Lissandra - League of Legends Champion
Win Rate
53.0%
Pick Rate
1.7%

Lissandravs Vex

SMage
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 4, 2026
MethodologyData Methodology

Lissandra vs Vex is a decisive matchup in LoL patch 26.11. Vex wins with a 60.5% win rate (+21.1%) over Lissandra based on 38 games. Vex holds the advantage in both the early and late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Vex matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 39.5% win rate in this matchup
Lissandra
39.5% WR
VS
Vex vs Lissandra matchup - 60.5% win rate
Vex
60.5% WR

Who Wins the Lissandra vs Vex Matchup?

Vex wins the Lissandra vs Vex matchup
Winner
Vex
Matches: 38
39.5%
Win Rate
60.5%
6.6
CS / min
6.2
802
DMG / min
1,033
12,139
Gold / game
13,011
140
Heal / min
100
436
DMG Mitigated / min
527
1.6
CC / min
1.1
37.5%
Early Game WR
62.5%
40.9%
Late Game WR
59.1%

Lissandra vs Vex Matchup Summary

The Lissandra vs Vex matchup is a decisive matchup in League of Legends ranked play. Based on 38 recent matches analyzed, Vex wins with a 60.5% win rate compared to Lissandra's 39.5%, giving Vex a 21.1 percentage point advantage. Vex dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Lissandra players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Lissandra leads by 0.5s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vex has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vex overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Vex Laning Phase Breakdown

Vex wins the laning phase against Lissandra in League of Legends

Vex is favored during the laning phase against Lissandra, winning 3 out of 5 key stat categories. Vex holds advantages in damage, gold income and sustain, making them the stronger laner in this matchup.

Farming
6.6Lissandra
6.2Vex
Lissandra edges out Vex by 0.3 CS per minute — a moderate farming advantage that adds up to roughly 5 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Lissandra.
Damage
802Lissandra
1,033Vex
Vex heavily out-damages Lissandra by 231 DMG/min, dominating both short trades and all-in fights. Lissandra should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vex's sustained damage advantage take over.
Economy
12,139Lissandra
13,011Vex
Vex generates a commanding 873 more gold per game than Lissandra. This substantial economic advantage means Vex consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Lissandra should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.6Lissandra
1.1Vex
Lissandra provides 0.5 seconds more crowd control per minute than Vex, offering better gank setup potential and slightly more team fight utility. This CC advantage helps Lissandra coordinate with their jungler and control the pace of skirmishes.
Sustain
576Lissandra
627Vex
Vex heals and mitigates 51 more damage per minute than Lissandra, providing moderate extra durability. This sustain edge allows Vex to stay in lane longer between recalls and gradually win extended wars of attrition. Consider building early grievous wounds if playing Lissandra.

Best Lissandra Build Against Vex

Spellslinger's Shoes is the optimal boots choice against Vex, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Vex are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 10 games, proving it to be a reliable item path when facing Vex. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Vex matchup.

Early Game vs Late Game

Early Game
Vex
62.5%
+25.0% advantage
Lissandra early game win rateLissandra37.5%
Vex early game win rateVex62.5%
Late Game
Vex
59.1%
+18.2% advantage
Lissandra late game win rateLissandra40.9%
Vex late game win rateVex59.1%

Vex dominates the early game (first 15 minutes) with a commanding 62.5% win rate — a 25.0 percentage point lead over Lissandra. This lopsided early game means Vex can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vex is far superior in the late game (25+ minutes), boasting a 59.1% win rate — 18.2 points above Lissandra. Extended games heavily favor Vex, whose kit and scaling make them a dominant force in team fights and objective control.

Vex holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Lissandra players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Lissandra Runes Against Vex

