Seraphine - League of Legends Champion
Win Rate
50.9%
Pick Rate
4.9%

Seraphinevs Senna

ASupportMage
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Seraphine vs Senna is a moderate matchup in LoL patch 26.7. Seraphine wins with a 51.6% win rate (+3.1%) over Senna based on 159 games. Seraphine wins the early laning phase while Senna scales better into the late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Senna matchup.

Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Senna - 51.6% win rateSenna(51.6%)
Seraphine - 51.6% win rate in this matchup
Seraphine
51.6% WR
VS
Senna vs Seraphine matchup - 48.4% win rate
Senna
48.4% WR

Who Wins the Seraphine vs Senna Matchup?

Seraphine wins the Seraphine vs Senna matchup
Winner
Seraphine
Matches: 159
51.6%
Win Rate
48.4%
1.5
CS / min
1.6
487
DMG / min
518
9,184
Gold / game
10,037
330
Heal / min
526
360
DMG Mitigated / min
342
1.2
CC / min
1.3
54.3%
Early Game WR
45.7%
49.4%
Late Game WR
50.6%

Seraphine vs Senna Matchup Summary

The Seraphine vs Senna matchup is a moderate matchup in League of Legends ranked play. Based on 159 recent matches analyzed, Seraphine wins with a 51.6% win rate compared to Senna's 48.4%, giving Seraphine a 3.1 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Senna leads by 178 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a statistical edge, but the margin is close enough that respecting Senna's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Senna Laning Phase Breakdown

Senna wins the laning phase against Seraphine in League of Legends

Senna is favored during the laning phase against Seraphine, winning 5 out of 5 key stat categories. Senna holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.

Farming
1.5Seraphine
1.6Senna
Seraphine and Senna farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
487Seraphine
518Senna
Senna deals 31 more champion damage per minute than Seraphine. While noticeable in extended trades, this gap can be offset by Seraphine choosing favorable fight windows, such as engaging when Senna's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
9,184Seraphine
10,037Senna
Senna generates a commanding 852 more gold per game than Seraphine. This substantial economic advantage means Senna consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.2Seraphine
1.3Senna
Both Seraphine and Senna provide similar amounts of crowd control (0.1s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
691Seraphine
868Senna
Senna vastly out-sustains Seraphine, healing and mitigating 178 more damage per minute. This massive durability gap means Senna can absorb significant punishment and remain in lane while Seraphine is forced to recall. Building grievous wounds early is essential for Seraphine, and focusing on burst trade patterns rather than sustained fights is critical.

Best Seraphine Build Against Senna

Ionian Boots of Lucidity is the optimal boots choice against Senna, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Senna are Echoes of Helia, Moonstone Renewer and Redemption. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 3 games — well above average and making it the top item path against Senna. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Senna matchup.

Early Game vs Late Game

Early Game
Seraphine
54.3%
+8.6% advantage
Seraphine early game win rateSeraphine54.3%
Senna early game win rateSenna45.7%
Late Game
Senna
50.6%
+1.1% advantage
Seraphine late game win rateSeraphine49.4%
Senna late game win rateSenna50.6%

Seraphine dominates the early game (first 15 minutes) with a commanding 54.3% win rate — a 8.6 percentage point lead over Senna. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Senna at 50.6% win rate — only 1.1 points ahead of Seraphine. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Seraphine has the edge early, but Senna gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Seraphine Runes Against Senna

Sorcery rune tree - Seraphine primary runes vs SennaSorcery
Summon Aery - best Seraphine rune vs SennaManaflow Band - best Seraphine rune vs SennaTranscendence - best Seraphine rune vs SennaScorch - best Seraphine rune vs Senna
Inspiration rune tree - Seraphine secondary runes vs SennaInspiration
Biscuit Delivery - best Seraphine rune vs SennaCosmic Insight - best Seraphine rune vs Senna
52.9% WR

