Cassiopeiavs Vayne
Cassiopeia vs Vayne is a decisive matchup in LoL patch 26.14. Vayne wins with a 77.8% win rate (+55.6%) over Cassiopeia based on 9 games. Vayne holds the advantage in both the early and late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Vayne matchup.
Cassiopeia Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Who Wins the Cassiopeia vs Vayne Matchup?
Cassiopeia vs Vayne Matchup Summary
The Cassiopeia vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Vayne wins with a 77.8% win rate compared to Cassiopeia's 22.2%, giving Vayne a 55.6 percentage point advantage. Vayne dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Cassiopeia players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in crowd control, where Cassiopeia leads by 1.0s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a strong advantage in this matchup. Cassiopeia players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Vayne overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Cassiopeia vs Vayne Laning Phase Breakdown
Cassiopeia is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in farming, damage, crowd control and sustain, making them the stronger laner in this matchup.
Best Cassiopeia Build Against Vayne
The top-performing core items for Cassiopeia against Vayne are Rod of Ages, Zhonya's Hourglass and Rylai's Crystal Scepter. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Vayne. This streamlined build focuses on the essentials for the Cassiopeia vs Vayne matchup, with room for situational adjustments based on team compositions and game state.
Early Game vs Late Game
Cassiopeia0.0%
Vayne100.0%Cassiopeia28.6%Vayne71.4%Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Cassiopeia. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Vayne is far superior in the late game (25+ minutes), boasting a 71.4% win rate — 42.9 points above Cassiopeia. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
Vayne holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Cassiopeia players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.
Best Cassiopeia Runes Against Vayne
Sorcery
Precision
The Sorcery and Precision rune setup gives Cassiopeia the best tools to compete against Vayne in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.
Cassiopeia matchup data for League of Legends patch 26.14. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 43.24% | 37 | 6.6 | 877 | 10,505 | 26.7% | 54.5% | |
| 50.00% | 30 | 5.9 | 865 | 10,458 | 45.5% | 52.6% | |
| 46.67% | 30 | 6.5 | 766 | 10,531 | 42.9% | 50.0% | |
| 48.28% | 29 | 6.5 | 964 | 11,073 | 56.3% | 38.5% | |
| 29.63% | 27 | 6.5 | 842 | 11,427 | 27.3% | 31.3% | |
| 56.52% | 23 | 5.5 | 650 | 10,054 | 40.0% | 69.2% | |
| 54.55% | 22 | 6.3 | 717 | 10,752 | 33.3% | 69.2% | |
| 66.67% | 21 | 6.3 | 793 | 9,592 | 77.8% | 58.3% | |
| 77.78% | 18 | 6.4 | 832 | 12,098 | 87.5% | 70.0% | |
| 41.18% | 17 | 6.2 | 859 | 10,987 | 0.0% | 63.6% | |
| 47.06% | 17 | 6.8 | 916 | 10,673 | 33.3% | 62.5% | |
| 58.82% | 17 | 6.8 | 883 | 11,902 | 50.0% | 66.7% | |
| 58.82% | 17 | 6.5 | 862 | 11,859 | 57.1% | 60.0% | |
| 41.18% | 17 | 6.1 | 696 | 10,424 | 14.3% | 60.0% | |
| 68.75% | 16 | 6.6 | 725 | 12,820 | 100.0% | 61.5% | |
| 25.00% | 16 | 6.6 | 644 | 10,619 | 22.2% | 28.6% | |
| 60.00% | 15 | 6.7 | 864 | 12,061 | 80.0% | 50.0% | |
| 28.57% | 14 | 5.2 | 947 | 11,215 | 20.0% | 33.3% | |
| 64.29% | 14 | 6.3 | 937 | 15,587 | 100.0% | 58.3% | |
| 30.77% | 13 | 7.2 | 660 | 10,238 | 33.3% | 28.6% | |
| 46.15% | 13 | 6.3 | 887 | 11,898 | 60.0% | 37.5% | |
| 38.46% | 13 | 6.0 | 749 | 11,493 | 25.0% | 44.4% | |
| 58.33% | 12 | 6.0 | 791 | 10,354 | 66.7% | 50.0% | |
| 18.18% | 11 | 6.4 | 816 | 13,124 | 0.0% | 20.0% | |
| 36.36% | 11 | 6.5 | 795 | 11,106 | 20.0% | 50.0% | |
| 45.45% | 11 | 6.4 | 698 | 11,236 | 60.0% | 33.3% | |
| 20.00% | 10 | 6.4 | 710 | 10,022 | 20.0% | 20.0% | |
| 77.78% | 9 | 6.1 | 969 | 12,632 | 66.7% | 83.3% | |