Sorcery rune tree - Lissandra primary runes vs VexSorcery
Arcane Comet - best Lissandra rune vs VexManaflow Band - best Lissandra rune vs VexTranscendence - best Lissandra rune vs VexScorch - best Lissandra rune vs Vex
Domination rune tree - Lissandra secondary runes vs VexDomination
Cheap Shot - best Lissandra rune vs VexUltimate Hunter - best Lissandra rune vs Vex
62.5% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Vex in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.11. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
58.02%1316.885811,86355.0%60.6%
61.60%1256.791812,36268.6%56.8%
54.47%1236.988112,08353.1%55.4%
54.95%1116.874811,41055.8%54.2%
51.52%996.684011,78453.5%50.0%
50.00%986.985712,17845.0%53.5%
55.56%816.992811,72160.5%51.2%
44.74%766.878111,74844.1%45.2%
57.53%736.785911,06161.5%52.9%
52.86%706.487411,10854.3%51.4%
48.53%687.090811,10755.0%39.3%
53.73%676.178010,94653.1%54.3%
48.28%586.778112,35453.9%43.8%
41.07%566.774210,62436.7%46.1%
58.93%566.573210,32060.6%56.5%
53.70%546.488811,71551.9%55.6%
52.08%486.888112,08468.2%38.5%
55.32%476.384311,46055.6%55.2%
51.16%436.883412,58750.0%51.9%
43.59%396.482510,76435.0%52.6%
46.15%396.577310,88341.2%50.0%
39.47%386.680212,13937.5%40.9%
56.76%376.374210,61842.1%72.2%
56.76%376.878712,41658.8%55.0%
56.76%376.880811,53576.9%45.8%
32.43%377.080410,61129.4%35.0%
48.65%377.083812,68066.7%40.0%
33.33%336.992311,15131.3%35.3%
66.67%306.784412,08075.0%61.1%
65.52%296.986511,46770.6%58.3%
53.57%286.785811,89133.3%63.2%
61.54%267.193811,18175.0%40.0%
37.50%246.470111,94744.4%33.3%
58.33%247.382212,59060.0%57.1%
50.00%227.076411,84454.5%45.5%
54.55%226.61,01413,02066.7%50.0%
31.82%226.768410,84522.2%38.5%
33.33%216.874611,90044.4%25.0%
57.14%215.782310,46554.5%60.0%
73.68%196.980510,70775.0%72.7%
57.89%196.985412,58375.0%45.5%
61.11%187.488713,06550.0%70.0%
38.89%187.294812,87866.7%25.0%
58.82%176.51,06612,41342.9%70.0%
62.50%166.268611,07572.7%40.0%
56.25%166.892312,01450.0%57.1%
66.67%156.984213,080100.0%54.5%
64.29%146.190813,43275.0%60.0%
50.00%144.254910,94350.0%50.0%
64.29%146.779211,67883.3%50.0%
57.14%147.01,08911,13070.0%25.0%
53.85%136.693411,37550.0%57.1%
58.33%127.51,05412,44966.7%50.0%
63.64%116.090612,08133.3%100.0%
45.45%115.590412,09425.0%57.1%
63.64%112.682511,48750.0%71.4%
30.00%105.47418,70242.9%0.0%
70.00%107.194411,75183.3%50.0%
70.00%106.21,13613,233100.0%50.0%
50.00%106.889914,6330.0%62.5%
70.00%106.481112,0790.0%87.5%
55.56%96.281411,09650.0%66.7%
33.33%96.885511,75450.0%20.0%
66.67%96.578212,16033.3%83.3%
22.22%92.55189,7830.0%40.0%
85.71%77.71,15311,498100.0%66.7%
71.43%76.482813,449100.0%66.7%
57.14%77.384211,22350.0%66.7%
100.00%78.28329,161100.0%100.0%
57.14%72.986810,35560.0%50.0%
42.86%77.48559,99550.0%33.3%
57.14%77.080513,44150.0%66.7%
50.00%66.469210,47333.3%66.7%
33.33%66.78659,25050.0%0.0%
50.00%65.784212,7490.0%50.0%
80.00%56.88199,894100.0%66.7%
60.00%57.671711,88250.0%66.7%
60.00%57.593814,8270.0%75.0%
40.00%52.155411,1230.0%40.0%
60.00%56.576611,909100.0%50.0%
40.00%56.95498,21433.3%50.0%
80.00%53.669512,683100.0%50.0%
60.00%52.24318,35366.7%50.0%
60.00%57.51,17014,036100.0%33.3%
40.00%55.596514,4230.0%40.0%
80.00%57.31,24116,644100.0%75.0%
80.00%56.388712,12650.0%100.0%
60.00%56.074710,44750.0%100.0%
20.00%56.67479,3500.0%33.3%

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Lissandra vs Vex - Frequently Asked Questions

How does Lissandra do against Vex in League of Legends?

Vex wins the Lissandra vs Vex matchup with a 60.5% win rate compared to Lissandra's 39.5%, a 21.1 percentage point difference. This data is based on 38 recent ranked games in patch 26.11.

How does Lissandra do against Vex in the early game?

In the early game, Vex has the advantage against Lissandra with a 62.5% win rate versus 37.5%. Vex players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Vex in the late game?

In the late game, Vex takes over the Lissandra vs Vex matchup with a 59.1% win rate compared to 40.9%. Vex scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Vex matchup?

Vex wins the matchup against Lissandra with a 60.5% win rate in League of Legends patch 26.11. The 21.1 percentage point advantage means Vex is significantly favored in this lane matchup based on 38 games analyzed.

What is the best Lissandra build against Vex?

The best Lissandra build against Vex includes Shadowflame, Zhonya's Hourglass, Malignance with Spellslinger's Shoes. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Vex?

The best Lissandra runes against Vex use the Sorcery primary tree with Domination secondary. This rune setup achieves a 62.5% win rate in the Lissandra vs Vex matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Vex?

No, Lissandra struggles against Vex with only a 39.5% win rate. Vex has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Vex's lead.

How do I play Lissandra against Vex?

When playing Lissandra against Vex, play cautiously and avoid Vex's power spikes. Look for jungle assistance and team-dependent plays since Vex has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.