Running Sorcery primary with Inspiration secondary allows Seraphine to press their advantage against Senna, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.7. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
54.18%2991.64439,72745.0%59.6%
44.49%2631.34388,73041.4%48.0%
53.94%2411.34619,24352.6%55.2%
53.01%1831.44589,30748.8%56.4%
53.59%1811.44469,09849.4%57.5%
53.66%1641.44779,15159.3%48.2%
51.57%1591.54879,18454.3%49.4%
56.96%1581.44609,12365.1%51.6%
51.45%1381.44108,92450.8%52.1%
57.58%1321.44559,01657.4%57.8%
44.44%1261.34078,50942.9%46.0%
48.72%1171.655210,13343.2%51.3%
55.17%1161.54939,75339.1%65.7%
48.28%1161.754110,06752.2%45.7%
54.29%1051.34268,52558.2%50.0%
47.57%1031.54449,60136.6%54.8%
53.92%1021.44648,93753.9%54.0%
50.50%1011.43578,58654.9%46.0%
65.31%982.04699,74265.0%65.5%
51.11%901.45449,00546.1%54.9%
60.67%891.45258,87651.2%69.6%
48.05%771.64329,06447.1%48.8%
48.48%661.64499,83052.0%46.3%
56.06%661.446210,05756.0%56.1%
59.09%661.34709,19553.3%63.9%
51.52%661.45339,38642.9%57.9%
50.00%561.34318,78350.0%50.0%
50.91%555.059410,15445.7%60.0%
61.11%541.45039,73561.1%61.1%
45.10%511.45549,19748.0%42.3%
56.00%501.64589,66571.4%44.8%
68.09%471.34338,79683.3%52.2%
41.30%461.44408,44340.7%42.1%
55.26%386.575312,73061.1%50.0%
41.67%361.55229,34566.7%23.8%
45.71%351.45389,51041.2%50.0%
51.43%356.577612,68062.5%42.1%
41.18%341.95239,70342.9%40.0%
62.50%324.466312,14861.5%63.2%
61.54%261.45069,89770.0%56.3%
57.69%265.866912,09666.7%50.0%
72.00%253.654911,21477.8%68.8%
47.83%231.34387,54662.5%14.3%
39.13%231.34279,80042.9%37.5%
45.45%225.768813,31257.1%40.0%
42.86%212.04569,77930.0%54.5%
60.00%206.873212,63062.5%58.3%
68.42%192.25288,37271.4%60.0%
52.63%194.566310,72362.5%45.5%
77.78%185.262111,90780.0%75.0%
50.00%182.23929,53214.3%72.7%
17.65%171.95419,5550.0%30.0%
68.75%166.175711,132100.0%44.4%
56.25%165.061711,17950.0%58.3%
37.50%161.44408,74328.6%44.4%
40.00%155.879112,89180.0%20.0%
53.33%152.65158,83558.3%33.3%
60.00%156.969012,35375.0%42.9%
57.14%141.65038,97662.5%50.0%
50.00%126.066912,17266.7%33.3%
58.33%121.95109,80057.1%60.0%
41.67%124.362911,9680.0%50.0%
50.00%125.572511,57837.5%75.0%
45.45%111.83348,40757.1%25.0%
45.45%111.448611,0260.0%50.0%
20.00%101.94449,6570.0%40.0%
30.00%106.083411,91850.0%16.7%
66.67%95.04869,88271.4%50.0%
66.67%96.791812,31350.0%100.0%
44.44%91.652310,69633.3%50.0%
66.67%95.06849,58460.0%75.0%
55.56%95.878611,74075.0%40.0%
62.50%86.375213,234100.0%50.0%
62.50%84.164710,851100.0%0.0%
62.50%86.072611,59850.0%75.0%
50.00%81.63948,88825.0%75.0%
50.00%82.659011,57450.0%50.0%
37.50%84.34689,60866.7%20.0%
50.00%86.075212,12750.0%50.0%
75.00%81.84619,71750.0%100.0%
50.00%84.75939,70720.0%100.0%
28.57%71.54699,3480.0%50.0%
57.14%72.24578,64566.7%50.0%
85.71%71.55068,91275.0%100.0%
42.86%71.44499,4630.0%60.0%
50.00%63.866510,38850.0%50.0%
50.00%61.253910,07150.0%50.0%
50.00%62.45769,27866.7%33.3%
50.00%65.060611,31766.7%33.3%
40.00%56.077711,01533.3%50.0%
20.00%55.151210,8920.0%25.0%
60.00%55.872310,033100.0%50.0%
20.00%51.43949,2580.0%33.3%
80.00%54.677910,15775.0%100.0%
40.00%52.76589,47233.3%50.0%

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Seraphine vs Senna - Frequently Asked Questions

How does Seraphine do against Senna in League of Legends?

Seraphine wins the Seraphine vs Senna matchup with a 51.6% win rate compared to Senna's 48.4%, a 3.1 percentage point difference. This data is based on 159 recent ranked games in patch 26.7.

How does Seraphine do against Senna in the early game?

In the early game, Seraphine has the advantage against Senna with a 54.3% win rate versus 45.7%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Senna in the late game?

In the late game, Senna takes over the Seraphine vs Senna matchup with a 50.6% win rate compared to 49.4%. Senna scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Senna matchup?

Seraphine wins the matchup against Senna with a 51.6% win rate in League of Legends patch 26.7. The 3.1 percentage point advantage means Seraphine is moderately favored in this lane matchup based on 159 games analyzed.

What is the best Seraphine build against Senna?

The best Seraphine build against Senna includes Echoes of Helia, Moonstone Renewer, Redemption with Ionian Boots of Lucidity. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Senna?

The best Seraphine runes against Senna use the Sorcery primary tree with Inspiration secondary. This rune setup achieves a 52.9% win rate in the Seraphine vs Senna matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Senna?

Yes, Seraphine has a favorable matchup against Senna with a 51.6% win rate. Seraphine has a solid advantage over Senna in lane based on current patch 26.7 data.

How do I play Seraphine against Senna?

When playing Seraphine against Senna, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.