Letter Opener•Relic

Is Letter Opener good in Slay the Spire 2?

Letter Opener is an uncommon relic in Slay the Spire 2. While carried, it does the following: Every time you play Skills in a single turn, deal damage to ALL enemies. It currently underperforms most relics, sitting at D tier in our Slay the Spire 2 relic rankings.

Across 607 recorded runs, decks carrying it win 33.9% of the time, comfortably clear of the 13.9% average, by 20.0%. It’s a more situational relic, showing up in just 5.3% of runs. The class that gets the most out of it is the Regent, at a 40.6% win rate. Regent players hold onto it in 5.1% of their runs.

It combos especially well with Demesne, worth a +49.4% win-rate swing together. Another strong card to run with it is Skim, worth +39.4% to its win rate. On average it’s acquired around floor 21 of a run. Its uncommon rarity shapes how frequently you’ll run into it.

It has 204 run wins against 397 losses in our tracked data. When runs carrying it end, the most frequent culprit is Knowledge Demon Boss, which closes out 7.1% of them. Read on for Letter Opener’s complete card, class, and threat breakdown before you decide to pick it up.

Pick or Skip: Letter Opener

Out of 1030 recorded offers Letter Opener is taken 60.5% of the time, and taking it is worth +5.7% in pick lift — 34.7% for runs that picked it against 28.9% for runs that skipped, across 617 decided runs.

Taken 623 times out of 1030 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Letter Opener

Ranked by win-rate lift, the best cards to run with Letter Opener are Demesne (+49.4%), Skim (+39.4%), and Bulk Up (+36.6%).

Demesne+49.4%18 runsSkim+39.4%15 runsBulk Up+36.6%17 runsShadow Shield+34.8%16 runsParry+32.7%21 runsBig Bang+31.4%26 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Letter Opener Win Rate by Class

Letter Opener shows up across 5 classes, led by Regent (40.6%), Defect (40.5%), and Necrobinder (37.3%) by win rate.

The Regent40.6%102 runsThe Defect40.5%90 runsThe Necrobinder37.3%110 runsThe Silent32.1%166 runsThe Ironclad22.7%135 runs

Letter Opener Details

Letter Opener is an uncommon relic carried in 5.3% of runs and usually picked up around floor 21.

Every time you play Skills in a single turn, deal damage to ALL enemies.

What Ends Runs with Letter Opener

Letter Opener’s most common run-enders are Knowledge Demon Boss (7.1%), Test Subject Boss (6.1%), and Aeonglass Boss (4.9%).

• Knowledge Demon Boss7.1% of runs
• Test Subject Boss6.1% of runs
• Aeonglass Boss4.9% of runs
• Queen Boss4.1% of runs
• Entomancer Elite3.1% of runs

See Also

Compare Letter Opener with the rest of the best Slay the Spire 2 relics, cards, and classes below.