Lissandra - League of Legends Champion
Win Rate
50.4%
Pick Rate
1.7%

Lissandravs Nautilus

BMage
Patch26.14
Matches491,560
LaneAll Lanes
TierAll Tiers
Last UpdatedJul 21, 2026
MethodologyData Methodology

Lissandra vs Nautilus is a decisive matchup in LoL patch 26.14. Nautilus wins with a 60.0% win rate (+20.0%) over Lissandra based on 5 games. Lissandra wins the early laning phase while Nautilus scales better into the late game. Below you'll find the best Lissandra build, runes, laning stats, and strategies for the Lissandra vs Nautilus matchup.

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Lissandra Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Lissandra performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Lissandra - 40.0% win rate in this matchup
Lissandra
40.0% WR
VS
Nautilus vs Lissandra matchup - 60.0% win rate
Nautilus
60.0% WR

Who Wins the Lissandra vs Nautilus Matchup?

Nautilus wins the Lissandra vs Nautilus matchup
Winner
Nautilus
Matches: 5
40.0%
Win Rate
60.0%
3.1
CS / min
1.8
638
DMG / min
375
12,160
Gold / game
10,542
139
Heal / min
125
403
DMG Mitigated / min
1,646
1.8
CC / min
2.0
100.0%
Early Game WR
0.0%
25.0%
Late Game WR
75.0%

Lissandra vs Nautilus Matchup Summary

The Lissandra vs Nautilus matchup is a decisive matchup in League of Legends ranked play. Based on 5 recent matches analyzed, Nautilus wins with a 60.0% win rate compared to Lissandra's 40.0%, giving Nautilus a 20.0 percentage point advantage. Game phase dynamics play a critical role here: Lissandra controls the early laning stage, but Nautilus outscales as the game goes longer. The matchup shifts dramatically depending on game length — Lissandra needs to press advantages before Nautilus reaches their power spikes, while Nautilus should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in sustain, where Nautilus leads by 1,229 HP/min — a difference that heavily influences the outcome of trades and skirmishes. Nautilus has a strong advantage in this matchup. Lissandra players should play defensively, prioritize safe farming under tower, and look for opportunities created by jungle pressure or Nautilus overextending. Avoid prolonged trades and wait for team fights where positioning and coordination matter more. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Lissandra vs Nautilus Laning Phase Breakdown

Lissandra wins the laning phase against Nautilus in League of Legends

Lissandra is favored during the laning phase against Nautilus, winning 3 out of 5 key stat categories. Lissandra holds advantages in farming, damage and gold income, making them the stronger laner in this matchup.

Farming
3.1Lissandra
1.8Nautilus
Lissandra significantly out-farms Nautilus by 1.3 CS per minute, accumulating an estimated 20 CS lead by mid game. This substantial farming gap gives Lissandra a major gold advantage and earlier item completions. Nautilus players should prioritize wave management techniques like freezing near tower and using abilities efficiently to minimize the deficit.
Damage
638Lissandra
375Nautilus
Lissandra heavily out-damages Nautilus by 263 DMG/min, dominating both short trades and all-in fights. Nautilus should avoid extended combat and instead focus on burst trade patterns — short engages followed by immediate disengagement — to avoid letting Lissandra's sustained damage advantage take over.
Economy
12,160Lissandra
10,542Nautilus
Lissandra generates a commanding 1,618 more gold per game than Nautilus. This substantial economic advantage means Lissandra consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Nautilus should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.8Lissandra
2.0Nautilus
Both Lissandra and Nautilus provide similar amounts of crowd control (0.2s/min difference), meaning neither has a significant advantage in locking down opponents for ganks or team fights. Lane ganks are equally effective for both sides.
Sustain
542Lissandra
1,771Nautilus
Nautilus vastly out-sustains Lissandra, healing and mitigating 1,229 more damage per minute. This massive durability gap means Nautilus can absorb significant punishment and remain in lane while Lissandra is forced to recall. Building grievous wounds early is essential for Lissandra, and focusing on burst trade patterns rather than sustained fights is critical.

Best Lissandra Build Against Nautilus

Ionian Boots of Lucidity is the optimal boots choice against Nautilus, providing the mobility and stats Lissandra needs most in this matchup. The top-performing core items for Lissandra against Nautilus are Shadowflame, Zhonya's Hourglass and Malignance. This combination gives Lissandra an effective balance of damage, survivability, and utility for the matchup. This build achieves a solid 50.0% win rate across 2 games, proving it to be a reliable item path when facing Nautilus. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Lissandra vs Nautilus matchup.

Early Game vs Late Game

Early Game
Lissandra
100.0%
+100.0% advantage
Lissandra early game win rateLissandra100.0%
Nautilus early game win rateNautilus0.0%
Late Game
Nautilus
75.0%
+50.0% advantage
Lissandra late game win rateLissandra25.0%
Nautilus late game win rateNautilus75.0%

Lissandra dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Nautilus. This lopsided early game means Lissandra can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Nautilus is far superior in the late game (25+ minutes), boasting a 75.0% win rate — 50.0 points above Lissandra. Extended games heavily favor Nautilus, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Lissandra must aggressively press their early advantage and close out the game before Nautilus reaches their scaling breakpoints. If Nautilus survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Lissandra Runes Against Nautilus

Sorcery rune tree - Lissandra primary runes vs NautilusSorcery
Arcane Comet - best Lissandra rune vs NautilusManaflow Band - best Lissandra rune vs NautilusTranscendence - best Lissandra rune vs NautilusScorch - best Lissandra rune vs Nautilus
Domination rune tree - Lissandra secondary runes vs NautilusDomination
Cheap Shot - best Lissandra rune vs NautilusUltimate Hunter - best Lissandra rune vs Nautilus
25.0% WR

The Sorcery and Domination rune setup gives Lissandra the best tools to compete against Nautilus in this difficult matchup, compensating for the statistical disadvantages with optimal rune synergies.


