Lizard Tail
Win Rate
43.8%
Pick Rate
2.5%
Δ vs Avg
+29.9

Lizard Tail Relic

Rare
Rarity
Rare
Methodology
Data Methodology
Author
Dakota Chinnick

When your HP would be reduced to 0, heal to % of your Max HP instead (works once).

Is Lizard Tail good in Slay the Spire 2?

In Slay the Spire 2, Lizard Tail is a rare relic you can pick up on your climb. Its effect: When your HP would be reduced to 0, heal to % of your Max HP instead (works once). The data marks it as a weaker relic, settling at D tier — rarely a run-defining grab.

Over 530 tracked runs the win rate of decks holding it sits at 43.8%, 29.9% ahead of the 13.8% all-run baseline. It sees lighter play, carried in only 2.5% of runs. It does its best work in the hands of the Necrobinder, who post a 47.3% win rate with it. Within Necrobinder runs specifically, it’s carried 2.1% of the time.

Its standout card pairing is Mad Science, which lifts the relic’s win rate by +30.8% when both are in play. It also works nicely with Conflagration, good for a +29.9% win-rate change. It typically enters the deck near floor 22. As a rare relic, how often it’s offered depends on its rarity tier.

Of the runs that carried it, 229 ended in victory while 294 fell to a defeat. Its most common run-ender is Queen Boss, finishing 7.5% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Lizard Tail is worth grabbing.

Lizard Tail Win Rate & Pick Rate

At a 43.8% win rate, Lizard Tail runs 29.9% ahead of the 13.8% all-run baseline — the bars below put the two side by side.

Win rate43.8%
Average run13.8%
+29.9% vs averagePick rate: 2.5%530 runs

Run Outcomes with Lizard Tail

Across the 530 runs that carried Lizard Tail, 229 ended in a win and 301 in a loss — a 43.2% win share, counting abandons as losses.

  • Wins 43.2%
  • Losses 56.8%

Pick or Skip: Lizard Tail

Players take Lizard Tail in 65.7% of the 813 offers it appears in; those runs win 43.8% against 28.6% for runs that passed, a pick lift of +14.9% over 525 decided runs.

Pick rate when offered65.7%813 offers

Taken 534 times out of 813 offers.

Win rate when picked43.8%525 runs
Win rate when skipped28.6%266 runs
+15.2% vs skippingPick lift: +14.9%Sample OK

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

Best Cards with Lizard Tail

The cards that gain the most from carrying Lizard Tail are Mad Science (+30.8%), Conflagration (+29.9%), and Tools of the Trade (+28.2%), each shown with its win-rate swing.

Mad ScienceMad Science+30.8%60 runsConflagrationConflagration+29.9%19 runsTools of the TradeTools of the Trade+28.2%26 runsDecayDecay+27.6%21 runsTacticianTactician+27.0%24 runsAccelerantAccelerant+25.2%30 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Lizard Tail Win Rate by Class

Of the 5 classes that carry Lizard Tail, it performs best with Necrobinder (47.3%), Silent (47.0%), and Ironclad (45.5%).

The NecrobinderThe Necrobinder47.3%76 runsThe SilentThe Silent47.0%135 runsThe IroncladThe Ironclad45.5%134 runsThe DefectThe Defect42.2%84 runsThe RegentThe Regent37.0%95 runs

Lizard Tail Details

Carried in 2.5% of runs, Lizard Tail is a rare relic typically acquired near floor 22.

When your HP would be reduced to 0, heal to % of your Max HP instead (works once).

RarityRare
Typical pickup floor22
Pick rate2.5%
Runs tracked530

What Ends Runs with Lizard Tail

Runs carrying Lizard Tail end most often against Queen Boss (7.5%), Test Subject Boss (6.8%), and Aeonglass Boss (4.3%) — the share of its runs each accounts for is shown.

  • Queen Boss7.5% of runs
  • Test Subject Boss6.8% of runs
  • Aeonglass Boss4.3% of runs
  • Knowledge Demon Boss4.0% of runs
  • Kaiser Crab Boss3.4% of runs
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Lizard Tail – Frequently Asked Questions

Is Lizard Tail good in Slay the Spire 2?

Across 530 tracked runs carrying it, Lizard Tail wins 43.8% of the time — +29.9% above the average run. Win rate reflects how often runs with the relic end in victory.

What does Lizard Tail do in Slay the Spire 2?

When your HP would be reduced to 0, heal to % of your Max HP instead (works once).

How rare is Lizard Tail in Slay the Spire 2?

Lizard Tail is a Rare relic, picked up in 2.5% of tracked runs.

What is the best card to use with Lizard Tail?

In tracked runs, Lizard Tail has performed best alongside Mad Science, which lifts its win rate by +30.8% over 60 runs together.

Which class is Lizard Tail best in?

Lizard Tail has its highest win rate with The Necrobinder (47.3%).

Should I take Lizard Tail when it is offered?

Players take Lizard Tail in 65.7% of its 813 recorded offers. Runs that picked it win 43.8% (525 decided runs) against 28.6% for runs that skipped it (266 decided runs) — a +15.2% difference, and a +14.9% pick lift once sample size is accounted for.

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.

All Slay the Spire 2 relicsAll Slay the Spire 2 cards