Snecko SkullRelic
Whenever you apply Poison, apply an additional Poison.
Is Snecko Skull good in Slay the Spire 2?
In Slay the Spire 2, Snecko Skull is a common relic you can pick up on your climb. Its effect: Whenever you apply Poison, apply an additional Poison. Right now it’s a high-value grab, sitting at B tier — one of the relics most worth taking.
Over 45 tracked runs the win rate of decks holding it sits at 47.7%, 28.8% ahead of the 18.9% all-run baseline. It sees lighter play, carried in only 1.2% of runs. It does its best work in the hands of the Silent, who post a 47.7% win rate with it. Within Silent runs specifically, it’s carried 4.6% of the time.
Its standout card pairing is Expertise, which lifts the relic’s win rate by +52.3% when both are in play. It also works nicely with Precise Cut, good for a +52.3% win-rate change. It typically enters the deck near floor 23. As a common relic, how often it’s offered depends on its rarity tier.
Of the runs that carried it, 21 ended in victory while 23 fell to a defeat. Its most common run-ender is Queen Boss, finishing 6.7% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Snecko Skull is worth grabbing.
Snecko Skull Win Rate & Pick Rate
At a 47.7% win rate, Snecko Skull runs 28.8% ahead of the 18.9% all-run baseline — the bars below put the two side by side.
Run Outcomes with Snecko Skull
Across the 45 runs that carried Snecko Skull, 21 ended in a win and 24 in a loss — a 46.7% win share, counting abandons as losses.
- Wins 46.7%
- Losses 53.3%
Best Cards with Snecko Skull
The cards that gain the most from carrying Snecko Skull are Expertise (+52.3%), Precise Cut (+52.3%), and Knife Trap (+41.2%), each shown with its win-rate swing.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Snecko Skull Win Rate by Class
Snecko Skull’s class data comes mostly from the Silent, at a 47.7% win rate over 45 runs.
The Silentappears in 4.6% of its runs (45 tracked)Snecko Skull Details
Carried in 1.2% of runs, Snecko Skull is a common relic typically acquired near floor 23.
Whenever you apply Poison, apply an additional Poison.
What Ends Runs with Snecko Skull
Runs carrying Snecko Skull end most often against Queen Boss (6.7%), The Kin Boss (6.7%), and Entomancer Elite (6.7%) — the share of its runs each accounts for is shown.
- Queen Boss6.7% of runs
- The Kin Boss6.7% of runs
- Entomancer Elite6.7% of runs
- Vantom Boss4.4% of runs
- Kaiser Crab Boss4.4% of runs
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Snecko Skull – Frequently Asked Questions
Is Snecko Skull good in Slay the Spire 2?
Across 45 tracked runs carrying it, Snecko Skull wins 47.7% of the time — +28.8% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Snecko Skull do in Slay the Spire 2?
Whenever you apply Poison, apply an additional Poison.
How rare is Snecko Skull in Slay the Spire 2?
Snecko Skull is a Common relic, picked up in 1.2% of tracked runs.
What is the best card to use with Snecko Skull?
In tracked runs, Snecko Skull has performed best alongside Expertise, which lifts its win rate by +52.3% over 4 runs together.
See Also
Keep exploring Slay the Spire 2 tier lists and stats below.