Lissandra matchup data for League of Legends patch 26.14. The table below shows Lissandra's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Lissandra build, runes, laning stats, and early vs late game analysis for that specific matchup.

Lissandra matchup win rates and stats in League of Legends patch 26.14
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
56.00%1006.882911,70950.0%60.0%
54.88%826.590211,76663.3%50.0%
48.15%816.587811,63150.0%46.8%
55.07%696.780112,59753.6%56.1%
43.55%626.673910,94353.9%36.1%
56.45%626.780810,82951.9%60.0%
54.39%576.388510,87848.1%60.0%
49.12%576.790211,34841.7%54.5%
46.15%526.686710,75050.0%42.9%
42.00%506.883311,88752.4%34.5%
54.76%426.788411,04464.7%48.0%
51.28%395.570811,60125.0%63.0%
50.00%386.677811,40442.9%54.2%
44.44%366.671011,33130.8%52.2%
45.45%336.881012,15938.5%50.0%
33.33%276.072311,76540.0%31.8%
44.44%276.777012,01450.0%42.1%
62.96%276.383710,83475.0%53.3%
64.00%256.974910,01473.3%50.0%
47.83%236.492011,17444.4%50.0%
45.45%226.785912,50133.3%50.0%
50.00%226.279312,36850.0%50.0%
57.14%216.381813,51980.0%50.0%
61.90%216.890211,20380.0%45.5%
72.22%186.677311,19650.0%90.0%
50.00%186.697313,12450.0%50.0%
76.47%177.087313,897100.0%71.4%
41.18%176.589312,80260.0%33.3%
58.82%176.284911,48685.7%40.0%
41.18%176.175310,54540.0%41.7%
46.67%156.480510,47440.0%50.0%
46.67%157.078512,21266.7%41.7%
57.14%146.481012,30166.7%54.5%
42.86%146.979311,28742.9%42.9%
46.15%134.17129,62942.9%50.0%
61.54%136.991813,162100.0%50.0%
16.67%126.79369,20416.7%16.7%
63.64%117.095613,587100.0%50.0%
54.55%116.384011,6570.0%75.0%
27.27%116.891713,30433.3%25.0%
66.67%95.193511,97080.0%50.0%
44.44%96.880212,256100.0%28.6%
77.78%96.788814,322100.0%71.4%
33.33%96.47468,58540.0%25.0%
66.67%96.87559,92940.0%100.0%
55.56%97.384311,38566.7%50.0%
44.44%97.01,00813,81266.7%33.3%
87.50%86.71,21811,330100.0%66.7%
37.50%86.488010,16050.0%33.3%
42.86%74.673111,07625.0%66.7%
57.14%72.06357,01560.0%50.0%
33.33%65.382710,99950.0%25.0%
33.33%67.01,16514,7130.0%33.3%
50.00%65.885012,748100.0%25.0%
50.00%66.476310,65033.3%66.7%
66.67%62.86079,991100.0%50.0%
33.33%65.390911,5150.0%50.0%
20.00%51.84187,0570.0%100.0%
20.00%55.865910,91350.0%0.0%
80.00%56.792012,965100.0%66.7%
40.00%54.91,02512,6540.0%50.0%
40.00%53.163812,160100.0%25.0%
40.00%57.21,22913,57550.0%33.3%
40.00%55.872314,8620.0%40.0%
60.00%56.27519,297100.0%33.3%
100.00%57.21,07011,231100.0%100.0%

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Lissandra vs Nautilus - Frequently Asked Questions

How does Lissandra do against Nautilus in League of Legends?

Nautilus wins the Lissandra vs Nautilus matchup with a 60.0% win rate compared to Lissandra's 40.0%, a 20.0 percentage point difference. This data is based on 5 recent ranked games in patch 26.14.

How does Lissandra do against Nautilus in the early game?

In the early game, Lissandra has the advantage against Nautilus with a 100.0% win rate versus 0.0%. Lissandra players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Lissandra do against Nautilus in the late game?

In the late game, Nautilus takes over the Lissandra vs Nautilus matchup with a 75.0% win rate compared to 25.0%. Nautilus scales better into team fights and objective contests after 25 minutes.

Who wins the Lissandra vs Nautilus matchup?

Nautilus wins the matchup against Lissandra with a 60.0% win rate in League of Legends patch 26.14. The 20.0 percentage point advantage means Nautilus is significantly favored in this lane matchup based on 5 games analyzed.

What is the best Lissandra build against Nautilus?

The best Lissandra build against Nautilus includes Shadowflame, Zhonya's Hourglass, Malignance with Ionian Boots of Lucidity. This build achieves a 50.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Lissandra runes against Nautilus?

The best Lissandra runes against Nautilus use the Sorcery primary tree with Domination secondary. This rune setup achieves a 25.0% win rate in the Lissandra vs Nautilus matchup. See the full rune breakdown in the matchup comparison above.

Does Lissandra counter Nautilus?

No, Lissandra struggles against Nautilus with only a 40.0% win rate. Nautilus has the advantage in this matchup. Lissandra players should focus on safe farming and avoiding extended trades to minimize Nautilus's lead.

How do I play Lissandra against Nautilus?

When playing Lissandra against Nautilus, play cautiously and avoid Nautilus's power spikes. Look for jungle assistance and team-dependent plays since Nautilus has the statistical advantage at most stages. Use the matchup-specific build and runes above to optimize your chances.