Genesis•Power

Is Genesis good in Slay the Spire 2?

Genesis is a rare Regent power in Slay the Spire 2. In combat it resolves as: At the start of your turn, gain Stars. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 172 recorded runs, decks running it win 29.2% of the time, comfortably clear of the 14.1% average, by 15.2%. It’s a more selective pick, turning up in just 1.6% of decks that could run it. Taken in 48.6% of its offers, it still trails on the pick-versus-skip split: 32.4% for runs that took it against 40.2% for runs that left it, a -7.3% pick lift over 145 decided runs. Regent players keep it in 9.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Dying Star — together they post a +20.6% swing in win rate. It also has strong chemistry with the relic Kusarigama, which moves its win rate by +25.4%. At 2 energy, it’s upgraded in 37.2% of runs and usually joins the deck around floor 16.

That’s 50 wins, 121 deaths, and 1 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Kaiser Crab Boss, which closes out 5.2% of its appearances. Read on for Genesis’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Pick or Skip: Genesis

Out of 315 recorded offers Genesis is taken 48.6% of the time, and taking it is worth -7.3% in pick lift — 32.4% for runs that picked it against 40.2% for runs that skipped, across 145 decided runs.

Taken 153 times out of 315 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Genesis

Genesis is strongest when it joins the deck in Act 2, where runs win 47.8% across 46 runs — one of 2 recorded pickup windows.

Win rate of runs by the act Genesis entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Genesis

Ranked by win-rate lift, Genesis performs best alongside Dying Star (+20.6%), Manifest Authority (+20.5%), and Void Form (+18.9%).

Dying Star+20.6%30 runsManifest Authority+20.5%24 runsVoid Form+18.9%21 runsGUARDS!!!+18.5%15 runsBEGONE!+17.4%22 runsThe Smith+17.2%20 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Win Rate by Class

Genesis is drafted only by the Regent, where it holds a 29.6% win rate across 170 runs.

The Regentappears in 9.2% of its runs (170 tracked)

Best Relics for Genesis

Genesis pairs best with the relics Kusarigama (+25.4%), War Paint (+24.4%), and Pendulum (+21.8%), ranked by win-rate lift.

Kusarigama+25.4%21 runsWar Paint+24.4%29 runsPendulum+21.8%33 runsLantern+20.6%28 runsFencing Manual+20.5%22 runsPantograph+20.5%18 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Card Details

Genesis is a rare power costing 2 energy; it’s upgraded in 37.2% of runs and usually picked up by floor 16.

At the start of your turn, gain Stars.

What Ends Runs with Genesis

Genesis’s most common run-enders are Kaiser Crab Boss (5.2%), Knowledge Demon Boss (4.7%), and Decimillipede Elite (4.1%).

• Kaiser Crab Boss5.2% of runs
• Knowledge Demon Boss4.7% of runs
• Decimillipede Elite4.1% of runs
• Entomancer Elite4.1% of runs
• Infested Prisms Elite4.1% of runs

See Also

Compare Genesis with the rest of the best Slay the Spire 2 cards, relics, and classes below.