Genesis•Power

Is Genesis good in Slay the Spire 2?

Genesis is a rare Regent power in Slay the Spire 2. In combat it resolves as: At the start of your turn, gain Stars. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 9 recorded runs, decks running it win 22.2% of the time, comfortably clear of the 12.6% average, by 9.6%. It’s a more selective pick, turning up in just 1.7% of decks that could run it. Regent players keep it in 5.4% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Spectrum Shift — together they post a +44.5% swing in win rate. It also has strong chemistry with the relic Lantern, which moves its win rate by +11.1%. At 2 energy, it’s upgraded in 44.4% of runs and usually joins the deck around floor 10.

That’s 2 wins, 7 deaths, and 0 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Byrdonis Elite, which closes out 22.2% of its appearances. Read on for Genesis’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Genesis

Ranked by win-rate lift, Genesis performs best alongside Spectrum Shift (+44.5%), Quasar (+44.5%), and Crescent Spear (+27.8%).

Spectrum Shift+44.5%3 runsQuasar+44.5%3 runsCrescent Spear+27.8%4 runsGamma Blast+27.8%4 runsDevastate+27.8%4 runsReflect+27.8%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Win Rate by Class

Genesis is drafted only by the Regent, where it holds a 22.2% win rate across 9 runs.

The Regentappears in 5.4% of its runs (9 tracked)

Best Relics for Genesis

Genesis pairs best with the relics Lantern (+11.1%), Prayer Wheel (+11.1%), and Divine Right (0.0%), ranked by win-rate lift.

Lantern+11.1%3 runsPrayer Wheel+11.1%3 runsDivine Right0.0%9 runsHefty Tablet-22.2%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Card Details

Genesis is a rare power costing 2 energy; it’s upgraded in 44.4% of runs and usually picked up by floor 10.

At the start of your turn, gain Stars.

What Ends Runs with Genesis

Genesis’s most common run-enders are Byrdonis Elite (22.2%).

• Byrdonis Elite22.2% of runs

See Also

Compare Genesis with the rest of the best Slay the Spire 2 cards, relics, and classes below.