Cassiopeiavs Vayne
Cassiopeia vs Vayne is a decisive matchup in LoL patch 26.10. Cassiopeia wins with a 55.6% win rate (+11.1%) over Vayne based on 9 games. Cassiopeia wins the early laning phase while Vayne scales better into the late game. Below you'll find the best Cassiopeia build, runes, laning stats, and strategies for the Cassiopeia vs Vayne matchup.
Cassiopeia Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Cassiopeia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Vayne(55.6%)Who Wins the Cassiopeia vs Vayne Matchup?
Cassiopeia vs Vayne Matchup Summary
The Cassiopeia vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 9 recent matches analyzed, Cassiopeia wins with a 55.6% win rate compared to Vayne's 44.4%, giving Cassiopeia a 11.1 percentage point advantage. Game phase dynamics play a critical role here: Cassiopeia controls the early laning stage, but Vayne outscales as the game goes longer. The matchup shifts dramatically depending on game length — Cassiopeia needs to press advantages before Vayne reaches their power spikes, while Vayne should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Cassiopeia leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Cassiopeia players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Cassiopeia vs Vayne Laning Phase Breakdown
Cassiopeia is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Cassiopeia holds advantages in farming, damage, crowd control and sustain, making them the stronger laner in this matchup.
Best Cassiopeia Build Against Vayne
The top-performing core items for Cassiopeia against Vayne are Rod of Ages, Liandry's Torment and Zhonya's Hourglass. This combination gives Cassiopeia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. This streamlined build focuses on the essentials for the Cassiopeia vs Vayne matchup, with room for situational adjustments based on team compositions and game state.
Early Game vs Late Game
Cassiopeia80.0%Vayne20.0%Cassiopeia25.0%Vayne75.0%Cassiopeia dominates the early game (first 15 minutes) with a commanding 80.0% win rate — a 60.0 percentage point lead over Vayne. This lopsided early game means Cassiopeia can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Vayne is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Cassiopeia. Extended games heavily favor Vayne, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Cassiopeia must aggressively press their early advantage and close out the game before Vayne reaches their scaling breakpoints. If Vayne survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Cassiopeia Runes Against Vayne
Precision
Resolve
Running Precision primary with Resolve secondary allows Cassiopeia to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.
Cassiopeia matchup data for League of Legends patch 26.10. The table below shows Cassiopeia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Cassiopeia build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 46.55% | 58 | 6.4 | 823 | 11,864 | 63.6% | 36.1% | |
| 46.81% | 47 | 6.8 | 918 | 11,960 | 44.4% | 48.3% | |
| 51.06% | 47 | 6.5 | 746 | 11,163 | 57.1% | 46.1% | |
| 37.78% | 45 | 6.9 | 869 | 11,133 | 40.9% | 34.8% | |
| 53.49% | 43 | 6.6 | 805 | 10,958 | 56.5% | 50.0% | |
| 51.43% | 35 | 6.8 | 767 | 12,320 | 77.8% | 42.3% | |
| 26.47% | 34 | 6.2 | 767 | 11,334 | 15.4% | 33.3% | |
