Kai'Sa - League of Legends Champion
Win Rate
46.6%
Pick Rate
4.3%

Kai'Savs Seraphine

FMarksmanMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 6, 2026
MethodologyData Methodology

Kai'Sa vs Seraphine is a moderate matchup in LoL patch 26.11. Seraphine wins with a 51.5% win rate (+3.0%) over Kai'Sa based on 33 games. Seraphine wins the early laning phase while Kai'Sa scales better into the late game. Below you'll find the best Kai'Sa build, runes, laning stats, and strategies for the Kai'Sa vs Seraphine matchup.

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Kai'Sa Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Kai'Sa performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kai'Sa - 48.5% win rate in this matchup
Kai'Sa
48.5% WR
VS
Seraphine vs Kai'Sa matchup - 51.5% win rate
Seraphine
51.5% WR

Who Wins the Kai'Sa vs Seraphine Matchup?

Seraphine wins the Kai'Sa vs Seraphine matchup
Winner
Seraphine
Matches: 33
48.5%
Win Rate
51.5%
7.2
CS / min
6.8
805
DMG / min
787
12,424
Gold / game
11,426
166
Heal / min
124
471
DMG Mitigated / min
430
0.1
CC / min
1.1
41.2%
Early Game WR
58.8%
56.3%
Late Game WR
43.8%

Kai'Sa vs Seraphine Matchup Summary

The Kai'Sa vs Seraphine matchup is a moderate matchup in League of Legends ranked play. Based on 33 recent matches analyzed, Seraphine wins with a 51.5% win rate compared to Kai'Sa's 48.5%, giving Seraphine a 3.0 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Kai'Sa outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Kai'Sa reaches their power spikes, while Kai'Sa should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Seraphine leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. While Seraphine is slightly favored, Kai'Sa can absolutely win this lane through smart trading patterns and wave management. Focus on playing around your cooldowns, conceding CS only when necessary, and capitalizing on Seraphine's mistakes. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Kai'Sa vs Seraphine Laning Phase Breakdown

Kai'Sa wins the laning phase against Seraphine in League of Legends

Kai'Sa is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Kai'Sa holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
7.2Kai'Sa
6.8Seraphine
Kai'Sa edges out Seraphine by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
805Kai'Sa
787Seraphine
Damage output is virtually even between Kai'Sa and Seraphine, with only 18 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
12,424Kai'Sa
11,426Seraphine
Kai'Sa generates a commanding 999 more gold per game than Seraphine. This substantial economic advantage means Kai'Sa consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.1Kai'Sa
1.1Seraphine
Seraphine brings significantly more crowd control than Kai'Sa, with 1.0 more seconds of CC per minute. This large utility gap makes Seraphine far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
637Kai'Sa
554Seraphine
Kai'Sa heals and mitigates 83 more damage per minute than Seraphine, providing moderate extra durability. This sustain edge allows Kai'Sa to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Seraphine.

Early Game vs Late Game

Early Game
Seraphine
58.8%
+17.6% advantage
Kai'Sa early game win rateKai'Sa41.2%
Seraphine early game win rateSeraphine58.8%
Late Game
Kai'Sa
56.3%
+12.5% advantage
Kai'Sa late game win rateKai'Sa56.3%
Seraphine late game win rateSeraphine43.8%

Seraphine dominates the early game (first 15 minutes) with a commanding 58.8% win rate — a 17.6 percentage point lead over Kai'Sa. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Kai'Sa is far superior in the late game (25+ minutes), boasting a 56.3% win rate — 12.5 points above Seraphine. Extended games heavily favor Kai'Sa, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Kai'Sa reaches their scaling breakpoints. If Kai'Sa survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Kai'Sa Runes Against Seraphine

Inspiration rune tree - Kai'Sa primary runes vs SeraphineInspiration
First Strike - best Kai'Sa rune vs SeraphineMagical Footwear - best Kai'Sa rune vs SeraphineTriple Tonic - best Kai'Sa rune vs SeraphineCosmic Insight - best Kai'Sa rune vs Seraphine
Sorcery rune tree - Kai'Sa secondary runes vs SeraphineSorcery
Manaflow Band - best Kai'Sa rune vs SeraphineScorch - best Kai'Sa rune vs Seraphine
100.0% WR

The Inspiration and Sorcery rune setup gives Kai'Sa the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Kai'Sa matchup data for League of Legends patch 26.11. The table below shows Kai'Sa's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Kai'Sa build, runes, laning stats, and early vs late game analysis for that specific matchup.

