Neutralize•Attack

Is Neutralize good in Slay the Spire 2?

In Slay the Spire 2, Neutralize is a basic attack from the Silent card pool. Its effect: Deal 3 damage. Apply 1 Weak. The data flags it as a weaker pick, settling at F tier — usually one to pass on unless your deck specifically wants it.

Over 949 tracked runs its win rate sits at 20.2%, 1.2% ahead of the 18.9% all-deck baseline. Players reach for it often — it shows up in 25.1% of runs that can take it. Within Silent runs it’s drafted 96.6% of the time, making it a regular part of that class’s decks. Decks that include it run about 1.0 copies on average.

Its standout pairing so far is Mad Science, which lifts its win rate by +37.8% when the two share a deck. On the relic side, Sword of Jade is its standout companion, worth a +39.9% win-rate swing alongside it. It costs 0 energy, gets upgraded 17.4% of the time, and tends to be picked up near floor 1.

Upgrading the card adds +1 Damage, +1 Weak to its stat line. Of the runs that drafted it, 135 ended in victory against 534 deaths and 280 abandons. Its most common run-ender is Knowledge Demon Boss, finishing 3.8% of the runs it shows up in. See the synergies, class split, and threats below for the full picture of where Neutralize fits a Silent deck.

Best Cards to Pair with Neutralize

Neutralize’s strongest card pairings so far are Mad Science (+37.8%), Knife Trap (+32.6%), and Afterimage (+27.1%), each shown with the win-rate lift it adds.

Mad Science+37.8%28 runsKnife Trap+32.6%72 runsAfterimage+27.1%89 runsApotheosis+26.6%6 runsFlanking+24.6%28 runsReflex+23.7%89 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Win Rate by Class

Exclusive to the Silent, Neutralize posts a 20.2% win rate over 949 tracked runs.

The Silentappears in 96.6% of its runs (949 tracked)

Best Relics for Neutralize

The relics that swing Neutralize’s win rate the most are Sword of Jade (+39.9%), Signet Ring (+36.4%), and Fragrant Mushroom (+36.3%), with each lift shown.

Sword of Jade+39.9%15 runsSignet Ring+36.4%14 runsFragrant Mushroom+36.3%29 runsBeautiful Bracelet+32.5%9 runsSai+32.5%9 runsForgotten Soul+31.3%25 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Neutralize Card Details

A 0-energy basic attack, Neutralize is upgraded 17.4% of the time and tends to enter the deck around floor 1.

Deal 3 damage. Apply 1 Weak.

Upgrade: +1 Damage, +1 Weak

What Ends Runs with Neutralize

Runs holding Neutralize end most often against Knowledge Demon Boss (3.8%), Lagavulin Matriarch Boss (3.6%), and Entomancer Elite (3.2%) — the share of its runs each accounts for is shown.

• Knowledge Demon Boss3.8% of runs
• Lagavulin Matriarch Boss3.6% of runs
• Entomancer Elite3.2% of runs
• Ceremonial Beast Boss2.8% of runs
• Vantom Boss2.4% of runs

See Also

Keep exploring Slay the Spire 2 tier lists and stats below.