Snakebite•Skill

Is Snakebite good in Slay the Spire 2?

Snakebite is a common Silent skill in Slay the Spire 2. In combat it resolves as: Apply 7 Poison. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 302 recorded runs, decks running it win 26.7% of the time, comfortably clear of the 14.1% average, by 12.6%. It’s a more selective pick, turning up in just 2.9% of decks that could run it. Offer data backs the pick — taken 9.6% of the time it is shown, with 27.6% for runs that took it against 23.5% for runs that did not, a +4.0% pick lift across 228 decided runs. Silent players keep it in 11.5% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Mad Science — together they post a +25.7% swing in win rate. It also has strong chemistry with the relic Miniature Cannon, which moves its win rate by +28.0%. At 2 energy, it’s upgraded in 33.6% of runs and usually joins the deck around floor 12.

Upgraded, it gains +3 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 80 wins, 220 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Kaiser Crab Boss, which closes out 5.6% of its appearances. Read on for Snakebite’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Pick or Skip: Snakebite

Out of 2614 recorded offers Snakebite is taken 9.6% of the time, and taking it is worth +4.0% in pick lift — 27.6% for runs that picked it against 23.5% for runs that skipped, across 228 decided runs.

Taken 252 times out of 2614 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Snakebite

Snakebite is strongest when it joins the deck in Act 3, where runs win 45.0% across 20 runs — one of 4 recorded pickup windows.

Win rate of runs by the act Snakebite entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Snakebite

Ranked by win-rate lift, Snakebite performs best alongside Mad Science (+25.7%), Skewer (+22.1%), and Well-Laid Plans (+21.8%).

Mad Science+25.7%18 runsSkewer+22.1%18 runsWell-Laid Plans+21.8%43 runsAdrenaline+20.1%47 runsBlade of Ink+19.2%22 runsExpertise+19.2%22 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Win Rate by Class

Snakebite is drafted only by the Silent, where it holds a 26.5% win rate across 300 runs.

The Silentappears in 11.5% of its runs (300 tracked)

Best Relics for Snakebite

Snakebite pairs best with the relics Miniature Cannon (+28.0%), Nunchaku (+26.9%), and Blood Vial (+26.7%), ranked by win-rate lift.

Miniature Cannon+28.0%15 runsNunchaku+26.9%23 runsBlood Vial+26.7%40 runsStrawberry+26.1%50 runsBag of Marbles+26.0%52 runsThe Courier+25.9%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Card Details

Snakebite is a common skill costing 2 energy; it’s upgraded in 33.6% of runs and usually picked up by floor 12.

Apply 7 Poison.

Upgrade: +3 Poison

What Ends Runs with Snakebite

Snakebite’s most common run-enders are Kaiser Crab Boss (5.6%), Test Subject Boss (5.0%), and Knowledge Demon Boss (3.6%).

• Kaiser Crab Boss5.6% of runs
• Test Subject Boss5.0% of runs
• Knowledge Demon Boss3.6% of runs
• Decimillipede Elite3.3% of runs
• Infested Prisms Elite3.0% of runs

See Also

Compare Snakebite with the rest of the best Slay the Spire 2 cards, relics, and classes below.