Vaynevs Cassiopeia
Vayne vs Cassiopeia is a decisive matchup in LoL patch 26.7. Cassiopeia wins with a 60.0% win rate (+20.0%) over Vayne based on 5 games. Vayne wins the early laning phase while Cassiopeia scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Cassiopeia matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Cassiopeia(40.0%)Who Wins the Vayne vs Cassiopeia Matchup?
Vayne vs Cassiopeia Matchup Summary
The Vayne vs Cassiopeia matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Cassiopeia wins with a 60.0% win rate compared to Vayne's 40.0%, giving Cassiopeia a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Cassiopeia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Cassiopeia reaches their power spikes, while Cassiopeia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.4s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia has a strong advantage in this matchup. Vayne players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Cassiopeia overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Cassiopeia Laning Phase Breakdown
Cassiopeia is favored during the laning phase against Vayne, winning 3 out of 5 key stat categories. Cassiopeia holds advantages in damage, crowd control and sustain, making them the stronger laner in this matchup.
Early Game vs Late Game
Vayne0.0%Cassiopeia0.0%Vayne40.0%Cassiopeia60.0%The early game (first 15 minutes) is a toss-up between Vayne and Cassiopeia, with Vayne holding a razor-thin 0.0% win rate edge (+0.0%). Individual skill and jungle proximity will matter more than champion advantage in the early laning phase.
Cassiopeia is far superior in the late game (25+ minutes), boasting a 60.0% win rate — 20.0 points above Vayne. Extended games heavily favor Cassiopeia, whose kit and scaling make them a dominant force in team fights and objective control.
The power dynamics shift as the game progresses — Vayne has the edge early, but Cassiopeia gradually takes over. However, the margins are slim enough that either champion can win at any stage with the right plays. Focus on taking advantages when you have them rather than waiting for a specific game phase.
Best Vayne Runes Against Cassiopeia
Precision
Sorcery
The Precision and Sorcery rune setup gives Vayne the best tools to compete against Cassiopeia in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Vayne matchup data for League of Legends patch 26.7. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 49.02% | 357 | 6.0 | 817 | 13,231 | 45.3% | 52.0% | |
| 52.47% | 324 | 6.2 | 898 | 13,596 | 49.3% | 55.2% | |
| 48.09% | 314 | 6.2 | 832 | 12,819 | 44.0% | 52.7% | |
| 49.01% | 302 | 5.9 | 825 | 12,937 | 47.5% | 50.3% | |
| 52.94% | 272 | 6.0 | 839 | 13,071 | 52.8% | 53.1% | |
| 45.37% | 227 | 6.4 | 960 | 14,254 | 46.9% | 44.2% | |
| 50.00% | 222 | 6.4 | 937 | 13,717 | 50.0% | 50.0% | |
| 52.71% | 203 | 6.5 | 856 | 13,741 | 48.9% | 56.0% | |
| 52.32% | 151 | 6.5 | 828 | 13,287 | 55.4% | 49.4% | |
| 58.39% | 149 | 6.6 | 953 | 12,700 | 51.6% | 63.5% | |
| 51.30% | 115 | 5.8 | 813 | 13,717 | 61.5% | 42.9% | |
| 47.71% | 109 | 6.0 | 882 | 13,239 | 38.2% | 57.4% | |
| 55.67% | 97 | 6.4 | 880 | 12,625 | 59.6% | 51.1% | |
| 51.55% | 97 | 6.3 | 806 | 12,735 | 52.5% | 50.0% | |
| 50.00% | 94 | 5.9 | 832 | 13,595 | 46.7% | 53.1% | |
| 36.36% | 88 | 6.2 | 790 | 12,983 | 30.0% | 41.7% | |
| 47.44% | 78 | 6.6 | 928 | 13,284 | 46.3% | 48.6% | |
| 61.33% | 75 | 6.6 | 924 | 12,102 | 66.7% | 55.6% | |
