Diana - League of Legends Champion
Win Rate
49.5%
Pick Rate
6.1%

Dianavs Karthus

CFighterAssassin
Patch26.11
Matches776,441
LaneAll Lanes
TierAll Tiers
Last UpdatedJun 5, 2026
MethodologyData Methodology

Diana vs Karthus is a decisive matchup in LoL patch 26.11. Diana wins with a 65.8% win rate (+31.6%) over Karthus based on 38 games. Diana holds the advantage in both the early and late game. Below you'll find the best Diana build, runes, laning stats, and strategies for the Diana vs Karthus matchup.

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Diana Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Diana performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Diana - 65.8% win rate in this matchup
Diana
65.8% WR
VS
Karthus vs Diana matchup - 34.2% win rate
Karthus
34.2% WR

Who Wins the Diana vs Karthus Matchup?

Diana wins the Diana vs Karthus matchup
Winner
Diana
Matches: 38
65.8%
Win Rate
34.2%
1.7
CS / min
1.9
695
DMG / min
1,067
13,343
Gold / game
12,867
291
Heal / min
263
1,168
DMG Mitigated / min
446
0.4
CC / min
0.6
60.0%
Early Game WR
40.0%
69.6%
Late Game WR
30.4%

Diana vs Karthus Matchup Summary

The Diana vs Karthus matchup is a decisive matchup in League of Legends ranked play. Based on 38 recent matches analyzed, Diana wins with a 65.8% win rate compared to Karthus's 34.2%, giving Diana a 31.6 percentage point advantage. Diana dominates at every stage — from early laning through late game team fights. This consistent advantage makes it difficult for Karthus players to find favorable windows, so team-dependent strategies and avoiding solo confrontations are essential. The most significant statistical gap is in sustain, where Diana leads by 749 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Diana players can confidently pick into Karthus and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Karthus away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Diana vs Karthus Laning Phase Breakdown

Karthus wins the laning phase against Diana in League of Legends

Karthus is favored during the laning phase against Diana, winning 3 out of 5 key stat categories. Karthus holds advantages in farming, damage and crowd control, making them the stronger laner in this matchup.

Farming
1.7Diana
1.9Karthus
Diana and Karthus farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
695Diana
1,067Karthus
Karthus heavily out-damages Diana by 373 DMG/min, dominating both short trades and all-in fights. Diana should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Karthus's sustained damage advantage take over.
Economy
13,343Diana
12,867Karthus
Diana earns 477 more gold per game than Karthus, equivalent to roughly one additional component item. This economic edge comes from a combination of better farming, kill participation, and objective control, giving Diana slightly faster item completions.
Utility
0.4Diana
0.6Karthus
Both Diana and Karthus provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
1,458Diana
709Karthus
Diana vastly out-sustains Karthus, healing and mitigating 749 more damage per minute. This massive durability gap means Diana can absorb significant punishment and remain in lane while Karthus is forced to recall. Building grievous wounds early is essential for Karthus, and focusing on burst trade patterns rather than sustained fights is critical.

Best Diana Build Against Karthus

Sorcerer's Shoes is the optimal boots choice against Karthus, providing the mobility and stats Diana needs most in this matchup. The top-performing core items for Diana against Karthus are Liandry's Torment, Riftmaker and Zhonya's Hourglass. This combination gives Diana an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 3 games — well above average and making it the top item path against Karthus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Diana vs Karthus matchup.

Early Game vs Late Game

Early Game
Diana
60.0%
+20.0% advantage
Diana early game win rateDiana60.0%
Karthus early game win rateKarthus40.0%
Late Game
Diana
69.6%
+39.1% advantage
Diana late game win rateDiana69.6%
Karthus late game win rateKarthus30.4%

Diana dominates the early game (first 15 minutes) with a commanding 60.0% win rate — a 20.0 percentage point lead over Karthus. This lopsided early game means Diana can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Diana is far superior in the late game (25+ minutes), boasting a 69.6% win rate — 39.1 points above Karthus. Extended games heavily favor Diana, whose kit and scaling make them a dominant force in team fights and objective control.

Diana holds the advantage at every stage of the game, making this a consistently favorable matchup from lane through late game team fights. Karthus players should look for outplays, team-dependent strategies, and picks rather than relying on scaling to win this matchup.

