Vayne - League of Legends Champion
Win Rate
49.5%
Pick Rate
5.3%

Vaynevs K'Sante

DMarksmanAssassin
Patch26.7
Matches949,984
LaneAll Lanes
TierAll Tiers
Last UpdatedApr 21, 2026
MethodologyData Methodology

Vayne vs K'Sante is a decisive matchup in LoL patch 26.7. Vayne wins with a 56.3% win rate (+12.5%) over K'Sante based on 16 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs K'Sante matchup.

Vayne Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
K'Sante - 56.3% win rateK'Sante(56.3%)
Vayne - 56.3% win rate in this matchup
Vayne
56.3% WR
VS
K'Sante vs Vayne matchup - 43.8% win rate
K'Sante
43.8% WR

Who Wins the Vayne vs K'Sante Matchup?

Vayne wins the Vayne vs K'Sante matchup
Winner
Vayne
Matches: 16
56.3%
Win Rate
43.8%
6.6
CS / min
6.2
907
DMG / min
435
11,527
Gold / game
10,188
239
Heal / min
159
515
DMG Mitigated / min
1,556
0.4
CC / min
0.9
57.1%
Early Game WR
42.9%
55.6%
Late Game WR
44.4%

Vayne vs K'Sante Matchup Summary

The Vayne vs K'Sante matchup is a decisive matchup in League of Legends ranked play. Based on 16 recent matches analyzed, Vayne wins with a 56.3% win rate compared to K'Sante's 43.8%, giving Vayne a 12.5 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for K'Sante players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where K'Sante leads by 962 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne players can confidently pick into K'Sante and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone K'Sante away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Vayne vs K'Sante Laning Phase Breakdown

Vayne wins the laning phase against K'Sante in League of Legends

Vayne is favored during the laning phase against K'Sante, winning 3 out of 5 key stat categories. Vayne holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
6.6Vayne
6.2K'Sante
Vayne edges out K'Sante by 0.5 CS per minute — a moderate farming advantage that adds up to roughly 7 CS over a 15-minute laning phase. This translates to earlier component purchases and slightly faster power spikes for Vayne.
Damage
907Vayne
435K'Sante
Vayne heavily out-damages K'Sante by 471 DMG/min, dominating both short trades and all-in fights. K'Sante should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Vayne's sustained damage advantage take over.
Economy
11,527Vayne
10,188K'Sante
Vayne generates a commanding 1,340 more gold per game than K'Sante. This substantial economic advantage means Vayne consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. K'Sante should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
0.4Vayne
0.9K'Sante
K'Sante provides 0.5 seconds more crowd control per minute than Vayne, offering better gank setup potential and slightly more team fight utility. This CC advantage helps K'Sante coordinate with their jungler and control the pace of skirmishes.
Sustain
753Vayne
1,715K'Sante
K'Sante vastly out-sustains Vayne, healing and mitigating 962 more damage per minute. This massive durability gap means K'Sante can absorb significant punishment and remain in lane while Vayne is forced to recall. Building grievous wounds early is essential for Vayne, and focusing on burst trade patterns rather than sustained fights is critical.

Best Vayne Build Against K'Sante

Berserker's Greaves is the optimal boots choice against K'Sante, providing the mobility and stats Vayne needs most in this matchup. The top-performing core items for Vayne against K'Sante are Terminus, Blade of The Ruined King and Guinsoo's Rageblade. This combination gives Vayne an effective balance of damage, survivability, and utility for the matchup. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Vayne vs K'Sante matchup.

Early Game vs Late Game

Early Game
Vayne
57.1%
+14.3% advantage
Vayne early game win rateVayne57.1%
K'Sante early game win rateK'Sante42.9%
Late Game
Vayne
55.6%
+11.1% advantage
Vayne late game win rateVayne55.6%
K'Sante late game win rateK'Sante44.4%

Vayne dominates the early game (first 15 minutes) with a commanding 57.1% win rate — a 14.3 percentage point lead over K'Sante. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Vayne is far superior in the late game (25+ minutes), boasting a 55.6% win rate — 11.1 points above K'Sante. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.

Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. K'Sante players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Vayne Runes Against K'Sante

Precision rune tree - Vayne primary runes vs K'SantePrecision
Lethal Tempo - best Vayne rune vs K'SanteTriumph - best Vayne rune vs K'SanteLegend: Alacrity - best Vayne rune vs K'SanteCoup de Grace - best Vayne rune vs K'Sante
Domination rune tree - Vayne secondary runes vs K'SanteDomination
Sudden Impact - best Vayne rune vs K'SanteUltimate Hunter - best Vayne rune vs K'Sante
100.0% WR

Running Precision primary with Domination secondary allows Vayne to press their advantage against K'Sante, amplifying the strengths that make this a favorable matchup.


Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.

Vayne matchup win rates and stats in League of Legends patch 26.7
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
49.02%3576.081713,23145.3%52.0%
52.47%3246.289813,59649.3%55.2%
48.09%3146.283212,81944.0%52.7%
49.01%3025.982512,93747.5%50.3%
52.94%2726.083913,07152.8%53.1%
45.37%2276.496014,25446.9%44.2%
50.00%2226.493713,71750.0%50.0%
52.71%2036.585613,74148.9%56.0%
52.32%1516.582813,28755.4%49.4%
58.39%1496.695312,70051.6%63.5%
51.30%1155.881313,71761.5%42.9%
47.71%1096.088213,23938.2%57.4%
55.67%976.488012,62559.6%51.1%
51.55%976.380612,73552.5%50.0%
50.00%945.983213,59546.7%53.1%
36.36%886.279012,98330.0%41.7%
47.44%786.692813,28446.3%48.6%
61.33%756.692412,10266.7%55.6%
55.56%726.185813,24745.2%63.4%
57.35%686.085313,57456.0%58.1%
36.76%686.288112,39436.7%36.8%
52.54%596.383712,51848.5%57.7%
42.37%596.287012,82834.4%51.9%
38.60%575.760511,22540.0%37.0%
37.50%565.560110,77030.4%42.4%
43.40%536.21,04512,46744.4%42.3%
44.00%506.188613,06147.8%40.7%
53.06%496.11,21413,80450.0%55.2%
65.91%446.186913,29266.7%65.4%
56.82%445.692114,04761.1%53.9%
43.18%445.799611,54831.3%50.0%
50.00%406.384813,58435.3%60.9%
55.00%405.989314,58823.1%70.4%
57.50%406.395114,24860.0%56.7%
48.72%396.595213,49157.9%40.0%
57.89%386.01,02912,41355.0%61.1%
42.11%386.192313,74144.4%40.0%
54.05%377.092811,69252.4%56.3%
40.54%375.880412,22541.2%40.0%
40.00%355.71,14111,80838.9%41.2%
55.88%346.585611,12557.9%53.3%
50.00%326.098613,59966.7%43.5%
66.67%306.289612,54050.0%81.3%
56.67%306.298113,89653.9%58.8%
48.28%296.785812,18028.6%66.7%
55.17%296.31,02413,69462.5%46.1%
51.85%275.798412,39145.5%56.3%
61.54%266.185111,71961.5%61.5%
64.00%256.080811,77055.6%68.8%
44.00%256.892712,26342.9%45.5%
33.33%246.483511,60541.7%25.0%
56.52%235.592112,42462.5%53.3%
43.48%236.383712,92160.0%30.8%
40.91%226.678811,10141.7%40.0%
52.38%215.992313,47740.0%63.6%
60.00%205.290914,35220.0%73.3%
47.37%196.91,00811,89263.6%25.0%
50.00%186.273213,04560.0%37.5%
50.00%186.21,05312,78455.6%44.4%
44.44%186.483711,79542.9%45.5%
50.00%185.875412,37328.6%63.6%
76.47%176.91,02114,29680.0%75.0%
29.41%176.982911,89737.5%22.2%
41.18%176.086215,19160.0%33.3%
43.75%166.083811,77362.5%25.0%
56.25%166.690711,52757.1%55.6%
37.50%165.465913,20816.7%50.0%
68.75%166.793713,92583.3%60.0%
53.33%155.968611,41937.5%71.4%
73.33%156.485112,62177.8%66.7%
50.00%145.785111,11416.7%75.0%
42.86%144.364512,05114.3%71.4%
53.85%133.388514,16275.0%44.4%
53.85%135.71,05513,76250.0%55.6%
58.33%125.656210,02757.1%60.0%
25.00%124.586213,08325.0%25.0%
50.00%126.378413,32833.3%66.7%
27.27%116.277113,46233.3%25.0%
63.64%116.387415,82666.7%62.5%
36.36%116.665110,70650.0%20.0%
45.45%115.591912,62950.0%40.0%
72.73%116.474510,85071.4%75.0%
45.45%116.01,06414,50840.0%50.0%
70.00%106.699613,49075.0%66.7%
40.00%106.887613,21633.3%50.0%
55.56%96.393712,28633.3%100.0%
44.44%96.21,07715,702100.0%28.6%
33.33%96.877411,06920.0%50.0%
25.00%85.569310,37825.0%25.0%
50.00%85.99738,78533.3%100.0%
37.50%81.983414,72733.3%40.0%
42.86%75.690112,809100.0%20.0%
0.00%76.655810,7000.0%0.0%
42.86%74.665114,53850.0%40.0%
71.43%76.168213,12675.0%66.7%
57.14%75.588812,31625.0%100.0%
57.14%75.489512,10050.0%66.7%
42.86%74.077311,64333.3%50.0%
57.14%72.51,31315,57625.0%100.0%
33.33%64.65709,10525.0%50.0%
66.67%65.91,08915,49350.0%75.0%
50.00%65.776213,18250.0%50.0%
50.00%61.989114,832100.0%40.0%
16.67%65.384410,4420.0%33.3%
0.00%65.979510,7240.0%0.0%
83.33%66.196311,361100.0%50.0%
50.00%66.380413,574100.0%40.0%
40.00%54.793914,778100.0%0.0%
60.00%51.71,19517,6480.0%75.0%
20.00%51.56919,37833.3%0.0%
60.00%55.31,10015,380100.0%50.0%
20.00%56.891512,5530.0%33.3%
40.00%56.51,02117,6030.0%40.0%

