SnakebiteSkill
Apply 7 Poison.
Is Snakebite good in Slay the Spire 2?
Snakebite is a common Silent skill in Slay the Spire 2. In combat it resolves as: Apply 7 Poison. It ranks among the strongest cards its class can draft right now, earning a spot at B tier in our Slay the Spire 2 card tier list.
Across 20 recorded runs, decks running it win 25.0% of the time, comfortably clear of the 12.6% average, by 12.4%. It’s a more selective pick, turning up in just 3.9% of decks that could run it. Silent players keep it in 19.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.
It performs best next to Ultimate Defend — together they post a +75.0% swing in win rate. It also has strong chemistry with the relic Miniature Cannon, which moves its win rate by +75.0%. At 2 energy, it’s upgraded in 39.1% of runs and usually joins the deck around floor 8.
Upgraded, it gains +3 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 4 wins, 12 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Lagavulin Matriarch Boss, which closes out 10.0% of its appearances. Read on for Snakebite’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.
Snakebite Win Rate & Pick Rate
Snakebite’s 25.0% win rate clears the 12.6% all-deck average by 12.4%, the gap charted below.
Run Outcomes with Snakebite
Snakebite has 4 wins and 16 losses over 20 tracked runs (20.0% won); abandoned runs count as losses.
- Wins 20.0%
- Losses 80.0%
Best Cards to Pair with Snakebite
Ranked by win-rate lift, Snakebite performs best alongside Ultimate Defend (+75.0%), Ultimate Strike (+41.7%), and Tools of the Trade (+41.7%).
Ultimate Defend3 runs
Ultimate Strike3 runs
Tools of the Trade3 runs
Adrenaline5 runs
Flechettes4 runs
Bouncing Flask4 runsBased on small co-occurring samples — treat these as early signals, not final verdicts.
Snakebite Win Rate by Class
Snakebite is drafted only by the Silent, where it holds a 25.0% win rate across 20 runs.
The Silentappears in 19.2% of its runs (20 tracked)Best Relics for Snakebite
Snakebite pairs best with the relics Miniature Cannon (+75.0%), Bag of Marbles (+50.0%), and Blood Vial (+41.7%), ranked by win-rate lift.
Miniature Cannon3 runs
Bag of Marbles4 runs
Blood Vial3 runs
Looming Fruit3 runs
Festive Popper4 runs
Silver Crucible4 runsBased on small co-occurring samples — treat these as early signals, not final verdicts.
Snakebite Card Details
Snakebite is a common skill costing 2 energy; it’s upgraded in 39.1% of runs and usually picked up by floor 8.
Apply 7 Poison.
Upgrade: +3 Poison
What Ends Runs with Snakebite
Snakebite’s most common run-enders are Lagavulin Matriarch Boss (10.0%).
- Lagavulin Matriarch Boss10.0% of runs
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Snakebite – Frequently Asked Questions
Is Snakebite good in Slay the Spire 2?
Across 20 tracked runs, Snakebite has a 25.0% win rate — +12.4% above the average deck. Win rate reflects how often runs that include the card end in victory.
What does Snakebite do in Slay the Spire 2?
Snakebite costs 2 energy. Apply 7 Poison.
What class is Snakebite in Slay the Spire 2?
Snakebite is a Common Silent Skill.
Is Snakebite worth upgrading in Slay the Spire 2?
Players upgrade Snakebite in 39.1% of runs. Upgrading it grants +3 Poison.
What is the best relic for Snakebite?
In tracked runs, Snakebite has performed best alongside Miniature Cannon, which lifts its win rate by +75.0% over 3 runs together.
See Also
Compare Snakebite with the rest of the best Slay the Spire 2 cards, relics, and classes below.