| 53.13% | 32 | 6.8 | 916 | 11,160 | 38.5% | 63.2% | |
| 70.97% | 31 | 6.8 | 902 | 13,393 | 63.6% | 75.0% | |
| 54.84% | 31 | 6.1 | 768 | 10,217 | 35.7% | 70.6% | |
| 40.00% | 30 | 6.2 | 700 | 11,380 | 44.4% | 38.1% | |
| 50.00% | 30 | 6.0 | 857 | 11,744 | 35.7% | 62.5% | |
| 55.56% | 27 | 6.5 | 776 | 11,552 | 36.4% | 68.8% | |
| 61.54% | 26 | 6.3 | 974 | 11,518 | 45.5% | 73.3% | |
| 61.54% | 26 | 6.2 | 835 | 10,709 | 72.7% | 53.3% | |
| 42.31% | 26 | 6.3 | 851 | 11,684 | 40.0% | 43.8% | |
| 37.50% | 24 | 6.5 | 826 | 11,344 | 25.0% | 43.8% | |
| 54.17% | 24 | 6.6 | 916 | 11,235 | 38.5% | 72.7% | |
| 45.83% | 24 | 6.8 | 698 | 11,753 | 40.0% | 50.0% | |
| 52.17% | 23 | 6.6 | 882 | 12,794 | 72.7% | 33.3% | |
| 43.48% | 23 | 6.6 | 683 | 10,320 | 50.0% | 36.4% | |
| 42.86% | 21 | 6.3 | 837 | 11,139 | 40.0% | 45.5% | |
| 28.57% | 21 | 6.4 | 944 | 12,064 | 10.0% | 45.5% | |
| 57.89% | 19 | 7.1 | 881 | 11,388 | 66.7% | 50.0% | |
| 52.63% | 19 | 7.3 | 801 | 11,762 | 70.0% | 33.3% | |
| 66.67% | 18 | 6.8 | 851 | 11,463 | 66.7% | 66.7% | |
| 50.00% | 18 | 6.7 | 693 | 11,025 | 33.3% | 66.7% | |
| 61.11% | 18 | 6.5 | 1,011 | 13,869 | 80.0% | 53.9% | |
| 68.75% | 16 | 6.8 | 915 | 12,424 | 66.7% | 70.0% | |
| 25.00% | 16 | 6.7 | 975 | 10,887 | 20.0% | 33.3% | |
| 40.00% | 15 | 6.4 | 812 | 12,482 | 40.0% | 40.0% | |
| 46.67% | 15 | 6.6 | 880 | 11,312 | 33.3% | 66.7% | |
| 53.33% | 15 | 7.0 | 758 | 10,331 | 75.0% | 28.6% | |
| 46.67% | 15 | 5.6 | 837 | 9,418 | 57.1% | 37.5% | |
| 60.00% | 15 | 6.7 | 775 | 11,889 | 50.0% | 66.7% | |
| 53.33% | 15 | 6.4 | 959 | 15,252 | 80.0% | 40.0% | |
| 42.86% | 14 | 6.5 | 843 | 14,399 | 60.0% | 33.3% | |
| 42.86% | 14 | 5.6 | 999 | 12,810 | 40.0% | 44.4% | |
| 57.14% | 14 | 6.8 | 745 | 10,704 | 66.7% | 40.0% | |
| 46.15% | 13 | 6.1 | 773 | 11,116 | 75.0% | 33.3% | |
| 46.15% | 13 | 6.2 | 752 | 13,065 | 25.0% | 55.6% | |
| 38.46% | 13 | 6.8 | 886 | 12,280 | 40.0% | 37.5% | |
| 38.46% | 13 | 6.5 | 871 | 12,229 | 25.0% | 44.4% | |
| 46.15% | 13 | 6.3 | 677 | 10,365 | 50.0% | 42.9% | |
| 33.33% | 12 | 6.5 | 846 | 11,525 | 40.0% | 28.6% | |
| 75.00% | 12 | 6.0 | 953 | 12,125 | 66.7% | 77.8% | |
| 33.33% | 12 | 7.1 | 886 | 13,281 | 33.3% | 33.3% | |
| 40.00% | 10 | 6.7 | 748 | 10,251 | 50.0% | 33.3% | |
| 70.00% | 10 | 6.2 | 760 | 13,234 | 66.7% | 71.4% | |
| 40.00% | 10 | 6.6 | 951 | 12,296 | 25.0% | 50.0% | |
| 30.00% | 10 | 5.0 | 771 | 9,954 | 20.0% | 40.0% | |
| 60.00% | 10 | 6.8 | 596 | 10,762 | 60.0% | 60.0% | |
| 33.33% | 9 | 6.6 | 664 | 9,943 | 40.0% | 25.0% | |
| 55.56% | 9 | 5.8 | 940 | 9,891 | 80.0% | 25.0% | |
| 55.56% | 9 | 6.2 | 643 | 12,386 | 75.0% | 40.0% | |
| 37.50% | 8 | 6.5 | 937 | 11,123 | 50.0% | 25.0% | |
| 75.00% | 8 | 6.8 | 692 | 12,901 | 66.7% | 80.0% | |
| 50.00% | 8 | 7.6 | 936 | 13,631 | 50.0% | 50.0% | |
| 62.50% | 8 | 5.0 | 738 | 12,673 | 100.0% | 57.1% | |
| 42.86% | 7 | 6.2 | 813 | 10,953 | 33.3% | 50.0% | |
| 42.86% | 7 | 6.7 | 950 | 9,396 | 50.0% | 33.3% | |
| 28.57% | 7 | 6.0 | 919 | 14,773 | 100.0% | 16.7% | |
| 42.86% | 7 | 6.5 | 844 | 13,416 | 100.0% | 33.3% | |
| 57.14% | 7 | 7.3 | 887 | 12,390 | 66.7% | 50.0% | |
| 57.14% | 7 | 6.7 | 837 | 13,612 | 66.7% | 50.0% | |
| 57.14% | 7 | 6.7 | 835 | 9,916 | 60.0% | 50.0% | |
| 42.86% | 7 | 4.7 | 751 | 11,302 | 0.0% | 50.0% | |
