Vaynevs Senna
Vayne vs Senna is a moderate matchup in LoL patch 26.4. Vayne wins with a 51.1% win rate (+2.2%) over Senna based on 92 games. Vayne wins the early laning phase while Senna scales better into the late game. Below you'll find the best Vayne build, runes, laning stats, and strategies for the Vayne vs Senna matchup.
Vayne Matchup Breakdown
Use the dropdown to select an opponent and see a detailed breakdown of how Vayne performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.
Senna(51.1%)Who Wins the Vayne vs Senna Matchup?
Vayne vs Senna Matchup Summary
The Vayne vs Senna matchup is a very close matchup in League of Legends ranked play. Based on 92 recent matches analyzed, Vayne wins with a 51.1% win rate compared to Senna's 48.9%, giving Vayne a 2.2 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Senna outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Senna reaches their power spikes, while Senna should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Senna leads by 0.8s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Vayne has a statistical edge, but the margin is close enough that respecting Senna's strengths is important. Trade when cooldowns are favorable, track the enemy jungler, and build toward your strongest item spikes to convert the slight advantage into a decisive lead. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.
Vayne vs Senna Laning Phase Breakdown
Senna is favored during the laning phase against Vayne, winning 5 out of 5 key stat categories. Senna holds advantages in farming, damage, gold income, crowd control and sustain, making them the stronger laner in this matchup.
Early Game vs Late Game
Vayne56.1%Senna43.9%Vayne47.1%Senna52.9%Vayne dominates the early game (first 15 minutes) with a commanding 56.1% win rate — a 12.2 percentage point lead over Senna. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.
Senna is far superior in the late game (25+ minutes), boasting a 52.9% win rate — 5.9 points above Vayne. Extended games heavily favor Senna, whose kit and scaling make them a dominant force in team fights and objective control.
This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Senna reaches their scaling breakpoints. If Senna survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.
Best Vayne Runes Against Senna
Precision
Resolve
The Precision primary with Resolve secondary combination helps Vayne maximize their potential in this closely contested matchup, providing the right mix of offensive and defensive tools to edge out Senna.
Vayne matchup data for League of Legends patch 26.4. The table below shows Vayne's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Vayne build, runes, laning stats, and early vs late game analysis for that specific matchup.
Opponent | Win Rate | Matches | CS/min | DMG/min | Gold/game | Early WR | Late WR |
|---|---|---|---|---|---|---|---|
