Vayne - League of Legends Champion
Win Rate
49.2%
Pick Rate
4.8%

Vaynevs Ambessa

DMarksmanAssassin
Patch26.14
Matches226,800
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Vayne vs Ambessa is a decisive matchup in LoL patch 26.14. Vayne wins with a 63.6% win rate (+27.3%) over Ambessa based on 11 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Ambessa matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 63.6% win rate in this matchup
Vayne
63.6% WR
VS
Ambessa vs Vayne matchup - 36.4% win rate
Ambessa
36.4% WR

Who Wins the Vayne vs Ambessa Matchup?

Vayne wins the Vayne vs Ambessa matchup
Winner
Vayne
Matches: 11
63.6%
Win Rate
36.4%
7.0
CS / min
5.7
783
DMG / min
640
10,111
Gold / game
8,649
187
Heal / min
190
389
DMG Mitigated / min
1,000
0.4
CC / min
0.3
71.4%
Early Game WR
28.6%
50.0%
Late Game WR
50.0%

Vayne vs Ambessa Matchup Summary

The Vayne vs Ambessa matchup is a decisive matchup in League of Legends ranked play. Based on 11 recent matches analyzed, Vayne wins with a 63.6% win rate compared to Ambessa's 36.4%, giving Vayne a 27.3 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Ambessa players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Ambessa leads by 615 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into Ambessa and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Ambessa away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Ambessa Laning Phase Breakdown

Vayne wins the laning phase against Ambessa in League of Legends

Vayne is favored during the laning phase against Ambessa, winning 4 out of 5 key stat categories. Vayne holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
7.0Vayne
5.7Ambessa
Vayne significantly out-farms Ambessa by 1.3 CS per minute, accumulating an estimated 20 CS lead by mid game. This substantial farming gap gives Vayne a major gold advantage and earlier item completions. Ambessa players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
783Vayne
640Ambessa
Vayne heavily out-damages Ambessa by 143 DMG/min, dominating both short trades and all-in fights. Ambessa should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
10,111Vayne
8,649Ambessa
Vayne generates a commanding 1,462 more gold per game than Ambessa. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Ambessa should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.3Ambessa
Both Vayne and Ambessa provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
576Vayne
1,190Ambessa
Ambessa vastly out-sustains Vayne, healing and mitigating 615 more damage per minute. This massive durability gap means Ambessa can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Ambessa

Berserker's Greaves is the optimal boots choice against Ambessa, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Ambessa are Jak'Sho, The Protean, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Ambessa matchup.

Early Game vs Late Game

Early Game
Vayne
71.4%
+42.9% advantage
Vayne early game win rateVayne71.4%
Ambessa early game win rateAmbessa28.6%
Late Game
Vayne
50.0%
+0.0% advantage
Vayne late game win rateVayne50.0%
Ambessa late game win rateAmbessa50.0%

Vayne dominates the early game (first 15 minutes) with a commanding 71.4% win rate — a 42.9 percentage point lead over Ambessa. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Late game (25+ minutes) is equally balanced, with Vayne at 50.0% win rate — only 0.0 points ahead of Ambessa. Team fight execution and macro play determine the winner at this stage, not champion matchup advantage.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Ambessa players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against Ambessa

Precision rune tree - Vayne primary runes vs AmbessaPrecision
Lethal Tempo - best Vayne rune vs AmbessaTriumph - best Vayne rune vs AmbessaLegend: Alacrity - best Vayne rune vs AmbessaCoup de Grace - best Vayne rune vs Ambessa
Resolve rune tree - Vayne secondary runes vs AmbessaResolve
Conditioning - best Vayne rune vs AmbessaOvergrowth - best Vayne rune vs Ambessa
60.0% WR