| 42.86% | 7 | 7.0 | 979 | 12,947 | 50.0% | 33.3% | |
| 50.00% | 6 | 8.5 | 729 | 11,198 | 75.0% | 0.0% | |
| 66.67% | 6 | 6.6 | 857 | 11,941 | 100.0% | 33.3% | |
| 50.00% | 6 | 5.4 | 1,106 | 10,452 | 66.7% | 33.3% | |
| 33.33% | 6 | 5.1 | 940 | 12,713 | 50.0% | 25.0% | |
| 50.00% | 6 | 6.4 | 683 | 10,567 | 50.0% | 50.0% | |
| 50.00% | 6 | 7.5 | 856 | 10,704 | 66.7% | 33.3% | |
| 50.00% | 6 | 6.0 | 1,003 | 11,645 | 66.7% | 33.3% | |
| 50.00% | 6 | 6.6 | 782 | 11,734 | 0.0% | 60.0% | |
| 50.00% | 6 | 6.8 | 800 | 10,458 | 50.0% | 50.0% | |
| 50.00% | 6 | 6.4 | 900 | 11,371 | 66.7% | 33.3% | |
| 80.00% | 5 | 5.9 | 1,142 | 10,330 | 100.0% | 75.0% | |
| 80.00% | 5 | 5.8 | 1,064 | 12,017 | 100.0% | 75.0% | |
| 20.00% | 5 | 5.8 | 686 | 8,918 | 25.0% | 0.0% | |
| 80.00% | 5 | 6.5 | 688 | 11,435 | 100.0% | 0.0% | |
| 40.00% | 5 | 7.1 | 937 | 13,629 | 33.3% | 50.0% | |
| 60.00% | 5 | 6.6 | 952 | 14,593 | 100.0% | 50.0% | |
| 60.00% | 5 | 6.2 | 629 | 10,932 | 0.0% | 100.0% | |
| 40.00% | 5 | 6.3 | 1,099 | 9,667 | 50.0% | 33.3% | |
| 20.00% | 5 | 3.5 | 543 | 6,595 | 25.0% | 0.0% | |
| 60.00% | 5 | 7.8 | 1,183 | 13,861 | 66.7% | 50.0% | |
| 60.00% | 5 | 7.7 | 977 | 11,450 | 100.0% | 33.3% | |
| 40.00% | 5 | 6.7 | 703 | 13,789 | 0.0% | 50.0% | |
| 40.00% | 5 | 6.7 | 827 | 11,932 | 50.0% | 33.3% | |
| 60.00% | 5 | 5.9 | 869 | 12,342 | 100.0% | 50.0% | |
| 60.00% | 5 | 7.4 | 798 | 12,165 | 50.0% | 66.7% | |
| 100.00% | 5 | 7.2 | 946 | 13,607 | 100.0% | 100.0% | |
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Cassiopeia vs Vayne - Frequently Asked Questions
How does Cassiopeia do against Vayne in League of Legends?
Cassiopeia wins the Cassiopeia vs Vayne matchup with a 55.6% win rate compared to Vayne's 44.4%, a 11.1 percentage point difference. This data is based on 9 recent ranked games in patch 26.10.
How does Cassiopeia do against Vayne in the early game?
In the early game, Cassiopeia has the advantage against Vayne with a 80.0% win rate versus 20.0%. Cassiopeia players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Cassiopeia do against Vayne in the late game?
In the late game, Vayne takes over the Cassiopeia vs Vayne matchup with a 75.0% win rate compared to 25.0%. Vayne scales better into team fights and objective contests after 25 minutes.
Who wins the Cassiopeia vs Vayne matchup?
Cassiopeia wins the matchup against Vayne with a 55.6% win rate in League of Legends patch 26.10. The 11.1 percentage point advantage means Cassiopeia is significantly favored in this lane matchup based on 9 games analyzed.
What is the best Cassiopeia build against Vayne?
The best Cassiopeia build against Vayne includes Rod of Ages, Liandry's Torment, Zhonya's Hourglass. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.
What are the best Cassiopeia runes against Vayne?
The best Cassiopeia runes against Vayne use the Precision primary tree with Resolve secondary. This rune setup achieves a 100.0% win rate in the Cassiopeia vs Vayne matchup. See the full rune breakdown in the matchup comparison above.
Does Cassiopeia counter Vayne?
Yes, Cassiopeia has a favorable matchup against Vayne with a 55.6% win rate. Cassiopeia strongly counters Vayne in lane based on current patch 26.10 data.
How do I play Cassiopeia against Vayne?
When playing Cassiopeia against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.