| 50.82% | 732 | 6.1 | 803 | 13,258 | 51.6% | 50.3% | |
| 50.47% | 643 | 5.9 | 819 | 13,610 | 51.8% | 49.5% | |
| 50.16% | 626 | 6.3 | 860 | 13,314 | 48.9% | 51.4% | |
| 53.35% | 529 | 6.1 | 868 | 13,348 | 52.2% | 54.2% | |
| 49.25% | 475 | 6.5 | 904 | 13,936 | 44.6% | 53.5% | |
| 56.36% | 402 | 6.4 | 918 | 13,991 | 52.9% | 59.4% | |
| 46.70% | 395 | 6.0 | 802 | 13,251 | 41.1% | 51.1% | |
| 52.87% | 354 | 6.4 | 922 | 14,147 | 51.2% | 53.9% | |
| 48.04% | 282 | 6.0 | 843 | 13,505 | 56.5% | 42.2% | |
| 51.29% | 271 | 6.5 | 870 | 13,472 | 53.7% | 49.3% | |
| 52.54% | 239 | 6.2 | 888 | 13,139 | 52.5% | 52.6% | |
| 54.25% | 212 | 6.5 | 917 | 14,465 | 58.5% | 51.5% | |
| 51.26% | 200 | 6.2 | 837 | 13,336 | 57.7% | 44.2% | |
| 55.00% | 200 | 6.1 | 821 | 13,161 | 49.5% | 60.0% | |
| 47.40% | 192 | 6.3 | 891 | 13,424 | 49.0% | 45.8% | |
| 55.56% | 181 | 6.0 | 858 | 13,653 | 58.1% | 53.8% | |
| 49.11% | 170 | 6.2 | 873 | 13,702 | 46.5% | 51.0% | |
| 49.63% | 135 | 5.9 | 854 | 14,043 | 46.3% | 51.9% | |
| 55.65% | 115 | 6.1 | 902 | 13,632 | 58.8% | 53.1% | |
| 53.15% | 111 | 6.0 | 842 | 11,670 | 52.9% | 53.3% | |
| 57.41% | 109 | 6.5 | 908 | 12,767 | 54.2% | 60.0% | |
| 50.00% | 106 | 6.2 | 838 | 13,925 | 48.7% | 50.8% | |
| 60.20% | 99 | 6.1 | 994 | 12,481 | 61.9% | 58.9% | |
| 54.74% | 96 | 5.8 | 1,031 | 14,056 | 43.6% | 62.5% | |
| 51.09% | 92 | 6.1 | 914 | 13,612 | 56.1% | 47.1% | |
| 45.65% | 92 | 6.3 | 845 | 13,980 | 43.6% | 47.2% | |
| 51.65% | 91 | 6.4 | 893 | 14,004 | 47.4% | 54.7% | |
| 50.59% | 87 | 6.3 | 949 | 12,103 | 52.9% | 49.0% | |
| 45.88% | 86 | 6.1 | 859 | 13,540 | 56.8% | 37.5% | |
| 45.12% | 83 | 5.7 | 603 | 11,339 | 33.3% | 54.4% | |
| 46.15% | 78 | 6.0 | 897 | 11,415 | 28.9% | 62.5% | |
| 44.16% | 77 | 6.3 | 1,391 | 12,481 | 36.7% | 48.9% | |
| 39.47% | 77 | 6.2 | 885 | 14,180 | 28.0% | 45.1% | |
| 53.73% | 68 | 5.5 | 640 | 11,628 | 26.1% | 68.2% | |
| 45.45% | 66 | 6.6 | 969 | 14,142 | 46.9% | 44.1% | |
| 49.23% | 66 | 6.3 | 1,021 | 12,932 | 52.0% | 47.5% | |
| 53.13% | 64 | 6.0 | 1,005 | 11,451 | 51.5% | 54.8% | |
| 45.31% | 64 | 6.2 | 858 | 13,545 | 44.4% | 46.0% | |
| 50.00% | 64 | 6.3 | 987 | 12,060 | 41.4% | 57.1% | |
| 59.32% | 59 | 6.1 | 997 | 11,684 | 57.1% | 61.3% | |
| 50.00% | 56 | 6.5 | 919 | 13,452 | 55.6% | 44.8% | |
| 50.00% | 54 | 6.4 | 949 | 12,100 | 40.0% | 55.9% | |
| 57.14% | 49 | 6.3 | 843 | 12,077 | 54.2% | 60.0% | |
| 53.06% | 49 | 6.4 | 945 | 12,154 | 60.9% | 46.1% | |
| 47.92% | 48 | 6.3 | 804 | 12,125 | 34.8% | 60.0% | |
| 46.81% | 48 | 6.5 | 970 | 12,453 | 47.6% | 46.1% | |
| 51.06% | 47 | 6.5 | 926 | 11,295 | 46.1% | 57.1% | |
| 51.11% | 45 | 7.2 | 998 | 13,306 | 47.6% | 54.2% | |
| 32.56% | 43 | 5.8 | 700 | 9,815 | 20.7% | 57.1% | |
| 69.77% | 43 | 6.8 | 903 | 15,255 | 71.4% | 69.0% | |
| 51.16% | 43 | 6.1 | 986 | 11,825 | 45.8% | 57.9% | |
| 52.38% | 42 | 6.6 | 877 | 12,788 | 47.6% | 57.1% | |
