Lizard TailRelic
When your HP would be reduced to 0, heal to % of your Max HP instead (works once).
Is Lizard Tail good in Slay the Spire 2?
In Slay the Spire 2, Lizard Tail is a rare relic you can pick up on your climb. Its effect: When your HP would be reduced to 0, heal to % of your Max HP instead (works once). Right now it’s a high-value grab, sitting at B tier — one of the relics most worth taking.
Over 107 tracked runs the win rate of decks holding it sits at 52.7%, 33.7% ahead of the 18.9% all-run baseline. It sees lighter play, carried in only 2.8% of runs. It does its best work in the hands of the Necrobinder, who post a 58.8% win rate with it. Within Necrobinder runs specifically, it’s carried 2.4% of the time.
Its standout card pairing is Inferno, which lifts the relic’s win rate by +47.3% when both are in play. It also works nicely with Hemokinesis, good for a +47.3% win-rate change. It typically enters the deck near floor 21. As a rare relic, how often it’s offered depends on its rarity tier.
Of the runs that carried it, 49 ended in victory while 44 fell to a defeat. Its most common run-ender is Knowledge Demon Boss, finishing 4.7% of the runs it appears in. See the best cards, class split, and threats below for the full read on whether Lizard Tail is worth grabbing.
Lizard Tail Win Rate & Pick Rate
At a 52.7% win rate, Lizard Tail runs 33.7% ahead of the 18.9% all-run baseline — the bars below put the two side by side.
Run Outcomes with Lizard Tail
Across the 107 runs that carried Lizard Tail, 49 ended in a win and 58 in a loss — a 45.8% win share, counting abandons as losses.
- Wins 45.8%
- Losses 54.2%
Best Cards with Lizard Tail
The cards that gain the most from carrying Lizard Tail are Inferno (+47.3%), Hemokinesis (+47.3%), and Offering (+47.3%), each shown with its win-rate swing.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Lizard Tail Win Rate by Class
Of the 5 classes that carry Lizard Tail, it performs best with Necrobinder (58.8%), Ironclad (57.1%), and Silent (54.2%).
Lizard Tail Details
Carried in 2.8% of runs, Lizard Tail is a rare relic typically acquired near floor 21.
When your HP would be reduced to 0, heal to % of your Max HP instead (works once).
What Ends Runs with Lizard Tail
Runs carrying Lizard Tail end most often against Knowledge Demon Boss (4.7%), Queen Boss (4.7%), and Test Subject Boss (3.7%) — the share of its runs each accounts for is shown.
- Knowledge Demon Boss4.7% of runs
- Queen Boss4.7% of runs
- Test Subject Boss3.7% of runs
- The Insatiable Boss2.8% of runs
- Infested Prisms Elite2.8% of runs
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Lizard Tail – Frequently Asked Questions
Is Lizard Tail good in Slay the Spire 2?
Across 107 tracked runs carrying it, Lizard Tail wins 52.7% of the time — +33.7% above the average run. Win rate reflects how often runs with the relic end in victory.
What does Lizard Tail do in Slay the Spire 2?
When your HP would be reduced to 0, heal to % of your Max HP instead (works once).
How rare is Lizard Tail in Slay the Spire 2?
Lizard Tail is a Rare relic, picked up in 2.8% of tracked runs.
What is the best card to use with Lizard Tail?
In tracked runs, Lizard Tail has performed best alongside Inferno, which lifts its win rate by +47.3% over 4 runs together.
Which class is Lizard Tail best in?
Lizard Tail has its highest win rate with The Necrobinder (58.8%).
See Also
Keep exploring Slay the Spire 2 tier lists and stats below.