Neutralize Attack

Is Neutralize good in Slay the Spire 2?

In Slay the Spire 2, Neutralize is a basic attack from the Silent card pool. Its effect: Deal 3 damage. Apply 1 Weak. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 5536 tracked runs its win rate sits at 14.9%, almost exactly the overall average. Players reach for it often — it shows up in 20.5% of runs that can take it. Within Silent runs it’s drafted 94.4% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +42.9% when the two share a deck. On the relic side, History Course is its standout companion, worth a +57.0% win-rate swing alongside it. It costs 0 energy, gets upgraded 20.2% of the time, and tends to be picked up near floor 1.

Upgrading the card adds +1 Damage, +1 Weak to its stat line. Of the runs that drafted it, 812 ended in victory against 4642 deaths and 82 abandons. Its most common run-ender is Lagavulin Matriarch Boss, finishing 3.9% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Neutralize fits a Silent deck.

When to Pick Up Neutralize

Of the 2 pickup windows recorded for Neutralize, Act 2 is the best: 57.1% across 14 runs.

Win rate of runs by the act Neutralize entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Neutralize

Neutralize’s strongest card pairings so far are Mad Science (+42.9%), Apotheosis (+39.1%), and Bad Luck (+37.6%), each shown with the win-rate lift it adds.

Mad Science+42.9%221 runsApotheosis+39.1%52 runsBad Luck+37.6%50 runsApparition+35.1%25 runsFolly+34.4%58 runsFlanking+34.1%148 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Win Rate by Class

Exclusive to the Silent, Neutralize posts a 14.9% win rate over 5536 tracked runs.

The Silentappears in 94.4% of its runs (5536 tracked)

Best Relics for Neutralize

The relics that swing Neutralize’s win rate the most are History Course (+57.0%), Sword of Jade (+54.3%), and Iron Club (+52.0%), with each lift shown.

History Course+57.0%38 runsSword of Jade+54.3%76 runsIron Club+52.0%70 runsCrossbow+46.9%41 runsSai+45.2%79 runsFragrant Mushroom+45.2%159 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Card Details

A 0-energy basic attack, Neutralize is upgraded 20.2% of the time and tends to enter the deck around floor 1.

Deal 3 damage. Apply 1 Weak.

Upgrade: +1 Damage, +1 Weak

What Ends Runs with Neutralize

Runs holding Neutralize end most often against Lagavulin Matriarch Boss (3.9%), Knowledge Demon Boss (3.5%), and Phrog Parasite Elite (3.1%) — the share of its runs each accounts for is shown.

• Lagavulin Matriarch Boss3.9% of runs
• Knowledge Demon Boss3.5% of runs
• Phrog Parasite Elite3.1% of runs
• Kaiser Crab Boss3.0% of runs
• Test Subject Boss2.8% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.