| 22.22% | 9 | 6.0 | 954 | 14,954 | 0.0% | 28.6% | |
| 77.78% | 9 | 7.0 | 835 | 8,421 | 85.7% | 50.0% | |
| 44.44% | 9 | 6.5 | 930 | 12,248 | 66.7% | 33.3% | |
| 66.67% | 9 | 6.8 | 1,033 | 12,455 | 66.7% | 66.7% | |
| 77.78% | 9 | 6.0 | 864 | 13,088 | 100.0% | 71.4% | |
| 37.50% | 8 | 6.6 | 965 | 14,894 | 33.3% | 40.0% | |
| 37.50% | 8 | 6.4 | 739 | 11,899 | 50.0% | 33.3% | |
| 57.14% | 7 | 7.4 | 1,131 | 11,888 | 100.0% | 40.0% | |
| 71.43% | 7 | 6.8 | 910 | 11,391 | 75.0% | 66.7% | |
| 42.86% | 7 | 6.7 | 910 | 11,030 | 33.3% | 50.0% | |
| 42.86% | 7 | 5.2 | 618 | 8,805 | 25.0% | 66.7% | |
| 42.86% | 7 | 7.2 | 974 | 13,071 | 0.0% | 75.0% | |
| 85.71% | 7 | 6.4 | 929 | 14,882 | 50.0% | 100.0% | |
| 0.00% | 7 | 5.9 | 643 | 9,853 | 0.0% | 0.0% | |
| 42.86% | 7 | 6.3 | 851 | 10,539 | 0.0% | 75.0% | |
| 85.71% | 7 | 6.8 | 1,021 | 12,042 | 100.0% | 66.7% | |
| 42.86% | 7 | 6.4 | 833 | 11,762 | 33.3% | 50.0% | |
| 57.14% | 7 | 6.3 | 900 | 8,838 | 66.7% | 50.0% | |
| 42.86% | 7 | 7.7 | 735 | 10,618 | 50.0% | 33.3% | |
| 57.14% | 7 | 5.6 | 864 | 9,854 | 100.0% | 0.0% | |
| 42.86% | 7 | 6.2 | 703 | 12,072 | 50.0% | 40.0% | |
| 57.14% | 7 | 6.7 | 776 | 9,868 | 75.0% | 33.3% | |
| 33.33% | 6 | 6.1 | 729 | 9,176 | 0.0% | 50.0% | |
| 16.67% | 6 | 4.8 | 717 | 11,929 | 0.0% | 20.0% | |
| 33.33% | 6 | 6.2 | 648 | 8,582 | 66.7% | 0.0% | |
| 33.33% | 6 | 6.3 | 598 | 8,920 | 25.0% | 50.0% | |
| 50.00% | 6 | 6.6 | 947 | 13,805 | 50.0% | 50.0% | |
| 16.67% | 6 | 6.0 | 712 | 9,879 | 33.3% | 0.0% | |
| 50.00% | 6 | 6.0 | 834 | 12,882 | 0.0% | 75.0% | |
| 33.33% | 6 | 6.4 | 952 | 13,204 | 0.0% | 40.0% | |
| 50.00% | 6 | 7.2 | 1,092 | 9,784 | 25.0% | 100.0% | |
| 20.00% | 5 | 6.0 | 720 | 10,789 | 0.0% | 33.3% | |
| 60.00% | 5 | 7.2 | 1,062 | 12,030 | 50.0% | 66.7% | |
| 40.00% | 5 | 6.5 | 692 | 12,201 | 50.0% | 33.3% | |
| 80.00% | 5 | 8.2 | 930 | 11,461 | 100.0% | 50.0% | |
Help us maintain accuracy! If you notice incorrect stats, missing data, or any issues, your feedback directly improves the quality of our data for the entire community.
Cassiopeia vs Vayne - Frequently Asked Questions
How does Cassiopeia do against Vayne in League of Legends?
Vayne wins the Cassiopeia vs Vayne matchup with a 77.8% win rate compared to Cassiopeia's 22.2%, a 55.6 percentage point difference. This data is based on 9 recent ranked games in patch 26.14.
How does Cassiopeia do against Vayne in the early game?
In the early game, Vayne has the advantage against Cassiopeia with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Cassiopeia do against Vayne in the late game?
In the late game, Vayne takes over the Cassiopeia vs Vayne matchup with a 71.4% win rate compared to 28.6%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Cassiopeia vs Vayne matchup?
Vayne wins the matchup against Cassiopeia with a 77.8% win rate in League of Legends patch 26.14. The 55.6 percentage point advantage means Vayne is significantly favored in this lane matchup based on 9 games analyzed.
What is the best Cassiopeia build against Vayne?
The best Cassiopeia build against Vayne includes Rod of Ages, Zhonya's Hourglass, Rylai's Crystal Scepter. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Cassiopeia runes against Vayne?
The best Cassiopeia runes against Vayne use the Sorcery primary tree with Precision secondary. This rune setup achieves a 50.0% win rate in the Cassiopeia vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Cassiopeia counter Vayne?
No, Cassiopeia struggles against Vayne with only a 22.2% win rate. Vayne has the advantage in this matchup. Cassiopeia players should focus on safe farming and avoiding extended trades to minimize Vayne's lead.
How do I play Cassiopeia against Vayne?
When playing Cassiopeia against Vayne, play cautiously and avoid Vayne's power spikes. Look for jungle assistance and team-dependent plays since Vayne has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.