Qiyana - League of Legends Champion
Win Rate
47.2%
Pick Rate
1.2%

Qiyanavs Karthus

FAssassin
Patch26.9
Matches514,344
LaneAll Lanes
TierAll Tiers
Last UpdatedMay 9, 2026
MethodologyData Methodology

Qiyana vs Karthus is a decisive matchup in LoL patch 26.9. Karthus wins with a 80.0% win rate (+60.0%) over Qiyana based on 5 games. Karthus wins the early laning phase while Qiyana scales better into the late game. Below you'll find the best Qiyana build, runes, laning stats, and strategies for the Qiyana vs Karthus matchup.

Qiyana Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Qiyana performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Karthus - 20.0% win rateKarthus(20.0%)
Qiyana - 20.0% win rate in this matchup
Qiyana
20.0% WR
VS
Karthus vs Qiyana matchup - 80.0% win rate
Karthus
80.0% WR

Who Wins the Qiyana vs Karthus Matchup?

Karthus wins the Qiyana vs Karthus matchup
Winner
Karthus
Matches: 5
20.0%
Win Rate
80.0%
2.2
CS / min
2.9
880
DMG / min
1,246
11,986
Gold / game
14,608
242
Heal / min
268
563
DMG Mitigated / min
451
0.8
CC / min
0.5
0.0%
Early Game WR
100.0%
100.0%
Late Game WR
0.0%

Qiyana vs Karthus Matchup Summary

The Qiyana vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Karthus wins with a 80.0% win rate compared to Qiyana's 20.0%, giving Karthus a 60.0 percentage point advantage. Game phase dynamics play a critical role here: Karthus controls the early laning stage, but Qiyana outscales as the game goes longer. The matchup shifts dramatically depending on game length — Karthus needs to press advantages before Qiyana reaches their power spikes, while Qiyana should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Qiyana leads by 0.3s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Karthus has a strong advantage in this matchup. Qiyana players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Karthus overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Qiyana vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Qiyana in League of Legends

Karthus is favored during the laning phase against Qiyana, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
2.2Qiyana
2.9Karthus
Karthus edges out Qiyana by 0.7 CS per minute — a moderate farming advantage that adds up to roughly 11 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Karthus.
Damage
880Qiyana
1,246Karthus
Karthus heavily out-damages Qiyana by 366 DMG/min, dominating both short trades and all-in fights. Qiyana should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
11,986Qiyana
14,608Karthus
Karthus generates a commanding 2,622 more gold per game than Qiyana. This substantial economic advantage means Karthus consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Qiyana should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.8Qiyana
0.5Karthus
Qiyana provides 0.3 seconds more crowd control per minute than Karthus, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Qiyana coordinate with their jungler and control the pace of skirmishes.
Sustain
805Qiyana
719Karthus
Qiyana heals and mitigates 86 more damage per minute than Karthus, providing moderate extra durability. This sustain edge allows Qiyana to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Karthus.

Best Qiyana Build Against Karthus

Slightly Magical Footwear is the optimal boots choice against Karthus, providing the mobility and stats Qiyana needs most in this matchup. The top-performing core items for Qiyana against Karthus are Voltaic Cyclosword, Axiom Arc and Edge of Night. This combination gives Qiyana an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Qiyana vs Karthus matchup.

Early Game vs Late Game

Early Game
Karthus
100.0%
+100.0% advantage
Qiyana early game win rateQiyana0.0%
Karthus early game win rateKarthus100.0%
Late Game
Qiyana
100.0%
+100.0% advantage
Qiyana late game win rateQiyana100.0%
Karthus late game win rateKarthus0.0%

Karthus dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Qiyana. This lopsided early game means Karthus can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Qiyana is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Karthus. Extended games heavily favor Qiyana, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Karthus must aggressively press their early advantage and close out the game before Qiyana reaches their scaling breakpoints. If Qiyana survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Qiyana Runes Against Karthus

Domination rune tree - Qiyana primary runes vs KarthusDomination
Electrocute - best Qiyana rune vs KarthusSudden Impact - best Qiyana rune vs KarthusGrisly Mementos - best Qiyana rune vs KarthusTreasure Hunter - best Qiyana rune vs Karthus
Precision rune tree - Qiyana secondary runes vs KarthusPrecision
Presence of Mind - best Qiyana rune vs KarthusLast Stand - best Qiyana rune vs Karthus
100.0% WR

The Domination and Precision rune setup gives Qiyana the best tools to compete against Karthus in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Qiyana matchup data for League of Legends patch 26.9. The table below shows Qiyana's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Qiyana build, runes, laning stats, and early vs late game analysis for that specific matchup.

