Seraphine - League of Legends Champion
Win Rate
52.3%
Pick Rate
7.8%

Seraphinevs Kai'Sa

SSupportMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 5, 2026
MethodologyData Methodology

Seraphine vs Kai'Sa is a moderate matchup in LoL patch 26.11. Seraphine wins with a 51.5% win rate (+3.0%) over Kai'Sa based on 33 games. Seraphine wins the early laning phase while Kai'Sa scales better into the late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Kai'Sa matchup.

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Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 51.5% win rate in this matchup
Seraphine
51.5% WR
VS
Kai'Sa vs Seraphine matchup - 48.5% win rate
Kai'Sa
48.5% WR

Who Wins the Seraphine vs Kai'Sa Matchup?

Seraphine wins the Seraphine vs Kai'Sa matchup
Winner
Seraphine
Matches: 33
51.5%
Win Rate
48.5%
6.8
CS / min
7.2
787
DMG / min
805
11,426
Gold / game
12,424
124
Heal / min
166
430
DMG Mitigated / min
471
1.1
CC / min
0.1
58.8%
Early Game WR
41.2%
43.8%
Late Game WR
56.3%

Seraphine vs Kai'Sa Matchup Summary

The Seraphine vs Kai'Sa matchup is a moderate matchup in League of Legends ranked play. Based on 33 recent matches analyzed, Seraphine wins with a 51.5% win rate compared to Kai'Sa's 48.5%, giving Seraphine a 3.0 percentage point advantage. Game phase dynamics play a critical role here: Seraphine controls the early laning stage, but Kai'Sa outscales as the game goes longer. The matchup shifts dramatically depending on game length — Seraphine needs to press advantages before Kai'Sa reaches their power spikes, while Kai'Sa should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Seraphine leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine has a statistical edge, but the margin is close enough that respecting Kai'Sa's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Kai'Sa Laning Phase Breakdown

Kai'Sa wins the laning phase against Seraphine in League of Legends

Kai'Sa is favored during the laning phase against Seraphine, winning 4 out of 5 key stat categories. Kai'Sa holds advantages in farming, damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.8Seraphine
7.2Kai'Sa
Kai'Sa edges out Seraphine by 0.4 CS per minute — a moderate farming advantage that adds up to roughly 6 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
787Seraphine
805Kai'Sa
Damage output is virtually even between Seraphine and Kai'Sa, with only 18 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
11,426Seraphine
12,424Kai'Sa
Kai'Sa generates a commanding 999 more gold per game than Seraphine. This substantial economic advantage means Kai'Sa consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Seraphine should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.1Seraphine
0.1Kai'Sa
Seraphine brings significantly more crowd control than Kai'Sa, with 1.0 more seconds of CC per minute. This large utility gap makes Seraphine far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
554Seraphine
637Kai'Sa
Kai'Sa heals and mitigates 83 more damage per minute than Seraphine, providing moderate extra durability. This sustain edge allows Kai'Sa to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Seraphine.

Best Seraphine Build Against Kai'Sa

Crimson Lucidity is the optimal boots choice against Kai'Sa, providing the mobility and stats Seraphine needs most in this matchup. The top-performing core items for Seraphine against Kai'Sa are Imperial Mandate, Rylai's Crystal Scepter and Bandlepipes. This combination gives Seraphine an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Seraphine vs Kai'Sa matchup.

Early Game vs Late Game

Early Game
Seraphine
58.8%
+17.6% advantage
Seraphine early game win rateSeraphine58.8%
Kai'Sa early game win rateKai'Sa41.2%
Late Game
Kai'Sa
56.3%
+12.5% advantage
Seraphine late game win rateSeraphine43.8%
Kai'Sa late game win rateKai'Sa56.3%

Seraphine dominates the early game (first 15 minutes) with a commanding 58.8% win rate — a 17.6 percentage point lead over Kai'Sa. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Kai'Sa is far superior in the late game (25+ minutes), boasting a 56.3% win rate — 12.5 points above Seraphine. Extended games heavily favor Kai'Sa, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Seraphine must aggressively press their early advantage and close out the game before Kai'Sa reaches their scaling breakpoints. If Kai'Sa survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Seraphine Runes Against Kai'Sa

