Synchronize•Skill

Is Synchronize good in Slay the Spire 2?

Synchronize is an uncommon Defect skill in Slay the Spire 2. In combat it resolves as: Gain 2 Focus this turn for each unique Orb you have. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 39 recorded runs, decks running it win 29.4% of the time, comfortably clear of the 18.9% average, by 10.5%. It’s a more selective pick, turning up in just 1.0% of decks that could run it. Defect players keep it in 6.7% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to All for One — together they post a +23.5% swing in win rate. It also has strong chemistry with the relic Bag of Marbles, which moves its win rate by +20.3%. At 1 energy, it’s upgraded in 28.9% of runs and usually joins the deck around floor 16.

That’s 10 wins, 24 deaths, and 5 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Test Subject Boss, which closes out 7.7% of its appearances. Read on for Synchronize’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Defect run.

Best Cards to Pair with Synchronize

Ranked by win-rate lift, Synchronize performs best alongside All for One (+23.5%), Compact (+16.9%), and Flak Cannon (+16.3%).

All for One+23.5%5 runsCompact+16.9%6 runsFlak Cannon+16.3%3 runsAdaptive Strike+14.0%6 runsChaos+14.0%7 runsOverclock+14.0%6 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Synchronize Win Rate by Class

Synchronize is drafted only by the Defect, where it holds a 29.4% win rate across 39 runs.

The Defectappears in 6.7% of its runs (39 tracked)

Best Relics for Synchronize

Synchronize pairs best with the relics Bag of Marbles (+20.3%), Meal Ticket (+20.2%), and Red Mask (+17.3%), ranked by win-rate lift.

Bag of Marbles+20.3%8 runsMeal Ticket+20.2%6 runsRed Mask+17.3%8 runsAmethyst Aubergine+16.9%7 runsJoss Paper+16.3%3 runsMango???+16.3%4 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Synchronize Card Details

Synchronize is an uncommon skill costing 1 energy; it’s upgraded in 28.9% of runs and usually picked up by floor 16.

Gain 2 Focus this turn for each unique Orb you have.

What Ends Runs with Synchronize

Synchronize’s most common run-enders are Test Subject Boss (7.7%), The Obscura Normal (5.1%), and Slumbering Beetle Normal (5.1%).

• Test Subject Boss7.7% of runs
• The Obscura Normal5.1% of runs
• Slumbering Beetle Normal5.1% of runs
• Aeonglass Boss5.1% of runs

See Also

Compare Synchronize with the rest of the best Slay the Spire 2 cards, relics, and classes below.