Qiyana matchup win rates and stats in League of Legends patch 26.9
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
53.33%456.379911,74756.0%50.0%
37.21%436.276612,07344.4%32.0%
48.78%416.187711,85662.5%40.0%
45.00%406.185212,62052.9%39.1%
62.16%376.690013,54761.5%62.5%
48.57%356.688111,45945.5%53.9%
35.29%344.074110,62222.7%58.3%
50.00%326.075511,37642.9%55.6%
56.25%326.272710,95764.3%50.0%
51.85%276.391312,52364.3%38.5%
51.85%276.591011,96937.5%72.7%
50.00%265.971510,00440.0%63.6%
38.46%265.584111,13929.4%55.6%
45.83%244.686511,99642.9%50.0%
59.09%226.079412,30166.7%53.9%
45.45%226.489712,60733.3%53.9%
38.10%214.264710,62941.7%33.3%
52.38%216.284012,48842.9%57.1%
42.86%211.174412,95540.0%45.5%
31.58%195.971710,70833.3%28.6%
31.58%191.169312,64320.0%44.4%
33.33%186.085712,01330.0%37.5%
61.11%185.91,10012,45160.0%62.5%
58.82%175.892412,15363.6%50.0%
58.82%175.994212,14962.5%55.6%
56.25%166.89259,84272.7%20.0%
37.50%161.274813,74680.0%18.2%
62.50%166.192412,72566.7%60.0%
43.75%166.378411,64340.0%50.0%
25.00%166.067911,36233.3%20.0%
43.75%166.71,03412,14660.0%16.7%
50.00%146.294312,50544.4%60.0%
42.86%146.277512,60980.0%22.2%
57.14%141.480514,32533.3%75.0%
64.29%146.798112,48962.5%66.7%
30.77%134.874311,51728.6%33.3%
61.54%132.11,01813,30066.7%57.1%
38.46%136.081212,67933.3%42.9%
23.08%131.070112,71233.3%14.3%
53.85%135.877711,48057.1%50.0%
16.67%126.572111,0800.0%28.6%
25.00%126.074110,9310.0%37.5%
45.45%111.360410,86437.5%66.7%
70.00%101.394917,314100.0%66.7%
60.00%101.187215,45450.0%62.5%
50.00%106.01,07514,77366.7%42.9%
70.00%102.587413,05575.0%66.7%
33.33%92.474412,42860.0%0.0%
77.78%96.31,01112,18960.0%100.0%
66.67%95.995112,11775.0%60.0%
33.33%95.272013,15950.0%28.6%
22.22%90.980314,4010.0%33.3%
55.56%90.975215,45250.0%60.0%
44.44%92.898611,07725.0%60.0%
37.50%81.172614,78850.0%33.3%
75.00%86.51,31015,06360.0%100.0%
37.50%86.891412,78133.3%40.0%
25.00%85.370412,0580.0%50.0%
37.50%80.784110,74840.0%33.3%
71.43%72.566913,88280.0%50.0%
71.43%71.472112,33475.0%66.7%
71.43%73.079412,5650.0%100.0%
71.43%71.388612,56780.0%50.0%
28.57%71.172813,51250.0%20.0%
57.14%73.777911,9120.0%100.0%
33.33%66.31,05912,9900.0%50.0%
33.33%61.290015,90625.0%50.0%
50.00%60.760312,25866.7%33.3%
66.67%67.41,21415,143100.0%33.3%
50.00%65.71,06814,06150.0%50.0%
83.33%61.284013,79850.0%100.0%
20.00%51.270614,9820.0%20.0%
40.00%51.193115,946100.0%25.0%
0.00%52.96659,7450.0%0.0%
60.00%50.979210,16966.7%50.0%
20.00%53.966010,30550.0%0.0%
20.00%52.288011,9860.0%100.0%
20.00%50.89969,9510.0%50.0%
80.00%55.177211,53566.7%100.0%

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Qiyana vs Karthus - Frequently Asked Questions

How does Qiyana do against Karthus in League of Legends?

Karthus wins the Qiyana vs Karthus matchup with a 80.0% win rate compared to Qiyana's 20.0%, a 60.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.9.

How does Qiyana do against Karthus in the early game?

In the early game, Karthus has the advantage against Qiyana with a 100.0% win rate versus 0.0%. Karthus players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Qiyana do against Karthus in the late game?

In the late game, Qiyana takes over the Qiyana vs Karthus matchup with a 100.0% win rate compared to 0.0%. Qiyana scales better into team fights and objective contests after 25 minutes.

Who wins the Qiyana vs Karthus matchup?

Karthus wins the matchup against Qiyana with a 80.0% win rate in League of Legends patch 26.9. The 60.0 percentage point advantage means Karthus is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Qiyana build against Karthus?

The best Qiyana build against Karthus includes Voltaic Cyclosword, Axiom Arc, Edge of Night with Slightly Magical Footwear. Check the matchup breakdown above for the full item path and build order.

What are the best Qiyana runes against Karthus?

The best Qiyana runes against Karthus use the Domination primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Qiyana vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Qiyana counter Karthus?

No, Qiyana struggles against Karthus with only a 20.0% win rate. Karthus has the advantage in this matchup. Qiyana players should focus on safe farming and avoiding extended trades to minimize Karthus's lead.

How do I play Qiyana against Karthus?

When playing Qiyana against Karthus, play cautiously and avoid Karthus's power spikes. Focus on safe farming — you outscale Karthus in the late game. Use the matchup-specific build and runes above to optimize your chances.