Doubt Curse

Is Doubt good in Slay the Spire 2?

Doubt is a curse Curse curse in Slay the Spire 2. In combat it resolves as: At the end of your turn, if this is in your Hand, gain 1 Weak. It’s a dependable, middle-of-the-pack option, landing at C tier in our rankings.

Across 433 recorded runs, decks running it win 32.9% of the time, comfortably clear of the 14.3% average, by 18.6%. It’s a more selective pick, turning up in just 1.6% of decks that could run it. Across 49 recorded offers it is picked 100.0% of the time (49 runs took it, 0 passed), which is still short of the sample needed to publish a pick-versus-skip win rate. Ironclad players keep it in 1.8% of their runs, so it’s a familiar sight in those decks. On average it shows up 1.1 times in the decks that take it.

It performs best next to Ultimate Defend — together they post a +23.3% swing in win rate. It also has strong chemistry with the relic Sword of Jade, which moves its win rate by +23.3%. At - energy, it’s upgraded in 0.0% of runs and usually joins the deck around floor 30.

That’s 142 wins, 290 deaths, and 1 abandoned runs with it in the deck. The encounter that most often ends a run carrying it is Queen Boss, which closes out 9.7% of its appearances. Read on for Doubt’s complete synergy, class, and threat breakdown to decide whether it earns a slot in your Curse run.

Pick or Skip: Doubt

Doubt is taken in 100.0% of its 49 recorded offers, but with 49 runs picking it and 0 passing, neither side has enough decided runs for a win rate yet.

Taken 49 times out of 49 offers.

A win rate is only shown once that side clears the sample floor. Below it you get the run counts and nothing else — a 0% here would be a reporting artefact, not a result.

Pick rate when offered counts offers, not runs: out of every time the game put this in front of a player, how often it was taken. It is not the same number as the share of runs that end up containing it.

Pick lift is the sample-adjusted gap between runs that took the option and runs that passed on it. It is the fair way to rank choices, because raw win rates put the smallest samples on top.

When to Pick Up Doubt

Doubt is strongest when it joins the deck in Act 3, where runs win 48.1% across 283 runs — one of 3 recorded pickup windows.

Win rate of runs by the act Doubt entered the deck. Acts that have not reached the sample floor show their run count only.

Best Cards to Pair with Doubt

Ranked by win-rate lift, Doubt performs best alongside Ultimate Defend (+23.3%), One-Two Punch (+23.3%), and Pyre (+22.9%).

Ultimate Defend+23.3%19 runsOne-Two Punch+23.3%19 runsPyre+22.9%21 runsMad Science+21.5%31 runsOrbit+21.4%20 runsEvil Eye+20.3%15 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Doubt Win Rate by Class

Doubt is played across 5 classes, led by Ironclad (37.9%), Regent (37.3%), and Silent (34.3%) by win rate.

The Ironclad37.9%103 runsThe Regent37.3%67 runsThe Silent34.3%108 runsThe Necrobinder30.3%66 runsThe Defect23.8%85 runs

Best Relics for Doubt

Doubt pairs best with the relics Sword of Jade (+23.3%), Sparkling Rouge (+22.8%), and Toxic Egg (+22.1%), ranked by win-rate lift.

Sword of Jade+23.3%19 runsSparkling Rouge+22.8%40 runsToxic Egg+22.1%16 runsBag of Preparation+19.9%72 runsNunchaku+19.5%45 runsPear+18.7%41 runs

Based on small co-occurring samples — treat these as early signals, not final verdicts.

Doubt Card Details

Doubt is a curse curse costing - energy; it’s upgraded in 0.0% of runs and usually picked up by floor 30.

At the end of your turn, if this is in your Hand, gain 1 Weak.

What Ends Runs with Doubt

Doubt’s most common run-enders are Queen Boss (9.7%), Test Subject Boss (8.5%), and Aeonglass Boss (6.5%).

• Queen Boss9.7% of runs
• Test Subject Boss8.5% of runs
• Aeonglass Boss6.5% of runs
• Knowledge Demon Boss2.8% of runs
• Mecha Knight Elite2.8% of runs

See Also

Compare Doubt with the rest of the best Slay the Spire 2 cards, relics, and classes below.