Envenom•Power

Is Envenom good in Slay the Spire 2?

Envenom is a rare Silent power in Slay the Spire 2. In combat it resolves as: Whenever an Attack deals unblocked damage, apply 1 Poison. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 245 recorded runs, decks running it win 31.4% of the time, comfortably clear of the 13.9% average, by 17.4%. It’s a more selective pick, turning up in just 2.1% of decks that could run it. Taken in 42.2% of its offers, it still trails on the pick-versus-skip split: 33.6% for runs that took it against 37.6% for runs that left it, a -3.8% pick lift over 211 decided runs. Silent players keep it in 8.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Storm of Steel — together they post a +25.3% swing in win rate. It also has strong chemistry with the relic Horn Cleat, which moves its win rate by +27.1%. At 2 energy, it’s upgraded in 39.7% of runs and usually joins the deck around floor 18.

That’s 76 wins, 166 deaths, and 3 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Test Subject Boss, which closes out 8.2% of its appearances. Read on for Envenom’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Pick or Skip: Envenom

Out of 528 recorded offers Envenom is taken 42.2% of the time, and taking it is worth -3.8% in pick lift — 33.6% for runs that picked it against 37.6% for runs that skipped, across 211 decided runs.

Taken 223 times out of 528 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Envenom

Envenom is strongest when it joins the deck in Act 2, where runs win 48.7% across 77 runs — one of 4 recorded pickup windows.

Win rate of runs by the act Envenom entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Envenom

Ranked by win-rate lift, Envenom performs best alongside Storm of Steel (+25.3%), Blade of Ink (+24.5%), and Serpent Form (+23.3%).

Storm of Steel+25.3%24 runsBlade of Ink+24.5%27 runsSerpent Form+23.3%37 runsMad Science+21.0%17 runsKnife Trap+17.9%44 runsFan of Knives+17.8%35 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Envenom Win Rate by Class

Envenom is drafted only by the Silent, where it holds a 31.2% win rate across 240 runs.

The Silentappears in 8.3% of its runs (240 tracked)

Best Relics for Envenom

Envenom pairs best with the relics Horn Cleat (+27.1%), Art of War (+26.8%), and Vambrace (+26.6%), ranked by win-rate lift.

Horn Cleat+27.1%22 runsArt of War+26.8%17 runsVambrace+26.6%25 runsGorget+26.6%43 runsNunchaku+25.3%23 runsAkabeko+23.6%24 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Envenom Card Details

Envenom is a rare power costing 2 energy; it’s upgraded in 39.7% of runs and usually picked up by floor 18.

Whenever an Attack deals unblocked damage, apply 1 Poison.

What Ends Runs with Envenom

Envenom’s most common run-enders are Test Subject Boss (8.2%), Kaiser Crab Boss (5.7%), and Decimillipede Elite (4.5%).

• Test Subject Boss8.2% of runs
• Kaiser Crab Boss5.7% of runs
• Decimillipede Elite4.5% of runs
• Queen Boss4.5% of runs
• Infested Prisms Elite4.1% of runs

See Also

Compare Envenom with the rest of the best Slay the Spire 2 cards, relics, and classes below.