Seraphine - League of Legends Champion
Win Rate
52.4%
Pick Rate
10.0%

Seraphinevs Kai'Sa

SSupportMage
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Seraphine vs Kai'Sa is a decisive matchup in LoL patch 26.14. Seraphine wins with a 69.2% win rate (+38.5%) over Kai'Sa based on 26 games. Seraphine holds the advantage in both the early and late game. Below you'll find the best Seraphine build, runes, laning stats, and strategies for the Seraphine vs Kai'Sa matchup.

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Seraphine Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Seraphine performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Seraphine - 69.2% win rate in this matchup
Seraphine
69.2% WR
VS
Kai'Sa vs Seraphine matchup - 30.8% win rate
Kai'Sa
30.8% WR

Who Wins the Seraphine vs Kai'Sa Matchup?

Seraphine wins the Seraphine vs Kai'Sa matchup
Winner
Seraphine
Matches: 26
69.2%
Win Rate
30.8%
5.7
CS / min
6.1
761
DMG / min
724
10,570
Gold / game
10,790
135
Heal / min
149
391
DMG Mitigated / min
458
1.2
CC / min
0.1
85.7%
Early Game WR
14.3%
50.0%
Late Game WR
50.0%

Seraphine vs Kai'Sa Matchup Summary

The Seraphine vs Kai'Sa matchup is a decisive matchup in League of Legends ranked play. Based on 26 recent matches analyzed, Seraphine wins with a 69.2% win rate compared to Kai'Sa's 30.8%, giving Seraphine a 38.5 percentage point advantage. Seraphine dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Kai'Sa players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Seraphine leads by 1.2s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Seraphine players can confidently pick into Kai'Sa and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Kai'Sa away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Seraphine vs Kai'Sa Laning Phase Breakdown

Kai'Sa wins the laning phase against Seraphine in League of Legends

Kai'Sa is favored during the laning phase against Seraphine, winning 3 out of 5 key stat categories. Kai'Sa holds advantages in farming, gold income and sustain, making them the stronger laner in this matchup.

Farming
5.7Seraphine
6.1Kai'Sa
Kai'Sa edges out Seraphine by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Kai'Sa.
Damage
761Seraphine
724Kai'Sa
Seraphine deals 37 more champion damage per minute than Kai'Sa. While noticeable in extended trades, this gap can be offset by Kai'Sa choosing favorable fight windows, such as engaging when Seraphine's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
10,570Seraphine
10,790Kai'Sa
Seraphine and Kai'Sa generate nearly equal gold per game, with just a 220 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
1.2Seraphine
0.1Kai'Sa
Seraphine brings significantly more crowd control than Kai'Sa, with 1.2 more seconds of CC per minute. This large utility gap makes Seraphine far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Kai'Sa should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
527Seraphine
607Kai'Sa
Kai'Sa heals and mitigates 80 more damage per minute than Seraphine, providing moderate extra durability. This sustain edge allows Kai'Sa to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Seraphine.

Early Game vs Late Game

Early Game
Seraphine
85.7%
+71.4% advantage
Seraphine early game win rateSeraphine85.7%
Kai'Sa early game win rateKai'Sa14.3%
Late Game
Seraphine
50.0%
+0.0% advantage
Seraphine late game win rateSeraphine50.0%
Kai'Sa late game win rateKai'Sa50.0%

Seraphine dominates the early game (first 15 minutes) with a commanding 85.7% win rate — a 71.4 percentage point lead over Kai'Sa. This lopsided early game means Seraphine can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Seraphine at 50.0% win rate — only 0.0 points ahead of Kai'Sa. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Seraphine holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Kai'Sa players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Seraphine Runes Against Kai'Sa

Sorcery rune tree - Seraphine primary runes vs Kai'SaSorcery
Arcane Comet - best Seraphine rune vs Kai'SaManaflow Band - best Seraphine rune vs Kai'SaTranscendence - best Seraphine rune vs Kai'SaGathering Storm - best Seraphine rune vs Kai'Sa
Precision rune tree - Seraphine secondary runes vs Kai'SaPrecision
Cut Down - best Seraphine rune vs Kai'SaLegend: Haste - best Seraphine rune vs Kai'Sa
66.7% WR

Running Sorcery primary with Precision secondary allows Seraphine to press their advantage against Kai'Sa, amplifying the strengths that make this a favorable matchup.


Seraphine matchup data for League of Legends patch 26.14. The table below shows Seraphine's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Seraphine build, runes, laning stats, and early vs late game analysis for that specific matchup.

