Snakebite Skill

Is Snakebite good in Slay the Spire 2?

Snakebite is a common Silent skill in Slay the Spire 2. In combat it resolves as: Apply 7 Poison. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 828 recorded runs, decks running it win 25.0% of the time, comfortably clear of the 14.3% average, by 10.7%. It’s a more selective pick, turning up in just 3.1% of decks that could run it. Offer data is close to a wash — 12.4% of offers taken, 24.8% for runs that picked it against 25.8% for runs that skipped, a pick lift of just -1.0% over 657 decided runs. Silent players keep it in 13.9% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.

It performs best next to Mad Science — together they post a +29.8% swing in win rate. It also has strong chemistry with the relic Iron Club, which moves its win rate by +38.8%. At 2 energy, it’s upgraded in 34.1% of runs and usually joins the deck around floor 11.

Upgraded, it gains +3 Poison, which is why so many decks invest a rest-site upgrade in it. That’s 205 wins, 616 deaths, and 7 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Test Subject Boss, which closes out 6.4% of its appearances. Read on for Snakebite’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Pick or Skip: Snakebite

Out of 6230 recorded offers Snakebite is taken 12.4% of the time, and taking it is worth -1.0% in pick lift — 24.8% for runs that picked it against 25.8% for runs that skipped, across 657 decided runs.

Taken 771 times out of 6230 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Snakebite

Snakebite is strongest when it joins the deck in Act 3, where runs win 55.3% across 48 runs — one of 4 recorded pickup windows.

Win rate of runs by the act Snakebite entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Snakebite

Ranked by win-rate lift, Snakebite performs best alongside Mad Science (+29.8%), Flanking (+27.6%), and Skewer (+23.8%).

Mad Science+29.8%53 runsFlanking+27.6%29 runsSkewer+23.8%30 runsAdrenaline+22.8%146 runsProduction+22.2%25 runsFinesse+21.8%21 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Win Rate by Class

Snakebite is drafted only by the Silent, where it holds a 24.7% win rate across 817 runs.

The Silentappears in 13.9% of its runs (817 tracked)

Best Relics for Snakebite

Snakebite pairs best with the relics Iron Club (+38.8%), Sword of Jade (+33.0%), and Art of War (+32.7%), ranked by win-rate lift.

Iron Club+38.8%19 runsSword of Jade+33.0%15 runsArt of War+32.7%29 runsLooming Fruit+29.0%15 runsJeweled Mask+28.5%19 runsMiniature Cannon+27.8%44 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Snakebite Card Details

Snakebite is a common skill costing 2 energy; it’s upgraded in 34.1% of runs and usually picked up by floor 11.

Apply 7 Poison.

Upgrade: +3 Poison

What Ends Runs with Snakebite

Snakebite’s most common run-enders are Test Subject Boss (6.4%), Aeonglass Boss (5.0%), and Kaiser Crab Boss (4.5%).

• Test Subject Boss6.4% of runs
• Aeonglass Boss5.0% of runs
• Kaiser Crab Boss4.5% of runs
• Infested Prisms Elite4.0% of runs
• Decimillipede Elite3.9% of runs

See Also

Compare Snakebite with the rest of the best Slay the Spire 2 cards, relics, and classes below.