Anivia - League of Legends Champion
Win Rate
49.7%
Pick Rate
1.9%

Aniviavs Vayne

CMage
Patch26.4
Matches1,089,240
LaneAll Lanes
TierAll Tiers
Last UpdatedMar 4, 2026
MethodologyData Methodology

Anivia vs Vayne is a decisive matchup in LoL patch 26.4. Anivia wins with a 66.7% win rate (+33.3%) over Vayne based on 6 games. Vayne wins the early laning phase while Anivia scales better into the late game. Below you'll find the best Anivia build, runes, laning stats, and strategies for the Anivia vs Vayne matchup.

Anivia Matchup Breakdown

Use the dropdown to select an opponent and see a detailed breakdown of how Anivia performs against them. You'll get head-to-head win rates, laning stats, the best build and runes for the matchup, and early vs late game analysis — all based on real ranked data.

Compare against an opponent
Vayne - 66.7% win rateVayne(66.7%)
Anivia - 66.7% win rate in this matchup
Anivia
66.7% WR
VS
Vayne vs Anivia matchup - 33.3% win rate
Vayne
33.3% WR

Who Wins the Anivia vs Vayne Matchup?

Anivia wins the Anivia vs Vayne matchup
Winner
Anivia
Matches: 6
66.7%
Win Rate
33.3%
7.1
CS / min
6.9
761
DMG / min
753
13,343
Gold / game
11,851
184
Heal / min
232
545
DMG Mitigated / min
499
1.4
CC / min
0.4
0.0%
Early Game WR
100.0%
100.0%
Late Game WR
0.0%

Anivia vs Vayne Matchup Summary

The Anivia vs Vayne matchup is a decisive matchup in League of Legends ranked play. Based on 6 recent matches analyzed, Anivia wins with a 66.7% win rate compared to Vayne's 33.3%, giving Anivia a 33.3 percentage point advantage. Game phase dynamics play a critical role here: Vayne controls the early laning stage, but Anivia outscales as the game goes longer. The matchup shifts dramatically depending on game length — Vayne needs to press advantages before Anivia reaches their power spikes, while Anivia should focus on safe farming and hitting key item breakpoints. The most significant statistical gap is in crowd control, where Anivia leads by 1.1s CC/min — a difference that heavily influences the outcome of trades and skirmishes. Anivia players can confidently pick into Vayne and play aggressively from level 1. Look to establish lane dominance early through favorable trades and zone Vayne away from CS whenever possible. Understanding these matchup dynamics is essential for champion select decisions and in-game strategy when facing this lane opponent.

Anivia vs Vayne Laning Phase Breakdown

Anivia wins the laning phase against Vayne in League of Legends

Anivia is favored during the laning phase against Vayne, winning 4 out of 5 key stat categories. Anivia holds advantages in farming, damage, gold income and crowd control, making them the stronger laner in this matchup.

Farming
7.1Anivia
6.9Vayne
Anivia and Vayne farm at nearly identical rates in this matchup, with only a 0.2 CS/min difference. Neither champion holds a meaningful farming advantage, so lane dominance will come from trading and jungle interaction rather than CS leads.
Damage
761Anivia
753Vayne
Damage output is virtually even between Anivia and Vayne, with only 8 DMG/min separating them. Fights in this matchup are decided more by ability timing and positioning than raw damage numbers, making mechanical skill the deciding factor in trades.
Economy
13,343Anivia
11,851Vayne
Anivia generates a commanding 1,493 more gold per game than Vayne. This substantial economic advantage means Anivia consistently reaches key item breakpoints earlier, creating a compounding lead that grows throughout the game. Vayne should focus on cost-effective item choices and avoid unnecessary deaths to prevent falling further behind.
Utility
1.4Anivia
0.4Vayne
Anivia brings significantly more crowd control than Vayne, with 1.1 more seconds of CC per minute. This large utility gap makes Anivia far more valuable in setting up jungle ganks, controlling objectives, and locking down targets in team fights. Vayne should invest in tenacity and position carefully to avoid being chain-CC'd.
Sustain
729Anivia
731Vayne
Anivia and Vayne have comparable sustain profiles, with only 2 HP/min separating their healing and damage mitigation. Neither champion can out-attrition the other in lane, so trades will be decided by burst potential and ability usage rather than sustain.

Best Anivia Build Against Vayne

Plated Steelcaps is the optimal boots choice against Vayne, providing the mobility and stats Anivia needs most in this matchup. The top-performing core items for Anivia against Vayne are Liandry's Torment, Malignance and Rylai's Crystal Scepter. This combination gives Anivia an effective balance of damage, survivability, and utility for the matchup. This build performs exceptionally well, achieving a 100.0% win rate across 1 games — well above average and making it the top item path against Vayne. Adjustments may be needed based on team compositions and game state, but this build provides the strongest foundation for the Anivia vs Vayne matchup.