Seraphine matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
55.85%2991.74719,29548.1%60.0%
49.76%2071.55128,84357.0%45.3%
47.70%1741.55109,00848.0%47.4%
49.13%1731.44618,48850.0%48.5%
49.12%1711.64808,75953.7%46.1%
47.06%1531.55109,22549.1%45.8%
48.30%1471.95329,70651.0%46.9%
50.38%1331.54679,03049.0%51.2%
45.97%1241.44288,53360.0%36.5%
48.21%1121.44729,01753.3%44.8%
54.55%1102.35059,68744.4%59.5%
46.79%1091.55018,61150.0%44.4%
57.41%1081.45369,50765.8%52.2%
55.32%941.85399,07347.4%60.7%
50.56%891.44849,28360.0%45.8%
52.87%871.34668,26252.8%52.9%
57.65%851.54169,35765.6%52.8%
57.50%805.372411,20659.3%56.6%
45.45%771.64769,99525.0%50.8%
63.16%761.55059,33854.8%68.9%
57.89%761.75148,58067.6%48.7%
50.00%721.64569,53364.0%42.5%
50.00%662.04959,25747.8%51.2%
50.77%651.46317,61950.0%51.6%
53.85%656.077710,54060.0%48.6%
46.88%641.34479,18159.1%40.5%
52.46%611.54608,55950.0%54.0%
51.72%581.45178,94657.7%46.9%
53.45%581.35148,75145.5%58.3%
43.86%571.45249,59460.0%38.1%
54.55%551.55419,53777.8%43.2%
52.83%531.44887,86337.5%65.5%
52.94%513.765010,65950.0%54.3%
53.49%436.17089,63055.2%50.0%
56.10%411.44789,02957.1%55.0%
36.84%385.975311,16633.3%38.5%
51.52%331.55048,36043.8%58.8%
54.55%331.44978,85036.4%63.6%
62.50%325.476410,80441.7%75.0%
35.48%311.54698,95836.4%35.0%
54.84%311.94618,75463.6%50.0%
55.17%293.267211,13925.0%66.7%
60.71%284.15919,88872.7%52.9%
32.14%286.176410,58033.3%31.3%
69.23%265.776110,57085.7%50.0%
70.83%241.45079,19650.0%81.3%
56.52%236.182912,78350.0%60.0%
56.52%231.85069,03258.3%54.5%
47.62%213.564410,63366.7%40.0%
57.14%211.66148,42960.0%54.5%
42.86%211.648511,10033.3%44.4%
63.16%195.569112,81460.0%64.3%
63.16%191.75289,58566.7%60.0%
47.37%196.387810,25960.0%33.3%
50.00%186.580110,04650.0%50.0%
50.00%186.280711,85837.5%60.0%
50.00%186.885311,27550.0%50.0%
56.25%165.472113,6070.0%69.2%
50.00%164.861610,99950.0%50.0%
56.25%165.866011,976100.0%36.4%
75.00%162.24547,74077.8%71.4%
80.00%152.472410,151100.0%66.7%
66.67%152.474310,11660.0%70.0%
42.86%145.879310,92340.0%44.4%
61.54%131.44069,43660.0%62.5%
66.67%126.279211,77420.0%100.0%
33.33%125.16559,89640.0%28.6%
54.55%113.46429,30060.0%50.0%
40.00%101.35288,42020.0%60.0%
40.00%105.289411,60625.0%50.0%
80.00%102.254811,212100.0%71.4%
55.56%94.86278,88680.0%25.0%
44.44%96.47018,84342.9%50.0%
55.56%91.655510,08533.3%66.7%
25.00%85.075011,78850.0%16.7%
85.71%75.55249,75775.0%100.0%
57.14%71.55089,13366.7%50.0%
42.86%75.566910,94833.3%50.0%
85.71%76.187613,23166.7%100.0%
42.86%74.36429,62220.0%100.0%
57.14%73.050210,97250.0%60.0%
57.14%72.667710,02866.7%50.0%
71.43%73.04619,27766.7%75.0%
28.57%73.673212,7790.0%33.3%
66.67%65.886412,97750.0%75.0%
50.00%64.85639,34966.7%33.3%
33.33%66.786113,96850.0%25.0%
66.67%65.56098,223100.0%0.0%
83.33%64.062711,888100.0%80.0%
50.00%64.249210,633100.0%25.0%
100.00%64.68619,415100.0%100.0%
80.00%52.45339,18466.7%100.0%
60.00%51.55748,068100.0%33.3%
80.00%55.787512,964100.0%75.0%
40.00%51.64836,62350.0%33.3%
60.00%53.08026,67733.3%100.0%
100.00%52.36298,546100.0%100.0%
60.00%54.26028,77833.3%100.0%
60.00%54.74626,532100.0%33.3%
40.00%56.485013,194100.0%0.0%
20.00%53.473711,9840.0%33.3%
100.00%55.51,02313,201100.0%100.0%

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Seraphine vs Kai'Sa - Frequently Asked Questions

How does Seraphine do against Kai'Sa in League of Legends?

Seraphine wins the Seraphine vs Kai'Sa matchup with a 69.2% win rate compared to Kai'Sa's 30.8%, a 38.5 percentage point difference. This data is based on 26 recent ranked games in patch 26.14.

How does Seraphine do against Kai'Sa in the early game?

In the early game, Seraphine has the advantage against Kai'Sa with a 85.7% win rate versus 14.3%. Seraphine players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Seraphine do against Kai'Sa in the late game?

In the late game, Seraphine takes over the Seraphine vs Kai'Sa matchup with a 50.0% win rate compared to 50.0%. Seraphine scales better into team fights and objective contests after 25 minutes.

Who wins the Seraphine vs Kai'Sa matchup?

Seraphine wins the matchup against Kai'Sa with a 69.2% win rate in League of Legends patch 26.14. The 38.5 percentage point advantage means Seraphine is significantly favored in this lane matchup based on 26 games analyzed.

What is the best Seraphine build against Kai'Sa?

The best Seraphine build against Kai'Sa includes optimized core items. Check the matchup breakdown above for the full item path and build order.

What are the best Seraphine runes against Kai'Sa?

The best Seraphine runes against Kai'Sa use the Sorcery primary tree with Precision secondary. This rune setup achieves a 66.7% win rate in the Seraphine vs Kai'Sa matchup. See the full rune breakdown in the matchup comparison above.

Does Seraphine counter Kai'Sa?

Yes, Seraphine has a favorable matchup against Kai'Sa with a 69.2% win rate. Seraphine strongly counters Kai'Sa in lane based on current patch 26.14 data.

How do I play Seraphine against Kai'Sa?

When playing Seraphine against Kai'Sa, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.