| 55.56% | 72 | 6.1 | 858 | 13,247 | 45.2% | 63.4% | |
| 57.35% | 68 | 6.0 | 853 | 13,574 | 56.0% | 58.1% | |
| 36.76% | 68 | 6.2 | 881 | 12,394 | 36.7% | 36.8% | |
| 52.54% | 59 | 6.3 | 837 | 12,518 | 48.5% | 57.7% | |
| 42.37% | 59 | 6.2 | 870 | 12,828 | 34.4% | 51.9% | |
| 38.60% | 57 | 5.7 | 605 | 11,225 | 40.0% | 37.0% | |
| 37.50% | 56 | 5.5 | 601 | 10,770 | 30.4% | 42.4% | |
| 43.40% | 53 | 6.2 | 1,045 | 12,467 | 44.4% | 42.3% | |
| 44.00% | 50 | 6.1 | 886 | 13,061 | 47.8% | 40.7% | |
| 53.06% | 49 | 6.1 | 1,214 | 13,804 | 50.0% | 55.2% | |
| 65.91% | 44 | 6.1 | 869 | 13,292 | 66.7% | 65.4% | |
| 56.82% | 44 | 5.6 | 921 | 14,047 | 61.1% | 53.9% | |
| 43.18% | 44 | 5.7 | 996 | 11,548 | 31.3% | 50.0% | |
| 50.00% | 40 | 6.3 | 848 | 13,584 | 35.3% | 60.9% | |
| 55.00% | 40 | 5.9 | 893 | 14,588 | 23.1% | 70.4% | |
| 57.50% | 40 | 6.3 | 951 | 14,248 | 60.0% | 56.7% | |
| 48.72% | 39 | 6.5 | 952 | 13,491 | 57.9% | 40.0% | |
| 57.89% | 38 | 6.0 | 1,029 | 12,413 | 55.0% | 61.1% | |
| 42.11% | 38 | 6.1 | 923 | 13,741 | 44.4% | 40.0% | |
| 54.05% | 37 | 7.0 | 928 | 11,692 | 52.4% | 56.3% | |
| 40.54% | 37 | 5.8 | 804 | 12,225 | 41.2% | 40.0% | |
| 40.00% | 35 | 5.7 | 1,141 | 11,808 | 38.9% | 41.2% | |
| 55.88% | 34 | 6.5 | 856 | 11,125 | 57.9% | 53.3% | |
| 50.00% | 32 | 6.0 | 986 | 13,599 | 66.7% | 43.5% | |
| 66.67% | 30 | 6.2 | 896 | 12,540 | 50.0% | 81.3% | |
| 56.67% | 30 | 6.2 | 981 | 13,896 | 53.9% | 58.8% | |
| 48.28% | 29 | 6.7 | 858 | 12,180 | 28.6% | 66.7% | |
| 55.17% | 29 | 6.3 | 1,024 | 13,694 | 62.5% | 46.1% | |
| 51.85% | 27 | 5.7 | 984 | 12,391 | 45.5% | 56.3% | |
| 61.54% | 26 | 6.1 | 851 | 11,719 | 61.5% | 61.5% | |
| 64.00% | 25 | 6.0 | 808 | 11,770 | 55.6% | 68.8% | |
| 44.00% | 25 | 6.8 | 927 | 12,263 | 42.9% | 45.5% | |
| 33.33% | 24 | 6.4 | 835 | 11,605 | 41.7% | 25.0% | |
| 56.52% | 23 | 5.5 | 921 | 12,424 | 62.5% | 53.3% | |
| 43.48% | 23 | 6.3 | 837 | 12,921 | 60.0% | 30.8% | |
| 40.91% | 22 | 6.6 | 788 | 11,101 | 41.7% | 40.0% | |
| 52.38% | 21 | 5.9 | 923 | 13,477 | 40.0% | 63.6% | |
| 60.00% | 20 | 5.2 | 909 | 14,352 | 20.0% | 73.3% | |
| 47.37% | 19 | 6.9 | 1,008 | 11,892 | 63.6% | 25.0% | |
| 50.00% | 18 | 6.2 | 732 | 13,045 | 60.0% | 37.5% | |
| 50.00% | 18 | 6.2 | 1,053 | 12,784 | 55.6% | 44.4% | |
| 44.44% | 18 | 6.4 | 837 | 11,795 | 42.9% | 45.5% | |
| 50.00% | 18 | 5.8 | 754 | 12,373 | 28.6% | 63.6% | |
| 76.47% | 17 | 6.9 | 1,021 | 14,296 | 80.0% | 75.0% | |
| 29.41% | 17 | 6.9 | 829 | 11,897 | 37.5% | 22.2% | |
| 41.18% | 17 | 6.0 | 862 | 15,191 | 60.0% | 33.3% | |
| 43.75% | 16 | 6.0 | 838 | 11,773 | 62.5% | 25.0% | |
| 56.25% | 16 | 6.6 | 907 | 11,527 | 57.1% | 55.6% | |
| 37.50% | 16 | 5.4 | 659 | 13,208 | 16.7% | 50.0% | |
| 68.75% | 16 | 6.7 | 937 | 13,925 | 83.3% | 60.0% | |
| 53.33% | 15 | 5.9 | 686 | 11,419 | 37.5% | 71.4% | |
| 73.33% | 15 | 6.4 | 851 | 12,621 | 77.8% | 66.7% | |
| 50.00% | 14 | 5.7 | 851 | 11,114 | 16.7% | 75.0% | |
| 42.86% | 14 | 4.3 | 645 | 12,051 | 14.3% | 71.4% | |
| 53.85% | 13 | 3.3 | 885 | 14,162 | 75.0% | 44.4% | |
| 53.85% | 13 | 5.7 | 1,055 | 13,762 | 50.0% | 55.6% | |
| 58.33% | 12 | 5.6 | 562 | 10,027 | 57.1% | 60.0% | |
| 25.00% | 12 | 4.5 | 862 | 13,083 | 25.0% | 25.0% | |
| 50.00% | 12 | 6.3 | 784 | 13,328 | 33.3% | 66.7% | |
| 27.27% | 11 | 6.2 | 771 | 13,462 | 33.3% | 25.0% | |
| 63.64% | 11 | 6.3 | 874 | 15,826 | 66.7% | 62.5% | |
| 36.36% | 11 | 6.6 | 651 | 10,706 | 50.0% | 20.0% | |
| 45.45% | 11 | 5.5 | 919 | 12,629 | 50.0% | 40.0% | |