Sorcery rune tree - Seraphine primary runes vs Kai'SaSorcery
Arcane Comet - best Seraphine rune vs Kai'SaManaflow Band - best Seraphine rune vs Kai'SaTranscendence - best Seraphine rune vs Kai'SaGathering Storm - best Seraphine rune vs Kai'Sa
Precision rune tree - Seraphine secondary runes vs Kai'SaPrecision
Presence of Mind - best Seraphine rune vs Kai'SaLegend: Haste - best Seraphine rune vs Kai'Sa
100.0% WR

Running Sorcery primary with Precision secondary allows Seraphine to press their advantage against Kai'Sa, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.11. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.75%7791.74669,35944.9%49.5%
50.91%5501.44939,17358.0%45.0%
49.45%5481.44879,00751.2%48.0%
50.83%5431.44879,19746.8%53.9%
52.69%5011.54979,35248.8%55.5%
50.21%4781.85269,25551.6%49.0%
48.69%4211.54709,01249.2%48.3%
50.00%3341.44539,01050.4%49.7%
50.91%3301.95249,71553.4%49.2%
51.72%3191.44699,56046.7%55.4%
52.44%3071.44938,93052.7%52.2%
53.17%2841.74839,53147.7%56.6%
52.84%2821.44878,90149.2%55.8%
50.78%2581.54449,24750.5%51.0%
47.97%2461.54669,32744.7%50.4%
54.85%2371.85849,76454.8%54.9%
54.85%2371.44528,96551.9%57.4%
53.07%2281.53918,66358.8%46.8%
54.63%2271.84989,66455.6%54.0%
43.13%2111.35028,90135.6%48.8%
52.22%2031.45229,03758.4%47.4%
43.22%1991.54988,96147.1%40.4%
48.44%1921.44979,41851.2%46.3%
53.45%1741.84629,23249.4%56.7%
49.70%1691.66149,70344.4%52.2%
52.26%1551.44799,11856.9%48.2%
57.53%1461.45699,69067.9%51.1%
54.48%1454.566211,52162.3%50.0%
52.52%1391.44899,05164.1%42.7%
61.29%1241.64819,07567.7%54.8%
50.00%1221.44628,51250.8%49.1%
50.00%1201.45089,23252.8%47.8%
51.30%1151.44638,90542.2%57.1%
59.13%1156.281412,23054.7%62.9%
53.49%861.54809,03567.5%41.3%
54.88%825.867711,89860.0%51.9%
61.25%804.878912,00275.9%52.9%
56.76%746.880712,47863.9%50.0%
53.42%732.05109,99152.0%54.2%
56.16%731.55149,44956.8%55.6%
46.88%641.54679,51052.0%43.6%
43.33%601.65579,12160.7%28.1%
48.33%602.14408,59548.3%48.4%
54.24%596.283112,84042.1%60.0%
54.24%593.359210,05860.9%50.0%
60.34%585.375111,90651.9%67.7%
63.16%572.056710,73279.0%55.3%
44.23%521.75759,42052.0%37.0%
51.06%472.04629,10847.6%53.9%
50.00%402.260810,02652.6%47.6%
56.76%376.389112,39562.5%52.4%
44.44%362.55159,08730.8%52.2%
60.61%334.259811,53455.6%62.5%
51.52%335.366611,60061.5%45.0%
42.42%336.281310,73542.1%42.9%
51.52%336.878711,42658.8%43.8%
65.63%321.64749,16373.3%58.8%
65.63%324.168110,15666.7%64.7%
58.06%311.64859,79966.7%52.6%
56.67%306.673310,93362.5%50.0%
41.38%291.45019,36630.8%50.0%
44.44%275.167710,72263.6%31.3%
62.96%271.649810,32862.5%63.2%
54.17%244.26249,65645.5%61.5%
50.00%222.45679,74940.0%58.3%
45.45%223.04909,41825.0%57.1%
63.64%222.250811,56760.0%64.7%
40.00%206.580113,55633.3%41.2%
55.00%206.779212,47966.7%45.5%
55.00%202.04629,45857.1%53.9%
45.00%205.871411,07240.0%50.0%
70.00%201.464510,69887.5%58.3%
63.16%191.443410,16060.0%64.3%
61.11%185.67038,05964.3%50.0%
58.82%176.286512,02650.0%63.6%
35.29%171.244610,23775.0%23.1%
75.00%166.791813,62771.4%77.8%
37.50%161.54798,92840.0%36.4%
60.00%156.776112,98866.7%55.6%
40.00%155.359710,54633.3%44.4%
60.00%151.646310,50775.0%54.5%
50.00%143.264710,32850.0%50.0%
50.00%142.65519,74250.0%50.0%
42.86%144.85849,77450.0%37.5%
53.85%136.392112,20066.7%42.9%
30.77%134.16039,87733.3%28.6%
61.54%133.15949,46842.9%83.3%
58.33%126.78259,19670.0%0.0%
50.00%124.36669,42433.3%66.7%
58.33%126.076411,19160.0%57.1%
72.73%116.175811,907100.0%66.7%
27.27%114.55499,3630.0%50.0%
54.55%116.266011,06050.0%60.0%
60.00%105.680311,24250.0%75.0%
80.00%101.44777,16187.5%50.0%
66.67%94.552110,244100.0%62.5%
44.44%91.84238,69366.7%33.3%
37.50%86.293011,95740.0%33.3%
62.50%81.66239,74233.3%80.0%
37.50%81.53958,01025.0%50.0%
37.50%81.34679,59625.0%50.0%
25.00%85.367010,06850.0%16.7%
25.00%83.45779,67325.0%25.0%
62.50%81.457011,7740.0%71.4%
75.00%85.470711,28850.0%83.3%
50.00%81.14638,69050.0%50.0%
50.00%86.298713,25366.7%40.0%
75.00%81.648710,73550.0%83.3%
85.71%71.45378,417100.0%0.0%
42.86%71.949210,03133.3%50.0%
71.43%73.163510,657100.0%60.0%
57.14%73.473912,184100.0%50.0%
100.00%73.15957,466100.0%100.0%
71.43%73.05208,01175.0%66.7%
33.33%67.382210,97625.0%50.0%
100.00%62.35489,903100.0%100.0%
83.33%62.247410,918100.0%80.0%
50.00%61.63829,86350.0%50.0%
100.00%55.957011,5490.0%100.0%
40.00%51.649610,44750.0%33.3%
60.00%51.256510,3000.0%75.0%
40.00%56.06469,77425.0%100.0%
40.00%53.864610,54966.7%0.0%
80.00%51.549910,15550.0%100.0%

