Kai'Sa - League of Legends Champion
Win Rate
46.9%
Pick Rate
4.8%

Kai'Savs Seraphine

FMarksmanMage
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Kai'Sa vs Seraphine is a decisive matchup in LoL patch 26.14. Seraphine wins with a 69.2% win rate (+38.5%) over Kai'Sa based on 26 games. Seraphine wins the early laning phase while Kai'Sa scales better into the late game. Below you'll find the best Kai'Sa build, runes, laning stats, and strategies for the Kai'Sa vs Seraphine matchup.

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Kai'Sa Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Kai'Sa performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Kai'Sa - 30.8% win rate in this matchup
Kai'Sa
30.8% WR
VS
Seraphine vs Kai'Sa matchup - 69.2% win rate
Seraphine
69.2% WR

Who Wins the Kai'Sa vs Seraphine Matchup?

Seraphine wins the Kai'Sa vs Seraphine matchup
Winner
Seraphine
Matches: 26
30.8%
Win Rate
69.2%
6.1
CS / min
5.7
724
DMG / min
761
10,790
Gold / game
10,570
149
Heal / min
135
458
DMG Mitigated / min
391
0.1
CC / min
1.2
14.3%
Early Game WR
85.7%
50.0%
Late Game WR
50.0%

Kai'Sa vs Seraphine Matchup Summary

The Kai'Sa vs Seraphine matchup is a decisive matchup in League of Legends ranked play. Based on 26 recent matches analyzed, Seraphine wins with a 69.2% win rate compared to Kai'Sa's 30.8%, giving Seraphine a 38.5 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Kai'Sa outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Kai'Sa reaches their power spikes, while Kai'Sa should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Seraphine leads by 1.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a strong advantage in this matchup. Kai'Sa players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Seraphine overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Kai'Sa vs Seraphine Laning Phase Breakdown

Kai'Sa wins the laning phase against Seraphine in League of Legends

Kai'Sa is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Kai'Sa holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.1Kai'Sa
5.7Seraphine
Kai'Sa edges out Seraphine by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
724Kai'Sa
761Seraphine
Seraphine deals 37 more champion damage per minute than Kai'Sa. While noticeable in extended trades, this gap can be offset by Kai'Sa choosing favorable fight windows, such as engaging when Seraphine's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
10,790Kai'Sa
10,570Seraphine
Kai'Sa and Seraphine generate nearly equal gold per game, with just a 220 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.1Kai'Sa
1.2Seraphine
Seraphine brings significantly more crowd control than Kai'Sa, with 1.2 more seconds of CC per minute. This large utility gap makes Seraphine far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
607Kai'Sa
527Seraphine
Kai'Sa heals and mitigates 80 more damage per minute than Seraphine, providing moderate extra durability. This sustain edge allows Kai'Sa to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Seraphine.

Early Game vs Late Game

Early Game
Seraphine
85.7%
+71.4% advantage
Kai'Sa early game win rateKai'Sa14.3%
Seraphine early game win rateSeraphine85.7%
Late Game
Kai'Sa
50.0%
+0.0% advantage
Kai'Sa late game win rateKai'Sa50.0%
Seraphine late game win rateSeraphine50.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 85.7% win rate — a 71.4 percentage point lead over Kai'Sa. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Kai'Sa at 50.0% win rate — only 0.0 points ahead of Seraphine. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

The power dynamics shift as the game progresses — Seraphine has the edge early, but Kai'Sa gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.

Best Kai'Sa Runes Against Seraphine

Precision rune tree - Kai'Sa primary runes vs SeraphinePrecision
Lethal Tempo - best Kai'Sa rune vs SeraphinePresence of Mind - best Kai'Sa rune vs SeraphineLegend: Bloodline - best Kai'Sa rune vs SeraphineCoup de Grace - best Kai'Sa rune vs Seraphine
Inspiration rune tree - Kai'Sa secondary runes vs SeraphineInspiration
Biscuit Delivery - best Kai'Sa rune vs SeraphineMagical Footwear - best Kai'Sa rune vs Seraphine
33.3% WR

The Precision and Inspiration rune setup gives Kai'Sa the best tools to compete against Seraphine in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Kai'Sa matchup data for League of Legends patch 26.14. The table below shows Kai'Sa's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Kai'Sa build, runes, laning stats, and early vs late game analysis for that specific matchup.

