Neutralize•Attack

Is Neutralize good in Slay the Spire 2?

In Slay the Spire 2, Neutralize is a basic attack from the Silent card pool. Its effect: Deal 3 damage. Apply 1 Weak. The data flags it as a weaker pick, settling at D tier — usually one to pass on unless your deck specifically wants it.

Over 99 tracked runs its win rate sits at 11.9%, almost exactly the overall average. Players reach for it often — it shows up in 19.1% of runs that can take it. Within Silent runs it’s drafted 95.2% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Doubt, which lifts its win rate by +88.1% when the two share a deck. On the relic side, Pael's Wing is its standout companion, worth a +88.1% win-rate swing alongside it. It costs 0 energy, gets upgraded 31.3% of the time, and tends to be picked up near floor 1.

Upgrading the card adds +1 Damage, +1 Weak to its stat line. Of the runs that drafted it, 7 ended in victory against 52 deaths and 40 abandons. Its most common run-ender is Vantom Boss, finishing 6.1% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Neutralize fits a Silent deck.

Best Cards to Pair with Neutralize

Neutralize’s strongest card pairings so far are Doubt (+88.1%), Tracking (+88.1%), and Pinpoint (+38.1%), each shown with the win-rate lift it adds.

Doubt+88.1%3 runsTracking+88.1%4 runsPinpoint+38.1%5 runsHidden Daggers+38.1%9 runsMayhem+38.1%4 runsUltimate Defend+38.1%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Win Rate by Class

Exclusive to the Silent, Neutralize posts a 11.9% win rate over 99 tracked runs.

The Silentappears in 95.2% of its runs (99 tracked)

Best Relics for Neutralize

The relics that swing Neutralize’s win rate the most are Pael's Wing (+88.1%), Miniature Cannon (+88.1%), and Shovel (+88.1%), with each lift shown.

Pael's Wing+88.1%3 runsMiniature Cannon+88.1%4 runsShovel+88.1%3 runsOddly Smooth Stone+63.1%8 runsYummy Cookie+54.8%5 runsRing of the Drake+54.8%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Card Details

A 0-energy basic attack, Neutralize is upgraded 31.3% of the time and tends to enter the deck around floor 1.

Deal 3 damage. Apply 1 Weak.

Upgrade: +1 Damage, +1 Weak

What Ends Runs with Neutralize

Runs holding Neutralize end most often against Vantom Boss (6.1%), Phrog Parasite Elite (5.1%), and Lagavulin Matriarch Boss (4.0%) — the share of its runs each accounts for is shown.

• Vantom Boss6.1% of runs
• Phrog Parasite Elite5.1% of runs
• Lagavulin Matriarch Boss4.0% of runs
• Entomancer Elite3.0% of runs
• Queen Boss2.0% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.