Kai'Sa - League of Legends Champion
Win Rate
47.8%
Pick Rate
5.2%

Kai'SaRunes

FMarksmanMage
Patch26.5
Matches469,660
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 12, 2026
MethodologyData Methodology

Best Kai'Sa runes for LoL Patch 26.5 - Lethal Tempo from the Precision tree with Inspiration secondary (66.7% WR, 0.3% pick rate). Kai'Sa's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down. Secondary tree: Magical Footwear, Biscuit Delivery.

Kai'Sa performs best with Lethal Tempo as the keystone rune from the Precision tree. Kai'Sa's optimal primary runes are Lethal Tempo, Presence of Mind, Legend: Bloodline, Cut Down. Kai'Sa's secondary rune tree is Inspiration with Magical Footwear, Biscuit Delivery. This rune setup achieves a 66.67% win rate (+18.9% win rate difference) with a 0.3% pick rate across 15 Kai'Sa games.
66.7%Win Rate
+18.9%WR Diff
0.3%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

Presence of MindPresence of Mind

Damaging an enemy champion restores 6-50 (80% for ranged) mana or 6 energy.

Takedowns restore 15% of your maximum mana or energy.

Cooldown for damage restoration: 8s

Legend: BloodlineLegend: Bloodline

Gain 0.45% Life Steal for every Legend stack (max 15 stacks). At maximum Legend stacks, gain 85 max health.

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Cut DownCut Down

Deal 8% more damage to champions who have more than 60% health.

Magical FootwearMagical Footwear

You get free Slightly Magical Footwear at 12 min, but you cannot buy boots before then. For each takedown you acquire the boots 45s sooner.

Slightly Magical Footwear grants you an additional 10 Move Speed.

Biscuit DeliveryBiscuit Delivery

Biscuit Delivery: Gain a Total Biscuit of Everlasting Will every 2 mins, until 6 min.

Biscuits restore 20 + 2% of your maximum health, increased by up to 100% based on missing Health. Consuming or selling a Biscuit permanently increases your max health by 30.

This alternative Kai'Sa rune build uses Lethal Tempo as the keystone from the Precision tree. The primary runes are Lethal Tempo, Triumph, Legend: Bloodline, Coup de Grace. Kai'Sa's secondary rune tree is Inspiration with Cash Back, Triple Tonic. This setup achieves a 64.71% win rate (+16.9% win rate difference) with a 0.4% pick rate across 17 games.
64.7%Win Rate
+16.9%WR Diff
0.4%Pick Rate
Lethal TempoLethal Tempo

Attacking an enemy champion grants you [6% Melee || 4% Ranged] Attack Speed for 6 seconds, up to 6. At max stacks, deal [9 - 30 Melee || 6 - 24 Ranged] bonus adaptive damage On-Attack, increased by 1% per 1% Bonus Attack Speed.

TriumphTriumph

Takedowns restore 5% of your missing health, 2.5% of your max health, and grant an additional 20 gold.



'The most dangerous game brings the greatest glory.'
—Noxian Reckoner

Legend: BloodlineLegend: Bloodline

Gain 0.45% Life Steal for every Legend stack (max 15 stacks). At maximum Legend stacks, gain 85 max health.

Earn progress toward Legend stacks for every champion takedown, epic monster takedown, large monster kill, and minion kill.

Coup de GraceCoup de Grace

Deal 8% more damage to champions who have less than 40% health.

Cash BackCash Back

Get 7.5% Gold back when you purchase Legendary Items.

Triple TonicTriple Tonic

Upon reaching level 3, gain an Elixir of Avarice.
Upon reaching level 6, gain an Elixir of Force.
Upon reaching level 9, gain an Elixir of Skill.

These champions share at least 4 runes with Kai'Sa's recommended rune builds. use similar keystone and secondary runes, making them good alternatives if you enjoy Kai'Sa's playstyle or want to learn champions with familiar rune setups.Smolder, Xayah, Vayne, Aphelios, Jinx and 5 others

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Kai'Sa Runes - Frequently Asked Questions

What are the best Kai'Sa runes in patch 26.5?

The best Kai'Sa runes in patch 26.5 use the Precision tree with Lethal Tempo, Presence of Mind, Legend: Bloodline, and Cut Down, and the Inspiration tree with Magical Footwear and Biscuit Delivery. This rune setup achieves a 66.7% win rate with a 0.3% pick rate.

What is the win rate for Kai'Sa's best rune page?

Kai'Sa's best rune page has a 66.7% win rate in patch 26.5, which is +18.9% compared to Kai'Sa's average win rate. This rune setup has a 0.3% pick rate among Kai'Sa players.

What keystone should I use on Kai'Sa?

Lethal Tempo from the Precision tree is the best keystone rune for Kai'Sa in patch 26.5. This keystone synergizes well with Kai'Sa's kit and provides a 66.7% win rate.

What is Kai'Sa's primary rune tree?

Kai'Sa's primary rune tree is Precision. The optimal Precision runes for Kai'Sa are Lethal Tempo, Presence of Mind, Legend: Bloodline, and Cut Down, with Lethal Tempo being the keystone of choice.

What is Kai'Sa's secondary rune tree?

Kai'Sa's best secondary rune tree is Inspiration. The recommended Inspiration runes are Magical Footwear and Biscuit Delivery, which complement Kai'Sa's Precision primary tree.

What are alternative rune setups for Kai'Sa?

An alternative Kai'Sa rune setup uses Lethal Tempo from the Precision tree. This alternate build may be preferred in certain matchups or playstyles. Check the alternative rune page above for full details including win rate and pick rate.

How popular are Kai'Sa's runes?

Kai'Sa's top rune page has a 0.3% pick rate in patch 26.5. This indicates that 0.3% of Kai'Sa players use the Lethal Tempo setup with Precision and Inspiration trees.