Anivia - League of Legends Champion
Win Rate
47.2%
Pick Rate
1.5%

Aniviavs Seraphine

FMage
Patch26.14
Matches134,440
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 20, 2026
MethodologyData Methodology

Anivia vs Seraphine is a decisive matchup in LoL patch 26.14. Seraphine wins with a 77.8% win rate (+55.6%) over Anivia based on 9 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Anivia build, runes, laning stats, and strategies for the Anivia vs Seraphine matchup.

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Anivia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Anivia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Anivia - 22.2% win rate in this matchup
Anivia
22.2% WR
VS
Seraphine vs Anivia matchup - 77.8% win rate
Seraphine
77.8% WR

Who Wins the Anivia vs Seraphine Matchup?

Seraphine wins the Anivia vs Seraphine matchup
Winner
Seraphine
Matches: 9
22.2%
Win Rate
77.8%
2.2
CS / min
1.4
496
DMG / min
611
8,473
Gold / game
8,960
83
Heal / min
232
370
DMG Mitigated / min
306
1.6
CC / min
1.2
33.3%
Early Game WR
66.7%
16.7%
Late Game WR
83.3%

Anivia vs Seraphine Matchup Summary

The Anivia vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Seraphine wins with a 77.8% win rate compared to Anivia's 22.2%, giving Seraphine a 55.6 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Anivia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in CS, where Anivia leads by 0.8 CS/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Anivia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Anivia vs Seraphine Laning Phase Breakdown

Seraphine wins the laning phase against Anivia in League of Legends

Seraphine is favored during the laning phase against Anivia, winning 3 out of 5 key stat categories. Seraphine holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
2.2Anivia
1.4Seraphine
Anivia significantly out-farms Seraphine by 0.8 CS per minute, accumulating an estimated 12 CS lead by mid game. This substantial farming gap gives Anivia a major gold advantage and earlier item completions. Seraphine players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
496Anivia
611Seraphine
Seraphine heavily out-damages Anivia by 115 DMG/min, dominating both short trades and all-in fights. Anivia should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Seraphine's sustained damage advantage take over.
Economy
8,473Anivia
8,960Seraphine
Seraphine earns 487 more gold per game than Anivia, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Seraphine slightly faster item completions.
Utility
1.6Anivia
1.2Seraphine
Anivia provides 0.4 seconds more crowd control per minute than Seraphine, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Anivia coordinate with their jungler and control the pace of skirmishes.
Sustain
453Anivia
538Seraphine
Seraphine heals and mitigates 85 more damage per minute than Anivia, providing moderate extra durability. This sustain edge allows Seraphine to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Anivia.

Best Anivia Build Against Seraphine

Boots of Swiftness is the optimal boots choice against Seraphine, providing the mobility and stats Anivia needs most in this matchup. The top-performing core items for Anivia against Seraphine are Rod of Ages, Zhonya's Hourglass and Malignance. This combination gives Anivia an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Anivia vs Seraphine matchup.

Early Game vs Late Game

Early Game
Seraphine
66.7%
+33.3% advantage
Anivia early game win rateAnivia33.3%
Seraphine early game win rateSeraphine66.7%
Late Game
Seraphine
83.3%
+66.7% advantage
Anivia late game win rateAnivia16.7%
Seraphine late game win rateSeraphine83.3%

Seraphine dominates the early game (first 15 minutes) with a commanding 66.7% win rate — a 33.3 percentage point lead over Anivia. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Seraphine is far superior in the late game (25+ minutes), boasting a 83.3% win rate — 66.7 points above Anivia. Extended games heavily favor Seraphine, whose kit and scaling make them a dominant force in team fights and objective control.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Anivia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Anivia Runes Against Seraphine

Domination rune tree - Anivia primary runes vs SeraphineDomination
Electrocute - best Anivia rune vs SeraphineCheap Shot - best Anivia rune vs SeraphineGrisly Mementos - best Anivia rune vs SeraphineRelentless Hunter - best Anivia rune vs Seraphine
Precision rune tree - Anivia secondary runes vs SeraphinePrecision
Coup de Grace - best Anivia rune vs SeraphinePresence of Mind - best Anivia rune vs Seraphine
66.7% WR

The Domination and Precision rune setup gives Anivia the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Anivia matchup data for League of Legends patch 26.14. The table below shows Anivia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Anivia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Anivia matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
33.33%156.358510,55016.7%44.4%
50.00%144.364810,03233.3%62.5%
50.00%145.776111,08920.0%66.7%
30.77%136.475210,66740.0%25.0%
38.46%136.97058,53416.7%57.1%
33.33%126.769211,90933.3%33.3%
50.00%107.285713,04350.0%50.0%
88.89%96.993113,945100.0%80.0%
11.11%96.862610,3340.0%20.0%
66.67%96.76398,79380.0%50.0%
22.22%92.24968,47333.3%16.7%
33.33%96.993510,18225.0%40.0%
50.00%85.459911,7940.0%50.0%
75.00%86.583310,752100.0%66.7%
57.14%76.892712,90550.0%66.7%
42.86%76.975713,235100.0%33.3%
42.86%76.46029,7560.0%60.0%
14.29%76.07839,9170.0%33.3%
71.43%75.56019,86175.0%66.7%
42.86%72.15599,15850.0%33.3%
50.00%67.56577,04350.0%50.0%
33.33%66.664312,4400.0%33.3%
50.00%65.960210,3820.0%75.0%
50.00%66.61,04612,92550.0%50.0%
40.00%57.574511,04733.3%50.0%
60.00%52.36757,80350.0%66.7%
40.00%56.16008,69025.0%100.0%
40.00%56.45767,956100.0%0.0%
40.00%54.799214,0690.0%50.0%
20.00%51.73817,60633.3%0.0%

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Anivia vs Seraphine - Frequently Asked Questions

How does Anivia do against Seraphine in League of Legends?

Seraphine wins the Anivia vs Seraphine matchup with a 77.8% win rate compared to Anivia's 22.2%, a 55.6 percentage point difference. This data is based on 9 recent ranked games in patch 26.14.

How does Anivia do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Anivia with a 66.7% win rate versus 33.3%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Anivia do against Seraphine in the late game?

In the late game, Seraphine takes over the Anivia vs Seraphine matchup with a 83.3% win rate compared to 16.7%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Anivia vs Seraphine matchup?

Seraphine wins the matchup against Anivia with a 77.8% win rate in League of Legends patch 26.14. The 55.6 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 9 games analyzed.

What is the best Anivia build against Seraphine?

The best Anivia build against Seraphine includes Rod of Ages, Zhonya's Hourglass, Malignance with Boots of Swiftness. Check the matchup breakdown above for the full item path and build order.

What are the best Anivia runes against Seraphine?

The best Anivia runes against Seraphine use the Domination primary tree with Precision secondary. This rune setup achieves a 66.7% win rate in the Anivia vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Anivia counter Seraphine?

No, Anivia struggles against Seraphine with only a 22.2% win rate. Seraphine has the advantage in this matchup. Anivia players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Anivia against Seraphine?

When playing Anivia against Seraphine, play cautiously and avoid Seraphine's power spikes. Look for jungle assistance and team-dependent plays since Seraphine has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.