Devastate•Attack

Is Devastate good in Slay the Spire 2?

In Slay the Spire 2, Devastate is an uncommon attack from the Regent card pool. Its effect: Deal 30 damage. Right now it’s a premium pick that sits at B tier — one of the better cards you can add to a deck this run.

Over 21 tracked runs its win rate sits at 28.6%, 15.9% ahead of the 12.6% all-deck baseline. It sees niche play, included in only 4.0% of eligible runs. Within Regent runs it’s drafted 12.7% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.1 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +71.4% when the two share a deck. On the relic side, Pear is its standout companion, worth a +71.4% win-rate swing alongside it. It costs 1 energy, gets upgraded 34.8% of the time, and tends to be picked up near floor 11.

Upgrading the card adds +10 Damage to its stat line. Of the runs that drafted it, 6 ended in victory against 15 deaths and 0 abandons. Its most common run-ender is Vantom Boss, finishing 14.3% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Devastate fits a Regent deck.

Best Cards to Pair with Devastate

Devastate’s strongest card pairings so far are Mad Science (+71.4%), Neutron Aegis (+71.4%), and Child of the Stars (+51.4%), each shown with the win-rate lift it adds.

Mad Science+71.4%3 runsNeutron Aegis+71.4%3 runsChild of the Stars+51.4%5 runsSupermassive+46.4%4 runsBombardment+46.4%4 runsGuiding Star+38.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Devastate Win Rate by Class

Exclusive to the Regent, Devastate posts a 28.6% win rate over 21 tracked runs.

The Regentappears in 12.7% of its runs (21 tracked)

Best Relics for Devastate

The relics that swing Devastate’s win rate the most are Pear (+71.4%), Mummified Hand (+71.4%), and War Paint (+71.4%), with each lift shown.

Pear+71.4%3 runsMummified Hand+71.4%3 runsWar Paint+71.4%3 runsPendulum+51.4%5 runsFestive Popper+38.1%3 runsLucky Fysh+38.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Devastate Card Details

A 1-energy uncommon attack, Devastate is upgraded 34.8% of the time and tends to enter the deck around floor 11.

Deal 30 damage.

Upgrade: +10 Damage

What Ends Runs with Devastate

Runs holding Devastate end most often against Vantom Boss (14.3%), Terror Eel Elite (9.5%), and Skulking Colony Elite (9.5%) — the share of its runs each accounts for is shown.

• Vantom Boss14.3% of runs
• Terror Eel Elite9.5% of runs
• Skulking Colony Elite9.5% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.