Envenom•Power

Is Envenom good in Slay the Spire 2?

Envenom is a rare Silent power in Slay the Spire 2. In combat it resolves as: Whenever an Attack deals unblocked damage, apply 1 Poison. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 82 recorded runs, decks running it win 33.8% of the time, comfortably clear of the 19.0% average, by 14.8%. It’s a more selective pick, turning up in just 2.2% of decks that could run it. Defect players keep it in 0.2% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Mad Science — together they post a +18.9% swing in win rate. It also has strong chemistry with the relic Blood Vial, which moves its win rate by +25.2%. At 2 energy, it’s upgraded in 33.3% of runs and usually joins the deck around floor 16.

That’s 25 wins, 49 deaths, and 8 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Hunter Killer Normal, which closes out 6.1% of its appearances. Read on for Envenom’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Envenom

Ranked by win-rate lift, Envenom performs best alongside Mad Science (+18.9%), Reflex (+18.3%), and Expose (+15.7%).

Mad Science+18.9%4 runsReflex+18.3%9 runsExpose+15.7%13 runsAbrasive+15.6%9 runsStorm of Steel+15.4%5 runsKnife Trap+13.6%15 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Envenom Win Rate by Class

Envenom is played across 2 classes, led by Defect (100.0%) and Silent (32.9%) by win rate.

The Defect100.0%1 runsThe Silent32.9%81 runs

Best Relics for Envenom

Envenom pairs best with the relics Blood Vial (+25.2%), Nunchaku (+23.9%), and Eternal Feather (+23.9%), ranked by win-rate lift.

Blood Vial+25.2%11 runsNunchaku+23.9%8 runsEternal Feather+23.9%8 runsLantern+22.7%20 runsToolbox+22.1%5 runsHorn Cleat+21.4%7 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Envenom Card Details

Envenom is a rare power costing 2 energy; it’s upgraded in 33.3% of runs and usually picked up by floor 16.

Whenever an Attack deals unblocked damage, apply 1 Poison.

What Ends Runs with Envenom

Envenom’s most common run-enders are Hunter Killer Normal (6.1%), Queen Boss (6.1%), and Infested Prisms Elite (4.9%).

• Hunter Killer Normal6.1% of runs
• Queen Boss6.1% of runs
• Infested Prisms Elite4.9% of runs
• Test Subject Boss3.7% of runs
• Knowledge Demon Boss3.7% of runs

See Also

Compare Envenom with the rest of the best Slay the Spire 2 cards, relics, and classes below.