| 55.00% | 40 | 6.0 | 970 | 11,813 | 55.6% | 54.5% | |
| 55.00% | 40 | 5.8 | 914 | 14,584 | 47.4% | 61.9% | |
| 58.97% | 39 | 6.0 | 810 | 12,831 | 46.7% | 66.7% | |
| 48.65% | 38 | 6.0 | 840 | 11,264 | 47.6% | 50.0% | |
| 43.24% | 37 | 5.7 | 825 | 11,627 | 40.0% | 47.1% | |
| 45.71% | 35 | 6.0 | 946 | 12,638 | 27.3% | 54.2% | |
| 33.33% | 33 | 6.5 | 888 | 13,389 | 20.0% | 39.1% | |
| 48.48% | 33 | 6.0 | 728 | 13,059 | 40.0% | 55.6% | |
| 48.39% | 32 | 6.2 | 927 | 13,031 | 46.1% | 50.0% | |
| 54.84% | 31 | 6.1 | 823 | 11,632 | 50.0% | 58.8% | |
| 46.67% | 30 | 6.0 | 768 | 12,083 | 46.1% | 47.1% | |
| 63.33% | 30 | 6.4 | 886 | 12,702 | 72.7% | 57.9% | |
| 44.44% | 27 | 5.4 | 952 | 12,114 | 58.3% | 33.3% | |
| 50.00% | 26 | 6.5 | 889 | 11,516 | 46.1% | 53.9% | |
| 61.54% | 26 | 6.8 | 1,087 | 14,277 | 62.5% | 61.1% | |
| 46.15% | 26 | 5.2 | 849 | 13,311 | 70.0% | 31.3% | |
| 50.00% | 26 | 6.5 | 792 | 12,810 | 66.7% | 35.7% | |
| 46.15% | 26 | 6.6 | 1,144 | 12,906 | 46.7% | 45.5% | |
| 50.00% | 26 | 6.8 | 1,090 | 14,263 | 66.7% | 41.2% | |
| 50.00% | 24 | 6.1 | 885 | 12,729 | 54.5% | 46.1% | |
| 40.91% | 23 | 6.5 | 876 | 14,599 | 40.0% | 41.7% | |
| 60.87% | 23 | 6.3 | 909 | 14,131 | 63.6% | 58.3% | |
| 52.38% | 22 | 5.5 | 860 | 13,670 | 55.6% | 50.0% | |
| 42.86% | 21 | 6.5 | 845 | 11,534 | 33.3% | 55.6% | |
| 50.00% | 20 | 6.0 | 738 | 10,241 | 54.5% | 44.4% | |
| 63.16% | 19 | 6.3 | 1,061 | 15,663 | 100.0% | 53.3% | |
| 52.63% | 19 | 5.9 | 839 | 12,951 | 42.9% | 58.3% | |
| 52.94% | 17 | 6.0 | 1,020 | 12,523 | 40.0% | 71.4% | |
| 43.75% | 16 | 5.7 | 624 | 10,933 | 25.0% | 62.5% | |
| 62.50% | 16 | 6.8 | 817 | 11,303 | 63.6% | 60.0% | |
| 26.67% | 15 | 6.5 | 666 | 9,617 | 22.2% | 33.3% | |
| 40.00% | 15 | 4.0 | 897 | 12,231 | 57.1% | 25.0% | |
| 35.71% | 14 | 6.4 | 637 | 11,280 | 33.3% | 40.0% | |
| 42.86% | 14 | 6.9 | 846 | 11,763 | 28.6% | 57.1% | |
| 42.86% | 14 | 6.3 | 925 | 11,744 | 42.9% | 42.9% | |
| 38.46% | 13 | 4.7 | 827 | 13,522 | 16.7% | 57.1% | |
| 46.15% | 13 | 5.8 | 961 | 12,416 | 20.0% | 62.5% | |
| 46.15% | 13 | 5.9 | 982 | 14,623 | 42.9% | 50.0% | |
| 50.00% | 12 | 5.7 | 897 | 15,265 | 33.3% | 55.6% | |
| 41.67% | 12 | 6.7 | 976 | 15,743 | 40.0% | 42.9% | |
| 58.33% | 12 | 4.5 | 832 | 12,199 | 50.0% | 62.5% | |
| 58.33% | 12 | 5.9 | 781 | 11,830 | 20.0% | 85.7% | |
| 41.67% | 12 | 4.4 | 763 | 11,164 | 50.0% | 25.0% | |
| 54.55% | 11 | 2.9 | 1,055 | 15,239 | 50.0% | 57.1% | |
| 36.36% | 11 | 6.6 | 750 | 13,007 | 0.0% | 44.4% | |
| 45.45% | 11 | 4.2 | 807 | 12,513 | 50.0% | 40.0% | |
| 36.36% | 11 | 6.3 | 904 | 12,259 | 50.0% | 28.6% | |
| 22.22% | 10 | 4.2 | 658 | 9,348 | 14.3% | 50.0% | |
| 50.00% | 10 | 5.9 | 1,132 | 12,118 | 60.0% | 40.0% | |
| 40.00% | 10 | 4.8 | 773 | 12,409 | 33.3% | 50.0% | |
| 33.33% | 9 | 3.4 | 732 | 12,844 | 0.0% | 42.9% | |
| 44.44% | 9 | 4.4 | 695 | 12,824 | 50.0% | 40.0% | |