Best Diana Runes Against Karthus

Precision rune tree - Diana primary runes vs KarthusPrecision
Conqueror - best Diana rune vs KarthusTriumph - best Diana rune vs KarthusLegend: Alacrity - best Diana rune vs KarthusCut Down - best Diana rune vs Karthus
Inspiration rune tree - Diana secondary runes vs KarthusInspiration
Cosmic Insight - best Diana rune vs KarthusCash Back - best Diana rune vs Karthus
100.0% WR

Running Precision primary with Inspiration secondary allows Diana to press their advantage against Karthus, amplifying the strengths that make this a favorable matchup.


Diana matchup data for League of Legends patch 26.11. The table below shows Diana's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Diana build, runes, laning stats, and early vs late game analysis for that specific matchup.

Diana matchup win rates and stats in League of Legends patch 26.11
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
50.00%3001.367312,45350.7%49.3%
45.97%2981.371112,72646.1%45.8%
55.93%2951.374613,01556.6%55.4%
49.11%2811.476512,99853.9%45.0%
47.50%2401.270312,26050.4%44.4%
42.98%2351.476512,29942.6%43.3%
43.42%2281.470412,67140.2%46.3%
55.70%2286.091412,08759.0%52.9%
38.79%2141.272412,58736.4%40.9%
40.09%2122.383312,61539.8%40.3%
50.24%2093.789912,23049.1%51.5%
44.71%2081.471912,63940.6%48.6%
50.00%2003.281812,41052.6%47.6%
53.44%1891.474012,87352.9%53.9%
48.88%1783.380212,19652.3%45.6%
46.02%1766.089912,36448.0%44.4%
53.57%1685.392312,44553.1%54.0%
48.21%1685.890612,03748.6%48.0%
45.45%1545.186812,37849.3%41.8%
45.14%1445.884111,74640.8%50.0%
42.14%1406.093411,54448.0%35.8%
50.36%1375.695411,30250.0%50.7%
54.07%1352.983512,85756.3%52.1%
52.67%1311.371713,17650.9%54.0%
55.38%1306.292312,59249.2%61.2%
42.24%1161.270712,58043.6%41.0%
52.78%1085.790412,29151.1%54.1%
50.00%1065.888812,46842.0%57.1%
50.96%1041.476212,97551.1%50.9%
48.08%1041.271112,53252.1%44.6%
51.46%1031.376313,18353.1%50.0%
57.00%1001.378112,79650.9%63.8%
61.62%991.477713,79566.7%58.3%
45.92%981.679212,80846.1%45.8%
55.91%931.477114,06948.6%60.3%
54.35%921.574112,39452.0%57.1%
42.22%901.372812,78537.2%46.8%
50.00%865.989111,98644.4%54.0%
53.57%846.190812,80160.6%49.0%
57.50%805.783912,62171.0%49.0%
47.50%805.777411,49148.7%46.3%
53.85%781.179812,86940.0%65.1%
48.05%771.167712,52147.2%48.8%
45.33%756.085611,72350.0%41.5%
54.67%752.275413,05843.8%62.8%
50.68%731.574412,64851.6%50.0%
42.03%691.375012,75226.7%53.9%
56.52%695.779712,17769.0%47.5%
54.41%681.272313,06868.0%46.5%
51.47%686.285312,04863.6%40.0%
47.76%671.578012,78155.2%42.1%
59.38%646.191812,43151.6%66.7%
45.31%645.789011,58651.7%40.0%
67.19%645.987412,01769.0%65.7%
48.39%624.383112,47056.0%43.2%
50.85%596.091513,46960.0%46.1%
41.07%566.287010,95839.4%43.5%
48.21%565.893012,29948.1%48.3%
58.18%553.585712,36970.0%44.0%
65.45%556.297912,77167.9%63.0%
40.74%545.81,06911,90444.0%37.9%
47.17%533.172112,60355.0%42.4%
59.62%526.486311,70963.6%52.6%
56.86%516.01,01212,38165.2%50.0%
33.33%512.182013,13436.4%31.0%
52.00%502.979813,03966.7%41.4%
50.00%485.91,01912,63757.9%44.8%
42.22%451.685813,39039.1%45.5%
46.51%435.81,00011,30545.5%47.6%
52.38%425.693013,17957.9%47.8%
45.24%422.081412,35055.6%37.5%
45.24%421.476913,60540.0%48.1%
41.03%392.783112,82937.5%43.5%
41.03%396.494711,89652.9%31.8%
53.85%392.081011,85561.1%47.6%
71.05%384.883212,92681.3%63.6%
65.79%381.769513,34360.0%69.6%
50.00%361.583313,31450.0%50.0%
60.61%335.887713,25483.3%55.6%
48.48%336.290011,78057.1%42.1%
53.13%325.986810,80461.9%36.4%
56.67%301.991911,90953.3%60.0%
41.38%292.590812,98563.6%27.8%
57.14%282.181111,66660.0%53.9%
53.57%281.185412,70760.0%46.1%
50.00%284.082813,41337.5%55.0%
46.43%281.674613,50038.5%53.3%
48.15%271.866912,40750.0%46.1%
55.56%271.674614,14777.8%44.4%
38.46%264.788011,98636.4%40.0%
73.08%261.764913,14181.8%66.7%
34.62%266.384811,31941.2%22.2%
48.00%252.976112,33828.6%55.6%
48.00%253.196011,77266.7%37.5%
40.00%255.382813,16314.3%50.0%
52.00%255.097612,71658.3%46.1%
32.00%251.465210,52729.4%37.5%
58.33%243.477412,22571.4%40.0%
52.17%231.889613,73762.5%46.7%
43.48%235.790311,88244.4%42.9%
50.00%225.681212,42644.4%53.9%
47.62%213.286913,39233.3%53.3%
60.00%201.571212,63658.3%62.5%
36.84%191.770512,57744.4%30.0%
47.06%175.697411,34328.6%60.0%
58.82%175.590913,09640.0%66.7%
56.25%161.184413,81750.0%66.7%
46.67%154.276210,22866.7%16.7%
42.86%145.989912,97140.0%44.4%
58.33%124.579112,72871.4%40.0%
81.82%116.684711,55283.3%80.0%
50.00%101.283113,41950.0%50.0%
60.00%104.183912,70050.0%75.0%
50.00%105.682911,75425.0%66.7%
30.00%104.072812,83240.0%20.0%
77.78%94.386512,51266.7%83.3%
44.44%93.862811,42866.7%33.3%
33.33%94.597615,538100.0%25.0%
55.56%96.41,09313,20450.0%66.7%
55.56%94.777510,40866.7%50.0%
44.44%94.095412,67450.0%40.0%
75.00%84.784012,21350.0%83.3%
37.50%86.487412,21850.0%25.0%
25.00%81.377212,34125.0%25.0%
12.50%84.589512,83950.0%0.0%
25.00%85.182513,02233.3%20.0%
71.43%74.380613,835100.0%50.0%
28.57%75.675911,63625.0%33.3%
16.67%65.896214,4240.0%16.7%
66.67%64.71,02614,444100.0%50.0%
100.00%55.41,13915,101100.0%100.0%
60.00%56.785114,168100.0%50.0%
40.00%53.785811,079100.0%0.0%
80.00%53.885316,562100.0%75.0%

