Alchemize Skill

Is Alchemize good in Slay the Spire 2?

Alchemize is a rare Colorless skill in Slay the Spire 2. In combat it resolves as: Procure a random potion. It ranks among the strongest cards its class can draft right now, earning a spot at B tier in our Slay the Spire 2 card tier list.

Across 105 recorded runs, decks running it win 48.1% of the time, comfortably clear of the 13.8% average, by 34.2%. It’s a more selective pick, turning up in just 0.5% of decks that could run it. Offer data backs the pick — taken 1.5% of the time it is shown, with 71.4% for runs that took it against 29.0% for runs that did not, a +28.7% pick lift across 21 decided runs. Silent players keep it in 0.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Backflip — together they post a +10.5% swing in win rate. It also has strong chemistry with the relic Reptile Trinket, which moves its win rate by +25.3%. At 1 energy, it’s upgraded in 41.7% of runs and usually joins the deck around floor 22.

Upgraded, it gains -1 EnergyCost, which is why so many decks invest a rest-site upgrade in it. That’s 50 wins, 54 deaths, and 1 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Test Subject Boss, which closes out 7.6% of its appearances. Read on for Alchemize’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Pick or Skip: Alchemize

Out of 1368 recorded offers Alchemize is taken 1.5% of the time, and taking it is worth +28.7% in pick lift — 71.4% for runs that picked it against 29.0% for runs that skipped, across 21 decided runs.

Taken 21 times out of 1368 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Alchemize

Alchemize is strongest when it joins the deck in Act 3, where runs win 84.0% across 26 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Alchemize entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Alchemize

Ranked by win-rate lift, Alchemize performs best alongside Backflip (+10.5%), Venerate (+8.4%), and Prepared (+8.4%).

Backflip+10.5%17 runsVenerate+8.4%18 runsPrepared+8.4%18 runsLeading Strike+7.2%15 runsDefend+6.8%17 runsDefend+4.5%23 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alchemize Win Rate by Class

Alchemize is played across 5 classes, led by Silent (60.0%), Regent (57.9%), and Ironclad (50.0%) by win rate.

The Silent60.0%31 runsThe Regent57.9%19 runsThe Ironclad50.0%16 runsThe Necrobinder40.0%20 runsThe Defect26.3%19 runs

Best Relics for Alchemize

Alchemize pairs best with the relics Reptile Trinket (+25.3%), Blood Vial (+21.0%), and Bag of Preparation (+20.7%), ranked by win-rate lift.

Reptile Trinket+25.3%18 runsBlood Vial+21.0%24 runsBag of Preparation+20.7%30 runsTiny Mailbox+20.4%17 runsBag of Marbles+20.2%20 runsRed Mask+19.0%22 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Alchemize Card Details

Alchemize is a rare skill costing 1 energy; it’s upgraded in 41.7% of runs and usually picked up by floor 22.

Procure a random potion.

Upgrade: -1 EnergyCost

What Ends Runs with Alchemize

Alchemize’s most common run-enders are Test Subject Boss (7.6%), Knowledge Demon Boss (7.6%), and Aeonglass Boss (5.7%).

• Test Subject Boss7.6% of runs
• Knowledge Demon Boss7.6% of runs
• Aeonglass Boss5.7% of runs
• Kaiser Crab Boss3.8% of runs
• The Insatiable Boss3.8% of runs

See Also

Compare Alchemize with the rest of the best Slay the Spire 2 cards, relics, and classes below.