Serpent Form•Power

Is Serpent Form good in Slay the Spire 2?

Serpent Form is a rare Silent power in Slay the Spire 2. In combat it resolves as: Whenever you play a card, deal 4 damage to a random enemy. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 250 recorded runs, decks running it win 32.9% of the time, comfortably clear of the 13.9% average, by 19.0%. It’s a more selective pick, turning up in just 2.2% of decks that could run it. Offer data backs the pick — taken 33.7% of the time it is shown, with 37.2% for runs that took it against 34.0% for runs that did not, a +3.0% pick lift across 183 decided runs. Silent players keep it in 8.3% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Shadowmeld — together they post a +24.2% swing in win rate. It also has strong chemistry with the relic Eternal Feather, which moves its win rate by +25.3%. At 3 energy, it’s upgraded in 35.8% of runs and usually joins the deck around floor 17.

That’s 81 wins, 165 deaths, and 4 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Knowledge Demon Boss, which closes out 7.2% of its appearances. Read on for Serpent Form’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Silent run.

Pick or Skip: Serpent Form

Out of 564 recorded offers Serpent Form is taken 33.7% of the time, and taking it is worth +3.0% in pick lift — 37.2% for runs that picked it against 34.0% for runs that skipped, across 183 decided runs.

Taken 190 times out of 564 offers.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Serpent Form

Serpent Form is strongest when it joins the deck in Act 3, where runs win 70.6% across 17 runs — one of 4 recorded pickup windows.

Win rate of runs by the act Serpent Form entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Serpent Form

Ranked by win-rate lift, Serpent Form performs best alongside Shadowmeld (+24.2%), Adrenaline (+22.9%), and Escape Plan (+22.6%).

Shadowmeld+24.2%23 runsAdrenaline+22.9%47 runsEscape Plan+22.6%50 runsEnvenom+22.1%37 runsMad Science+20.9%24 runsKnife Trap+19.0%32 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Serpent Form Win Rate by Class

Serpent Form is drafted only by the Silent, where it holds a 34.0% win rate across 242 runs.

The Silentappears in 8.3% of its runs (242 tracked)

Best Relics for Serpent Form

Serpent Form pairs best with the relics Eternal Feather (+25.3%), Fragrant Mushroom (+25.3%), and Happy Flower (+23.9%), ranked by win-rate lift.

Eternal Feather+25.3%31 runsFragrant Mushroom+25.3%18 runsHappy Flower+23.9%39 runsJoss Paper+23.7%18 runsRipple Basin+23.3%20 runsLasting Candy+22.9%23 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Serpent Form Card Details

Serpent Form is a rare power costing 3 energy; it’s upgraded in 35.8% of runs and usually picked up by floor 17.

Whenever you play a card, deal 4 damage to a random enemy.

What Ends Runs with Serpent Form

Serpent Form’s most common run-enders are Knowledge Demon Boss (7.2%), Aeonglass Boss (5.6%), and Decimillipede Elite (5.2%).

• Knowledge Demon Boss7.2% of runs
• Aeonglass Boss5.6% of runs
• Decimillipede Elite5.2% of runs
• Queen Boss3.6% of runs
• Test Subject Boss3.6% of runs

See Also

Compare Serpent Form with the rest of the best Slay the Spire 2 cards, relics, and classes below.