Kai'Sa matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
42.60%2236.682513,01546.4%39.7%
36.87%1986.781212,32045.4%30.4%
46.47%1706.690413,77143.3%48.2%
47.37%1336.887513,05544.3%50.8%
50.39%1276.883912,71959.3%42.6%
55.17%1166.894213,85758.1%53.4%
48.94%947.188312,78752.1%45.6%
44.09%936.786512,05654.4%34.0%
50.56%896.987813,13761.8%43.6%
47.62%636.787013,73847.8%47.5%
50.00%586.587014,29652.6%48.7%
53.85%526.81,00614,31455.0%53.1%
49.02%516.993412,55948.0%50.0%
52.08%486.792213,96575.0%35.7%
54.55%447.380614,05750.0%57.7%
53.49%437.290512,68135.0%69.6%
47.22%366.785113,53566.7%33.3%
60.61%336.882313,27171.4%52.6%
40.74%277.480712,16746.7%33.3%
42.31%267.087613,65245.5%40.0%
30.77%266.172410,79014.3%50.0%
50.00%267.087512,41738.5%61.5%
54.17%246.484514,40845.5%61.5%
50.00%246.796115,01333.3%60.0%
54.55%226.478110,06969.2%33.3%
52.38%216.01,01214,21742.9%57.1%
68.75%167.381713,27942.9%88.9%
40.00%156.81,09014,46525.0%45.5%
46.67%156.872312,73450.0%44.4%
57.14%147.295014,28257.1%57.1%
30.77%136.775612,17120.0%37.5%
33.33%127.392913,54616.7%50.0%
41.67%126.783510,32640.0%42.9%
63.64%117.11,02013,02880.0%50.0%
60.00%107.588210,12162.5%50.0%
55.56%96.41,06418,38450.0%57.1%
37.50%86.183712,60960.0%0.0%
75.00%87.599115,86166.7%80.0%
28.57%76.51,20813,03525.0%33.3%
66.67%67.41,02515,39550.0%75.0%
66.67%67.21,02217,1270.0%100.0%
16.67%66.886013,8570.0%25.0%
60.00%57.094811,882100.0%33.3%
20.00%57.47269,57020.0%0.0%
60.00%56.585516,2250.0%75.0%

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Kai'Sa vs Seraphine - Frequently Asked Questions

How does Kai'Sa do against Seraphine in League of Legends?

Seraphine wins the Kai'Sa vs Seraphine matchup with a 69.2% win rate compared to Kai'Sa's 30.8%, a 38.5 percentage point difference. This data is based on 26 recent ranked games in patch 26.14.

How does Kai'Sa do against Seraphine in the early game?

In the early game, Seraphine has the advantage against Kai'Sa with a 85.7% win rate versus 14.3%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Kai'Sa do against Seraphine in the late game?

In the late game, Kai'Sa takes over the Kai'Sa vs Seraphine matchup with a 50.0% win rate compared to 50.0%. Kai'Sa scales better into team fights and objective contests after 25 minutes.

Who wins the Kai'Sa vs Seraphine matchup?

Seraphine wins the matchup against Kai'Sa with a 69.2% win rate in League of Legends patch 26.14. The 38.5 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 26 games analyzed.

What is the best Kai'Sa build against Seraphine?

The best Kai'Sa build against Seraphine includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Kai'Sa runes against Seraphine?

The best Kai'Sa runes against Seraphine use the Precision primary tree with Inspiration secondary. This rune setup achieves a 33.3% win rate in the Kai'Sa vs Seraphine matchup. See the full rune breakdown in the matchup comparison above.

Does Kai'Sa counter Seraphine?

No, Kai'Sa struggles against Seraphine with only a 30.8% win rate. Seraphine has the advantage in this matchup. Kai'Sa players should focus on safe farming and avoiding extended trades to minimize Seraphine's lead.

How do I play Kai'Sa against Seraphine?

When playing Kai'Sa against Seraphine, play cautiously and avoid Seraphine's power spikes. Focus on safe farming — you outscale Seraphine in the late game. Use the matchup-specific build and runes above to optimize your chances.