Lissandra - League of Legends Champion
Win Rate
50.4%
Pick Rate
3.0%
Ban Rate
2.3%

Lissandravs Karma

BMage
Patch26.17
Games2,980
LaneAll Lanes
TierAll Tiers
Last UpdatedSep 6, 2026 UTC
MethodologyData Methodology

Lissandra vs Karma is a decisive matchup in LoL patch 26.17. Karma wins with a 60.0% win rate (+20.0%) over Lissandra based on 5 games. Karma wins the early laning phase while Lissandra scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Karma matchup.

Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 40.0% win rate in this matchup
Lissandra
40.0% WR
VS
Karma vs Lissandra matchup - 60.0% win rate
Karma
60.0% WR

Who Wins the Lissandra vs Karma Matchup?

Karma wins the Lissandra vs Karma matchup
Winner
Karma
Matches: 5
40.0%
Win Rate
60.0%
2.8
CS / min
2.4
530
DMG / min
686
10,608
Gold / game
11,144
119
Heal / min
186
340
DMG Mitigated / min
458
1.5
CC / min
1.0
0.0%
Early Game WR
100.0%
66.7%
Late Game WR
33.3%

Lissandra vs Karma Matchup Summary

The Lissandra vs Karma matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Karma wins with a 60.0% win rate compared to Lissandra's 40.0%, giving Karma a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Karma controls the early laning stage, but Lissandra outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karma needs to press advantages before Lissandra reaches their power spikes, while Lissandra should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in healing, where Karma leads by 67 HP healed/min — a difference that heavily influences the outcome of trades and skirmishes. Karma has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Karma overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Very small sampleBased on 5 matches. This is far too small a sample to draw conclusions from — treat these numbers as provisional.

Lissandra vs Karma Laning Phase Breakdown

Karma wins the laning phase against Lissandra in League of Legends

Karma is favored during the laning phase against Lissandra, winning 2 out of 4 key stat categories. Karma holds advantages in damage and gold income, making them the stronger laner in this matchup.

Farming
2.8Lissandra
2.4Karma
Lissandra edges out Karma by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
530Lissandra
686Karma
Karma heavily out-damages Lissandra by 156 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karma's sustained damage advantage take over.
Economy
10,608Lissandra
11,144Karma
Karma earns 536 more gold per game than Lissandra, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Karma slightly faster item completions.
Utility
1.5Lissandra
1.0Karma
Lissandra provides 0.5 seconds more crowd control per minute than Karma, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Healing
119Lissandra
186Karma
Karma heals 67 HP/min more than Lissandra. It helps Karma recover between trades, but the gap is not large enough to justify an early anti-heal item.
Durability
340Lissandra
458Karma
Karma mitigates 118 more damage per minute than Lissandra through shields and resistances, so Karma can take slightly longer trades. This is durability, not healing: anti-heal does nothing against it.

Best Lissandra Build Against Karma

Not enough matchup-specific build data: only 1 of 3 Lissandra games against Karma carried a complete build, which is too few to recommend an item path from. Use Lissandra's standard build instead.

Early Game vs Late Game

Early Game
Karma
100.0%
+100.0% advantage
Lissandra early game win rateLissandra0.0%
Karma early game win rateKarma100.0%
Late Game
Lissandra
66.7%
+33.3% advantage
Lissandra late game win rateLissandra66.7%
Karma late game win rateKarma33.3%

Karma dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Lissandra. This lopsided early game means Karma can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Lissandra is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Karma. Extended games heavily favor Lissandra, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karma must aggressively press their early advantage and close out the game before Lissandra reaches their scaling breakpoints. If Lissandra survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Lissandra Runes Against Karma

Sorcery rune tree - Lissandra primary runes vs KarmaSorcery
Arcane Comet - best Lissandra rune vs KarmaManaflow Band - best Lissandra rune vs KarmaTranscendence - best Lissandra rune vs KarmaScorch - best Lissandra rune vs Karma
Domination rune tree - Lissandra secondary runes vs KarmaDomination
Cheap Shot - best Lissandra rune vs KarmaUltimate Hunter - best Lissandra rune vs Karma
50.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Karma in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.17. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

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Lissandra vs Karma - Frequently Asked Questions

How does Lissandra do against Karma in League of Legends?

Karma wins the Lissandra vs Karma matchup with a 60.0% win rate compared to Lissandra's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.17.

How does Lissandra do against Karma in the early game?

In the early game, Karma has the advantage against Lissandra with a 100.0% win rate versus 0.0%. Karma players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Karma in the late game?

In the late game, Lissandra takes over the Lissandra vs Karma matchup with a 66.7% win rate compared to 33.3%. Lissandra scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Karma matchup?

Karma wins the matchup against Lissandra with a 60.0% win rate in League of Legends patch 26.17. The 20.0 percentage point advantage means Karma is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Lissandra build against Karma?

There is not enough matchup-specific build data to recommend an item path for Lissandra against Karma yet. Use Lissandra's standard build for the current patch and adapt situational items to Karma.

What are the best Lissandra runes against Karma?

The best Lissandra runes against Karma use the Sorcery primary tree with Domination secondary. This rune setup achieves a 50.0% win rate in the Lissandra vs Karma matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Karma?

No, Lissandra struggles against Karma with only a 40.0% win rate. Karma has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Karma's lead.

How do I play Lissandra against Karma?

When playing Lissandra against Karma, play cautiously and avoid Karma's power spikes. Focus on safe farming — you outscale Karma in the late game. Use the matchup-specific build and runes above to optimize your chances.