Vayne - League of Legends Champion
Win Rate
50.4%
Pick Rate
4.9%

Vaynevs Ambessa

BMarksmanAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 5, 2026
MethodologyData Methodology

Vayne vs Ambessa is a decisive matchup in LoL patch 26.11. Ambessa wins with a 57.9% win rate (+15.8%) over Vayne based on 19 games. Vayne wins the early laning phase while Ambessa scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Ambessa matchup.

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Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 42.1% win rate in this matchup
Vayne
42.1% WR
VS
Ambessa vs Vayne matchup - 57.9% win rate
Ambessa
57.9% WR

Who Wins the Vayne vs Ambessa Matchup?

Ambessa wins the Vayne vs Ambessa matchup
Winner
Ambessa
Matches: 19
42.1%
Win Rate
57.9%
5.8
CS / min
5.7
817
DMG / min
786
12,142
Gold / game
11,947
228
Heal / min
245
469
DMG Mitigated / min
1,171
0.3
CC / min
0.4
57.1%
Early Game WR
42.9%
33.3%
Late Game WR
66.7%

Vayne vs Ambessa Matchup Summary

The Vayne vs Ambessa matchup is a decisive matchup in League of Legends ranked play. Based on 19 recent matches analyzed, Ambessa wins with a 57.9% win rate compared to Vayne's 42.1%, giving Ambessa a 15.8 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Ambessa outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Ambessa reaches their power spikes, while Ambessa should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Ambessa leads by 719 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Ambessa has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Ambessa overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs Ambessa Laning Phase Breakdown

Vayne wins the laning phase against Ambessa in League of Legends

Vayne is favored during the laning phase against Ambessa, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
5.8Vayne
5.7Ambessa
Vayne and Ambessa farm at nearly identical rates in this matchup, with only a 0.1 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
817Vayne
786Ambessa
Vayne deals 30 more champion damage per minute than Ambessa. While noticeable in extended trades, this gap can be offset by Ambessa choosing favorable fight windows, such as engaging when Vayne's key abilities are on cooldown or trading immediately after dodging a skillshot.
Economy
12,142Vayne
11,947Ambessa
Vayne and Ambessa generate nearly equal gold per game, with just a 196 gold difference. Neither champion has a clear economic advantage, so gold leads will depend on individual play quality, kill participation, and objective contributions.
Utility
0.3Vayne
0.4Ambessa
Both Vayne and Ambessa provide similar amounts of crowd control (0.0s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
697Vayne
1,416Ambessa
Ambessa vastly out-sustains Vayne, healing and mitigating 719 more damage per minute. This massive durability gap means Ambessa can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against Ambessa

Berserker's Greaves is the optimal boots choice against Ambessa, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against Ambessa are Kraken Slayer, Experimental Hexplate and Infinity Edge. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs Ambessa matchup.

Early Game vs Late Game

Early Game
Vayne
57.1%
+14.3% advantage
Vayne early game win rateVayne57.1%
Ambessa early game win rateAmbessa42.9%
Late Game
Ambessa
66.7%
+33.3% advantage
Vayne late game win rateVayne33.3%
Ambessa late game win rateAmbessa66.7%

Vayne dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over Ambessa. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Ambessa is far superior in the late game (25+ minutes), boasting a 66.7% win rate — 33.3 points above Vayne. Extended games heavily favor Ambessa, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Ambessa reaches their scaling breakpoints. If Ambessa survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Vayne Runes Against Ambessa

Precision rune tree - Vayne primary runes vs AmbessaPrecision
Press the Attack - best Vayne rune vs AmbessaTriumph - best Vayne rune vs AmbessaLegend: Alacrity - best Vayne rune vs AmbessaCoup de Grace - best Vayne rune vs Ambessa
Resolve rune tree - Vayne secondary runes vs AmbessaResolve
Conditioning - best Vayne rune vs AmbessaOvergrowth - best Vayne rune vs Ambessa
100.0% WR

