?

Lissandra wins the Lissandra vs Cassiopeia matchup with a 66.7% win rate compared to Cassiopeia's 33.3%, a 33.3 percentage point difference. This data is based on 15 recent ranked games in patch 26.11.

How does Lissandra do against Cassiopeia in the early game?

In the early game, Lissandra has the advantage against Cassiopeia with a 100.0% win rate versus 0.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Cassiopeia in the late game?

In the late game, Lissandra takes over the Lissandra vs Cassiopeia matchup with a 54.5% win rate compared to 45.5%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Cassiopeia matchup?

Lissandra wins the matchup against Cassiopeia with a 66.7% win rate in League of Legends patch 26.11. The 33.3 percentage point advantage means Lissandra is significantly favored in this lane matchup based on 15 games analyzed.

What is the best Lissandra build against Cassiopeia?

The best Lissandra build against Cassiopeia includes Shadowflame, Zhonya's Hourglass, Malignance with Spellslinger's Shoes. This build achieves a 60.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Cassiopeia?

The best Lissandra runes against Cassiopeia use the Domination primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Lissandra vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Cassiopeia?

Yes, Lissandra has a favorable matchup against Cassiopeia with a 66.7% win rate. Lissandra strongly counters Cassiopeia in lane based on current patch 26.11 data.

How do I play Lissandra against Cassiopeia?

When playing Lissandra against Cassiopeia, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.