Snakebite•Skill

Is Snakebite good in Slay the Spire 2?

Snakebite is a common Silent skill in Slay the Spire 2. In combat it resolves as: Apply 7 Poison. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 86 recorded runs, decks running it win 24.7% of the time, comfortably clear of the 18.9% average, by 5.7%. It’s a more selective pick, turning up in just 2.3% of decks that could run it. Silent players keep it in 8.8% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Strangle — together they post a +19.9% swing in win rate. It also has strong chemistry with the relic Miniature Cannon, which moves its win rate by +22.4%. At 2 energy, it’s upgraded in 24.5% of runs and usually joins the deck around floor 9.

Upgraded, it gains +3 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 18 wins, 55 deaths, and 13 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Kaiser Crab Boss, which closes out 7.0% of its appearances. Read on for Snakebite’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Snakebite

Ranked by win-rate lift, Snakebite performs best alongside Strangle (+19.9%), Ultimate Defend (+17.4%), and Tools of the Trade (+16.8%).

Strangle+19.9%10 runsUltimate Defend+17.4%4 runsTools of the Trade+16.8%9 runsSerpent Form+15.8%7 runsFlechettes+14.6%9 runsTactician+13.4%9 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Win Rate by Class

Snakebite is drafted only by the Silent, where it holds a 24.7% win rate across 86 runs.

The Silentappears in 8.8% of its runs (86 tracked)

Best Relics for Snakebite

Snakebite pairs best with the relics Miniature Cannon (+22.4%), Mercury Hourglass (+22.0%), and Sturdy Clamp (+22.0%), ranked by win-rate lift.

Miniature Cannon+22.4%8 runsMercury Hourglass+22.0%7 runsSturdy Clamp+22.0%6 runsMeat on the Bone+21.5%4 runsGorget+19.9%18 runsStrawberry+19.4%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Card Details

Snakebite is a common skill costing 2 energy; it’s upgraded in 24.5% of runs and usually picked up by floor 9.

Apply 7 Poison.

Upgrade: +3 Poison

What Ends Runs with Snakebite

Snakebite’s most common run-enders are Kaiser Crab Boss (7.0%), Queen Boss (5.8%), and Phrog Parasite Elite (4.7%).

• Kaiser Crab Boss7.0% of runs
• Queen Boss5.8% of runs
• Phrog Parasite Elite4.7% of runs
• The Obscura Normal4.7% of runs
• Hunter Killer Normal3.5% of runs

See Also

Compare Snakebite with the rest of the best Slay the Spire 2 cards, relics, and classes below.