Iteration•Power

Is Iteration good in Slay the Spire 2?

In Slay the Spire 2, Iteration is an uncommon power from the Defect card pool. Its effect: The first time you draw a Status each turn, draw 2 cards. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 56 tracked runs its win rate sits at 27.9%, 9.0% ahead of the 18.9% all-deck baseline. It sees niche play, included in only 1.5% of eligible runs. Within Defect runs it’s drafted 9.4% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.3 copies on average.

Its standout pairing so far is Machine Learning, which lifts its win rate by +26.0% when the two share a deck. On the relic side, Pendulum is its standout companion, worth a +27.0% win-rate swing alongside it. It costs 1 energy, gets upgraded 29.2% of the time, and tends to be picked up near floor 15.

Of the runs that drafted it, 12 ended in victory against 31 deaths and 13 abandons. Its most common run-ender is Queen Boss, finishing 5.4% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Iteration fits a Defect deck.

Best Cards to Pair with Iteration

Iteration’s strongest card pairings so far are Machine Learning (+26.0%), Hailstorm (+23.8%), and Creative AI (+20.6%), each shown with the win-rate lift it adds.

Machine Learning+26.0%13 runsHailstorm+23.8%7 runsCreative AI+20.6%6 runsCold Snap+17.4%7 runsSpinner+17.4%7 runsEcho Form+15.4%9 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Iteration Win Rate by Class

Of the 2 classes that draft Iteration, it performs best with Defect (28.6%) and Silent (0.0%).

The Defect28.6%55 runsThe Silent0.0%1 runs

Best Relics for Iteration

The relics that swing Iteration’s win rate the most are Pendulum (+27.0%), Red Mask (+21.1%), and Blood Vial (+18.7%), with each lift shown.

Pendulum+27.0%7 runsRed Mask+21.1%11 runsBlood Vial+18.7%11 runsTouch of Orobas+17.4%6 runsInfused Core+17.4%6 runsOrichalcum+16.6%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Iteration Card Details

A 1-energy uncommon power, Iteration is upgraded 29.2% of the time and tends to enter the deck around floor 15.

The first time you draw a Status each turn, draw 2 cards.

What Ends Runs with Iteration

Runs holding Iteration end most often against Queen Boss (5.4%), Lagavulin Matriarch Boss (3.6%), and Aeonglass Boss (3.6%) — the share of its runs each accounts for is shown.

• Queen Boss5.4% of runs
• Lagavulin Matriarch Boss3.6% of runs
• Aeonglass Boss3.6% of runs
• Test Subject Boss3.6% of runs
• Bygone Effigy Elite3.6% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.