| 72.73% | 11 | 6.4 | 745 | 10,850 | 71.4% | 75.0% | |
| 45.45% | 11 | 6.0 | 1,064 | 14,508 | 40.0% | 50.0% | |
| 70.00% | 10 | 6.6 | 996 | 13,490 | 75.0% | 66.7% | |
| 40.00% | 10 | 6.8 | 876 | 13,216 | 33.3% | 50.0% | |
| 55.56% | 9 | 6.3 | 937 | 12,286 | 33.3% | 100.0% | |
| 44.44% | 9 | 6.2 | 1,077 | 15,702 | 100.0% | 28.6% | |
| 33.33% | 9 | 6.8 | 774 | 11,069 | 20.0% | 50.0% | |
| 25.00% | 8 | 5.5 | 693 | 10,378 | 25.0% | 25.0% | |
| 50.00% | 8 | 5.9 | 973 | 8,785 | 33.3% | 100.0% | |
| 37.50% | 8 | 1.9 | 834 | 14,727 | 33.3% | 40.0% | |
| 42.86% | 7 | 5.6 | 901 | 12,809 | 100.0% | 20.0% | |
| 0.00% | 7 | 6.6 | 558 | 10,700 | 0.0% | 0.0% | |
| 42.86% | 7 | 4.6 | 651 | 14,538 | 50.0% | 40.0% | |
| 71.43% | 7 | 6.1 | 682 | 13,126 | 75.0% | 66.7% | |
| 57.14% | 7 | 5.5 | 888 | 12,316 | 25.0% | 100.0% | |
| 57.14% | 7 | 5.4 | 895 | 12,100 | 50.0% | 66.7% | |
| 42.86% | 7 | 4.0 | 773 | 11,643 | 33.3% | 50.0% | |
| 57.14% | 7 | 2.5 | 1,313 | 15,576 | 25.0% | 100.0% | |
| 33.33% | 6 | 4.6 | 570 | 9,105 | 25.0% | 50.0% | |
| 66.67% | 6 | 5.9 | 1,089 | 15,493 | 50.0% | 75.0% | |
| 50.00% | 6 | 5.7 | 762 | 13,182 | 50.0% | 50.0% | |
| 50.00% | 6 | 1.9 | 891 | 14,832 | 100.0% | 40.0% | |
| 16.67% | 6 | 5.3 | 844 | 10,442 | 0.0% | 33.3% | |
| 0.00% | 6 | 5.9 | 795 | 10,724 | 0.0% | 0.0% | |
| 83.33% | 6 | 6.1 | 963 | 11,361 | 100.0% | 50.0% | |
| 50.00% | 6 | 6.3 | 804 | 13,574 | 100.0% | 40.0% | |
| 40.00% | 5 | 4.7 | 939 | 14,778 | 100.0% | 0.0% | |
| 60.00% | 5 | 1.7 | 1,195 | 17,648 | 0.0% | 75.0% | |
| 20.00% | 5 | 1.5 | 691 | 9,378 | 33.3% | 0.0% | |
| 60.00% | 5 | 5.3 | 1,100 | 15,380 | 100.0% | 50.0% | |
| 20.00% | 5 | 6.8 | 915 | 12,553 | 0.0% | 33.3% | |
| 40.00% | 5 | 6.5 | 1,021 | 17,603 | 0.0% | 40.0% | |
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Vayne vs Cassiopeia - Frequently Asked Questions
How does Vayne do against Cassiopeia in League of Legends?
Cassiopeia wins the Vayne vs Cassiopeia matchup with a 60.0% win rate compared to Vayne's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.7.
How does Vayne do against Cassiopeia in the early game?
In the early game, Vayne has the advantage against Cassiopeia with a 0.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Cassiopeia in the late game?
In the late game, Cassiopeia takes over the Vayne vs Cassiopeia matchup with a 60.0% win rate compared to 40.0%. Cassiopeia scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Cassiopeia matchup?
Cassiopeia wins the matchup against Vayne with a 60.0% win rate in League of Legends patch 26.7. The 20.0 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 5 games analyzed.
What is the best Vayne build against Cassiopeia?
The best Vayne build against Cassiopeia includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Cassiopeia?
The best Vayne runes against Cassiopeia use the Precision primary tree with Sorcery secondary. This rune setup achieves a 100.0% win rate in the Vayne vs Cassiopeia matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Cassiopeia?
No, Vayne struggles against Cassiopeia with only a 40.0% win rate. Cassiopeia has the advantage in this matchup. Vayne players should focus on safe farming and avoiding extended trades to minimize Cassiopeia's lead.
How do I play Vayne against Cassiopeia?
When playing Vayne against Cassiopeia, play cautiously and avoid Cassiopeia's power spikes. Look for jungle assistance and team-dependent plays since Cassiopeia has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.