EnvenomPower
Whenever an Attack deals unblocked damage, apply 1 Poison.
Is Envenom good in Slay the Spire 2?
Envenom is a rare Silent power in Slay the Spire 2. In combat it resolves as: Whenever an Attack deals unblocked damage, apply 1 Poison. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.
Across 9 recorded runs, decks running it win 16.7% of the time, comfortably clear of the 12.6% average, by 4.0%. It’s a more selective pick, turning up in just 1.7% of decks that could run it. Silent players keep it in 8.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.2 times in the decks that take it.
It performs best next to Ascender's Bane — together they post a +16.7% swing in win rate. It also has strong chemistry with the relic Vajra, which moves its win rate by +16.7%. At 2 energy, it’s upgraded in 18.2% of runs and usually joins the deck around floor 11.
That’s 1 wins, 5 deaths, and 3 abandoned runs with it in the deck. Read on for Envenom’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.
Envenom Win Rate & Pick Rate
Envenom’s 16.7% win rate clears the 12.6% all-deck average by 4.0%, the gap charted below.
Run Outcomes with Envenom
Envenom has 1 wins and 8 losses over 9 tracked runs (11.1% won); abandoned runs count as losses.
- Wins 11.1%
- Losses 88.9%
Best Cards to Pair with Envenom
Ranked by win-rate lift, Envenom performs best alongside Ascender's Bane (+16.7%), Infinite Blades (+16.7%), and Neutralize (+3.3%).
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Envenom Win Rate by Class
Envenom is drafted only by the Silent, where it holds a 16.7% win rate across 9 runs.
The Silentappears in 8.7% of its runs (9 tracked)Best Relics for Envenom
Envenom pairs best with the relics Vajra (+16.7%), Ring of the Snake (0.0%), and Neow's Bones (-16.7%), ranked by win-rate lift.
Based on small co-occurring samples — treat these as early signals, not final verdicts.
Envenom Card Details
Envenom is a rare power costing 2 energy; it’s upgraded in 18.2% of runs and usually picked up by floor 11.
Whenever an Attack deals unblocked damage, apply 1 Poison.
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Envenom – Frequently Asked Questions
Is Envenom good in Slay the Spire 2?
Across 9 tracked runs, Envenom has a 16.7% win rate — +4.0% above the average deck. Win rate reflects how often runs that include the card end in victory.
What does Envenom do in Slay the Spire 2?
Envenom costs 2 energy. Whenever an Attack deals unblocked damage, apply 1 Poison.
What class is Envenom in Slay the Spire 2?
Envenom is a Rare Silent Power.
Is Envenom worth upgrading in Slay the Spire 2?
Envenom can be upgraded at a rest site to improve its effect.
What is the best relic for Envenom?
In tracked runs, Envenom has performed best alongside Vajra, which lifts its win rate by +16.7% over 3 runs together.
See Also
Compare Envenom with the rest of the best Slay the Spire 2 cards, relics, and classes below.