Running Precision primary with Resolve secondary allows Vayne to press their advantage against Ambessa, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.14. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
52.41%1665.887913,17044.4%56.3%
46.27%1346.183513,57539.5%49.0%
56.06%1325.987913,82455.3%56.5%
44.27%1316.285112,50645.6%43.2%
55.91%936.287711,72645.6%66.0%
40.48%846.176912,13323.3%50.0%
54.29%706.394613,79337.5%63.0%
37.70%616.384913,09931.6%40.5%
55.00%606.280012,83058.8%53.5%
54.17%486.293313,52946.7%57.6%
48.84%436.179211,13752.0%44.4%
40.48%426.293813,11238.5%41.4%
56.41%396.190811,09956.3%56.5%
44.74%386.289812,49035.3%52.4%
44.74%385.774912,57938.5%48.0%
63.64%336.295512,53171.4%57.9%
65.63%326.294313,24788.9%56.5%
24.14%295.974010,47614.3%33.3%
41.38%295.882411,49025.0%52.9%
42.86%286.475911,22556.3%25.0%
40.00%256.369611,38123.1%58.3%
48.00%255.678211,35260.0%40.0%
36.00%256.074911,06135.7%36.4%
62.50%246.01,01911,75454.5%69.2%
58.33%245.971012,37433.3%73.3%
47.83%236.085513,59116.7%58.8%
43.48%236.285914,11650.0%40.0%
71.43%216.81,24312,48766.7%75.0%
42.86%215.975212,29833.3%50.0%
40.00%206.21,01212,81128.6%46.1%
45.00%206.383212,79730.0%60.0%
26.32%196.678813,93316.7%30.8%
26.32%195.668910,2660.0%45.5%
50.00%186.785111,30936.4%71.4%
52.94%176.082911,7830.0%75.0%
50.00%165.980911,91275.0%41.7%
62.50%166.41,0259,27955.6%71.4%
57.14%145.81,08212,12625.0%70.0%
46.15%136.28869,26137.5%60.0%
38.46%136.597112,85360.0%25.0%
46.15%136.196512,899100.0%36.4%
41.67%126.01,05712,08225.0%50.0%
66.67%127.11,29514,15950.0%75.0%
63.64%116.51,00311,93533.3%75.0%
36.36%116.667413,09450.0%33.3%
63.64%117.078310,11171.4%50.0%
36.36%116.11,06410,60920.0%50.0%
40.00%106.070311,47666.7%28.6%
60.00%106.184012,20375.0%50.0%
40.00%106.076411,72950.0%33.3%
40.00%105.585814,134100.0%33.3%
60.00%106.01,17912,61450.0%66.7%
50.00%107.190512,028100.0%28.6%
44.44%95.91,06213,23540.0%50.0%
66.67%96.383412,35133.3%83.3%
66.67%95.971012,22866.7%66.7%
55.56%95.788612,272100.0%33.3%
66.67%96.11,02415,000100.0%62.5%
50.00%84.81,02112,21625.0%75.0%
62.50%86.086212,21866.7%60.0%
50.00%85.884113,58533.3%60.0%
62.50%86.472810,59040.0%100.0%
25.00%86.067812,7370.0%28.6%
42.86%75.89059,65440.0%50.0%
71.43%76.31,08912,65775.0%66.7%
71.43%74.31,05011,288100.0%33.3%
71.43%76.081915,205100.0%60.0%
28.57%75.889614,8060.0%33.3%
57.14%76.086811,05860.0%50.0%
50.00%65.684313,0420.0%60.0%
16.67%65.193311,15633.3%0.0%
50.00%66.097112,154100.0%40.0%
0.00%63.375313,3700.0%0.0%
50.00%66.396012,8350.0%60.0%
66.67%66.092811,294100.0%33.3%
33.33%64.888710,6890.0%50.0%
20.00%55.356811,0040.0%33.3%
80.00%56.491116,3890.0%80.0%
80.00%55.284713,655100.0%75.0%
60.00%55.79367,78850.0%100.0%
80.00%56.088813,69250.0%100.0%
60.00%55.57479,88650.0%66.7%
60.00%56.785916,611100.0%50.0%
60.00%55.489312,01850.0%66.7%

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Vayne vs Ambessa - Frequently Asked Questions

How does Vayne do against Ambessa in League of Legends?

Vayne wins the Vayne vs Ambessa matchup with a 63.6% win rate compared to Ambessa's 36.4%, a 27.3 percentage point difference. This data is based on 11 recent ranked games in patch 26.14.

How does Vayne do against Ambessa in the early game?

In the early game, Vayne has the advantage against Ambessa with a 71.4% win rate versus 28.6%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Ambessa in the late game?

In the late game, Vayne takes over the Vayne vs Ambessa matchup with a 50.0% win rate compared to 50.0%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Ambessa matchup?

Vayne wins the matchup against Ambessa with a 63.6% win rate in League of Legends patch 26.14. The 27.3 percentage point advantage means Vayne is significantly favored in this lane matchup based on 11 games analyzed.

What is the best Vayne build against Ambessa?

The best Vayne build against Ambessa includes Jak'Sho, The Protean, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Ambessa?

The best Vayne runes against Ambessa use the Precision primary tree with Resolve secondary. This rune setup achieves a 60.0% win rate in the Vayne vs Ambessa matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Ambessa?

Yes, Vayne has a favorable matchup against Ambessa with a 63.6% win rate. Vayne strongly counters Ambessa in lane based on current patch 26.14 data.

How do I play Vayne against Ambessa?

When playing Vayne against Ambessa, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.