Letter OpenerRelic
Every time you play Skills in a single turn, deal damage to ALL enemies.
Is Letter Opener good in Slay the Spire 2?
Letter Opener is an uncommon relic in Slay the Spire 2. While carried, it does the following: Every time you play Skills in a single turn, deal damage to ALL enemies. It currently underperforms most relics, sitting at D tier in our Slay the Spire 2 relic rankings.
Across 19 recorded runs, decks carrying it win 26.7% of the time, comfortably clear of the 12.6% average, by 14.1%. It’s a more situational relic, showing up in just 3.7% of runs. The class that gets the most out of it is the Necrobinder, at a 33.3% win rate. Necrobinder players hold onto it in 4.1% of their runs.
It combos especially well with Wisp, worth a +40.0% win-rate swing together. Another strong card to run with it is Friendship, worth +40.0% to its win rate. On average it’s acquired around floor 13 of a run. Its uncommon rarity shapes how frequently you’ll run into it.
It has 4 run wins against 11 losses in our tracked data. When runs carrying it end, the most frequent culprit is Phrog Parasite Elite, which closes out 10.5% of them. Read on for Letter Opener’s complete card, class, and threat breakdown before you decide to pick it up.
Letter Opener Win Rate & Pick Rate
Letter Opener’s 26.7% win rate clears the 12.6% all-run average by 14.1%, the gap charted below.
Run Outcomes with Letter Opener
Letter Opener has 4 wins and 15 losses over 19 tracked runs (21.1% won); abandoned runs count as losses.
- Wins 21.1%
- Losses 78.9%
Best Cards with Letter Opener
Ranked by win-rate lift, the best cards to run with Letter Opener are Wisp (+40.0%), Friendship (+40.0%), and Bodyguard (+6.7%).
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Letter Opener Win Rate by Class
Letter Opener shows up across 4 classes, led by Necrobinder (33.3%), Silent (33.3%), and Ironclad (33.3%) by win rate.
Letter Opener Details
Letter Opener is an uncommon relic carried in 3.7% of runs and usually picked up around floor 13.
Every time you play Skills in a single turn, deal damage to ALL enemies.
What Ends Runs with Letter Opener
Letter Opener’s most common run-enders are Phrog Parasite Elite (10.5%) and Entomancer Elite (10.5%).
- Phrog Parasite Elite10.5% of runs
- Entomancer Elite10.5% of runs
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Letter Opener – Frequently Asked Questions
Is Letter Opener good in Slay the Spire 2?
Across 19 tracked runs carrying it, Letter Opener wins 26.7% of the time — +14.1% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Letter Opener do in Slay the Spire 2?
Every time you play Skills in a single turn, deal damage to ALL enemies.
How rare is Letter Opener in Slay the Spire 2?
Letter Opener is an Uncommon relic, picked up in 3.7% of tracked runs.
What is the best card to use with Letter Opener?
In tracked runs, Letter Opener has performed best alongside Wisp, which lifts its win rate by +40.0% over 3 runs together.
Which class is Letter Opener best in?
Letter Opener has its highest win rate with The Necrobinder (33.3%).
See Also
Compare Letter Opener with the rest of the best Slay the Spire 2 relics, cards, and classes below.