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Diana vs Karthus - Frequently Asked Questions

How does Diana do against Karthus in League of Legends?

Diana wins the Diana vs Karthus matchup with a 65.8% win rate compared to Karthus's 34.2%, a 31.6 percentage point difference. This data is based on 38 recent ranked games in patch 26.11.

How does Diana do against Karthus in the early game?

In the early game, Diana has the advantage against Karthus with a 60.0% win rate versus 40.0%. Diana players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Diana do against Karthus in the late game?

In the late game, Diana takes over the Diana vs Karthus matchup with a 69.6% win rate compared to 30.4%. Diana scales better into team fights and objective contests after 25 minutes.

Who wins the Diana vs Karthus matchup?

Diana wins the matchup against Karthus with a 65.8% win rate in League of Legends patch 26.11. The 31.6 percentage point advantage means Diana is significantly favored in this lane matchup based on 38 games analyzed.

What is the best Diana build against Karthus?

The best Diana build against Karthus includes Liandry's Torment, Riftmaker, Zhonya's Hourglass with Sorcerer's Shoes. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Diana runes against Karthus?

The best Diana runes against Karthus use the Precision primary tree with Inspiration secondary. This rune setup achieves a 100.0% win rate in the Diana vs Karthus matchup. See the full rune breakdown in the matchup comparison above.

Does Diana counter Karthus?

Yes, Diana has a favorable matchup against Karthus with a 65.8% win rate. Diana strongly counters Karthus in lane based on current patch 26.11 data.

How do I play Diana against Karthus?

When playing Diana against Karthus, leverage your statistical advantages by trading aggressively during favorable windows. You have early game priority — look for kills and zone control before first recall. Build the recommended items and runes for this specific matchup for the best results.