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Seraphine vs Kai'Sa - Frequently Asked Questions

How does Seraphine do against Kai'Sa in League of Legends?

Seraphine wins the Seraphine vs Kai'Sa matchup with a 51.5% win rate compared to Kai'Sa's 48.5%, a 3.0 percentage point difference. This data is based on 33 recent ranked games in patch 26.11.

How does Seraphine do against Kai'Sa in the early game?

In the early game, Seraphine has the advantage against Kai'Sa with a 58.8% win rate versus 41.2%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Kai'Sa in the late game?

In the late game, Kai'Sa takes over the Seraphine vs Kai'Sa matchup with a 56.3% win rate compared to 43.8%. Kai'Sa scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Kai'Sa matchup?

Seraphine wins the matchup against Kai'Sa with a 51.5% win rate in League of Legends patch 26.11. The 3.0 percentage point advantage means Seraphine is moderately favored in this lane matchup based on 33 games analyzed.

What is the best Seraphine build against Kai'Sa?

The best Seraphine build against Kai'Sa includes Imperial Mandate, Rylai's Crystal Scepter, Bandlepipes with Crimson Lucidity. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Kai'Sa?

The best Seraphine runes against Kai'Sa use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Seraphine vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Kai'Sa?

Yes, Seraphine has a favorable matchup against Kai'Sa with a 51.5% win rate. Seraphine has a solid advantage over Kai'Sa in lane based on current patch 26.11 data.

How do I play Seraphine against Kai'Sa?

When playing Seraphine against Kai'Sa, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.