Kai'Sa matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.48%5746.782113,77953.0%46.5%
45.83%5156.783213,58745.5%46.1%
47.01%5026.883413,80849.5%45.1%
45.38%4877.085413,52242.9%47.7%
45.23%4516.782713,74150.0%42.0%
45.81%4066.991614,34556.2%38.9%
54.32%4057.194014,56053.4%55.0%
46.10%2696.891714,46351.8%42.0%
45.73%1996.892514,44544.9%46.3%
44.50%1916.583013,88448.1%41.8%
48.92%1866.885913,85251.2%47.1%
46.29%1756.886314,64146.4%46.2%
52.98%1517.084413,53149.3%56.6%
39.16%1436.984013,54540.3%38.2%
44.20%1387.091813,85047.1%41.2%
46.72%1376.984313,64543.1%49.4%
51.47%1366.886013,85655.7%48.0%
46.46%1277.187813,73446.1%46.8%
40.17%1176.683713,92538.8%41.2%
40.91%1107.287214,35945.1%37.3%
46.30%1086.577813,38446.9%45.8%
37.88%666.585414,38836.0%39.0%
42.37%596.975914,13422.7%54.0%
60.00%557.180212,32965.6%52.2%
52.73%556.995012,79554.2%51.6%
42.59%547.181913,78132.0%51.7%
47.17%536.680313,16542.3%51.9%
40.43%476.879311,63737.9%44.4%
76.09%466.899615,15968.4%81.5%
51.16%436.685214,69760.0%46.4%
68.42%386.894014,50881.3%59.1%
48.48%337.280512,42441.2%56.3%
46.67%307.381813,04653.3%40.0%
32.14%286.885512,79026.7%38.5%
52.17%237.71,05015,12550.0%53.9%
50.00%206.61,01113,90762.5%41.7%
57.89%196.865314,05166.7%50.0%
47.06%176.599814,69433.3%54.5%
52.94%177.181115,14660.0%50.0%
47.06%176.51,07114,17433.3%54.5%
60.00%156.81,02216,63175.0%54.5%
50.00%147.01,04012,15850.0%50.0%
58.33%127.197414,38240.0%71.4%
40.00%107.31,05212,51116.7%75.0%
70.00%107.281613,986100.0%57.1%
44.44%96.31,27717,44050.0%42.9%
44.44%96.41,12514,30040.0%50.0%
33.33%97.276915,04033.3%33.3%
50.00%86.31,04916,20166.7%40.0%
50.00%86.31,24214,06450.0%50.0%
50.00%86.790214,99550.0%50.0%
87.50%85.188314,88550.0%100.0%
14.29%77.21,01015,18825.0%0.0%
42.86%75.095812,83933.3%50.0%
57.14%76.593811,82175.0%33.3%
42.86%76.21,04310,98333.3%50.0%
28.57%76.189311,25425.0%33.3%
57.14%76.874812,44166.7%50.0%
33.33%66.71,08215,3910.0%40.0%
50.00%66.91,53416,62033.3%66.7%
66.67%66.11,01313,539100.0%33.3%
33.33%65.186912,30633.3%33.3%
0.00%55.056210,2520.0%0.0%
20.00%55.888215,68250.0%0.0%
60.00%57.387413,08233.3%100.0%
20.00%57.357210,6390.0%33.3%
40.00%56.469713,15450.0%33.3%

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Kai'Sa vs Seraphine - Frequently Asked Questions

How does Kai'Sa do against Seraphine in League of Legends?

Seraphine wins the Kai'Sa vs Seraphine matchup with a 51.5% win rate compared to Kai'Sa's 48.5%, a 3.0 percentage point difference. This data is based on 33 recent ranked games in patch 26.11.

How does Kai'Sa do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Kai'Sa with a 58.8% win rate versus 41.2%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Kai'Sa do against Seraphine in the late game?

In the late game, Kai'Sa takes over the Kai'Sa vs Seraphine matchup with a 56.3% win rate compared to 43.8%. Kai'Sa scales better into team fights and objective contests after 25 minutes.

Who wins the Kai'Sa vs Seraphine matchup?

Seraphine wins the matchup against Kai'Sa with a 51.5% win rate in League of Legends patch 26.11. The 3.0 percentage point advantage means Seraphine is moderately favored in this lane matchup based on 33 games analyzed.

What is the best Kai'Sa build against Seraphine?

The best Kai'Sa build against Seraphine includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Kai'Sa runes against Seraphine?

The best Kai'Sa runes against Seraphine use the Inspiration primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Kai'Sa vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Kai'Sa counter Seraphine?

No, Kai'Sa struggles against Seraphine with only a 48.5% win rate. Seraphine has the advantage in this matchup. Kai'Sa players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Kai'Sa against Seraphine?

When playing Kai'Sa against Seraphine, play cautiously and avoid Seraphine's power spikes. Focus on safe farming — you outscale Seraphine in the late game. Use the matchup-specific build and runes above to optimize your chances.