Serpent Form•Power

Is Serpent Form good in Slay the Spire 2?

Serpent Form is a rare Silent power in Slay the Spire 2. In combat it resolves as: Whenever you play a card, deal 4 damage to a random enemy. It ranks among the strongest cards its class can draft right now, earning a spot at S tier in our Slay the Spire 2 card tier list.

Across 73 recorded runs, decks running it win 45.9% of the time, comfortably clear of the 18.9% average, by 26.9%. It’s a more selective pick, turning up in just 1.9% of decks that could run it. Silent players keep it in 7.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Escape Plan — together they post a +24.5% swing in win rate. It also has strong chemistry with the relic Lasting Candy, which moves its win rate by +22.3%. At 3 energy, it’s upgraded in 25.3% of runs and usually joins the deck around floor 16.

That’s 28 wins, 33 deaths, and 12 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 5.5% of its appearances. Read on for Serpent Form’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Best Cards to Pair with Serpent Form

Ranked by win-rate lift, Serpent Form performs best alongside Escape Plan (+24.5%), Adrenaline (+22.1%), and Infinite Blades (+20.5%).

Escape Plan+24.5%16 runsAdrenaline+22.1%10 runsInfinite Blades+20.5%18 runsAccuracy+19.4%21 runsPanache+15.5%5 runsAfterimage+14.1%17 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Serpent Form Win Rate by Class

Serpent Form is played across 2 classes, led by Silent (46.7%) and Necrobinder (0.0%) by win rate.

The Silent46.7%72 runsThe Necrobinder0.0%1 runs

Best Relics for Serpent Form

Serpent Form pairs best with the relics Lasting Candy (+22.3%), Lantern (+21.8%), and Potion Belt (+20.4%), ranked by win-rate lift.

Lasting Candy+22.3%8 runsLantern+21.8%18 runsPotion Belt+20.4%9 runsAnchor+18.8%11 runsSturdy Clamp+18.5%9 runsOddly Smooth Stone+18.5%8 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Serpent Form Card Details

Serpent Form is a rare power costing 3 energy; it’s upgraded in 25.3% of runs and usually picked up by floor 16.

Whenever you play a card, deal 4 damage to a random enemy.

What Ends Runs with Serpent Form

Serpent Form’s most common run-enders are Knowledge Demon Boss (5.5%), Decimillipede Elite (4.1%), and Ceremonial Beast Boss (2.7%).

• Knowledge Demon Boss5.5% of runs
• Decimillipede Elite4.1% of runs
• Ceremonial Beast Boss2.7% of runs
• Chompers Normal2.7% of runs
• Vantom Boss2.7% of runs

See Also

Compare Serpent Form with the rest of the best Slay the Spire 2 cards, relics, and classes below.