| 62.50% | 8 | 6.0 | 660 | 12,870 | 100.0% | 50.0% | |
| 25.00% | 8 | 4.2 | 758 | 11,745 | 0.0% | 66.7% | |
| 62.50% | 8 | 5.8 | 899 | 13,469 | 0.0% | 100.0% | |
| 14.29% | 7 | 6.0 | 1,054 | 15,482 | 0.0% | 16.7% | |
| 71.43% | 7 | 6.6 | 849 | 15,132 | 50.0% | 80.0% | |
| 71.43% | 7 | 4.4 | 834 | 12,500 | 100.0% | 50.0% | |
| 66.67% | 6 | 6.7 | 787 | 13,857 | 50.0% | 75.0% | |
| 33.33% | 6 | 6.9 | 753 | 11,851 | 100.0% | 0.0% | |
| 50.00% | 6 | 5.1 | 957 | 12,106 | 0.0% | 60.0% | |
| 50.00% | 6 | 6.5 | 898 | 10,842 | 75.0% | 0.0% | |
| 33.33% | 6 | 1.2 | 808 | 11,065 | 0.0% | 100.0% | |
| 50.00% | 6 | 4.0 | 775 | 15,502 | 100.0% | 40.0% | |
| 60.00% | 5 | 6.3 | 1,180 | 19,865 | 0.0% | 60.0% | |
| 25.00% | 5 | 2.4 | 567 | 11,133 | 50.0% | 0.0% | |
| 40.00% | 5 | 6.3 | 855 | 11,531 | 0.0% | 66.7% | |
| 60.00% | 5 | 6.4 | 1,099 | 15,068 | 100.0% | 33.3% | |
| 40.00% | 5 | 5.1 | 877 | 11,537 | 0.0% | 100.0% | |
| 40.00% | 5 | 3.1 | 1,070 | 12,851 | 50.0% | 0.0% | |
| 40.00% | 5 | 2.7 | 706 | 14,287 | 0.0% | 50.0% | |
| 0.00% | 5 | 6.0 | 781 | 12,150 | 0.0% | 0.0% | |
| 60.00% | 5 | 6.9 | 1,192 | 13,262 | 0.0% | 100.0% | |
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Vayne vs Senna - Frequently Asked Questions
How does Vayne do against Senna in League of Legends?
Vayne wins the Vayne vs Senna matchup with a 51.1% win rate compared to Senna's 48.9%, a 2.2 percentage point difference. This data is based on 92 recent ranked games in patch 26.4.
How does Vayne do against Senna in the early game?
In the early game, Vayne has the advantage against Senna with a 56.1% win rate versus 43.9%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.
How does Vayne do against Senna in the late game?
In the late game, Senna takes over the Vayne vs Senna matchup with a 52.9% win rate compared to 47.1%. Senna scales better into team fights and objective contests after 25 minutes.
Who wins the Vayne vs Senna matchup?
Vayne wins the matchup against Senna with a 51.1% win rate in League of Legends patch 26.4. The 2.2 percentage point advantage means Vayne is moderately favored in this lane matchup based on 92 games analyzed.
What is the best Vayne build against Senna?
The best Vayne build against Senna includes optimized core items. Check the matchup breakdown above for the full item path and build order.
What are the best Vayne runes against Senna?
The best Vayne runes against Senna use the Precision primary tree with Resolve secondary. This rune setup achieves a 62.5% win rate in the Vayne vs Senna matchup. See the full rune breakdown in the matchup comparison above.
Does Vayne counter Senna?
Yes, Vayne has a favorable matchup against Senna with a 51.1% win rate. Vayne has a solid advantage over Senna in lane based on current patch 26.4 data.
How do I play Vayne against Senna?
When playing Vayne against Senna, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.