Fisticuffs•Attack

Is Fisticuffs good in Slay the Spire 2?

Fisticuffs is an uncommon Colorless attack in Slay the Spire 2. In combat it resolves as: Deal 7 damage. Gain Block equal to damage dealt. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 25 recorded runs, decks running it win 31.6% of the time, comfortably clear of the 18.9% average, by 12.6%. It’s a more selective pick, turning up in just 0.7% of decks that could run it. Silent players keep it in 0.4% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.0 times in the decks that take it.

It performs best next to Stone Armor — together they post a +15.8% swing in win rate. It also has strong chemistry with the relic Pendulum, which moves its win rate by +15.8%. At 1 energy, it’s upgraded in 26.9% of runs and usually joins the deck around floor 12.

Upgraded, it gains +2 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 6 wins, 13 deaths, and 6 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 8.0% of its appearances. Read on for Fisticuffs’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Best Cards to Pair with Fisticuffs

Ranked by win-rate lift, Fisticuffs performs best alongside Stone Armor (+15.8%), Bloodletting (+12.4%), and Blood Wall (+12.4%).

Stone Armor+15.8%3 runsBloodletting+12.4%4 runsBlood Wall+12.4%4 runsBully+8.1%3 runsArmaments+8.1%3 runsBreakthrough+8.1%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Fisticuffs Win Rate by Class

Fisticuffs is played across 5 classes, led by Silent (66.7%), Ironclad (50.0%), and Regent (16.7%) by win rate.

The Silent66.7%4 runsThe Ironclad50.0%6 runsThe Regent16.7%10 runsThe Defect0.0%3 runsThe Necrobinder0.0%2 runs

Best Relics for Fisticuffs

Fisticuffs pairs best with the relics Pendulum (+15.8%), Blood Vial (+12.4%), and Letter Opener (+12.4%), ranked by win-rate lift.

Pendulum+15.8%3 runsBlood Vial+12.4%4 runsLetter Opener+12.4%4 runsRegal Pillow+12.4%4 runsVajra+12.4%6 runsWhetstone+11.4%3 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Fisticuffs Card Details

Fisticuffs is an uncommon attack costing 1 energy; it’s upgraded in 26.9% of runs and usually picked up by floor 12.

Deal 7 damage. Gain Block equal to damage dealt.

Upgrade: +2 Damage

What Ends Runs with Fisticuffs

Fisticuffs’s most common run-enders are Knowledge Demon Boss (8.0%) and The Insatiable Boss (8.0%).

• Knowledge Demon Boss8.0% of runs
• The Insatiable Boss8.0% of runs

See Also

Compare Fisticuffs with the rest of the best Slay the Spire 2 cards, relics, and classes below.