Vexing Puzzlebox
Win Rate
45.5%
Pick Rate
2.1%
Δ vs Avg
+32.8

Vexing PuzzleboxRelic

Rare
RarityRare
MethodologyData Methodology

At the start of each combat, add a random card into your Hand. It's free to play this turn.

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Is Vexing Puzzlebox good in Slay the Spire 2?

In Slay the Spire 2, Vexing Puzzlebox is a rare relic you can pick up on your climb. Its effect: At the start of each combat, add a random card into your Hand. It's free to play this turn. Right now it’s a high-value grab, sitting at B tier — one of the relics most worth taking.

Over 11 tracked runs the win rate of decks holding it sits at 45.5%, 32.8% ahead of the 12.6% all-run baseline. It sees lighter play, carried in only 2.1% of runs. It does its best work in the hands of the Necrobinder, who post a 100.0% win rate with it. Within Necrobinder runs specifically, it’s carried 1.2% of the time.

Its standout card pairing is Defend, which lifts the relic’s win rate by +21.2% when both are in play. It also works nicely with Prepared, good for a +21.2% win-rate change. It typically enters the deck near floor 24. As a rare relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 5 ended in victory while 6 fell to a defeat. See the best cards, class split, and threats below for the full read on whether Vexing Puzzlebox is worth grabbing.

Vexing Puzzlebox Win Rate & Pick Rate

At a 45.5% win rate, Vexing Puzzlebox runs 32.8% ahead of the 12.6% all-run baseline — the bars below put the two side by side.

Win rate45.5%
Average run12.6%
+32.8% vs averagePick rate: 2.1%11 runs

Run Outcomes with Vexing Puzzlebox

Across the 11 runs that carried Vexing Puzzlebox, 5 ended in a win and 6 in a loss — a 45.5% win share, counting abandons as losses.

  • Wins 45.5%
  • Losses 54.5%

Best Cards with Vexing Puzzlebox

The cards that gain the most from carrying Vexing Puzzlebox are Defend (+21.2%), Prepared (+21.2%), and Survivor (+21.2%), each shown with its win-rate swing.

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Vexing Puzzlebox Win Rate by Class

Of the 4 classes that carry Vexing Puzzlebox, it performs best with Necrobinder (100.0%), Silent (66.7%), and Regent (25.0%).

Vexing Puzzlebox Details

Carried in 2.1% of runs, Vexing Puzzlebox is a rare relic typically acquired near floor 24.

At the start of each combat, add a random card into your Hand. It's free to play this turn.

RarityRare
Typical pickup floor24
Pick rate2.1%
Runs tracked11

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Vexing Puzzlebox – Frequently Asked Questions

Is Vexing Puzzlebox good in Slay the Spire 2?

Across 11 tracked runs carrying it, Vexing Puzzlebox wins 45.5% of the time — +32.8% above the average run. Win rate reflects how often runs with the relic end in victory.

What does Vexing Puzzlebox do in Slay the Spire 2?

At the start of each combat, add a random card into your Hand. It's free to play this turn.

How rare is Vexing Puzzlebox in Slay the Spire 2?

Vexing Puzzlebox is a Rare relic, picked up in 2.1% of tracked runs.

What is the best card to use with Vexing Puzzlebox?

In tracked runs, Vexing Puzzlebox has performed best alongside Defend, which lifts its win rate by +21.2% over 3 runs together.

Which class is Vexing Puzzlebox best in?

Vexing Puzzlebox has its highest win rate with The Necrobinder (100.0%).

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.