Early Game vs Late Game

Early Game
Vayne
100.0%
+100.0% advantage
Anivia early game win rateAnivia0.0%
Vayne early game win rateVayne100.0%
Late Game
Anivia
100.0%
+100.0% advantage
Anivia late game win rateAnivia100.0%
Vayne late game win rateVayne0.0%

Vayne dominates the early game (first 15 minutes) with a commanding 100.0% win rate — a 100.0 percentage point lead over Anivia. This lopsided early game means Vayne can dictate the pace of the lane from level 1, controlling trades, wave state, and river priority.

Anivia is far superior in the late game (25+ minutes), boasting a 100.0% win rate — 100.0 points above Vayne. Extended games heavily favor Anivia, whose kit and scaling make them a dominant force in team fights and objective control.

This matchup features a dramatic power shift: Vayne must aggressively press their early advantage and close out the game before Anivia reaches their scaling breakpoints. If Anivia survives the laning phase without falling too far behind, the matchup flips in their favor. Dragon and Rift Herald control are pivotal — the team that secures early objectives can snowball or buy time to scale.

Best Anivia Runes Against Vayne

Sorcery rune tree - Anivia primary runes vs VayneSorcery
Arcane Comet - best Anivia rune vs VayneManaflow Band - best Anivia rune vs VayneTranscendence - best Anivia rune vs VayneScorch - best Anivia rune vs Vayne
Precision rune tree - Anivia secondary runes vs VaynePrecision
Coup de Grace - best Anivia rune vs VaynePresence of Mind - best Anivia rune vs Vayne
100.0% WR

Running Sorcery primary with Precision secondary allows Anivia to press their advantage against Vayne, amplifying the strengths that make this a favorable matchup.


Anivia matchup data for League of Legends patch 26.4. The table below shows Anivia's win rate, gold difference, and performance stats against every champion in the current meta. Click any champion name to see a detailed head-to-head breakdown including the best Anivia build, runes, laning stats, and early vs late game analysis for that specific matchup.

Anivia matchup win rates and stats in League of Legends patch 26.4
Opponent
Win Rate
Matches
CS/min
DMG/min
Gold/game
Early WR
Late WR
47.39%2126.872911,35850.0%44.9%
46.47%1706.681711,89743.4%48.9%
41.96%1436.872711,75952.5%34.5%
47.41%1164.671011,36142.5%50.7%
47.71%1106.680511,87837.2%54.5%
50.00%1047.068711,36543.1%56.6%
50.50%1026.073411,65553.5%48.3%
62.07%876.786511,87271.8%54.2%
52.38%856.973411,31653.3%51.3%
44.44%836.978311,06948.7%40.5%
51.85%826.575311,53250.0%53.5%
46.67%756.588211,74047.1%46.3%
42.67%756.276311,57831.3%51.2%
52.86%706.371211,25853.3%52.5%
53.97%637.387512,06963.3%45.5%
44.44%636.579611,83534.6%51.4%
39.68%631.65249,15750.0%32.4%
54.10%616.584411,01350.0%60.0%
44.83%596.974712,43543.5%45.7%
61.02%597.182112,56060.7%61.3%
58.49%536.783211,76045.5%67.7%
44.23%534.970411,30847.8%41.4%
57.69%536.768411,46255.6%60.0%
57.69%526.470411,06745.8%67.9%
63.46%526.775111,89165.2%62.1%
50.00%467.091811,85550.0%50.0%
44.19%446.478511,68533.3%52.0%
61.36%446.785812,42264.7%59.3%
46.51%436.781112,46760.0%39.3%
45.24%431.959711,17735.7%50.0%
54.76%422.661610,68362.5%50.0%
45.24%427.085211,67352.4%38.1%
47.62%426.973911,35457.9%39.1%
43.59%392.161710,43530.8%50.0%
57.89%386.979311,20769.6%40.0%
45.71%356.872912,32053.3%40.0%
47.06%342.659910,71660.0%41.7%
65.63%344.384710,77282.3%46.7%
54.55%331.859810,18240.0%66.7%
42.42%333.36609,94953.3%33.3%
53.33%306.584013,38455.6%52.4%
66.67%306.580912,18460.0%70.0%
50.00%305.069910,02856.3%42.9%
62.07%296.278513,33383.3%56.5%
29.63%276.599212,33718.2%37.5%
55.56%276.878412,61772.7%43.8%
53.85%266.892211,37761.5%46.1%
44.00%256.864310,57453.9%33.3%
60.00%256.178212,02575.0%52.9%
48.00%252.15979,76153.9%41.7%
56.00%256.91,01913,29442.9%61.1%
52.00%252.25969,58150.0%53.3%
54.17%242.76858,47147.1%71.4%
50.00%246.11,01312,35744.4%53.3%
52.17%245.692511,88257.1%50.0%
62.50%246.974211,31572.7%53.9%
50.00%241.959710,46557.1%47.1%
70.83%243.458710,14450.0%81.3%
68.18%236.679512,19566.7%69.2%
47.83%236.677811,63361.5%30.0%
52.38%227.482712,21666.7%41.7%
50.00%221.84898,88945.5%54.5%
63.64%222.16059,82350.0%75.0%
50.00%225.070511,62357.1%46.7%
54.55%221.95948,77572.7%36.4%
59.09%221.859110,31471.4%53.3%
45.45%221.95089,98150.0%42.9%
26.32%196.765511,72125.0%27.3%
52.94%176.488212,95744.4%62.5%
75.00%166.679412,43283.3%70.0%
53.33%164.174911,90880.0%40.0%
43.75%165.778611,93250.0%33.3%
37.50%167.07209,81554.5%0.0%
81.25%166.47889,85370.0%100.0%
46.67%155.77259,59050.0%40.0%
46.67%155.56748,96854.5%25.0%
40.00%156.877313,14857.1%25.0%
42.86%146.485212,17880.0%22.2%
35.71%141.65439,7230.0%55.6%
35.71%142.14728,22950.0%16.7%
38.46%136.052710,24833.3%50.0%
38.46%135.483113,811100.0%27.3%
30.77%135.87307,58730.0%33.3%
33.33%127.180411,57640.0%28.6%
25.00%123.46779,80150.0%0.0%
58.33%126.498411,96471.4%40.0%
33.33%121.65229,58342.9%20.0%
45.45%116.779111,7280.0%71.4%
63.64%111.558610,75666.7%62.5%
54.55%115.376410,61628.6%100.0%
63.64%117.786013,18366.7%60.0%
36.36%115.670711,49366.7%25.0%
36.36%116.07149,9750.0%80.0%
36.36%116.370310,54220.0%50.0%
63.64%116.780212,32850.0%71.4%
70.00%102.86199,52833.3%85.7%
50.00%107.272810,47633.3%75.0%
30.00%106.799312,58366.7%14.3%
20.00%106.999711,61625.0%16.7%
70.00%107.069712,15183.3%50.0%
40.00%106.579111,00457.1%0.0%
66.67%107.279210,89583.3%33.3%
37.50%93.859710,19933.3%40.0%
33.33%96.865510,69220.0%50.0%
55.56%96.578113,81533.3%66.7%
44.44%92.368711,15925.0%60.0%
25.00%86.981411,74220.0%33.3%
62.50%82.455610,25260.0%66.7%
14.29%75.373911,1050.0%33.3%
57.14%76.883311,81650.0%66.7%
71.43%71.65268,33875.0%66.7%
66.67%66.781413,15550.0%75.0%
33.33%62.25859,29366.7%0.0%
33.33%64.44827,28940.0%0.0%
66.67%66.81,12014,638100.0%60.0%
66.67%67.176113,3430.0%100.0%
50.00%67.080212,13733.3%66.7%
33.33%67.194612,48850.0%25.0%
66.67%66.087611,03766.7%66.7%
50.00%65.783711,72050.0%50.0%
50.00%56.767411,95350.0%50.0%
80.00%57.373011,290100.0%50.0%
80.00%56.187315,369100.0%75.0%
80.00%56.51,05512,320100.0%66.7%
60.00%57.086613,182100.0%33.3%
60.00%56.36319,13450.0%100.0%
60.00%56.479114,209100.0%33.3%
20.00%57.187712,6340.0%25.0%
20.00%56.81,03815,65650.0%0.0%
40.00%55.986713,92150.0%33.3%
🔍

