Strike•Attack

Is Strike good in Slay the Spire 2?

Strike is a basic Regent attack in Slay the Spire 2. In combat it resolves as: Deal 6 damage. It currently underperforms most alternatives, sitting at F tier in our Slay the Spire 2 card rankings.

Across 637 recorded runs, decks running it win 14.7% of the time, trailing the 18.9% average by 4.3%. It’s a popular draft, appearing in 16.8% of eligible decks. Regent players keep it in 93.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 3.4 times in the decks that take it.

It performs best next to Mad Science — together they post a +29.8% swing in win rate. It also has strong chemistry with the relic Mr. Struggles, which moves its win rate by +29.9%. At 1 energy, it’s upgraded in 5.2% of runs and usually joins the deck around floor 1.

Upgraded, it gains +3 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 66 wins, 383 deaths, and 188 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Phrog Parasite Elite, which closes out 4.1% of its appearances. Read on for Strike’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Regent run.

Best Cards to Pair with Strike

Ranked by win-rate lift, Strike performs best alongside Mad Science (+29.8%), Sword Sage (+25.0%), and Big Bang (+21.2%).

Mad Science+29.8%18 runsSword Sage+25.0%37 runsBig Bang+21.2%67 runsApotheosis+19.7%3 runsArsenal+19.0%28 runsCosmic Indifference+17.6%82 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Strike Win Rate by Class

Strike is drafted only by the Regent, where it holds a 14.7% win rate across 637 runs.

The Regentappears in 93.3% of its runs (637 tracked)

Best Relics for Strike

Strike pairs best with the relics Mr. Struggles (+29.9%), Anchor (+28.4%), and Permafrost (+26.3%), ranked by win-rate lift.

Mr. Struggles+29.9%9 runsAnchor+28.4%57 runsPermafrost+26.3%20 runsJeweled Mask+25.7%6 runsSai+25.7%6 runsDaughter of the Wind+25.6%16 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Strike Card Details

Strike is a basic attack costing 1 energy; it’s upgraded in 5.2% of runs and usually picked up by floor 1.

Deal 6 damage.

Upgrade: +3 Damage

What Ends Runs with Strike

Strike’s most common run-enders are Phrog Parasite Elite (4.1%), Decimillipede Elite (3.5%), and Knowledge Demon Boss (3.0%).

• Phrog Parasite Elite4.1% of runs
• Decimillipede Elite3.5% of runs
• Knowledge Demon Boss3.0% of runs
• Vantom Boss3.0% of runs
• Waterfall Giant Boss2.8% of runs

See Also

Compare Strike with the rest of the best Slay the Spire 2 cards, relics, and classes below.