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Vayne vs K'Sante - Frequently Asked Questions

How does Vayne do against K'Sante in League of Legends?

Vayne wins the Vayne vs K'Sante matchup with a 56.3% win rate compared to K'Sante's 43.8%, a 12.5 percentage point difference. This data is based on 16 recent ranked games in patch 26.7.

How does Vayne do against K'Sante in the early game?

In the early game, Vayne has the advantage against K'Sante with a 57.1% win rate versus 42.9%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Vayne do against K'Sante in the late game?

In the late game, Vayne takes over the Vayne vs K'Sante matchup with a 55.6% win rate compared to 44.4%. Vayne scales better into team fights and objective contests after 25 minutes.

Who wins the Vayne vs K'Sante matchup?

Vayne wins the matchup against K'Sante with a 56.3% win rate in League of Legends patch 26.7. The 12.5 percentage point advantage means Vayne is significantly favored in this lane matchup based on 16 games analyzed.

What is the best Vayne build against K'Sante?

The best Vayne build against K'Sante includes Terminus, Blade of The Ruined King, Guinsoo's Rageblade with Berserker's Greaves. Check the matchup breakdown above for the full item path and build order.

What are the best Vayne runes against K'Sante?

The best Vayne runes against K'Sante use the Precision primary tree with Domination secondary. This rune setup achieves a 100.0% win rate in the Vayne vs K'Sante matchup. See the full rune breakdown in the matchup comparison above.

Does Vayne counter K'Sante?

Yes, Vayne has a favorable matchup against K'Sante with a 56.3% win rate. Vayne strongly counters K'Sante in lane based on current patch 26.7 data.

How do I play Vayne against K'Sante?

When playing Vayne against K'Sante, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.