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Anivia vs Vayne - Frequently Asked Questions

How does Anivia do against Vayne in League of Legends?

Anivia wins the Anivia vs Vayne matchup with a 66.7% win rate compared to Vayne's 33.3%, a 33.3 percentage point difference. This data is based on 6 recent ranked games in patch 26.4.

How does Anivia do against Vayne in the early game?

In the early game, Vayne has the advantage against Anivia with a 100.0% win rate versus 0.0%. Vayne players should look to press their lane advantage through aggressive trades and wave control during the first 15 minutes.

How does Anivia do against Vayne in the late game?

In the late game, Anivia takes over the Anivia vs Vayne matchup with a 100.0% win rate compared to 0.0%. Anivia scales better into team fights and objective contests after 25 minutes.

Who wins the Anivia vs Vayne matchup?

Anivia wins the matchup against Vayne with a 66.7% win rate in League of Legends patch 26.4. The 33.3 percentage point advantage means Anivia is significantly favored in this lane matchup based on 6 games analyzed.

What is the best Anivia build against Vayne?

The best Anivia build against Vayne includes Liandry's Torment, Malignance, Rylai's Crystal Scepter with Plated Steelcaps. This build achieves a 100.0% win rate in the matchup. Check the matchup breakdown above for the full item path and build order.

What are the best Anivia runes against Vayne?

The best Anivia runes against Vayne use the Sorcery primary tree with Precision secondary. This rune setup achieves a 100.0% win rate in the Anivia vs Vayne matchup. See the full rune breakdown in the matchup comparison above.

Does Anivia counter Vayne?

Yes, Anivia has a favorable matchup against Vayne with a 66.7% win rate. Anivia strongly counters Vayne in lane based on current patch 26.4 data.

How do I play Anivia against Vayne?

When playing Anivia against Vayne, leverage your statistical advantages by trading aggressively during favorable windows. Play safe early and scale into your power spikes where you outperform Vayne. Build the recommended items and runes for this specific matchup for the best results.