Letter Opener•Relic

Is Letter Opener good in Slay the Spire 2?

Letter Opener is an uncommon relic in Slay the Spire 2. While carried, it does the following: Every time you play Skills in a single turn, deal damage to ALL enemies. It currently underperforms most relics, sitting at D tier in our Slay the Spire 2 relic rankings.

Across 200 recorded runs, decks carrying it win 38.3% of the time, comfortably clear of the 18.9% average, by 19.3%. It’s a more situational relic, showing up in just 5.3% of runs. The class that gets the most out of it is the Silent, at a 44.1% win rate. Silent players hold onto it in 6.3% of their runs.

It combos especially well with Iteration, worth a +61.8% win-rate swing together. Another strong card to run with it is Fight Me!, worth +61.8% to its win rate. On average it’s acquired around floor 20 of a run. Its uncommon rarity shapes how frequently you’ll run into it.

It has 70 run wins against 113 losses in our tracked data. When runs carrying it end, the most frequent culprit is Knowledge Demon Boss, which closes out 7.5% of them. Read on for Letter Opener’s complete card, class, and threat breakdown before you decide to pick it up.

Best Cards with Letter Opener

Ranked by win-rate lift, the best cards to run with Letter Opener are Iteration (+61.8%), Fight Me! (+61.8%), and Pyre (+61.8%).

Iteration+61.8%3 runsFight Me!+61.8%3 runsPyre+61.8%3 runsFlash of Steel+61.8%3 runsDelay+61.8%3 runsMachine Learning+61.8%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Letter Opener Win Rate by Class

Letter Opener shows up across 5 classes, led by Silent (44.1%), Regent (43.8%), and Defect (37.0%) by win rate.

The Silent44.1%62 runsThe Regent43.8%34 runsThe Defect37.0%30 runsThe Necrobinder33.3%39 runsThe Ironclad27.6%35 runs

Letter Opener Details

Letter Opener is an uncommon relic carried in 5.3% of runs and usually picked up around floor 20.

Every time you play Skills in a single turn, deal damage to ALL enemies.

What Ends Runs with Letter Opener

Letter Opener’s most common run-enders are Knowledge Demon Boss (7.5%), Test Subject Boss (5.5%), and Entomancer Elite (5.0%).

• Knowledge Demon Boss7.5% of runs
• Test Subject Boss5.5% of runs
• Entomancer Elite5.0% of runs
• Kaiser Crab Boss4.0% of runs
• Queen Boss3.0% of runs

See Also

Compare Letter Opener with the rest of the best Slay the Spire 2 relics, cards, and classes below.