Fisticuffs•Attack

Is Fisticuffs good in Slay the Spire 2?

Fisticuffs is an uncommon Colorless attack in Slay the Spire 2. In combat it resolves as: Deal 7 damage. Gain Block equal to damage dealt. It currently underperforms most alternatives, sitting at D tier in our Slay the Spire 2 card rankings.

Across 122 recorded runs, decks running it win 20.8% of the time, comfortably clear of the 13.9% average, by 6.9%. It’s a more selective pick, turning up in just 1.1% of decks that could run it. Taken in 6.3% of its offers, it still trails on the pick-versus-skip split: 19.4% for runs that took it against 24.7% for runs that left it, a -4.1% pick lift over 36 decided runs. Silent players keep it in 0.9% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Bloodletting — together they post a +18.3% swing in win rate. It also has strong chemistry with the relic Bronze Scales, which moves its win rate by +19.4%. At 1 energy, it’s upgraded in 41.4% of runs and usually joins the deck around floor 14.

Upgraded, it gains +2 Damage, which is why so many decks invest a rest-site upgrade in it. That’s 25 wins, 95 deaths, and 2 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 10.7% of its appearances. Read on for Fisticuffs’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Colorless run.

Pick or Skip: Fisticuffs

Out of 586 recorded offers Fisticuffs is taken 6.3% of the time, and taking it is worth -4.1% in pick lift — 19.4% for runs that picked it against 24.7% for runs that skipped, across 36 decided runs.

Taken 37 times out of 586 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Fisticuffs

Fisticuffs is strongest when it joins the deck in Act 2, where runs win 35.9% across 39 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Fisticuffs entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Fisticuffs

Ranked by win-rate lift, Fisticuffs performs best alongside Bloodletting (+18.3%), Colossus (+12.8%), and True Grit (+12.8%).

Bloodletting+18.3%26 runsColossus+12.8%17 runsTrue Grit+12.8%17 runsShrug It Off+11.9%30 runsAnger+11.5%15 runsBreakthrough+10.5%19 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Fisticuffs Win Rate by Class

Fisticuffs is played across 4 classes, led by Silent (28.0%), Ironclad (25.0%), and Necrobinder (15.4%) by win rate.

The Silent28.0%27 runsThe Ironclad25.0%52 runsThe Necrobinder15.4%13 runsThe Regent9.1%22 runs

Best Relics for Fisticuffs

Fisticuffs pairs best with the relics Bronze Scales (+19.4%), Centennial Puzzle (+18.8%), and Vajra (+18.3%), ranked by win-rate lift.

Bronze Scales+19.4%21 runsCentennial Puzzle+18.8%19 runsVajra+18.3%27 runsBlood Vial+17.9%17 runsWar Paint+17.4%20 runsOddly Smooth Stone+16.5%18 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Fisticuffs Card Details

Fisticuffs is an uncommon attack costing 1 energy; it’s upgraded in 41.4% of runs and usually picked up by floor 14.

Deal 7 damage. Gain Block equal to damage dealt.

Upgrade: +2 Damage

What Ends Runs with Fisticuffs

Fisticuffs’s most common run-enders are Knowledge Demon Boss (10.7%), Decimillipede Elite (5.7%), and Test Subject Boss (5.7%).

• Knowledge Demon Boss10.7% of runs
• Decimillipede Elite5.7% of runs
• Test Subject Boss5.7% of runs
• Kaiser Crab Boss4.9% of runs
• Aeonglass Boss4.9% of runs

See Also

Compare Fisticuffs with the rest of the best Slay the Spire 2 cards, relics, and classes below.