Vexing Puzzlebox Relic

Is Vexing Puzzlebox good in Slay the Spire 2?

In Slay the Spire 2, Vexing Puzzlebox is a rare relic you can pick up on your climb. Its effect: At the start of each combat, add a random card into your Hand. It's free to play this turn. The data marks it as a weaker relic, settling at D tier — rarely a run-defining grab.

Over 596 tracked runs the win rate of decks holding it sits at 38.7%, 24.4% ahead of the 14.3% all-run baseline. It sees lighter play, carried in only 2.2% of runs. It does its best work in the hands of the Necrobinder, who post a 43.7% win rate with it. Within Necrobinder runs specifically, it’s carried 2.3% of the time.

Its standout card pairing is Oblivion, which lifts the relic’s win rate by +40.3% when both are in play. It also works nicely with Genesis, good for a +37.8% win-rate change. It typically enters the deck near floor 22. As a rare relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 227 ended in victory while 360 fell to a defeat. Its most common run-ender is Test Subject Boss, finishing 7.4% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Vexing Puzzlebox is worth grabbing.

Pick or Skip: Vexing Puzzlebox

Players take Vexing Puzzlebox in 62.9% of the 953 offers it appears in; those runs win 39.1% against 35.6% for runs that passed, a pick lift of +3.5% over 590 decided runs.

Taken 599 times out of 953 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Vexing Puzzlebox

The cards that gain the most from carrying Vexing Puzzlebox are Oblivion (+40.3%), Genesis (+37.8%), and Dying Star (+36.3%), each shown with its win-rate swing.

Oblivion+40.3%19 runsGenesis+37.8%17 runsDying Star+36.3%16 runsStardust+36.3%16 runsNeurosurge+36.3%16 runsFinesse+34.7%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Vexing Puzzlebox Win Rate by Class

Of the 5 classes that carry Vexing Puzzlebox, it performs best with Necrobinder (43.7%), Regent (41.4%), and Silent (41.3%).

The Necrobinder43.7%104 runsThe Regent41.4%101 runsThe Silent41.3%128 runsThe Ironclad40.3%137 runsThe Defect27.6%124 runs

Vexing Puzzlebox Details

Carried in 2.2% of runs, Vexing Puzzlebox is a rare relic typically acquired near floor 22.

At the start of each combat, add a random card into your Hand. It's free to play this turn.

What Ends Runs with Vexing Puzzlebox

Runs carrying Vexing Puzzlebox end most often against Test Subject Boss (7.4%), Aeonglass Boss (6.7%), and Knowledge Demon Boss (6.2%) — the share of its runs each accounts for is shown.

• Test Subject Boss7.4% of runs
• Aeonglass Boss6.7% of runs
• Knowledge Demon Boss6.2% of runs
• Queen Boss5.0% of runs
• The Insatiable Boss3.7% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.