Genesis•Power

Is Genesis good in Slay the Spire 2?

Genesis is a rare Regent power in Slay the Spire 2. In combat it resolves as: At the start of your turn, gain Stars. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 67 recorded runs, decks running it win 31.0% of the time, comfortably clear of the 19.0% average, by 12.1%. It’s a more selective pick, turning up in just 1.8% of decks that could run it. Regent players keep it in 9.8% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to CHARGE!! — together they post a +22.5% swing in win rate. It also has strong chemistry with the relic Lucky Fysh, which moves its win rate by +19.6%. At 2 energy, it’s upgraded in 34.7% of runs and usually joins the deck around floor 16.

That’s 18 wins, 40 deaths, and 9 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Infested Prisms Elite, which closes out 6.0% of its appearances. Read on for Genesis’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Genesis

Ranked by win-rate lift, Genesis performs best alongside CHARGE!! (+22.5%), Child of the Stars (+21.2%), and Bombardment (+19.5%).

CHARGE!!+22.5%12 runsChild of the Stars+21.2%18 runsBombardment+19.5%8 runsRoyal Gamble+17.1%13 runsSupermassive+16.3%5 runsQuasar+14.0%9 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Win Rate by Class

Genesis is drafted only by the Regent, where it holds a 31.0% win rate across 67 runs.

The Regentappears in 9.8% of its runs (67 tracked)

Best Relics for Genesis

Genesis pairs best with the relics Lucky Fysh (+19.6%), Horn Cleat (+19.5%), and Fencing Manual (+19.5%), ranked by win-rate lift.

Lucky Fysh+19.6%7 runsHorn Cleat+19.5%8 runsFencing Manual+19.5%8 runsGorget+16.9%11 runsPendulum+16.6%7 runsThe Chosen Cheese+16.3%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Genesis Card Details

Genesis is a rare power costing 2 energy; it’s upgraded in 34.7% of runs and usually picked up by floor 16.

At the start of your turn, gain Stars.

What Ends Runs with Genesis

Genesis’s most common run-enders are Infested Prisms Elite (6.0%), Decimillipede Elite (4.5%), and Soul Nexus Elite (4.5%).

• Infested Prisms Elite6.0% of runs
• Decimillipede Elite4.5% of runs
• Soul Nexus Elite4.5% of runs
• Louse Progenitor Normal3.0% of runs
• Entomancer Elite3.0% of runs

See Also

Compare Genesis with the rest of the best Slay the Spire 2 cards, relics, and classes below.