Symbiotic Virus•Relic

Is Symbiotic Virus good in Slay the Spire 2?

In Slay the Spire 2, Symbiotic Virus is an uncommon relic you can pick up on your climb. Its effect: At the start of each combat, Channel Dark. The data marks it as a weaker relic, settling at D tier — rarely a run-defining grab.

Over 54 tracked runs the win rate of decks holding it sits at 38.9%, 24.9% ahead of the 13.9% all-run baseline. It sees lighter play, carried in only 0.5% of runs. It does its best work in the hands of the Defect, who post a 38.9% win rate with it. Within Defect runs specifically, it’s carried 3.2% of the time.

Its standout card pairing is Leap, which lifts the relic’s win rate by +19.0% when both are in play. It also works nicely with Darkness, good for a +17.4% win-rate change. It typically enters the deck near floor 21. As an uncommon relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 21 ended in victory while 33 fell to a defeat. Its most common run-ender is Test Subject Boss, finishing 11.1% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Symbiotic Virus is worth grabbing.

Pick or Skip: Symbiotic Virus

Players take Symbiotic Virus in 47.0% of the 117 offers it appears in; those runs win 40.0% against 32.3% for runs that passed, a pick lift of +6.5% over 55 decided runs.

Taken 55 times out of 117 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Symbiotic Virus

The cards that gain the most from carrying Symbiotic Virus are Leap (+19.0%), Darkness (+17.4%), and Hologram (+17.1%), each shown with its win-rate swing.

Leap+19.0%19 runsDarkness+17.4%16 runsHologram+17.1%25 runsWhite Noise+16.7%18 runsTURBO+11.1%20 runsBeam Cell+8.5%19 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Symbiotic Virus Win Rate by Class

Symbiotic Virus’s class data comes mostly from the Defect, at a 38.9% win rate over 54 runs.

The Defectappears in 3.2% of its runs (54 tracked)

Symbiotic Virus Details

Carried in 0.5% of runs, Symbiotic Virus is an uncommon relic typically acquired near floor 21.

At the start of each combat, Channel Dark.

What Ends Runs with Symbiotic Virus

Runs carrying Symbiotic Virus end most often against Test Subject Boss (11.1%), Knowledge Demon Boss (7.4%), and Aeonglass Boss (7.4%) — the share of its runs each accounts for is shown.

• Test Subject Boss11.1% of runs
• Knowledge Demon Boss7.4% of runs
• Aeonglass Boss7.4% of runs
• Queen Boss5.6% of runs
• Knights Elite3.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.