Alchemize•Skill

Is Alchemize good in Slay the Spire 2?

Alchemize is a rare Colorless skill in Slay the Spire 2. In combat it resolves as: Procure a random potion. It ranks among the strongest cards its class can draft right now, earning a spot at S tier in our Slay the Spire 2 card tier list.

Across 10 recorded runs, decks running it win 50.0% of the time, comfortably clear of the 18.9% average, by 31.1%. It’s a more selective pick, turning up in just 0.3% of decks that could run it. Defect players keep it in 0.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Ascender's Bane — together they post a 0.0% swing in win rate. It also has strong chemistry with the relic Anchor, which moves its win rate by +8.3%. At 1 energy, it’s upgraded in 30.0% of runs and usually joins the deck around floor 20.

Upgraded, it gains -1 EnergyCost, which is why so many decks invest a rest-site upgrade in it. That’s 4 wins, 4 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Entomancer Elite, which closes out 20.0% of its appearances. Read on for Alchemize’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Best Cards to Pair with Alchemize

Ranked by win-rate lift, Alchemize performs best alongside Ascender's Bane (0.0%), Hidden Cache (0.0%), and Defend (-3.9%).

Ascender's Bane0.0%3 runsHidden Cache0.0%3 runsDefend-3.9%4 runsFalling Star-3.9%4 runsVenerate-3.9%4 runsStrike-3.9%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alchemize Win Rate by Class

Alchemize is played across 5 classes, led by Defect (100.0%), Ironclad (100.0%), and Necrobinder (50.0%) by win rate.

The Defect100.0%2 runsThe Ironclad100.0%1 runsThe Necrobinder50.0%2 runsThe Regent33.3%4 runsThe Silent0.0%1 runs

Best Relics for Alchemize

Alchemize pairs best with the relics Anchor (+8.3%), Lantern (+3.9%), and Bag of Marbles (+3.9%), ranked by win-rate lift.

Anchor+8.3%3 runsLantern+3.9%3 runsBag of Marbles+3.9%3 runsOddly Smooth Stone+3.9%3 runsArcane Scroll+3.9%3 runsBag of Preparation+3.9%5 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alchemize Card Details

Alchemize is a rare skill costing 1 energy; it’s upgraded in 30.0% of runs and usually picked up by floor 20.

Procure a random potion.

Upgrade: -1 EnergyCost

What Ends Runs with Alchemize

Alchemize’s most common run-enders are Entomancer Elite (20.0%).

• Entomancer Elite20.0% of runs

See Also

Compare Alchemize with the rest of the best Slay the Spire 2 cards, relics, and classes below.