The Precision and Resolve rune setup gives Vayne the best tools to compete against Ambessa in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Vayne matchup data for League of Legends patch 26.11. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
46.01%4766.078912,87544.3%47.4%
47.20%4476.079112,72545.4%48.6%
46.26%4285.779612,71544.9%47.3%
53.92%3956.085712,96853.2%54.6%
47.85%3726.289413,18946.8%48.6%
52.99%3516.284313,14252.5%53.4%
52.98%2856.390413,45646.2%58.8%
53.90%2696.387713,73748.2%58.0%
52.38%1895.988612,46846.1%58.2%
51.92%1566.591311,98950.0%53.4%
54.30%1516.185913,22758.5%51.2%
50.33%1516.180413,00743.8%55.2%
45.95%1485.978013,60345.3%46.3%
45.38%1306.177613,08138.2%50.7%
47.83%1156.481213,76538.5%52.6%
42.61%1156.178112,08234.0%49.2%
50.88%1145.886612,98941.2%58.7%
45.19%1046.489913,17548.7%43.1%
59.80%1026.585413,18963.5%56.0%
31.00%1005.563510,36011.1%47.3%
45.83%965.885713,16444.4%46.7%
50.53%956.31,12012,73751.6%50.0%
58.06%936.379613,00854.8%60.8%
44.09%935.862511,33042.4%45.0%
45.56%905.883011,35543.6%47.1%
45.98%876.385113,57237.9%50.0%
55.81%866.189910,74843.2%65.3%
55.95%846.21,29211,54651.4%59.2%
56.41%786.388313,43557.1%55.8%
54.84%625.981412,06158.3%52.6%
45.76%596.287712,77548.0%44.1%
51.92%526.091311,59248.1%56.0%
45.10%516.592112,14440.9%48.3%
52.00%506.087513,62147.8%55.6%
35.42%486.272110,98228.0%43.5%
58.33%486.198911,81064.0%52.2%
45.83%486.21,00510,83851.9%38.1%
50.00%466.297013,36447.4%51.9%
58.70%466.291413,67162.5%54.5%
54.55%446.287414,06357.1%53.3%
44.19%436.683913,74455.0%34.8%
26.19%425.987411,67823.5%28.0%
48.78%415.983611,64443.5%55.6%
52.50%405.683813,60737.5%56.3%
38.46%396.785410,96150.0%28.6%
41.03%396.07439,57128.6%55.6%
67.57%376.589811,52662.5%76.9%
45.95%375.683211,99840.0%50.0%
52.94%346.475912,24550.0%54.5%
52.94%346.41,05111,47452.6%53.3%
66.67%336.393813,52461.5%70.0%
48.48%336.478411,26950.0%46.1%
48.48%336.597913,30562.5%44.0%
40.63%325.382011,34442.1%38.5%
62.50%325.779613,16341.7%75.0%
40.63%326.267610,36931.6%53.9%
58.06%316.484912,13864.3%52.9%
53.33%305.685512,15255.6%52.4%
60.00%306.095312,30876.9%47.1%
43.33%306.664611,44137.5%50.0%
55.56%275.379211,00650.0%60.0%
48.15%276.283411,46543.8%54.5%
50.00%265.969311,80141.7%57.1%
50.00%266.171011,42146.1%53.9%
30.77%265.370011,00127.3%33.3%
50.00%265.883412,30154.5%46.7%
48.00%256.081612,91020.0%66.7%
44.00%256.475811,84450.0%38.5%
54.17%246.399112,32564.3%40.0%
45.83%246.085011,12557.1%30.0%
56.52%235.761010,29945.5%66.7%
45.45%226.573412,18438.5%55.6%
40.91%226.080612,81544.4%38.5%
42.11%196.292010,37245.5%37.5%
63.16%196.387012,58950.0%72.7%
42.11%195.881712,14257.1%33.3%
61.11%185.61,00813,43366.7%58.3%
62.50%166.188511,54762.5%62.5%
80.00%152.288517,36850.0%84.6%
53.33%156.498513,30150.0%54.5%
60.00%156.583311,24437.5%85.7%
46.67%156.687611,53050.0%42.9%
46.67%155.491613,99225.0%54.5%
42.86%146.482413,96675.0%30.0%
42.86%146.084113,4470.0%66.7%
53.85%136.584913,506100.0%33.3%
46.15%135.275011,57950.0%42.9%
66.67%125.61,02512,92880.0%57.1%
33.33%126.092711,90033.3%33.3%
54.55%115.61,00213,29850.0%57.1%
63.64%116.164210,20450.0%80.0%
54.55%112.982014,06866.7%40.0%
81.82%116.277512,783100.0%71.4%
54.55%113.484613,74333.3%62.5%
54.55%115.576111,64971.4%25.0%
45.45%115.69159,80875.0%28.6%
40.00%104.670811,73250.0%25.0%
60.00%105.782012,59750.0%62.5%
50.00%103.877113,23733.3%57.1%
40.00%105.592611,89340.0%40.0%
66.67%93.81,03913,79866.7%66.7%
33.33%96.11,07613,2730.0%50.0%
55.56%96.793013,145100.0%20.0%
33.33%96.085513,01833.3%33.3%
55.56%93.986012,86033.3%66.7%
50.00%85.887014,56550.0%50.0%
62.50%87.368411,84766.7%50.0%
50.00%83.288313,47975.0%25.0%
25.00%85.26909,10216.7%50.0%
37.50%85.85269,89450.0%25.0%
57.14%74.076010,75033.3%75.0%
71.43%73.674311,42580.0%50.0%
42.86%74.572311,69733.3%50.0%
28.57%74.567612,0460.0%40.0%
50.00%63.578115,0220.0%60.0%
33.33%66.882313,7790.0%50.0%
33.33%62.998912,89833.3%33.3%
66.67%65.91,00614,14350.0%75.0%
20.00%54.75778,99933.3%0.0%
40.00%52.161112,29050.0%0.0%
40.00%56.41,17614,5940.0%50.0%
80.00%56.21,02413,762100.0%66.7%
40.00%55.996213,2480.0%50.0%
40.00%56.06739,21850.0%0.0%
40.00%56.47269,89240.0%0.0%

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Vayne vs Ambessa - Frequently Asked Questions

How does Vayne do against Ambessa in League of Legends?

Ambessa wins the Vayne vs Ambessa matchup with a 57.9% win rate compared to Vayne's 42.1%, a 15.8 percentage point difference. This data is based on 19 recent ranked games in patch 26.11.

How does Vayne do against Ambessa in the early game?

In the early game, Vayne has the advantage against Ambessa with a 57.1% win rate versus 42.9%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against Ambessa in the late game?

In the late game, Ambessa takes over the Vayne vs Ambessa matchup with a 66.7% win rate compared to 33.3%. Ambessa scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs Ambessa matchup?

Ambessa wins the matchup against Vayne with a 57.9% win rate in League of Legends patch 26.11. The 15.8 percentage point advantage means Ambessa is significantly favored in this lane matchup based on 19 games analyzed.

What is the best Vayne build against Ambessa?

The best Vayne build against Ambessa includes Kraken Slayer, Experimental Hexplate, Infinity Edge with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against Ambessa?

The best Vayne runes against Ambessa use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Ambessa matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter Ambessa?

No, Vayne struggles against Ambessa with only a 42.1% win rate. Ambessa has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Ambessa's lead.

How do I play Vayne against Ambessa?

When playing Vayne against Ambessa, play cautiously and avoid Ambessa's power spikes. Look for jungle assistance and team-dependent plays since Ambessa has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.